NPJ Parkinson's Disease最新文献

The effects of aquaporin-4 polymorphisms on glymphatic function and motor symptoms in Parkinson's disease.

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-10-08 DOI: 10.1038/s41531-025-01139-0

Jianmei Qin,Yi Fang,Xiaojie Duanmu,Jiaqi Wen,Haoting Wu,Chenqing Wu,Tao Guo,Cheng Zhou,Qianshi Zheng,Weijin Yuan,Zihao Zhu,Jingwen Chen,Jingjing Wu,Mengze Jiang,Baorong Zhang,Xiaojun Xu,Xiaojun Guan,Minming Zhang

{"title":"The effects of aquaporin-4 polymorphisms on glymphatic function and motor symptoms in Parkinson's disease.","authors":"Jianmei Qin,Yi Fang,Xiaojie Duanmu,Jiaqi Wen,Haoting Wu,Chenqing Wu,Tao Guo,Cheng Zhou,Qianshi Zheng,Weijin Yuan,Zihao Zhu,Jingwen Chen,Jingjing Wu,Mengze Jiang,Baorong Zhang,Xiaojun Xu,Xiaojun Guan,Minming Zhang","doi":"10.1038/s41531-025-01139-0","DOIUrl":"https://doi.org/10.1038/s41531-025-01139-0","url":null,"abstract":"Growing evidence suggests that the glymphatic system, driven by aquaporin-4 (AQP4) water channels, plays a key role in Parkinson's disease (PD). We examined the impact of specific AQP4 variants on glymphatic function using diffusion tensor imaging along the perivascular space (DTI-ALPS), and explored potential mechanisms underlying motor symptom severity and progression in PD. PD participants exhibited lower DTI-ALPS indices compared to controls. Reduced DTI-ALPS at baseline was linked to more severe motor symptoms and faster longitudinal motor decline, as assessed by the Movement Disorder Society-Unified Parkinson's Disease Rating Scale, Part III (MDS-UPDRS III). One specific AQP4 variant was associated with decreased DTI-ALPS and increased MDS-UPDRS III scores, with DTI-ALPS mediating this relationship at baseline and follow-up. Some variants exhibited indirect protective effects on motor symptoms via enhanced glymphatic function. These findings indicate that AQP4 polymorphisms contribute to glymphatic dysfunction and motor progression in PD, supporting strategies for disease modification.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"22 1","pages":"288"},"PeriodicalIF":8.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subjective cognitive decline in individuals with isolated REM sleep behavior disorder. 孤立的快速眼动睡眠行为障碍患者的主观认知能力下降。

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-10-07 DOI: 10.1038/s41531-025-01161-2

Anja Ophey,Sinah Röttgen,Christopher E J Doppler,Daniel Scharfenberg,Konstantin Kufer,Ezequiel Farrher,Gereon R Fink,Michael Sommerauer,Elke Kalbe

{"title":"Subjective cognitive decline in individuals with isolated REM sleep behavior disorder.","authors":"Anja Ophey,Sinah Röttgen,Christopher E J Doppler,Daniel Scharfenberg,Konstantin Kufer,Ezequiel Farrher,Gereon R Fink,Michael Sommerauer,Elke Kalbe","doi":"10.1038/s41531-025-01161-2","DOIUrl":"https://doi.org/10.1038/s41531-025-01161-2","url":null,"abstract":"Subjective cognitive decline (SCD) may constitute an early marker of mild cognitive impairment (MCI) in individuals with isolated REM sleep behavior disorder (iRBD). In this cross-sectional study, 80 individuals with iRBD were classified into iRBD with MCI (RBD.MCI), with SCD (RBD.SCD+), and without both (RBD.SCD-) based on neuropsychological testing and the Multi-SubCoDE questionnaire. The prevalence of SCD in iRBD was 36.3%, with predominance of the amnestic multi-domain SCD profile. RBD.SCD+ reported more severe depressive symptoms than RBD.SCD- and showed lower cognitive performance than RBD.SCD- in global cognition and attention & working memory. Magnetic resonance imaging analyses revealed lower grey matter volume in the left superior frontal gyrus for RBD.SCD+ than RBD.SCD-, which was associated with increased SCD-severity and lower global cognition. SCD without MCI in iRBD is associated with subtle cognitive deficits and structural brain changes. The prognostic value of SCD in iRBD should be further determined in longitudinal studies.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"128 1","pages":"287"},"PeriodicalIF":8.7,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Capsaicin and nicotine alleviate MPTP induced olfactory dysfunction by suppressing cGAS/TBK1/STING and MAPK mediated neuroinflammation. 辣椒素和尼古丁通过抑制cGAS/TBK1/STING和MAPK介导的神经炎症来缓解MPTP诱导的嗅觉功能障碍。

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-10-03 DOI: 10.1038/s41531-025-01135-4

Jingjing Wei,Linhai Wang,Dingzhong Wang,Weiwei Chen,Lulu Guo,Mengqian Ren,Fangxin Guo,Sisi Ruan,Hangcui Hu,Yao Zheng,Siqi Nan,Zhiwen Xu,Yan Li,Hang Yuan,Jian Mao,Yan Xu,Jianping Xie

{"title":"Capsaicin and nicotine alleviate MPTP induced olfactory dysfunction by suppressing cGAS/TBK1/STING and MAPK mediated neuroinflammation.","authors":"Jingjing Wei,Linhai Wang,Dingzhong Wang,Weiwei Chen,Lulu Guo,Mengqian Ren,Fangxin Guo,Sisi Ruan,Hangcui Hu,Yao Zheng,Siqi Nan,Zhiwen Xu,Yan Li,Hang Yuan,Jian Mao,Yan Xu,Jianping Xie","doi":"10.1038/s41531-025-01135-4","DOIUrl":"https://doi.org/10.1038/s41531-025-01135-4","url":null,"abstract":"Olfactory dysfunction serves as a potential early diagnostic biomarker for Parkinson's disease (PD), providing essential evidence for investigating PD pathogenesis and developing neuroprotective strategies. Capsaicin (CAP) and nicotine (Nic), pungent flavor compounds derived from Solanaceae plants, exhibit anti-inflammatory properties. Epidemiological studies indicate that higher levels of chili pepper consumption and smoking are inversely associated with PD risk. However, the mechanisms of CAP and Nic against PD-related olfactory dysfunction remain unclear. In this study, we observed that CAP and Nic ameliorated olfactory dysfunction in MPTP intranasal-treated PD mice and alleviated dopaminergic damage in key brain regions including the olfactory bulb, anterior olfactory nucleus, striatum and substantia nigra. Both compounds suppressed microglial activation in these regions, downregulated IL-6 expression, and upregulated TGF-β protein levels. Furthermore, our findings demonstrated that CAP and Nic could effectively mitigate MPTP-induced olfactory deficits by attenuating neuroinflammation mediated through the cGAS/TBK1/STING and MAPK signaling.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"78 1","pages":"285"},"PeriodicalIF":8.7,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating Parkinson's disease biomarkers in substantia nigra following sublethal γ-radiation exposure in a large animal model. 在大型动物模型中评估亚致死γ辐射暴露后黑质中的帕金森病生物标志物。

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-10-03 DOI: 10.1038/s41531-025-01136-3

Erin K Murphy,Daniel P Perl,Regina M Day,Diego Iacono

{"title":"Evaluating Parkinson's disease biomarkers in substantia nigra following sublethal γ-radiation exposure in a large animal model.","authors":"Erin K Murphy,Daniel P Perl,Regina M Day,Diego Iacono","doi":"10.1038/s41531-025-01136-3","DOIUrl":"https://doi.org/10.1038/s41531-025-01136-3","url":null,"abstract":"Idiopathic Parkinson's Disease (iPD) involves genetic and environmental factors, including ionizing radiation. While high-dose radiation induces neurodegeneration, the effects of low-dose radiation (LDR) remain unclear. This study examined the impact of a single acute total-body LDR exposure (1.79 Gy) on the substantia nigra (SN) of swine, a large mammal model closely resembling humans. Fourteen male Göttingen minipigs were assigned to radiation (RAD; n = 6) or sham (SH; n = 8) groups. We analyzed iPD-related markers (α-synuclein, phosphorylated α-syn, tyrosine hydroxylase), genetic PD markers (LRRK2, GBA, VPS13C, Cathepsin D), neuroinflammation (GFAP), and mitochondrial proteins (ATP5A, SDHB, NDUF8). No significant molecular, histological, or immunohistochemical differences were observed between RAD and SH animals. LRRK2 was undetectable, and no structural damage or neuroglial changes were found. These findings suggest that single acute LDR exposure does not elicit short-term PD-related alterations in the SN of swine, although long-term or cumulative effects warrant further investigation.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"105 1","pages":"286"},"PeriodicalIF":8.7,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resting and action tremor in Parkinson's disease: pathophysiological insights from long-term STN-DBS. 帕金森病的静息和活动性震颤：来自长期STN-DBS的病理生理学见解

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-10-02 DOI: 10.1038/s41531-025-01130-9

Alessandro Zampogna,Antonio Suppa,Martina Patera,Francesco Cavallieri,Francesco Bove,Valerie Fraix,Anna Castrioto,Emmanuelle Schmitt,Pierre Pelissier,Stephan Chabardes,Sara Meoni,Elena Moro

{"title":"Resting and action tremor in Parkinson's disease: pathophysiological insights from long-term STN-DBS.","authors":"Alessandro Zampogna,Antonio Suppa,Martina Patera,Francesco Cavallieri,Francesco Bove,Valerie Fraix,Anna Castrioto,Emmanuelle Schmitt,Pierre Pelissier,Stephan Chabardes,Sara Meoni,Elena Moro","doi":"10.1038/s41531-025-01130-9","DOIUrl":"https://doi.org/10.1038/s41531-025-01130-9","url":null,"abstract":"Tremor is a well-recognized sign of Parkinson's disease (PD), yet its long-term evolution remains unclear, particularly regarding the relationship between resting and action tremor. This retrospective study examined resting and action tremor using specific UPDRS-III subitems in 301 PD patients treated with bilateral subthalamic nucleus deep brain stimulation (STN-DBS), assessed preoperatively and at one-year follow-up, with 108 and 57 patients re-evaluated at ten and 15 years, respectively. Most patients (61.8%) had both tremor types, with smaller subsets showing isolated resting (14.3%), action (10.6%), or no tremor (13.3%). Resting tremor responded better to L-Dopa, STN-DBS, and their combination than action tremor (p < 0.05) and remained stable long-term. In contrast, action tremor worsened over time, particularly in tremor-dominant and mixed phenotypes (p < 0.05). A moderate association between tremor types was observed OFF-medication (ρ = 0.59), weakening under treatment (ρ = 0.23/0.30). Action tremor also correlated weakly with bradykinesia and rigidity (ρ = 0.19/0.21). Overall, these differences suggest distinct pathophysiology and neural circuits for resting and action tremor in PD.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"10 1","pages":"284"},"PeriodicalIF":8.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe GBA1 variants drive the GBA1-PD clinical phenotype: implications for counselling and clinical trials. 严重的GBA1变异驱动GBA1- pd临床表型：对咨询和临床试验的影响

IF 8.2 1区医学

NPJ Parkinson's Disease Pub Date : 2025-10-01 DOI: 10.1038/s41531-025-01063-3

Elisa Menozzi, Sara Lucas Del Pozo, Jane Macnaughtan, Roxana Mezabrovschi, Sofia Koletsi, Pierfrancesco Mitrotti, Luca Gallo, Rosaria Calabrese, Marco Toffoli, Nadine Loefflad, Franco Valzania, Francesco Cavallieri, Valentina Fioravanti, Selen Yalkic, Naomi Limbachiya, Fabio Blandini, Micol Avenali, Anthony Hv Schapira

引用次数: 0

Assessing prevalence and risk factors for REM sleep behavior disorder among patients with inflammatory bowel disease. 评估炎症性肠病患者快速眼动睡眠行为障碍的患病率和危险因素。

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-10-01 DOI: 10.1038/s41531-025-01051-7

Vijaya L Reddy,Zihan Chen,Sohail Dewain,Michelle Joo,Maya Bellomo,Erika Renkl,Sapna Patel,Emily Rivera,Laura Weisbein,Ahmed Ali,Michael D Kappelman,Brian B Koo

{"title":"Assessing prevalence and risk factors for REM sleep behavior disorder among patients with inflammatory bowel disease.","authors":"Vijaya L Reddy,Zihan Chen,Sohail Dewain,Michelle Joo,Maya Bellomo,Erika Renkl,Sapna Patel,Emily Rivera,Laura Weisbein,Ahmed Ali,Michael D Kappelman,Brian B Koo","doi":"10.1038/s41531-025-01051-7","DOIUrl":"https://doi.org/10.1038/s41531-025-01051-7","url":null,"abstract":"REM sleep behavior disorder (RBD) and inflammatory bowel disease (IBD) are associated with Parkinson's Disease. Using a cross-sectional design, we assessed RBD prevalence in IBD and controls. In total, 158 controls and 462 IBD patients completed IBD-related history questionnaires, the RBD Single-Question Screen (RBD1Q), and the RBD-Screening Questionnaire. RBD prevalence was compared using chi-squared testing. Logistic regression explored IBD-related factors associated with RBD (RBD1Q), adjusting for age, sex, race, and antidepressant usage. RBD prevalence was higher in IBD (14.1% vs. 5.1%; P = 0.002), driven by differences in women; 13.3% IBD and 1.0% controls had RBD. Among men, 16.0% IBD and 11.9% controls had RBD. IBD was associated with >threefold RBD odds (OR = 3.08, 95% CI [1.43, 6.62], P = 0.003). Men with RBD and IBD had higher IBD-related hospitalization rates than IBD males without RBD (95.2% vs. 63.0%; P = 0.004). RBD is more prevalent in IBD than in controls and is associated with severe IBD.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"19 1","pages":"282"},"PeriodicalIF":8.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered habenular and whole brain functional connectivity in early Parkinson's disease using 7 T MRI. 利用7t MRI观察早期帕金森病的habenal和全脑功能连通性改变。

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-10-01 DOI: 10.1038/s41531-025-00973-6

Bedia Samanci,Ulas Ay,Mark L Kuijf,Sonny Tan,Yasin Temel

{"title":"Altered habenular and whole brain functional connectivity in early Parkinson's disease using 7 T MRI.","authors":"Bedia Samanci,Ulas Ay,Mark L Kuijf,Sonny Tan,Yasin Temel","doi":"10.1038/s41531-025-00973-6","DOIUrl":"https://doi.org/10.1038/s41531-025-00973-6","url":null,"abstract":"Parkinson's disease (PD) is traditionally linked to basal ganglia dysfunction, yet evidence highlights broader network disruptions. Habenula, involved in regulating mood, reward, and motor functions, remains underexplored in PD. This study investigated whole-brain and habenular functional connectivity and their clinical correlates in early-stage PD using 7 T MRI. Functional connectivity was analyzed in 104 early-stage PD and 45 healthy controls. Whole-brain analysis revealed increased connectivity in two clusters in PD: the first involved paracentral lobule, middle frontal gyrus, orbital middle frontal gyrus, precentral gyrus, angular gyrus, middle cingulate gyrus, supplementary motor area; the second included middle cingulate gyrus and cerebellum Crus I. Left habenula showed increased connectivity with right middle temporal and angular gyri (p-FDR = 0.011). Levodopa equivalent daily dose positively correlated with connectivity between postcentral gyrus and cerebellum (p-FDR = 0.020). These findings highlight early motor and cognitive network disruptions and suggest these regions may serve as potential markers of PD-related neurobiological changes.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"29 1","pages":"283"},"PeriodicalIF":8.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Percentile scores for the revised University of Pennsylvania Smell Identification Test for 16,972 individuals 60 years of age and older. 对16972名60岁及以上的人进行了修订后的宾夕法尼亚大学嗅觉识别测试，百分位数得分。

IF 8.2 1区医学

NPJ Parkinson's Disease Pub Date : 2025-10-01 DOI: 10.1038/s41531-025-01095-9

Kerri A Pierz, Whitley Aamodt, Caroline Gochanour, Ryan Kurth, Michael C Brumm, Christopher S Coffey, Laura E Heathers, Michelle Totten, Richard L Doty, Kenneth Marek, Andrew Siderowf

{"title":"Percentile scores for the revised University of Pennsylvania Smell Identification Test for 16,972 individuals 60 years of age and older.","authors":"Kerri A Pierz, Whitley Aamodt, Caroline Gochanour, Ryan Kurth, Michael C Brumm, Christopher S Coffey, Laura E Heathers, Michelle Totten, Richard L Doty, Kenneth Marek, Andrew Siderowf","doi":"10.1038/s41531-025-01095-9","DOIUrl":"10.1038/s41531-025-01095-9","url":null,"abstract":"<p><p>The study goal was to use a very large study cohort to establish normative data for the revised UPSIT (UPSIT-R) and to compare the resultant percentiles to those of the original UPSIT. A second study was performed to compare the performance of these two tests in a cohort of persons with and without Parkinson's disease (PD). UPSIT-R percentiles were derived by age and sex in 16,972 volunteers. Non-parametric statistics were employed to compare the results of those with and without PD. UPSIT-R performance declined with increasing age; deficits were more pronounced in men than women. The magnitude of the difference between the original and revised test percentile scores differed by age and sex. Olfactory deficits in PD were confirmed on the UPSIT-R. This study provides normative data clinically useful for assessing the relative degree of dysfunction in persons 60 years of age and older using the UPSIT-R. Trial Registration Information: ClinicalTrials.gov NCT05065060 .</p>","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"11 1","pages":"280"},"PeriodicalIF":8.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thalamic nuclei volume changes associated with cognitive and motor manifestations of Parkinson's disease. 丘脑核体积变化与帕金森病的认知和运动表现相关。

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-09-30 DOI: 10.1038/s41531-025-01129-2

Vicente J Ferrer-Gallardo,Teresa Esteban-Peñalba,Maria C Rodriguez-Oroz,César Caballero-Gaudes,Pedro M Paz-Alonso

{"title":"Thalamic nuclei volume changes associated with cognitive and motor manifestations of Parkinson's disease.","authors":"Vicente J Ferrer-Gallardo,Teresa Esteban-Peñalba,Maria C Rodriguez-Oroz,César Caballero-Gaudes,Pedro M Paz-Alonso","doi":"10.1038/s41531-025-01129-2","DOIUrl":"https://doi.org/10.1038/s41531-025-01129-2","url":null,"abstract":"Motor and cognitive symptoms are key features of Parkinson's disease (PD), which typically appear over time as the disease progresses. The thalamus, a central hub within basal ganglia-thalamocortical circuits, plays a crucial role in motor, sensory, and cognitive functions. This study examined thalamic nuclei volume and lateralization in individuals with PD and healthy controls, and explored their associations with cognitive and motor measures using partial least squares analysis. We found that cognitive alterations were linked to volume changes in specific nuclei of the anterior, ventral, medial, and posterior thalamic nuclear groups. Notably, the anteroventral and ventral posterolateral nuclei showed strong associations with the Montreal Cognitive Assessment used to assess mild cognitive impairment. Motor impairment was associated with volume lateralization asymmetries in the centromedian, mediodorsal medial, pulvinar anterior, and pulvinar medial nuclei. These findings underscore the multifaceted role of the thalamus in the motor and cognitive manifestations of this neurodegenerative disorder.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"8 1","pages":"279"},"PeriodicalIF":8.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0