Oriental Journal Of Chemistry最新文献

{"title":"Novel Magnetism and Band Gap Tailoring in N-doped CdS:Cr Nanocomposites for Optomagnetic Applications","authors":"Surya Sekhar Reddy M, Kishore Kumar Y B","doi":"10.13005/ojc/390620","DOIUrl":"https://doi.org/10.13005/ojc/390620","url":null,"abstract":"Nitrogen and chromium co-doped cadmium sulfide nanocomposites (NCps) were successfully synthesized using a simple co-precipitation method (Cpm). To evaluate their structural attributes, X-ray diffraction (XRD) analysis, conducted with X’pert high score plus software, confirmed the composite nature and established their particle size within the nano range, measuring between 1 to 1.6 nm. Further characterization, employing Fourier transform infrared spectroscopy (FTIR) confirms the presence of Cr and N. The energy dispersive X- ray spectroscopy (EDX) provided compelling evidence of the integration of chromium and nitrogen into the CdS host matrix. An interesting outcome of the UV-VIS diffused reflectance spectra (DRS) analysis was the significant blue shift observed in the band gap resulting from the introduction of chromium, accompanied by a Burstein-Moss effect, leading to a red shift as the nitrogen concentration increased. The intense green light emission witnessed in photoluminescence (PL) studies was associated with the trapping of nitrogen and Cr2+ within F- centers. Moreover, vibrating sample magnetometer (VSM) investigations unveiled distinct magnetic behaviors of the nanocomposites, particularly at low magnetic fields. These findings reveal a potential for tailoring band gaps and presenting novel magnetic properties, which could hold substantial promise for applications in optomagnetic and spintronic smart devices.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"17 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Oxidative Stress level and some Antioxidant enzymes activity parameters in patients with type two diabetes mellitus","authors":"Darya Assi Younus, Rebaz M Mustaffa, Rezhna Adil Rashid, S. S. Hamad, Hemn R. Salih, Dlshad Saadulla Othman, Kamaran K. Abdulrahman","doi":"10.13005/ojc/390621","DOIUrl":"https://doi.org/10.13005/ojc/390621","url":null,"abstract":"Diabetes, a group of metabolic disorders characterized by dysregulation of oxidative stress and elevated blood glucose levels. It has been studied with emphasis on malondialdehyde (MDA) and glutathione (GSH) levels as biomarkers of lipid peroxidation and antioxidant activity in the serum of type II Diabetes examines patients. The study involved the analysis of 105 serum samples from 75 type II diabetes patients and 30 healthy individuals. MDA and GSH levels served as measures of oxidative stress and antioxidant activity, respectively. In addition, lipid profiles were examined, which include measurements such as total cholesterol (total C), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). The results showed significantly increased MDA, total cholesterol, triglycerides and glucose levels in the diabetic group compared to controls. In contrast, GSH and HDL levels were significantly lower in diabetics. In the type 2 diabetes patient group, a correlation between glucose levels and MDA concentration was observed, while no other significant associations were found between lipid profile parameters, glucose levels and MDA or GSH levels. Studies show the complex connection between diabetes and the increase in free radicals and the corresponding decrease in antioxidant synthesis. This dynamic interaction is an important factor in the development of oxidative stress.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"104 13","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, Synthesis, Molecular Docking, Invitro Anticancer and Antibacterial Evaluation of Novel Pyrazole Linked with Quinazoline Scaffolds","authors":"Mohd Afroz, G. S. kumar","doi":"10.13005/ojc/390635","DOIUrl":"https://doi.org/10.13005/ojc/390635","url":null,"abstract":"A novel series of compounds are synthesized N-(2-methyl-4-oxoquinazolin-3(4H)-yl)-3-oxo-3-(3,5-diphenyl-2H-pyrazol-1(5 H)-yl) propenamide (3a-l). All the synthesized compounds are characterized by different spectral tools 1HNMR, IR,13CNMR, and MASS. It was screened as in vitro anticancer and antibacterial activity. Among the synthesized compounds 3d and 3e exhibit potent against three cancer cell-line MCF7, PC-3, HT-29. IC50(µM) 3d (16.52, 13.24, 10.15 μg/ml) 3e (17.28, 15.26, 12.33 μg/ml) with standard drugs doxorubicin (15.29, 12.26, 9.06 μg/ml) and 5-fluorouracil (16.15, 13.73, 10.25 μg/ml). Antibacterial activity 3d, 3e, 3j, 3k scaffolds exhibit a promising activity with the standard drug ciprofloxacin. Insilico molecular docking is examined, Its predicted a good binding affinity against with 5C5S, 6XXN, 3K46 proteins.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"123 14","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, In Silico Studies, and Synthesis of Some Azole Derivatives as Antimicrobial Agents","authors":"Syeda Huma H. Zaidi, Abida Ash Mohd, Mohd Imran, Menwah Khalifah Alshammari, Khattab Fahed Alfrah","doi":"10.13005/ojc/390618","DOIUrl":"https://doi.org/10.13005/ojc/390618","url":null,"abstract":"This work relates to the discovery of safer and more potent triazole-pyridazinone hybrid (TP) compounds as an inhibitor of sterol 14α-demethylase (SDM). The chemical structures of thirty-three TPs (TP1 to TP33) were designed. The docking scores (DS) of TPs were determined by molecular docking software utilizing three different proteins of SDM (PDB IDs: 3LD6, 5FSA, and 5TZ1). The ProTox II web server predicted TPs' oral LD50 and toxicity class (TC), whereas the Swiss-ADME database anticipated their pharmacokinetic parameters. Based on the in silico study data, four TPs (TP18, TP22, TP27, and TP33) were synthesized and evaluated for their in vitro antifungal activity against seven fungi. The DS (kcal/mol) of TP18 (3LD6 = -8.27; 5FSA = -9.07; 5TZ1 = -9.42), TP22 (3LD6 = -8.23; 5FSA = -8.93; 5TZ1 = -9.57), TP27 (3LD6 = -8.31; 5FSA = -9.12; 5TZ1 = -9.38), and TP33 (3LD6 = -8.19; 5FSA = -8.98; 5TZ1 = -9.94) were better than the DS of fluconazole (3LD6 = -8.18; 5FSA = -8.79; 5TZ1 = -9.18) and ketoconazole (3LD6 = -8.16; 5FSA = -8.86; 5TZ1 = -9.06) implying high potency of TP18, TP22, TP27 and TP33 than fluconazole and ketoconazole against SDM. The anticipated LD50 and toxicity class (TC) of TP18 (500 mg/kg; TC 4), TP22 (500 mg/kg; TC 4), TP27 (1000 mg/kg; TC 4), and TP33 (1000 mg/kg; TC 4) was better than ketoconazole (166 mg/kg; TC 3). The Swiss-ADME database results revealed that TP18, TP22, TP27, and TP33 passed Lipinski’s drug-likeliness rule and demonstrated high oral absorption and bioavailability comparable to ketoconazole and fluconazole. The synthesized compounds' spectral data (FTIR, 1H-NMR, 13C-NMR, and Mass) aligned to their designed chemical structure. The antifungal activity data implies that TP18, TP22, TP27, and TP33 were better antifungal agents than fluconazole and ketoconazole against tested fungi. These findings concurred with the DS of TP18, TP22, TP27, and TP33. In conclusion, TP18, TP22, TP27, and TP33 represent a new chemical template for developing safer and better SDM inhibitors as antifungal agents.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"126 S10","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of Telmisartan and Azelnidipine Combination in using Liquid Chromatography: Stability Studies","authors":"B.S.A. Andrews, V D N Kumar Abbaraju, Shaik Lakshman, Sreeram V, Kancharla Vijayalakshm","doi":"10.13005/ojc/390525","DOIUrl":"https://doi.org/10.13005/ojc/390525","url":null,"abstract":"A stability-indicating RP-HPLC method for the development of Telmisartan (TTN) and Azelnidipine (ADN) is analyzed in tablet dosage form. The quantification of TTN and ADN combination is done by Supel cosil C18 column (250 mm, 4.6 mm, & 5 µm). Isocratic mobile phase had mobile phase consists of 0.10M Na2SO4(pH 3.6) and acetonitrile (pH 3.6) as 55:45v/v. For this analysis flow rate is measured as 1.00 ml/min. Wavelength is identified as 258nm to examine TTN and ADN. Stability for both these drugs under distinctive environments were performed. Injected volume is 10μL. Run time is 8min. Retention time is 2.8 and 3.7 respectively. The responses were linear in the concentrate range as 37.4-110.3 for TTN and 2.24-10.51 µg/mL for ADN respectively. Percent comparative standard deviance to precision is 0.193% for TTN, 0.195% for ADN. Percent assay to accuracy for both these drugs are 98.76% and 99.04% respectively. LOD values for TTN and ADN were 0.020μg/ml and 0.065μg/ml and LOQ values for TTN and ADN were 0.009μg/ml and 0.031μg/ml. Robustness studies revealed that this method is robust by percent comparative standard deviance. This stability-indicating RP-HPLC procedure to both TTN, ADN analysis is more simple, highly sensitive, more precise, highly specific and robust, making it appropriate to the assessment of TTN and ADN in formulation.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"40 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136068034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of Corrosion Resistant Property of Benzoxazine Synthesised from Euginol with N-Butylamine and Copolymerised with Polyurethane on Mild Steel","authors":"Jayanthi Kannaiyan, Sivaraju Mani","doi":"10.13005/ojc/390512","DOIUrl":"https://doi.org/10.13005/ojc/390512","url":null,"abstract":"In this work, we have synthesized a new eugenol based benzoxazine monomer from eugenol, paraformaldehyde and n-butyl amine. The synthesized monomer was characterized by 1H NMR, 13C NMR, UV-Visible and FT-IR spectroscopy. The monomer was then co-polymerized with isocyanate hardener on the surface of the mild steel with three different composition. After that it was cured in a muffle furnace to get poly(benzoxazine-urethane). The copolymer’s characterized by UV and FT-IR spectroscopic techniques. The anti-corrosive property of the co-polymer was investigated using polarization and EIS techniques against 3.5% NaCl solution. For additional support for this work, DFT studies also carried out for monomer and its copolymer. Water absorption and gel absorption studies were also done to add evidences for the hydrophobicity of the monomer and the copolymers.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"63 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136068896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cissus Quadrangularis is a Potential Anticancer Herb: A-Review","authors":"Arthi Rashmi D, Sangilimuthu Alagar Yadav, Harishchander A, Karpagavalli M, Ranjithkumar D","doi":"10.13005/ojc/390509","DOIUrl":"https://doi.org/10.13005/ojc/390509","url":null,"abstract":"Cancer is uncontrolled growth of abnormal cells due to heredity, mutation, genetic factors, environment factors, chain smoking, alcoholic addiction and exposure of chemical carcinogen. Treating modern medicine for cancer are producing numerous adverse effects. Hence natural remedy is essential to combat disease with less side effects. Eighty percentage of the peoples are used the medicinal plants for various illness in developing countries asper the WHO survey. The present review was written extensively with past scientific reports on Cissus quadrangularis (CQ) and its anticancer properties. From the ancient times the various parts of CQ have used for various diseases and disorders as folk medicine by traditional healer and practice. Traditionally CQ has vital role in various disease management. Its active extracts and ingredients reported against various diseases such as inflammation, cancer, ulcer, bone fracture and epilepsy. Still its therapeutic potentials not yet fully explored to use common people after clinical trial. Mainly CQ and its active phytoconstituents contains potential action for the treatment of various types of cancer which is scientifically proven upto the lab scale that needs to be evolved as medicine for world threatened disease cancer.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"9 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136068903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Cyclooxygenase-2 Inhibitory Activity Evaluation of Some Pyridazine Derivatives","authors":"Mohd Imran, Abida Ash Mohd, Naira Nayeem, Nawaf M. Al-Otaibi, Malik Homoud, Muhannad Thafi Alshammari","doi":"10.13005/ojc/390504","DOIUrl":"https://doi.org/10.13005/ojc/390504","url":null,"abstract":"This work aimed to discover safe and effective pyridazine-based cyclooxygenase-2 (COX-2) inhibitors. Thirty-three pyridazine-based compounds (compounds 1 to 33) were designed. The in silico studies were conducted to predict their toxicity, docking scores (DS), pharmacokinetic parameters, and drug-likeliness properties compared to celecoxib. Based on the safety and efficacy data obtained by in silico studies, four compounds (7, 12, 16, and 24) were synthesized, and the spectral analysis confirmed their chemical structures. Additionally, the in vitro COX-2 inhibitory activity of these four compounds was evaluated. Eleven compounds were predicted as non-toxic compounds. The DS of four compounds, 7 (DS = -9.72 kcal/mol), 12 (DS = -10.48 kcal/mol), 16 (DS = -9.71 kcal/mol), and 24 (DS = -9.46 kcal/mol), was better than celecoxib (DS = -9.15). These compounds (7, 12, 16, and 24) also demonstrated better oral absorption (83.53% each) than celecoxib (79.20%) in addition to their promising drug-likeliness properties. The compounds 7 (101.23%; p < 0.05), 12 (109.56%; p < 0.05), 16 (108.25%; p < 0.05), and 24 (103.90%; p < 0.05) also exhibited superior COX-2 inhibition to celecoxib (100%; p < 0.05). Compounds 7, 12, 16, and 24 are useful lead compounds in developing drugs for various diseases in which high levels of COX-2 are implicated.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136069186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Multi Residue Method for the Quantification of 45 Pesticides Using Gc-Ms/Ms and Study of Peeling Effect on Pesticide Residues in Citrus Fruits","authors":"R. Ramadevi, C. Ramachandraiah, G.V. Subba Reddy","doi":"10.13005/ojc/390507","DOIUrl":"https://doi.org/10.13005/ojc/390507","url":null,"abstract":"An analytical method was developed and validated for the determination of 45 multi-class pesticide residues in citrus fruit samples collected from and around Pulivendula, India, using GC-MS/MS (Gas chromatography with tandem mass spectrometry) followed by the QuEChERS extraction method . The linear regression coefficients (R-square) of the methods range from 0.998 to 0.999, and the Limit of Detection (LOD) and Limit of Quantification (LOQ) are 1.56 to 25.23 ng/mL and 4.72 to 76.47 ng/mL, respectively. Recoveries of all spiked pesticides range from 82.6 to 117.6%, with a RSD (Relative Standard Deviation) less than 11.2%. The results show that 42 out of 45 pesticides were detected in whole citrus fruit pulp (with peel) samples. Fenthion, bifenthrin, and fenvalerate were not detected. In the collected citrus samples, phorate (21.71 µg/kg), and ethion (51.47 µg/kg) insecticides are present above the Maximum Residue Level (MRL), but cypermethrin (25.89 µg/kg) was detected below the MRL. 13 out of 45 pesticides were detected in edible parts of citrus fruit (without peel) samples, with ethion having the highest residue. All pesticides were within the MRL limits prescribed by the European Union (EU) and Codex regulations for MRL in citrus fruits, and peeling was found to be one of the best ways to get rid of pesticide residues.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"58 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136069783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Characterization of 6-Amino Caproic Acid Tkp-Based Resin for Wastewater Treatment","authors":"Sugan Kanwar, A. V. Singh","doi":"10.13005/ojc/390536","DOIUrl":"https://doi.org/10.13005/ojc/390536","url":null,"abstract":"The natural polysaccharide-based resin of tamarind using functional group as 6-amino caproic acid has been synthesized by porath’s method. Their adsorption behavior also evaluated by determination of % adsorption of toxic metal ions from stock solution as well as industrial effluents by batch method and column separation experiment. Their physiochemical properties as bulk density, ion exchange capacity, and FTIR, were investigated. Using the batch equilibrium approach, Kd of five metal ions at various pH levels was investigated. The maximum removal % of metal ions of Cu+2, Fe+2, Zn+2, Cd+2, and Pb+2 at TACA resin were found at 97.97%,97.80%, 96.39%, 94.94%, and 91.90% respectively. Distribution ratio of these ions observed from pH 2 to 8 was Cu+2 &gt; Fe+2&gt; Zn+2&gt; Cd+2 &gt; Pb+2. The toxic metal ions from discharge samples of the metallurgical and mineral industries have been removed using ion exchange resins. Recovery of Zn (Ⅱ), Pb (Ⅱ), Cd (Ⅱ), Cu (Ⅱ), and Fe (Ⅱ) were obtained at 95.44, 96.27, 96.41, 98.82, and 100% respectively. The ion exchange capacity of TACA resin was found 2.24mmol/g","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"100 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136105553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}