Secondary central nervous system involvement in systemic ALK+ anaplastic large cell lymphoma: a case report

Abstract

: Systemic anaplastic large cell lymphoma is an infrequent form of non-Hodgkin lymphoma determined by the expression of CD30 with different clinical characteristics in its presentation. The majority of patients with anaplastic large cell lymphoma are in an advanced stage of the disease at the time of diagnosis but rarely with a leptomeningeal or central nervous system infiltration. We have presented a young patient with widespread systemic ALK+ anaplastic large cell lymphoma and a secondary central nervous system involvement verified by cytologic examination of the cerebrospinal fluid.