Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti最新文献_第2页

Aging, Calorie Restriction and Calorie Restriction Mimetics 衰老，卡路里限制和卡路里限制模拟

Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti Pub Date : 2019-12-17 DOI: 10.21857/9e31lhnddm

I. Čepelak, S. Dodig, D. Dodig

引用次数: 1

War Invalids and Disabled Soldiers in the Habsburg Army: The Case of the Đurđevac Regiment in 1860/61 哈布斯堡军队中的伤残军人:1860/ 1861年Đurđevac团的案例

Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti Pub Date : 2019-12-17 DOI: 10.21857/yl4okf3209

Ivana Horbec, D. Habek

引用次数: 0

Psychoneuroimmunology and skin diseases 精神神经免疫学和皮肤病

Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti Pub Date : 2019-07-01 DOI: 10.21857/Y6ZOLB8L7M

L. Mihić

{"title":"Psychoneuroimmunology and skin diseases","authors":"L. Mihić","doi":"10.21857/Y6ZOLB8L7M","DOIUrl":"https://doi.org/10.21857/Y6ZOLB8L7M","url":null,"abstract":"Psychoneuroimmunology has emerged as a broad interdisciplinary field examining the interaction between the psychological state, the nervous system, the endocrine system, and the immune system. Psychodermatology or psychocutaneous medicine is an intersection of psychiatry, psychology and dermatology. There is a growing awareness of the connection between psychosocial stress and somatic illnesses, including dermatological diseases. Psychosomatic factors are considered significant in more than a third of people suffering from skin diseases. Communication between the psyche and the skin is a complex interaction of psychological, immunologic and endocrine factors with the skin, involving a number of neuropeptides, interleukins and immune system mediators. The skin, being the largest organ of the body, is equipped with metabolic and endocrinological capacities that facilitate homeostatic control between internal and external environments. In addition to psychosocial stress, factors relevant for a psychoneuroimmunological approach to skin diseases include nutrition, gut and skin microbiota, sleep and circadian rhythm, physical activity, and orthomolecular medicine. Knowledge of psychoneuroimmunological mechanisms and factors relevant for a holistic approach is very important for a better and broader understanding of skin diseases, and for better therapeutic outcomes for patients.","PeriodicalId":195938,"journal":{"name":"Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125233565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Aortic stenosis from the perspective of the current guidelines 从目前的主动脉瓣狭窄指南来看

Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti Pub Date : 2019-07-01 DOI: 10.21857/YQ32OH40D9

M. Jelavic, H. Pintarić

{"title":"Aortic stenosis from the perspective of the current guidelines","authors":"M. Jelavic, H. Pintarić","doi":"10.21857/YQ32OH40D9","DOIUrl":"https://doi.org/10.21857/YQ32OH40D9","url":null,"abstract":"Aortic stenosis (AS) is one of the most common valvular diseases encountered in clinical practice. It is most frequently caused by degenerative aortic valve fibrosis and calcification, and in a lesser number of cases by the calcification of congenital deformed aortic valve (bicuspid); it may occasionally develop after rheumatic fever. Valve fibrosis and calcification lead to progressive valve restriction, obstruction and increased afterload with left ventricle remodelling for normalization of wall tension and cardiac output. During time, such hypertrophic and fibrotic myocardium deteriorates, resulting in heart failure. Generally, current guidelines of the European Society of Cardiology (ESC) recommend aortic valve replacement (AVR) when the aortic valve is severely stenotic and the patient is symptomatic. Most asymptomatic patients with severe AS should be managed conservatively, except for those with systolic LV dysfunction, an abnormal exercise test, very severe aortic stenosis, severe valve calcification, markedly elevated cardiac biomarkers, and severe pulmonary hypertension without other explanation. This article will review our current understanding of the pathophysiology of AS and provide detailed information about clinical presentation, diagnostic procedures, disease course, and different treatment strategies for various groups of these patients.","PeriodicalId":195938,"journal":{"name":"Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134134465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum immune markers differentiation in patients with Puumala or Dobrava virus infections 普马拉或多布拉瓦病毒感染患者血清免疫标记物的分化

Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti Pub Date : 2019-07-01 DOI: 10.21857/MJRL3UX1G9

A. Markotić, L. Zmak, A. Gagro, D. Dekaris

{"title":"Serum immune markers differentiation in patients with Puumala or Dobrava virus infections","authors":"A. Markotić, L. Zmak, A. Gagro, D. Dekaris","doi":"10.21857/MJRL3UX1G9","DOIUrl":"https://doi.org/10.21857/MJRL3UX1G9","url":null,"abstract":"Hemorrhagic fever with renal syndrome (HFRS) is widely distributed in Europe and caused mostly by two different orthohantaviruses: Puumala virus (PUUV) and Dobrava virus (DOBV). Several studies have implicated that HFRS is an immunologically mediated disease and that the proinflammatory cytokines may have a role in the immunopathogenesis of HFRS. In this study, we have detected: IL-2; IL-6; their soluble receptors (sIL-2R, sIL-6R); TNF-alpha; sCD23; and total IgE in two consecutive sera of HFRS patients, and have looked for their possible relation with the main blood and biochemical findings in order to determine their possible role in disease progression. The differences in the level of measured parameters between PUUVand DOBV-infected patients were also observed. The sIL-2R, sIL-6R and sCD23 levels were elevated in all HFRS patients, but we did not find any statistical difference between 1st and 2nd sera. The total IgE was elevated in about 1/3 of HFRS patients in both sera. We detected higher IL-6, sIL-2R and sCD23 levels in the sera of patients with DOBV infection than in patients with PUUV infection, with no statistically significant difference. The total IgE level was elevated in five of the six tested patients with DOBV infection, and they had a statistically higher level of total IgE than patients with PUUV infection. Almost all the listed biochemical and blood parameters in HFRS patients stand either in positive or in negative correlation with sIL-2Rapha. The levels of urea and creatinine, which are the hallmarks of HFRS severity, stand in positive correlation with sIL-2Rapha, IL-6, sIL-6R and sCD23. The level of the total IgE stands either in positive or in negative correlation with proteins and parameters of the liver function. We have also found a high positive correlation between the total IgE level and basophile count.","PeriodicalId":195938,"journal":{"name":"Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti","volume":"325 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129429651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebral venous sinus thrombosis in a 19 year old female with ulcerative colitis: long term follow-up and review from the literature

Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti Pub Date : 2019-07-01 DOI: 10.21857/94KL4CX2JM

A. Arsovska, P. Caliandro, V. Caso, Florin Scarlatescu, Marija Babunovska, Chiara Iakovelli, D. Dietrich

{"title":"Cerebral venous sinus thrombosis in a 19 year old female with ulcerative colitis: long term follow-up and review from the literature","authors":"A. Arsovska, P. Caliandro, V. Caso, Florin Scarlatescu, Marija Babunovska, Chiara Iakovelli, D. Dietrich","doi":"10.21857/94KL4CX2JM","DOIUrl":"https://doi.org/10.21857/94KL4CX2JM","url":null,"abstract":"Background: Cerebral venous sinus thrombosis is a rare complication of ulcerative colitis. Case presentation: We present a case report of a 19-year-old female patient with ulcerative colitis, who developed superior sagittal sinus thrombosis with haemorrhagic transformation. Despite the initial treatment with anticoagulant therapy, the patient became comatose, with symptomatic epileptic seizures and compromised cardiorespiratory function. She was transferred to the ICU and put on life-support for 3 weeks. She gradually improved and was discharged on low-molecular weight heparin and antiepileptic therapy. Oral anticoagulant therapy with warfarin was started 6 months later, when the subsequent D-dimers normalized. In the follow-up period, the patient experienced another series of symptomatic epileptic seizures and poorly regulated INRs. Therefore, antiepileptic and anticoagulation therapies were changed to oxcarbazepine and rivaroxaban. Conclusion: Physicians should be aware that treatment of cerebral venous sinus thrombosis with haemorrhagic transformation in a patient with ulcerative colitis is very challenging and demanding. These patients need to be closely monitored for possible complications that might arise due to the concomitant presence of both diseases and possible drug interactions.","PeriodicalId":195938,"journal":{"name":"Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti","volume":"74 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130923920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Aging and senotherapeutics 衰老和老年治疗

Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti Pub Date : 2019-07-01 DOI: 10.21857/MOXPJHGLZM

I. Čepelak, S. Dodig

引用次数: 1

Are multiple primary melanomas a rare entity? 多发性原发性黑色素瘤是一种罕见的实体吗?

Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti Pub Date : 1900-01-01 DOI: 10.21857/YPN4OC8JW9

N. Franceschi

引用次数: 0

The psychosocial burden of urticaria 荨麻疹的社会心理负担

Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti Pub Date : 1900-01-01 DOI: 10.21857/9xn31cogdy

Helena Jerković, I. Bešlić, Diana Ćesić, M. Šitum

引用次数: 3

Prevalence of incidental chronic kidney disease and patient characteristics - results of the EH-UH 2 study and the ENAH project 偶发性慢性肾脏疾病的患病率和患者特征——EH-UH 2研究和ENAH项目的结果

Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti Pub Date : 1900-01-01 DOI: 10.21857/y7v64tvl2y

Marija Domislović, L. Gellineo, A. Jelaković, Ž. Dika, V. Domislovic, Krešimir Đapić, S. Karanovic, I. Vuković Brinar, N. Bukal, M. Abramović Barić, Ivan Brzić, B. Jelaković

引用次数: 1