Are multiple primary melanomas a rare entity?

Multiple primary melanomas are described in literature as a relatively rare, but nevertheless well known entity. The incidence varies from 0.2 to 23 % worldwide. Many risk factors for the development of multiple primary melanomas have been observed, including multiple dysplastic nevi, positive family history, over 60 years of age at diagnosis of first melanoma, male sex and white race. The first primary melanoma in patients with multiple primary melanomas has the greatest tumour thickness, while subsequent melanomas are usually significantly less invasive, most probably due to strict follow-up schedules and regular self-examinations. We will report of two patients with multiple primary melanomas and follow-up methods for early detection of other primary melanomas.