Oriental Journal Of Chemistry最新文献

{"title":"An Investigative Study of Medicinal Herbs for Anti-obesity Potential: (A-Review)","authors":"R. Ghai, S. Chaudhary, Kandasamy Nagarajan, Richa Goel, Shardendu Kumar Mishra, Naveen Kumar Tholia, Nazakat Ali, Monika Kaurav","doi":"10.13005/ojc/390605","DOIUrl":"https://doi.org/10.13005/ojc/390605","url":null,"abstract":"Obesity is stated to be a notable concern for public health and plays a significant role in the development of numerous non-communicable diseases (NCDs), including conditions affecting the heart, metabolism, and the nervous system. The use of medicinal plants to maintain normal weight and excellent health has been researched for a very long time. However, sufficient empirical data are still lacking to support the scientific notion of the use of herbal products for weight management. Obesity has traditionally been treated with herbal remedies from both domestic and international sources, including Ayurveda (Indian Traditional Medicine System). This article provides a brief overview of obesity-related disorders and their epidemiology, then discusses the potential anti-obesity effects of plants including Salvia plebian, Glycine max, Curcuma longa, Camellia sinensis, Moringa citrifolia, and others using validated tested animal models. It also focuses on the active phytochemical components that give these substances their anti-obesity properties, such as daidzein, ginsenosides, curcuminoids, zingiberene, curcumene, and ellagitannin. The paper was compiled after going through marketed formulations used worldwide, clinical trials and patents based on herbal products for obesity. This review can assist numerous researchers in conducting additional research on exploring the potential.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"23 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Synthesis and Antimicrobial Activities of Some Aromatic Hydrazones","authors":"Vijay Kumar Yadav, Meena Bhandari, Satbir Singh","doi":"10.13005/ojc/390638","DOIUrl":"https://doi.org/10.13005/ojc/390638","url":null,"abstract":"The condensation reaction of Benzil with semicarbazide followed by a triazine ring formation and then subsequent interaction with substituted aromatic aldehydes, resulted in synthesis of aromatic hydrazone derivatives (C1 – C4). These derivatives have been synthesized via greener method using acetic acid rather than conc. Sulfuric acid. The resultant compounds were analyzed using spectral (1H-NMR, IR) and elemental analysis. The in-vitro analysis of these compounds portrayed prominent activity against bacterial and fungal strains.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"27 107","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Oral Toxicity of Litchi chinensis Pericarp Extract in Experimental Rats","authors":"Mayur Porwal, Phool Chandra, Vivek Kumar, Navneet Verma, Km. Monika","doi":"10.13005/ojc/390609","DOIUrl":"https://doi.org/10.13005/ojc/390609","url":null,"abstract":"A wide range of experiments have yielded empirical evidence pertaining to the efficacy of medicinal plants in the therapeutic treatment of several disorders. However, the use of herbs without conducting a thorough assessment of their effectiveness and safety can lead to sudden or harmful consequences that may pose a risk to the overall health of internal organs. Therefore, the current investigation’s goal was to determine the ethanolic extract of Litchi chinensis toxicological profile in rats. The Soxhlet extraction method extracted the fruit with ethanol as a solvent. The extract's susceptibility to acute, subacute, and subchronic toxicity was assessed. The histopathology of several organs (e.g., heart, liver, lungs, kidney and spleen) were also studied after treatment with plant extract. With the dosage of 2000 mg/kg, p.o., no deaths or adverse consequences were reported during the examination of acute toxicity. The Litchi chinensis extract produced no death or any observable changes in weight, behavior, organ weights, hematological or biochemical values in both oral subacute and subchronic toxicity experiments. Essential organs, including the heart, liver, lungs, kidney, and spleen, have regular planning when examined histopathologically, indicating no morphological changes. On the basis of results, the fruit (pericarp) extract of Litchi chinensis showed a lack of toxicity.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"7 5","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Magnetism and Band Gap Tailoring in N-doped CdS:Cr Nanocomposites for Optomagnetic Applications","authors":"Surya Sekhar Reddy M, Kishore Kumar Y B","doi":"10.13005/ojc/390620","DOIUrl":"https://doi.org/10.13005/ojc/390620","url":null,"abstract":"Nitrogen and chromium co-doped cadmium sulfide nanocomposites (NCps) were successfully synthesized using a simple co-precipitation method (Cpm). To evaluate their structural attributes, X-ray diffraction (XRD) analysis, conducted with X’pert high score plus software, confirmed the composite nature and established their particle size within the nano range, measuring between 1 to 1.6 nm. Further characterization, employing Fourier transform infrared spectroscopy (FTIR) confirms the presence of Cr and N. The energy dispersive X- ray spectroscopy (EDX) provided compelling evidence of the integration of chromium and nitrogen into the CdS host matrix. An interesting outcome of the UV-VIS diffused reflectance spectra (DRS) analysis was the significant blue shift observed in the band gap resulting from the introduction of chromium, accompanied by a Burstein-Moss effect, leading to a red shift as the nitrogen concentration increased. The intense green light emission witnessed in photoluminescence (PL) studies was associated with the trapping of nitrogen and Cr2+ within F- centers. Moreover, vibrating sample magnetometer (VSM) investigations unveiled distinct magnetic behaviors of the nanocomposites, particularly at low magnetic fields. These findings reveal a potential for tailoring band gaps and presenting novel magnetic properties, which could hold substantial promise for applications in optomagnetic and spintronic smart devices.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"17 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Oxidative Stress level and some Antioxidant enzymes activity parameters in patients with type two diabetes mellitus","authors":"Darya Assi Younus, Rebaz M Mustaffa, Rezhna Adil Rashid, S. S. Hamad, Hemn R. Salih, Dlshad Saadulla Othman, Kamaran K. Abdulrahman","doi":"10.13005/ojc/390621","DOIUrl":"https://doi.org/10.13005/ojc/390621","url":null,"abstract":"Diabetes, a group of metabolic disorders characterized by dysregulation of oxidative stress and elevated blood glucose levels. It has been studied with emphasis on malondialdehyde (MDA) and glutathione (GSH) levels as biomarkers of lipid peroxidation and antioxidant activity in the serum of type II Diabetes examines patients. The study involved the analysis of 105 serum samples from 75 type II diabetes patients and 30 healthy individuals. MDA and GSH levels served as measures of oxidative stress and antioxidant activity, respectively. In addition, lipid profiles were examined, which include measurements such as total cholesterol (total C), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). The results showed significantly increased MDA, total cholesterol, triglycerides and glucose levels in the diabetic group compared to controls. In contrast, GSH and HDL levels were significantly lower in diabetics. In the type 2 diabetes patient group, a correlation between glucose levels and MDA concentration was observed, while no other significant associations were found between lipid profile parameters, glucose levels and MDA or GSH levels. Studies show the complex connection between diabetes and the increase in free radicals and the corresponding decrease in antioxidant synthesis. This dynamic interaction is an important factor in the development of oxidative stress.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"104 13","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, Synthesis, Molecular Docking, Invitro Anticancer and Antibacterial Evaluation of Novel Pyrazole Linked with Quinazoline Scaffolds","authors":"Mohd Afroz, G. S. kumar","doi":"10.13005/ojc/390635","DOIUrl":"https://doi.org/10.13005/ojc/390635","url":null,"abstract":"A novel series of compounds are synthesized N-(2-methyl-4-oxoquinazolin-3(4H)-yl)-3-oxo-3-(3,5-diphenyl-2H-pyrazol-1(5 H)-yl) propenamide (3a-l). All the synthesized compounds are characterized by different spectral tools 1HNMR, IR,13CNMR, and MASS. It was screened as in vitro anticancer and antibacterial activity. Among the synthesized compounds 3d and 3e exhibit potent against three cancer cell-line MCF7, PC-3, HT-29. IC50(µM) 3d (16.52, 13.24, 10.15 μg/ml) 3e (17.28, 15.26, 12.33 μg/ml) with standard drugs doxorubicin (15.29, 12.26, 9.06 μg/ml) and 5-fluorouracil (16.15, 13.73, 10.25 μg/ml). Antibacterial activity 3d, 3e, 3j, 3k scaffolds exhibit a promising activity with the standard drug ciprofloxacin. Insilico molecular docking is examined, Its predicted a good binding affinity against with 5C5S, 6XXN, 3K46 proteins.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"123 14","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, In Silico Studies, and Synthesis of Some Azole Derivatives as Antimicrobial Agents","authors":"Syeda Huma H. Zaidi, Abida Ash Mohd, Mohd Imran, Menwah Khalifah Alshammari, Khattab Fahed Alfrah","doi":"10.13005/ojc/390618","DOIUrl":"https://doi.org/10.13005/ojc/390618","url":null,"abstract":"This work relates to the discovery of safer and more potent triazole-pyridazinone hybrid (TP) compounds as an inhibitor of sterol 14α-demethylase (SDM). The chemical structures of thirty-three TPs (TP1 to TP33) were designed. The docking scores (DS) of TPs were determined by molecular docking software utilizing three different proteins of SDM (PDB IDs: 3LD6, 5FSA, and 5TZ1). The ProTox II web server predicted TPs' oral LD50 and toxicity class (TC), whereas the Swiss-ADME database anticipated their pharmacokinetic parameters. Based on the in silico study data, four TPs (TP18, TP22, TP27, and TP33) were synthesized and evaluated for their in vitro antifungal activity against seven fungi. The DS (kcal/mol) of TP18 (3LD6 = -8.27; 5FSA = -9.07; 5TZ1 = -9.42), TP22 (3LD6 = -8.23; 5FSA = -8.93; 5TZ1 = -9.57), TP27 (3LD6 = -8.31; 5FSA = -9.12; 5TZ1 = -9.38), and TP33 (3LD6 = -8.19; 5FSA = -8.98; 5TZ1 = -9.94) were better than the DS of fluconazole (3LD6 = -8.18; 5FSA = -8.79; 5TZ1 = -9.18) and ketoconazole (3LD6 = -8.16; 5FSA = -8.86; 5TZ1 = -9.06) implying high potency of TP18, TP22, TP27 and TP33 than fluconazole and ketoconazole against SDM. The anticipated LD50 and toxicity class (TC) of TP18 (500 mg/kg; TC 4), TP22 (500 mg/kg; TC 4), TP27 (1000 mg/kg; TC 4), and TP33 (1000 mg/kg; TC 4) was better than ketoconazole (166 mg/kg; TC 3). The Swiss-ADME database results revealed that TP18, TP22, TP27, and TP33 passed Lipinski’s drug-likeliness rule and demonstrated high oral absorption and bioavailability comparable to ketoconazole and fluconazole. The synthesized compounds' spectral data (FTIR, 1H-NMR, 13C-NMR, and Mass) aligned to their designed chemical structure. The antifungal activity data implies that TP18, TP22, TP27, and TP33 were better antifungal agents than fluconazole and ketoconazole against tested fungi. These findings concurred with the DS of TP18, TP22, TP27, and TP33. In conclusion, TP18, TP22, TP27, and TP33 represent a new chemical template for developing safer and better SDM inhibitors as antifungal agents.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"126 S10","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of Telmisartan and Azelnidipine Combination in using Liquid Chromatography: Stability Studies","authors":"B.S.A. Andrews, V D N Kumar Abbaraju, Shaik Lakshman, Sreeram V, Kancharla Vijayalakshm","doi":"10.13005/ojc/390525","DOIUrl":"https://doi.org/10.13005/ojc/390525","url":null,"abstract":"A stability-indicating RP-HPLC method for the development of Telmisartan (TTN) and Azelnidipine (ADN) is analyzed in tablet dosage form. The quantification of TTN and ADN combination is done by Supel cosil C18 column (250 mm, 4.6 mm, & 5 µm). Isocratic mobile phase had mobile phase consists of 0.10M Na2SO4(pH 3.6) and acetonitrile (pH 3.6) as 55:45v/v. For this analysis flow rate is measured as 1.00 ml/min. Wavelength is identified as 258nm to examine TTN and ADN. Stability for both these drugs under distinctive environments were performed. Injected volume is 10μL. Run time is 8min. Retention time is 2.8 and 3.7 respectively. The responses were linear in the concentrate range as 37.4-110.3 for TTN and 2.24-10.51 µg/mL for ADN respectively. Percent comparative standard deviance to precision is 0.193% for TTN, 0.195% for ADN. Percent assay to accuracy for both these drugs are 98.76% and 99.04% respectively. LOD values for TTN and ADN were 0.020μg/ml and 0.065μg/ml and LOQ values for TTN and ADN were 0.009μg/ml and 0.031μg/ml. Robustness studies revealed that this method is robust by percent comparative standard deviance. This stability-indicating RP-HPLC procedure to both TTN, ADN analysis is more simple, highly sensitive, more precise, highly specific and robust, making it appropriate to the assessment of TTN and ADN in formulation.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"40 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136068034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of Corrosion Resistant Property of Benzoxazine Synthesised from Euginol with N-Butylamine and Copolymerised with Polyurethane on Mild Steel","authors":"Jayanthi Kannaiyan, Sivaraju Mani","doi":"10.13005/ojc/390512","DOIUrl":"https://doi.org/10.13005/ojc/390512","url":null,"abstract":"In this work, we have synthesized a new eugenol based benzoxazine monomer from eugenol, paraformaldehyde and n-butyl amine. The synthesized monomer was characterized by 1H NMR, 13C NMR, UV-Visible and FT-IR spectroscopy. The monomer was then co-polymerized with isocyanate hardener on the surface of the mild steel with three different composition. After that it was cured in a muffle furnace to get poly(benzoxazine-urethane). The copolymer’s characterized by UV and FT-IR spectroscopic techniques. The anti-corrosive property of the co-polymer was investigated using polarization and EIS techniques against 3.5% NaCl solution. For additional support for this work, DFT studies also carried out for monomer and its copolymer. Water absorption and gel absorption studies were also done to add evidences for the hydrophobicity of the monomer and the copolymers.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"63 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136068896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cissus Quadrangularis is a Potential Anticancer Herb: A-Review","authors":"Arthi Rashmi D, Sangilimuthu Alagar Yadav, Harishchander A, Karpagavalli M, Ranjithkumar D","doi":"10.13005/ojc/390509","DOIUrl":"https://doi.org/10.13005/ojc/390509","url":null,"abstract":"Cancer is uncontrolled growth of abnormal cells due to heredity, mutation, genetic factors, environment factors, chain smoking, alcoholic addiction and exposure of chemical carcinogen. Treating modern medicine for cancer are producing numerous adverse effects. Hence natural remedy is essential to combat disease with less side effects. Eighty percentage of the peoples are used the medicinal plants for various illness in developing countries asper the WHO survey. The present review was written extensively with past scientific reports on Cissus quadrangularis (CQ) and its anticancer properties. From the ancient times the various parts of CQ have used for various diseases and disorders as folk medicine by traditional healer and practice. Traditionally CQ has vital role in various disease management. Its active extracts and ingredients reported against various diseases such as inflammation, cancer, ulcer, bone fracture and epilepsy. Still its therapeutic potentials not yet fully explored to use common people after clinical trial. Mainly CQ and its active phytoconstituents contains potential action for the treatment of various types of cancer which is scientifically proven upto the lab scale that needs to be evolved as medicine for world threatened disease cancer.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"9 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136068903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}