Paediatric and perinatal epidemiology最新文献

{"title":"Clearing the Air on Reproductive Health: Unpacking the Impact of PM₂ _.5 Constituents on Fecundability.","authors":"Stefania Papatheodorou","doi":"10.1111/ppe.70008","DOIUrl":"10.1111/ppe.70008","url":null,"abstract":"","PeriodicalId":19698,"journal":{"name":"Paediatric and perinatal epidemiology","volume":" ","pages":"262-264"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postneonatal Cerebral Palsy in Europe: Prevalence and Clinical Characteristics According to Contributory Events: An SCPE Study.","authors":"Malika Delobel-Ayoub, Virginie Ehlinger, Dana Klapouszczak, Anja Troha Gergeli, Elodie Sellier, Katalin Hollody, Daniel Virella, Torstein Vik, Célia Perret, Nicolas Vidart d'Egurbide Bagazgoïtia, Karen Horridge, Catherine Arnaud","doi":"10.1111/ppe.13164","DOIUrl":"10.1111/ppe.13164","url":null,"abstract":"<p><strong>Background: </strong>Postneonatal cerebral palsy (PNCP) is rare and requires large databases to be studied over time.</p><p><strong>Objectives: </strong>To study the time trend of prevalence of PNCP overall and by cause, and to describe the clinical characteristics of children with PNCP according to cause and compared with children with pre/peri/neonatal CP (PPNCP).</p><p><strong>Methods: </strong>The Surveillance of Cerebral Palsy in Europe (SCPE) database was used. Primary events (the first known chronological event in the causal chain) were classified according to the SCPE classification (six main and 19 sub-categories). Prevalence trends for children born during 1976-2012 were modelled using multilevel generalised linear models. The clinical characteristics of PNCP and PPNCP cases born after 1998 were reported as proportions.</p><p><strong>Results: </strong>The prevalence rates of PNCP were 1.76 (95% confidence interval (CI) 1.37, 2.23) and 0.82 per 10,000 live births (95% CI 0.73, 0.92) in children born during 1976-1980 and 2006-2012, respectively. The models showed a 2% annual decline in overall prevalence (prevalence rate multiplied by 0.98 each year) and a 10% decline for infectious causes for every 5-year change. The prevalence rate in children born during 2006-2012 was 0.26 per 10,000 (95% CI 0.21, 0.32) for infectious causes, which remained the most frequent. No trend emerged for other causes. Unilateral spastic CP, associated impairments and severe gross motor dysfunction were more frequent in PNCP than in PPNCP, and PNCP showed predominantly grey matter injury (55.6%). Seventeen percent were born preterm. PNCP differed by cause, with cerebrovascular accidents presenting the least severe and hypoxic causes the most severe forms.</p><p><strong>Conclusion: </strong>Our study confirms the decrease in the prevalence of PNCP in children born up to 2012, particularly for CP, due to infectious causes, which remain the most frequent. Children with PNCP had more severe presentation overall than those with PPNCP, with severity depending on the cause.</p>","PeriodicalId":19698,"journal":{"name":"Paediatric and perinatal epidemiology","volume":" ","pages":"287-298"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11997238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surviving Severe Bleeding After Childbirth: Consequences Along the Life Course?","authors":"Ugochinyere Vivian Ukah, Cande V Ananth","doi":"10.1111/ppe.70015","DOIUrl":"10.1111/ppe.70015","url":null,"abstract":"","PeriodicalId":19698,"journal":{"name":"Paediatric and perinatal epidemiology","volume":" ","pages":"254-255"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11997235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Postneonatally Acquired Cerebral Palsy: Insights From a CP Surveillance Network.","authors":"Hayley Smithers-Sheedy, Sarah McIntyre","doi":"10.1111/ppe.70004","DOIUrl":"10.1111/ppe.70004","url":null,"abstract":"","PeriodicalId":19698,"journal":{"name":"Paediatric and perinatal epidemiology","volume":" ","pages":"299-300"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11997233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Influences on Maternal Health: A Norwegian Register-Based Study.","authors":"Darci N Johnson, Jennifer R Harris, Martin Flatø","doi":"10.1111/ppe.13167","DOIUrl":"10.1111/ppe.13167","url":null,"abstract":"<p><strong>Background: </strong>Maternal health is an important health indicator globally, and a major women's health issue. Efforts to improve maternal health can help ensure that women, their offspring, and their families reach their full potential for health and well-being.</p><p><strong>Objectives: </strong>We analysed how social factors influence adverse maternal health outcomes and non-spontaneous delivery.</p><p><strong>Methods: </strong>We leveraged data from the population-based Norwegian register, including use of the Medical Birth Registry of Norway (MBRN), the Norwegian Patient Registry (NPR), Statistics Norway (SSB) and the Norwegian Control and Payment of Health Reimbursements Database (KUHR), to analyse the relationships between education, income and immigrant status, and 11 adverse health and non-spontaneous delivery. The study included data from 596,306 pregnancies registered in Norway between 2009 and 2018.</p><p><strong>Results: </strong>We found that the frequency of adverse health outcomes and of non-spontaneous delivery decreased with each increase in educational attainment and income. Compared to completion of lower secondary education or less, achieving a graduate-level education was associated with a 36% lower risk of an adverse maternal health outcome after adjusting for age, parity and county. The risk was 18% lower for the highest compared to the lowest income quintile. The highest educated group had 35% lower risk of non-spontaneous delivery than the lowest educated, with the same adjustments. The highest income group had a 16% lower risk of such deliveries than the lowest. Descendants of immigrants face higher risk of adverse health outcomes than immigrants. Higher maternal age partly mitigates the higher health risk among women with low income and education.</p><p><strong>Conclusions: </strong>Even though access to care is more equitable in Norway than in many other countries, we still found a pattern of risk associated with social determinants of health.</p>","PeriodicalId":19698,"journal":{"name":"Paediatric and perinatal epidemiology","volume":" ","pages":"265-273"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technical and Conceptual Considerations When Studying Social Determinants of Maternal Health in Norway.","authors":"Corinne A Riddell","doi":"10.1111/ppe.70013","DOIUrl":"https://doi.org/10.1111/ppe.70013","url":null,"abstract":"","PeriodicalId":19698,"journal":{"name":"Paediatric and perinatal epidemiology","volume":"39 3","pages":"274-276"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Big Data Are Only as Good as the People and the Processes That Create Them: The EUROlinkCAT Success Story.","authors":"Babak Khoshnood","doi":"10.1111/ppe.70014","DOIUrl":"10.1111/ppe.70014","url":null,"abstract":"","PeriodicalId":19698,"journal":{"name":"Paediatric and perinatal epidemiology","volume":" ","pages":"285-286"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11997232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommendations for Improving Surveillance of Congenital Anomalies in Europe Using Healthcare Databases.","authors":"Maria Loane, Joan K Morris, Ester Garne","doi":"10.1111/ppe.13173","DOIUrl":"10.1111/ppe.13173","url":null,"abstract":"<p><strong>Background: </strong>Although accessing administrative data in healthcare databases may be a more time-efficient and cost-effective method of conducting surveillance, there is evidence suggesting that administrative data alone are not sufficient for population-based surveillance of congenital anomalies.</p><p><strong>Objective: </strong>To propose recommendations to maximise the potential use of healthcare databases for surveillance of congenital anomalies based on our data linkage experiences and results from the EUROlinkCAT study.</p><p><strong>Methods: </strong>EUROlinkCAT is a population-based cohort study of 99,416 children with anomalies born between 1995 and 2014. The congenital anomaly case records of children in 11 European congenital anomaly (EUROCAT) registries (eight countries) were linked to standardised administrative healthcare data (birth records, death records and hospital discharge records) to evaluate mortality and morbidity outcomes in these children. Overall, 97% of children with anomalies were successfully matched to their records in their national or regional administrative databases. Recommendations to improve surveillance of anomalies when using healthcare data were developed through establishing and analysing data from this cohort.</p><p><strong>Results: </strong>The primary recommendation is to develop systems to report anomalies diagnosed in foetuses who undergo a termination and link these data to their mothers. Each liveborn baby must be assigned a permanent unique identification number at birth to enable accurate linkage across healthcare databases. Implementing and improving existing algorithms to discriminate between major anomalies and suspected or minor anomalies will improve accuracy in coding. Heterogeneity in coding anomalies will improve by avoiding the use of 'unspecified' or 'other specified' codes in hospital databases. Relaxation of country-specific regulations concerning the suppression of small numbers are necessary to enable data to be combined across European countries.</p><p><strong>Conclusion: </strong>Implementation of these recommendations will enable the information in electronic healthcare databases, in conjunction with Congenital Anomaly registries, to be fully exploited and hence will improve the surveillance of anomalies in children.</p>","PeriodicalId":19698,"journal":{"name":"Paediatric and perinatal epidemiology","volume":" ","pages":"277-284"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11997239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Residential Exposure to PM_2.5 Constituents and Fecundability in a Danish Preconception Cohort.","authors":"Amelia K Wesselink, Benjamin R Johannesen, Tanran R Wang, Matthias Ketzel, Ellen M Mikkelsen, Jørgen Brandt, Jibran Khan, Ole Hertel, Anne Sofie Dam Laursen, Mary D Willis, Jonathan I Levy, Kenneth J Rothman, Henrik T Sørensen, Lauren A Wise, Elizabeth E Hatch","doi":"10.1111/ppe.13174","DOIUrl":"10.1111/ppe.13174","url":null,"abstract":"<p><strong>Background: </strong>Epidemiologic studies have demonstrated that ambient concentrations of particulate matter < 2.5 μm (PM_2.5) are associated with reduced fecundability, the per cycle probability of conception. The specific constituents driving this association are unknown.</p><p><strong>Objectives: </strong>We examined the association between ambient concentrations of PM_2.5 constituents and fecundability in a Danish preconception cohort study.</p><p><strong>Methods: </strong>During 2007-2018, we enrolled female pregnancy planners in an Internet-based preconception cohort study. We included the 5905 participants who had been trying to conceive for < 3 cycles at study enrollment. Participants completed a baseline questionnaire and follow-up questionnaires every 8 weeks to update pregnancy status. We geocoded time-varying residential addresses to estimate ambient concentrations of total PM_2.5 and the following PM_2.5 constituents: elemental carbon (EC), primary organic aerosol (POA), secondary organic aerosols (SOA), sulfate (SO₄ ^2-), ammonium (NH₄ ⁺), nitrate (NO₃ ^-), and sea salt. We averaged concentrations of each pollutant across each menstrual cycle at risk. We fit proportional probabilities regression models to estimate fecundability ratios (FR) and 95% confidence intervals (CI), adjusting for potential confounders and co-pollutants.</p><p><strong>Results: </strong>Total PM_2.5 concentrations were associated with reduced fecundability (the FR for an IQR increase, corresponding to 3.2 μg/m³, was 0.93 [95% CI 0.87, 0.99]). The association was strongest for POA: the FR for an IQR increase, corresponding to 1.3 μg/m³, was 0.92 (95% CI 0.84, 1.01). The corresponding FRs for the remaining PM_2.5 constituents were 0.96 (95% CI 0.87, 1.05) for EC (IQR = 0.5 μg/m³), 0.98 (95% CI 0.91, 1.06) for SOA (IQR = 0.5), 0.97 (95% CI 0.92, 1.02) for SO₂ ^4- (IQR = 0.4), 0.95 (95% CI 0.91, 1.01) for NH₄ ⁺ (IQR = 0.5), 0.97 (95% CI 0.93, 1.01) for NO₃ ^- (IQR = 1.0), and 1.00 (95% CI 0.95, 1.06) for sea salt (IQR = 0.4).</p><p><strong>Conclusions: </strong>In this Danish preconception cohort study, PM_2.5 constituents derived from biomass and transportation-related combustion may drive the association between PM_2.5 concentrations and fecundability.</p>","PeriodicalId":19698,"journal":{"name":"Paediatric and perinatal epidemiology","volume":" ","pages":"256-261"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Women exposed to famine in early gestation have increased mortality up to age 76 years.","authors":"Aline Marileen Wiegersma, Tessa J Roseboom, Susanne R de Rooij","doi":"10.1111/ppe.13131","DOIUrl":"10.1111/ppe.13131","url":null,"abstract":"<p><strong>Background: </strong>We have previously shown that exposure to famine in early gestation was associated with poorer adult health and, in women, with reduced survival up to age 64.</p><p><strong>Objectives: </strong>Here, we explore the association between prenatal famine exposure and mortality up to age 76 for men and women separately.</p><p><strong>Methods: </strong>We studied adult mortality (>18 years) in men (n = 989) and women (n = 1002) born as term singletons around the time of the 1944-1945 Dutch famine. We compared overall and cause-specific mortality among men and women exposed to famine in late, mid, or early gestation to that among unexposed persons (born before or conceived after the famine) using Cox regression.</p><p><strong>Results: </strong>In total, 500 persons (25.1%) had died after age 18. Women exposed to famine in early gestation had higher overall (HR 1.49, 95% CI 1.00, 2.23), cancer (HR 2.17, 95% CI 1.32,3.58) and cardiovascular mortality (HR 2.33, 95% CI 0.91, 5.95) compared to unexposed women. Mortality rates among men were not different between exposure groups.</p><p><strong>Conclusion: </strong>This study showed that women, but not men, exposed to famine in early gestation had increased overall, cardiovascular and cancer mortality up to age 76. Although prenatal famine exposure affects adult health of both men and women, it seems to only lead to increased mortality among women.</p>","PeriodicalId":19698,"journal":{"name":"Paediatric and perinatal epidemiology","volume":" ","pages":"236-241"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11997240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}