Ophthalmology最新文献

{"title":"Bilateral Acute Iris Depigmentation with a Free-Floating Pigmented Epithelial Cyst in the Anterior Chamber.","authors":"Francisco Calleja Casado, Valarmathy Vaiyavari, Mark Whiting","doi":"10.1016/j.ophtha.2025.06.001","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.06.001","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orbital Apex Syndrome Associated with Hypertrophic Pachymeningitis.","authors":"Yuya Maeda, Ken Fukuda, Kenji Yamashiro","doi":"10.1016/j.ophtha.2025.06.006","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.06.006","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conjunctival Mascaroma Presenting as Conjunctival Melanoma.","authors":"Shannon R Walsh, Tatyana Milman, Carol L Shields","doi":"10.1016/j.ophtha.2025.05.023","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.05.023","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Age at Surgery and Laterality of Cataract on Visual Acuity 5 years After Surgery in Infants Left Aphakic","authors":"Michael X. Repka MD MBA, Desirae R. Sutherland MPH, Sarah R. Hatt DBO, Bahram Rahmani MD, David A. Leske MS, Erick D. Bothun MD, Marielle P. Young MD, Mitchell B. Strominger MD, Susanna M. Tamkins OD, Wesley T. Beaulieu PhD, Raymond T. Kraker MSPH, Jonathan M. Holmes BM BCh, Susan A. Cotter OD MS, Pediatric Eye Disease Investigator Group","doi":"10.1016/j.ophtha.2025.06.022","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.06.022","url":null,"abstract":"To evaluate 5-year visual acuity (VA) outcomes by age at surgery and laterality among infants left aphakic at initial lensectomy.","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"2 1","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144515866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual Axis Opacification After Pediatric Cataract Surgery in the IRIS® Registry","authors":"Ju-Yeun Lee, Ju Hyun Jeon, Francisco Altamirano, Nadine AlMuasher, Tobias Elze, Joan W. Miller, Alice C. Lorch, Deborah K. VanderVeen, Isdin Oke, IRIS® Registry Analytic Center Consortium, Suzann Pershing MD, Leslie Hyman PhD, Julia A. Haller MD, Aaron Y. Lee MD MSCI, Cecilia S. Lee MD MS, Joan W. Miller MD, Alice C. Lorch MD MPH, Christina Thomas-Virnig PhD, Alex R. Miranda MD, Divya Srikumaran MD, Fasika A. Woreta MD MPH, Flora Lum MD","doi":"10.1016/j.ophtha.2025.06.021","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.06.021","url":null,"abstract":"In the IRIS® Registry, approximately one-third of children developed visual axis opacification within two years of cataract surgery. Children with a history of trauma or uveitis were most likely to develop visual axis opacification.","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"1 1","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144515870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline OCT Biomarkers Predicting Visual Outcomes in Neovascular Age-Related Macular Degeneration: A Meta-Analysis.","authors":"Keean Nanji, Justin Grad, Amin Hatamnejad, Tyler McKechnie, Mark Phillips, Chui Ming Gemmy Cheung, Praveen J Patel, Rosa Dolz Marco, Enrico Borrelli, David H Steel, SriniVas R Sadda, Tien Yin Wong, Sobha Sivaprasad, Robyn Guymer, Charles C Wykoff, Varun Chaudhary","doi":"10.1016/j.ophtha.2025.06.018","DOIUrl":"10.1016/j.ophtha.2025.06.018","url":null,"abstract":"<p><strong>Topic: </strong>To determine the effect estimates and certainty of evidence for baseline OCT biomarkers predicting visual acuity (VA) and changes in VA from baseline at 6, 12, and 24 months after anti-vascular endothelial growth factor therapy for neovascular age-related macular degeneration.</p><p><strong>Clinical relevance: </strong>Understanding the prognostic utility of biomarkers can improve treatment decisions.</p><p><strong>Methods: </strong>Results were reported in ETDRS letters. Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) guidelines for prognostic studies informed certainty of evidence. Results were interpreted using a 5-letter minimally important difference.</p><p><strong>Results: </strong>Twenty-nine reports (8863 eyes) evaluating 80 biomarkers were included. Two biomarkers predicted better VA at 12 months with a low-certainty: the presence of an intact external limiting membrane (+14.0; 95% confidence interval [CI], +3.1 to +24.8) and the presence of an intact ellipsoid zone (+6.8; 95% CI, +2.8 to +10.8). Three biomarkers predicted worse VA at 12 months with a low certainty; the presence of intraretinal fluid (IRF; -5.6; 95% CI, -9.7 to -1.5), the presence of IRF in the foveal center point (-7.4; 95% CI, -10.1 to -4.7), and the presence of subretinal hyperreflective material (-8.7; 95% CI, -19.0 to 1.6). No other biomarker predicted an effect size that crossed the minimally important difference. However, noteworthy results occurred when interpreting biomarkers with statistically significant findings relative to a threshold of 0 letters and moderate certainty: the presence of a pigment epithelial detachment, geographic atrophy (GA), and both IRF and subretinal fluid (SRF) predicted reduced vision at 12 months. The presence of SRF predicted a positive change in VA at 12 months. The absence of a posterior vitreous detachment predicted a negative change in VA at 12 months. Finally, the presence of IRF in the central 1 mm, retinal pigment epithelial elevation, and GA predicted negative changes in VA at 24 months.</p><p><strong>Discussion: </strong>With low-certainty evidence, the baseline presence of an intact external limiting membrane and ellipsoid zone predicted better VA at 12 months, and the presence of IRF, IRF in the foveal center point, and subretinal hyperreflective material predicted worse VA at 12 months. Improved standardization in biomarker classification and control of confounding variables is needed.</p><p><strong>Financial disclosure(s): </strong>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</p>","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":9.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Outcomes and Risk Factors for Failure in Childhood Glaucoma: Analysis of the IRIS® Registry (Intelligent Research in Sight).","authors":"Asahi Fujita, Daniel M Vu, Adam L Rothman, David S Friedman, Nazlee Zebardast, Ta Chen Chang","doi":"10.1016/j.ophtha.2025.06.017","DOIUrl":"10.1016/j.ophtha.2025.06.017","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the surgical outcomes and risk factors for failure in surgeries for childhood glaucoma.</p><p><strong>Design: </strong>Retrospective cohort study.</p><p><strong>Participants: </strong>Patients <18 years of age of who underwent a glaucoma-related procedure between January 1, 2013, and December 31, 2019, in the IRIS® Registry (Intelligent Research in Sight).</p><p><strong>Methods: </strong>Patient demographic information and clinical characteristics were extracted. Failure was defined as having any of the following: intraocular pressure (IOP) >21 mm Hg, IOP reduction <20% of baseline, IOP <5 mm Hg, any additional IOP-lowering procedure, loss of light perception, removal of eye or chemodenervation, or diagnosis of phthisis bulbi.</p><p><strong>Main outcome measures: </strong>Our primary outcome was the proportion of eyes that failed for glaucoma-related surgical procedures. Secondary outcomes included the factors associated with failure.</p><p><strong>Results: </strong>Among 2380 eyes, failure was recorded in 1081 eyes (45.4%) at a mean of 9.1 (10.4) months. Factors associated with a higher likelihood of failure were younger age (hazard ratio [HR], 1.12, 95% confidence interval [CI], 1.06-1.18, per 5 years), higher IOP on the index date (HR, 1.10, 95% CI, 1.08-1.12, per 3 mm Hg), worse visual acuity on the index date (HR, 1.33, 95% CI, 1.23-1.44, per 1 unit higher logarithm of the minimum angle of resolution), concurrent uveitis (HR, 1.41, CI, 1.16-1.71), more glaucoma medications on the index date (HR, 1.18, CI, 1.14-1.22, per 1 medication), systemic IOP-lowering medication (HR, 1.71, CI, 1.44-2.03), and complication of hyphema (HR, 13.5, CI, 5.03-36.46). Compared with ab interno angle incision surgery, iris-based surgery (HR, 2.26, CI, 1.64-3.12), iris-based laser (HR, 1.94, CI, 1.50-2.50), and trabecular/angle-based implants (HR, 3.83, CI, 2.00-7.33) were associated with higher failure rates. One or more reoperations were required in approximately 18% of the eyes. Three-year failure rates of angle surgery were 34.5% and 39.2% for primary congenital glaucoma (PCG) and juvenile open-angle glaucoma (JOAG), respectively. More poor vision eyes were aphakic, had higher medication burden, and had ocular comorbidities, than those without poor vision.</p><p><strong>Conclusions: </strong>Surgical failure was common in approximately half of all cases. Younger age, higher IOP and worse visual acuity at index, concurrent uveitis, and more intense preceding medication were predictors for failure.</p><p><strong>Financial disclosure(s): </strong>Proprietary or commercial disclosure may be found after the references.</p>","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":9.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between nucleoside and nucleotide reverse transcriptase inhibitor use and primary open-angle glaucoma risk in All of Us","authors":"Kenneth Pham BA, Fangming Jin MS, Roy Lee MS, Isabel Di Rosa AB, Rebecca Salowe MSE, Gui-Shuang Ying PhD, Joan M. O’Brien MD","doi":"10.1016/j.ophtha.2025.06.014","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.06.014","url":null,"abstract":"To assess the association between the systemic use of nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs) and primary open-angle glaucoma (POAG).","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"175 1","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Epidemiology of Sports-related Orbital Fractures in the United States","authors":"Niloufar Bineshfar, Chloe Shields, Natalia Davila, Samantha A. McLaughlin, Tejus Pradeep, Wendy W. Lee","doi":"10.1016/j.ophtha.2025.06.016","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.06.016","url":null,"abstract":"To characterize the epidemiology of sports-related orbital fractures in the United States, including incidence, demographic patterns, mechanisms of injury, and associated ocular injuries.","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"33 1","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cystic Peripapillary Staphyloma.","authors":"Lucas W Rowe, Lauren N Rowe, Kathryn M Haider","doi":"10.1016/j.ophtha.2025.05.022","DOIUrl":"10.1016/j.ophtha.2025.05.022","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}