NPJ Parkinson's Disease最新文献_第7页

EGFR phosphorylates DNAJB1 to suppress α-synuclein aggregation in Parkinson’s disease EGFR磷酸化DNAJB1抑制帕金森病α-突触核蛋白聚集

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-06-07 DOI: 10.1038/s41531-025-01006-y

Yun-Yu Huang, Sue-Jane Lin, Wei-Yu Chiang, Yuan-Teng Chang, Chan-Chih Yang, Chia-Yu Liao, Ya-Lan Chang, Chin-Hsien Lin, Shu-Chun Teng

引用次数: 0

Brain-clinical biotyping in patients with idiopathic REM sleep behavior disorder 特发性REM睡眠行为障碍患者的脑临床生物分型研究

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-06-07 DOI: 10.1038/s41531-025-01012-0

Shi Tang, Bei Huang, Yanlin Wang, Yaping Liu, Jing Wang, Li Zhou, Siyi Gong, Yuhua Yang, Joey WY Chan, Steven WH Chau, Winnie CW Chu, Jill Abrigo, Jean-François Gagnon, Yun Kwok Wing

{"title":"Brain-clinical biotyping in patients with idiopathic REM sleep behavior disorder","authors":"Shi Tang, Bei Huang, Yanlin Wang, Yaping Liu, Jing Wang, Li Zhou, Siyi Gong, Yuhua Yang, Joey WY Chan, Steven WH Chau, Winnie CW Chu, Jill Abrigo, Jean-François Gagnon, Yun Kwok Wing","doi":"10.1038/s41531-025-01012-0","DOIUrl":"https://doi.org/10.1038/s41531-025-01012-0","url":null,"abstract":"Idiopathic REM sleep behavior disorder (iRBD) is a prodromal stage of α-synucleinopathies including Parkinson’s disease (PD), yet its clinical heterogeneity remains underexplored. This study aimed to identify novel brain-clinical biotypes in iRBD by integrating structural MRI and clinical assessments. We included 172 patients with video-polysomnography-confirmed iRBD and 126 controls who underwent multimodal MRI and clinical evaluation. Similarity Network Fusion was used to integrate cortical thickness, surface area, subcortical volume, and clinical data, followed by spectral clustering to identify iRBD biotypes. Two distinct biotypes were identified: Biotype 1 showed widespread cortical-subcortical-cerebellar atrophy, functional hypoconnectivity, more motor and cognitive deficits with higher prodromal PD risk; Biotype 2 demonstrated increased surface area in limbic and parietal regions, cortical-cerebellar hyperconnectivity, and preserved neurocognitive function. These findings underscore the presence of distinct neurobiological subtypes in iRBD, highlighting the need for longitudinal monitoring to clarify their trajectories and implications for disease progression.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"70 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144237421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripheral inflammation’s variable impact on cognitive and symptomatic outcomes in Parkinson’s disease: a longitudinal and cross-sectional analysis 外周炎症对帕金森病认知和症状结局的可变影响：纵向和横断面分析

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-06-07 DOI: 10.1038/s41531-025-01019-7

Peikun He, Yanyi Li, Zhiheng Huang, Yuyuan Gao, Qingrui Duan, Yihui Qiu, Shujun Feng, Ruiyun Huang, Liangxu Gong, Guixian Ma, Yuhu Zhang, Lin Shi, Lijuan Wang, Kun Nie

{"title":"Peripheral inflammation’s variable impact on cognitive and symptomatic outcomes in Parkinson’s disease: a longitudinal and cross-sectional analysis","authors":"Peikun He, Yanyi Li, Zhiheng Huang, Yuyuan Gao, Qingrui Duan, Yihui Qiu, Shujun Feng, Ruiyun Huang, Liangxu Gong, Guixian Ma, Yuhu Zhang, Lin Shi, Lijuan Wang, Kun Nie","doi":"10.1038/s41531-025-01019-7","DOIUrl":"https://doi.org/10.1038/s41531-025-01019-7","url":null,"abstract":"Increasing evidence supported a link between peripheral inflammation and Parkinson’s disease (PD). However, the role of peripheral inflammation in the progression of PD clinical symptoms remained unclear. This study evaluates peripheral inflammation using serum differential leukocyte counts and their derived ratios. A total of 170 PD patients were retrospectively enrolled from Guangdong Provincial People’s Hospital (GDPH) and 68 from PPMI. Partial correlation analysis showed that neutrophil-to-lymphocyte ratio (NLR) negatively correlated with MoCA in GDPH but not in PPMI. Moreover, peripheral inflammation was shown to correlate with white matter integrity. The result of the longitudinal analysis showed that higher baseline NLR predicted worsening in letter number sequencing (LNS) score. Path analysis indicated that white matter integrity significantly mediated the relationship between NLR and cognitive change in the LNS score from Year 5 to baseline. Peripheral inflammation is associated with global cognition and white matter integrity in PD and predicts cognitive decline.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"6 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144237135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing wrist-worn wearable compliance with insights from two Parkinson’s disease cohort studies 根据两项帕金森病队列研究的见解优化腕戴式可穿戴设备的依从性

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-06-06 DOI: 10.1038/s41531-025-01016-w

Marjan J. Meinders, Laura Heathers, King Chung Ho, Laura Russell, Chris Li, Bastiaan R. Bloem, William J. Marks Jr, Ritu Kapur

{"title":"Optimizing wrist-worn wearable compliance with insights from two Parkinson’s disease cohort studies","authors":"Marjan J. Meinders, Laura Heathers, King Chung Ho, Laura Russell, Chris Li, Bastiaan R. Bloem, William J. Marks Jr, Ritu Kapur","doi":"10.1038/s41531-025-01016-w","DOIUrl":"https://doi.org/10.1038/s41531-025-01016-w","url":null,"abstract":"Wearable technologies enable real-time, continuous, noninvasive data collection, where long-term compliance is essential. The Personalized Parkinson Project (PPP) and the Parkinson’s Progression Markers Initiative (PPMI) utilized the Verily Study Watch. Participants, including people diagnosed with Parkinson’s disease (PD), prodromal PD, and healthy controls, were instructed to wear the watch for up to 23 h daily without data displaying or reporting data back to the participant. Compliance measures and user experiences were evaluated. A centralized support model identified barriers to data collection and enabled proactive outreach. Median daily wear time was 21.9 h for PPP and 21.1–22.2 h per day for PPMI over 2 years. Participants were highly motivated contributing to PD research. These results highlight strategies for achieving strong engagement without providing individual data. This approach offers valuable insights for study designs where returning data to participants could introduce bias or affect the data integrity.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"9 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automatic analysis of eyelid movement in de-novo Parkinson’s disease 新生帕金森病眼睑运动的自动分析

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-06-06 DOI: 10.1038/s41531-025-01021-z

Louis Kälble, Tereza Tykalova, David Zogala, Petr Dusek, Jan Rusz, Michal Novotny

{"title":"Automatic analysis of eyelid movement in de-novo Parkinson’s disease","authors":"Louis Kälble, Tereza Tykalova, David Zogala, Petr Dusek, Jan Rusz, Michal Novotny","doi":"10.1038/s41531-025-01021-z","DOIUrl":"https://doi.org/10.1038/s41531-025-01021-z","url":null,"abstract":"This study presents an automated, objective method for eyelid movement assessment in de-novo Parkinson’s disease(PD) using a one-dimensional camera setup during monologue. These measurements were related to Dopamine Transporter Single Photon Emission Tomography and clinical scores. State-of-the-art computer-vision technologies and deep-learning neural networks were utilized to measure fourteen eyelid movement markers describing blinking and eyelid kinematics. Video-recordings were collected from a total of 120 de-novo patients with PD and 55 healthy controls. Abnormal blinking was present in 38% of PD, indicated by a reduced blink rate (p < 0.001), an increased inter-blink interval (p < 0.001), and an increased rigidity of the palpebral aperture (p < 0.001). The classification experiment reached an area under the curve of 0.81 on a blinded test set. The blink rate correlated with the loss of nigral dopaminergic neurons (r = 0.35, p < 0.001). These findings suggest eyelid movement markers as strong reflections of striatal dopaminergic activity levels, underscoring the method’s potential as a reliable early PD biomarker.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"75 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144237140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New diagnostic and staging framework applied to established PD in the BioFIND cohort 新的诊断和分期框架应用于已建立的PD在BioFIND队列

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-06-04 DOI: 10.1038/s41531-025-00992-3

Marco J. Russo, Un Jung Kang

引用次数: 0

Lactobacillus reuteri-derived γ-amino butyric acid alleviates MPTP-induced Parkinson’s disease through inhibiting ferroptosis via the AKT-GSK3β-GPX4 axis 罗伊氏乳杆菌衍生的γ-氨基丁酸通过AKT-GSK3β-GPX4轴抑制铁下垂，减轻mptp诱导的帕金森病

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-06-04 DOI: 10.1038/s41531-025-01022-y

Xuechao Dong, Teng Yang, Zheng Jin

{"title":"Lactobacillus reuteri-derived γ-amino butyric acid alleviates MPTP-induced Parkinson’s disease through inhibiting ferroptosis via the AKT-GSK3β-GPX4 axis","authors":"Xuechao Dong, Teng Yang, Zheng Jin","doi":"10.1038/s41531-025-01022-y","DOIUrl":"https://doi.org/10.1038/s41531-025-01022-y","url":null,"abstract":"Parkinson’s disease (PD) is a debilitating neurological disorder characterized by motor dysfunction, which has been associated with alterations in the gut microbiota. Lactobacillus reuteri (L. reuteri), a safe and versatile probiotic, exhibits potent immunomodulatory functions and neuroprotective effects. However, the extent and mechanisms by which L. reuteri mitigates PD remain unclear. Here, we demonstrated that L. reuteri significantly alleviated MPTP-induced PD in mice. Importantly, we found that the protective effects of L. reuteri are mediated by its bioactive metabolites rather than the bacteria themselves. Specifically, L. reuteri elevated the levels of γ-aminobutyric acid (GABA). Administration of GABA to mice mitigated MPTP-induced PD. Mechanistically, GABA inhibited MPTP-induced ferroptosis in neuronal cells through activation of the AKT-GSK3β-GPX4 pathway via the GABA receptor. Collectively, our research elucidates that L. reuteri-derived GABA attenuates MPTP-induced PD by inhibiting ferroptosis via the AKT-GSK3β-GPX4 axis, providing a potential therapeutic approach for the prevention and treatment of PD.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"331 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of virtual reality on spatiotemporal gait parameters and freezing of gait in Parkinson’s disease 虚拟现实技术对帕金森病患者时空步态参数及步态冻结的影响

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-06-04 DOI: 10.1038/s41531-025-01017-9

Lei Ma, Bar Yosef, Ipek Talu, Daniel Batista, Emi Jenkens-Drake, Nanthia Suthana, Katy A Cross

引用次数: 0

Association between functional gastrointestinal disorders and Parkinson’s disease in a prospective cohort study 一项前瞻性队列研究中功能性胃肠疾病与帕金森病的关系

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-06-04 DOI: 10.1038/s41531-025-01000-4

Yixiang Lin, Haoling Xu, Jiayi Zheng, Tianxin Lin, Minhui Wang, Tingting Huang, Fabin Lin, Qinyong Ye, Guoen Cai

引用次数: 0

Lower prevalence of metabolic syndrome and its components in the prediagnostic phase of Parkinson’s disease 帕金森病诊断前阶段代谢综合征及其组成部分患病率较低

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-06-04 DOI: 10.1038/s41531-025-01003-1

Hila Avisar, Uri Greenbaum, Ruth Djaldetti, Boaz Lerner

{"title":"Lower prevalence of metabolic syndrome and its components in the prediagnostic phase of Parkinson’s disease","authors":"Hila Avisar, Uri Greenbaum, Ruth Djaldetti, Boaz Lerner","doi":"10.1038/s41531-025-01003-1","DOIUrl":"https://doi.org/10.1038/s41531-025-01003-1","url":null,"abstract":"Investigating the association between metabolic syndrome (MetS) and all its components with prediagnostic Parkinson’s disease (PD) may clarify PD pathogenesis and identify candidates for prevention strategies and neuroprotective trials. We conducted a retrospective study of 890 PD patients diagnosed during 2000-2020 and 8,100 matched controls, analyzing electronic health records up to 15 years before PD diagnosis. Prevalence was assessed annually to track changes in association strength over time. PD patients consistently showed lower MetS prevalence (OR = 0.57–0.8). Compared to controls, PD patients had lower triglycerides (OR = 0.44–0.75), BMI (OR = 0.54–0.65), and hyperglycemia (OR = 0.81–0.86) rates, and females showed higher high-density lipoprotein (HDL) (OR = 1.48–1.82), lower low-density lipoprotein/HDL ratio (OR = 0.46–0.64), and reduced hypertension (OR = 0.79–0.85). These findings suggest an inverse association between MetS and PD years before diagnosis. We propose a lipid–blood pressure index incorporating triglycerides, HDL, and hypertension as a potential clinical tool for PD risk stratification.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"51 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0