Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti最新文献

{"title":"Meralgia Paresthetica – Lateral Femoral Cutaneous Nerve Entrapment","authors":"Dora Madiraca Glasović, Nika Šlaus, M. Šitum, M. Pećina","doi":"10.21857/mzvkptq6v9","DOIUrl":"https://doi.org/10.21857/mzvkptq6v9","url":null,"abstract":"RAD 547. Medical Sciences 54-55 (2021) : 56-63 www.rad-med.com 56 June 2021 Vol 547 = 54-55 Abstract: Meralgia paresthetica (MP) is a neuropathy that involves pain and sensory symptoms in the distribution of the lateral femoral cutaneous nerve and is mostly caused by entrapment of the lateral femoral cutaneous nerve. The etiology of MP includes pregnancy, trauma, tumors, surgical complications and other conditions with increased intraabdominal pressure. The diagnosis of MP is usually based primarily upon clinical signs and symptoms, but other diagnostic tools can be used in patients with atypical clinical presentations. Treatment focuses on relieving symptoms caused by nerve compression and usually involves conservative approach. Surgical treatment may be considered it conservative methods fail.","PeriodicalId":195938,"journal":{"name":"Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116342286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in risk factors and cardiovascular outcomes in symptomatic peripheral artery disease patients","authors":"Mislav Vrsalović, T. Batinić, N. Kos","doi":"10.21857/yrvgqteq19","DOIUrl":"https://doi.org/10.21857/yrvgqteq19","url":null,"abstract":"","PeriodicalId":195938,"journal":{"name":"Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132500877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary central nervous system involvement in systemic ALK+ anaplastic large cell lymphoma: a case report","authors":"Žana Besser Silconi, Biljana Jelić Puškarić, F. Silconi, Dražen Perić","doi":"10.21857/y26kecl569","DOIUrl":"https://doi.org/10.21857/y26kecl569","url":null,"abstract":": Systemic anaplastic large cell lymphoma is an infrequent form of non-Hodgkin lymphoma determined by the expression of CD30 with different clinical characteristics in its presentation. The majority of patients with anaplastic large cell lymphoma are in an advanced stage of the disease at the time of diagnosis but rarely with a leptomeningeal or central nervous system infiltration. We have presented a young patient with widespread systemic ALK+ anaplastic large cell lymphoma and a secondary central nervous system involvement verified by cytologic examination of the cerebrospinal fluid.","PeriodicalId":195938,"journal":{"name":"Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115597321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in radiology","authors":"L. Filipović-Grčić","doi":"10.21857/Y26KEC3O79","DOIUrl":"https://doi.org/10.21857/Y26KEC3O79","url":null,"abstract":"Since its first use in medical purpose in the 1960s, the concept of artificial intelligence has been especially appealing to health care, particularly radiology. With the development of ever more powerful computers from the 1990s to the present, various forms of artificial intelligence have found their way into different medical specialties – most notably radiology, dermatology, ophthalmology, and pathology. Due to the growing presence of such systems, it is paramount for the specialists handling them to get acquainted with them in order to provide the best service for their patients. It is therefore the aim of this article to explain the most basic principles of artificial intelligence, accentuating the most prominent concepts used in radiology today, such as deep learning and neural networks. It will also mention some of the artificial intelligence systems approved for clinical use in the US, such as IDx-DR, used to discover more than mild diabetic retinopathy in patients over 22 years of age; and Arterys, used for cardiac segmentation and discovering liver and lung nodules. Same as in many other fields, there is a constant need for improvement – in construction, testing, and application of these new technologies. Many ethical questions are asked, considering privacy and liability of artificial intelligence systems in clinical use. One of the greatest concerns for radiologists is the possibility of being replaced by these systems. This scenario seems to be far-fetched, at least for the time being. Radiologists should use that time to get to know the “enemy”. If they accomplish this, they might discover that they had had an ally all along.","PeriodicalId":195938,"journal":{"name":"Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123897041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary trends in the surgical management of aortic valve disease","authors":"H. Gašparović, Petra Čerina, B. Golubić Ćepulić, T. Tokić, M. Urlić, T. Kopjar, I. Burčar, B. Biočina, D. Miličić","doi":"10.21857/y6zolbr1nm","DOIUrl":"https://doi.org/10.21857/y6zolbr1nm","url":null,"abstract":": Introduction: Aortic valve pathology carries a high mortality burden. Its incidence is growing in proportion to the continuous ageing of the population. Surgery remains the gold standard in the treat-ment of severe aortic valve disease. Methods: We performed a retrospective analysis of the University Hospital Center Zagreb’s cardiac surgical database from 2009 to 2020, focusing on surgical aortic valve replacement (SAVR). We dichoto-mized patients with respect to the date of their surgical procedures into two eras. Group 1 included patients operated from 2009-2014, whereas Group 2 included patients operated on from 2015-2020. Results: A total of 1012 SAVRs were identified during the study period. The procedural volume over the two identical 6-year time periods increased in the latter era from 413 to 598. When comparing groups 1 and 2, we have observed in increase in the number of patients with diabetes (19% vs. 26%, P=0.015) and coronary artery disease (14% vs. 18%, P=0.099). The composite risk assessment score increased significantly from 3.0 ± 2.4 to 3.2 ± 2.7, P=0.023. Despite an increase in the comorbidity burden of the targeted patient population, the periprocedural mortality remained the same (2.1% vs 2.5%, P=0.835). The per-patient averaged volume of transfused packed red blood cells decreased from 839±954 to 614±821 ml, P<0.001. An increase in the proportion of tissue valve implantations in comparison to mechanical prostheses was also noted in the present era (58% vs 68%, P=0.001) Conclusion: Despite an increasingly more complex patient population referred for SAVR in the contemporary era, the results have remained excellent. The introduction of transcatheter methods should measure up to the surgical standard.","PeriodicalId":195938,"journal":{"name":"Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121719126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergencies in movement disorders","authors":"M. Hero, V. Rački, V. Vuletić","doi":"10.21857/m3v76tel1y","DOIUrl":"https://doi.org/10.21857/m3v76tel1y","url":null,"abstract":": Movement disorders constitute a large group of diseases that affect the control of voluntary motor activity without a direct impact on sensation and strength. Usual clinical course is slow, progressive and can be treated in an outpatient clinic. However, there are several emergencies regarding movement disorders that are serious medical conditions and may result in death if not recognized and treated promptly. Every neurologist should be aware of these states because they can develop during the course of a patient’s illness. The aim of this review is to provide key features of the most common emergencies in movement disorders, including drug-induced emergencies, emergencies in Parkinson’s disease, chorea and ballismus, tics, myoclonus and dystonia.","PeriodicalId":195938,"journal":{"name":"Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti","volume":"170 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116871022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BMP1.3 protein as potential target in treatment of fibrosis","authors":"Tatjana Bordukalo Nikšić, Vera Kufner","doi":"10.21857/y7v64t0oxy","DOIUrl":"https://doi.org/10.21857/y7v64t0oxy","url":null,"abstract":": Bone morphogenetic protein 1 (BMP1) belongs to the procollagen C proteinase (PCP) family of proteases involved in development and pattern formation in various organisms. BMP1 proteinases mediate the cleavage of carboxyl peptides from procollagen molecules, which is a crucial step in fibrillar collagen synthesis. From six described alternatively spliced variants of human Bmp1 gene, only BMP1.3 protein was detected in human plasma and elevated plasma levels of this protein were found in pathological conditions such as chronic kidney disease and acute myocardial infarction. Since BMP1 is required to convert pro-collagen to collagen, its inhibition is a potential intervention for treating fibrosis. Inhibition of BMP1.3 was shown to decrease the progression of liver fibrosis in an animal model of liver cirrhosis. One of the major inflammatory signaling molecules involved in fibrogenesis in various organs is transforming growth factor beta 1 (TGF β 1), which expression is elevated in various models of induced fibrosis. Many studies have revealed that BMP1 proteases play a key role in regulation of TGF β activation. Here, we discuss BMP1.3 inhibition as a potential treatment in different pathological conditions related to the fibrosis. Testing BMP1.3 inhibition in these models indicates that the anti-BMP1.3 antibody targets relevant pathways in the development of fibrosis in different organs.","PeriodicalId":195938,"journal":{"name":"Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133492777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ataxia as an initial presentation of Sporadic Creutzfeld - Jakob disease : an atypical case report and literature review","authors":"Slaven Lasić, I. Mihaljevic, Nataša Katavić, Ivana Šušak Sporiš, J. Badžak, Petra Bago Rožanković","doi":"10.21857/yrvgqtw1o9","DOIUrl":"https://doi.org/10.21857/yrvgqtw1o9","url":null,"abstract":": Sporadic Creutzfeldt Jakob disease is a rare, fast-progressing neurodegenerative disease with a fatal outcome. Even though its treatment options are scarce, and there is no cure for the disease, adequate diagnosis can help patients and their families come to terms with the disease on time, and give them valuable time to plan accordingly. We report a case of a patient presenting to our emergency department with a 2-week history of ataxia, and oscillopsia. Her initial neurological examination revealed subtle dysarthria, diplopia with left gaze, wide-based ataxic gait with occasional small steps, sinistro-pulsion in the Romberg position, and ataxia of the limbs, predominantly of the left arm. The patient at that time did not exhibit cognitive impairment, movement disorders, or other neurological signs. Her initial brain MSCT was without lesions or other pathomorphological supstrate. During hospitalization, treatable causes were firstly excluded with blood and CSF lab tests excluding metabolic, toxic, infectious, autoimmune, and paraneoplastic causes. Detailed medical history revealed subtle personality changes, while cognitive testing revealed moderate cognitive impairment. Brain MRI and EEG 4 days after hospitalization reported typical changes seen with advanced prion disease surprisingly being the fact that the patient had a mild to moderate clinical picture. RtQuIC analysis of the CSF was performed to prove probable sCJD and was positive. The patient’s family were given instructions, while the wishes of the patient, and family members were fulfilled concerning planning future care. After-ward, the patient’s state deteriorated rapidly as per the tragic prognosis of sCJD resulting in akinetic mutism, and death. Ataxia without cognitive impairment, rigor, or movement disorders is an uncommon clinical presentation for a disease with a 1:1 000 000 incidence rate. Modern diagnostic methods in way of more advanced brain MRI capabilities, and RT-QuIC obviate the need for complicated, and potentially infectious brain biopsy in diagnosing sCJD. Alongside the case report, we present a short but comprehensive literature review of modern data regarding the sCJD. This case report and literature review serve to educate clinicians about this rare but devastating disease.","PeriodicalId":195938,"journal":{"name":"Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti","volume":"128 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132248647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Splenic infarction as a rare cause of left upper abdominal quadrant pain in an elderly woman","authors":"Josipa Živko, M. Sorić","doi":"10.21857/m8vqrtgjn9","DOIUrl":"https://doi.org/10.21857/m8vqrtgjn9","url":null,"abstract":"","PeriodicalId":195938,"journal":{"name":"Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134237352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of intrathecal morphine on pain score in total hip arthroplasty","authors":"Anita Mandarić, Z. Oreskovic, Ivan Marić, M. Zura, S. Morović","doi":"10.21857/m8vqrtgl09","DOIUrl":"https://doi.org/10.21857/m8vqrtgl09","url":null,"abstract":"","PeriodicalId":195938,"journal":{"name":"Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130375038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}