Ophthalmology最新文献

{"title":"Late-onset Leber hereditary optic neuropathy: disease triggers and prognostic factors in a large Italian cohort","authors":"Alfredo A. Sadun","doi":"10.1016/j.ophtha.2026.09.006","DOIUrl":"https://doi.org/10.1016/j.ophtha.2026.09.006","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"1 1","pages":""},"PeriodicalIF":13.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine versus Human Vertical Cup-Disc-Ratio Grading","authors":"Sophia Y. Wang","doi":"10.1016/j.ophtha.2026.09.008","DOIUrl":"https://doi.org/10.1016/j.ophtha.2026.09.008","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"24 1","pages":""},"PeriodicalIF":13.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RE: Cheng et al: A new intraocular lens power calculation formula for eyes undergoing lens exchange (Ophthalmology. 2026;133:700–708)","authors":"Christian Sabatiello,Pasquale Alfano","doi":"10.1016/j.ophtha.2026.08.037","DOIUrl":"https://doi.org/10.1016/j.ophtha.2026.08.037","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"30 1","pages":""},"PeriodicalIF":13.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149150084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Between Scylla and Charybdis: Weighing Salvage and Loss in Retinoblastoma","authors":"Jesse L. Berry","doi":"10.1016/j.ophtha.2026.09.021","DOIUrl":"https://doi.org/10.1016/j.ophtha.2026.09.021","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"1 1","pages":""},"PeriodicalIF":13.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-office and remote intraocular pressure metrics associated with visual field progression in treated open-angle glaucoma.","authors":"Maria C Pizarro Peñaranda, Aleks Mihailovic ScM, Shashi Chaudhary B Optom, Natalie Hamilton, Yulia Nam, Valerie W Wong, Michael S Jensen, Catherine Johnson, Devin Eddington, Jacob Kanter, Barbara M Wirostko, Thomas V Johnson","doi":"10.1016/j.ophtha.2026.09.031","DOIUrl":"https://doi.org/10.1016/j.ophtha.2026.09.031","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the association between various intraocular pressure (IOP) metrics and visual field progression in open-angle glaucoma (OAG), when derived from in-office or remote (home) tonometry.</p><p><strong>Design: </strong>Retrospective analysis of longitudinal data.</p><p><strong>Participants: </strong>94 treated patients (150 eyes) with diagnoses of primary OAG, juvenile OAG, pseudoexfoliative glaucoma, or pigmentary glaucoma who were prescribed remote tonometry.</p><p><strong>Methods: </strong>Remote tonometry (iCare HOME, ≥ 7days) and in-office IOP measurements were analyzed using standard IOP metrics (mean, maximum, minimum, range, standard deviation, coefficient of variation) and three novel threshold-based IOP metrics: percentage of measurements above threshold (PMAT), average IOP excess (AIE), and total IOP excess (TIE), which gauge the frequency and magnitude of IOP measurements exceeding a target IOP, each calculated across five thresholds (12, 15, 18, 21mmHg and each patient's target IOP set by their glaucoma specialist). Remote tonometry metrics were computed across the entire monitoring period (\"absolute\") and as daily aggregated averages (\"daily\"). Visual field progression rate was assessed through the mean deviation slope derived from ≥3 reliable Humphrey visual fields (HVFs). Generalized estimating equations evaluated associations between IOP metrics and HVF progression rates.</p><p><strong>Main outcome measures: </strong>Association between tonometry-derived IOP metrics and HVF progression rate (dB/year).</p><p><strong>Results: </strong>Mean IOP was between 13-14mmHg and similar between remote and in-office tonometry (p=0.62), while all other standard metrics differed significantly. No standard IOP metric was significantly associated with HVF progression. In contrast, remote tonometry-derived AIE and TIE at the patient-specific target IOP were significantly associated with faster progression (absolute AIE β=-0.34, p=0.003; absolute TIE β=-0.35, p=0.048; daily AIE β=-0.29, p=0.024; daily TIE β=-0.40, p=0.035), while in-office equivalents were not associated with progression rate.</p><p><strong>Conclusions: </strong>In this retrospective cohort, remote tonometry-derived, novel threshold-based IOP metrics describing the frequency and degree of exceeding patient-specific IOP targets were significantly associated with HVF progression in patients with OAG under treatment, whereas standard and in-office IOP metrics were not. These findings suggest that remote tonometry may capture clinically relevant IOP burden not reflected in conventional settings and metrics, and support prospective validation of both remote IOP monitoring and individualized, threshold-based metrics as potential complements to current approaches of glaucoma monitoring.</p>","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholesteryl Ester Transfer Protein Inhibition and Risk of Age-Related Macular Degeneration.","authors":"Can Can Xue, Hengtong Li, Sushan Wang, Qiao Fan, Marco Yu, Miao Li Chee, Ruifang Li-Gao, Ko Willems van Dijk, Chiea Chuen Khor, Anna C S Tan, Tien Yin Wong, Ching-Yu Cheng","doi":"10.1016/j.ophtha.2026.09.027","DOIUrl":"https://doi.org/10.1016/j.ophtha.2026.09.027","url":null,"abstract":"<p><strong>Purpose: </strong>Cholesteryl ester transfer protein (CETP) inhibitors have shown cardiovascular benefits, but genetically proxied CETP inhibition may increase age-related macular degeneration (AMD) risk. We evaluated this association in European- and East Asian-ancestry populations.</p><p><strong>Design: </strong>Drug-target Mendelian randomization (MR) and observational genetic association analyses in the UK Biobank and the Singapore Epidemiology of Eye Diseases (SEED) study.</p><p><strong>Participants: </strong>457,242 UK Biobank participants without AMD at baseline and 7,058 SEED participants.</p><p><strong>Methods: </strong>In drug-target MR, CETP inhibition was instrumented using a CETP protein quantitative trait locus (pQTL) instrument in Europeans and a high-density lipoprotein (HDL)-weighted CETP-region instrument in East Asians. Outcomes included advanced and early AMD in Europeans and exudative AMD, typical neovascular AMD (nAMD), and polypoidal choroidal vasculopathy (PCV) in East Asians. In observational analyses, a CETP pQTL score was evaluated against incident AMD in the UK Biobank, and an HDL-weighted CETP genetic score against prevalent AMD in SEED.</p><p><strong>Main outcome measures: </strong>Risk of AMD RESULTS: In drug-target MR, greater genetically proxied CETP inhibition was associated with higher risks of advanced AMD (OR, 1.45; 95% CI, 1.25, 1.67) and early AMD (OR, 1.29; 95% CI, 1.19, 1.41) in Europeans, and exudative AMD (OR, 3.14; 95% CI, 2.16, 4.57), typical nAMD (OR, 2.84; 95% CI, 1.69, 4.79), and PCV (OR, 3.18; 95% CI, 2.05, 4.93) in East Asians (all P<0.001). In UK Biobank, each 1-SD decrease in the CETP pQTL score, representing greater genetically proxied CETP inhibition, was associated with higher incident AMD risk (HR,1.03; 95% CI, 1.01, 1.06; P=0.008). In SEED, the HDL-weighted CETP genetic score showed a U-shaped association with prevalent early AMD. Compared with the midrange group, higher odds were observed in the highest decile, representing greater genetically proxied CETP inhibition (OR, 1.74; 95% CI, 1.07, 2.72; P=0.019), and the lowest tertile, representing weaker inhibition (OR, 1.50; 95% CI, 1.13, 1.99; P=0.005).</p><p><strong>Conclusions: </strong>Greater genetically proxied CETP inhibition was associated with higher AMD risk across genetic analyses in European- and East Asian-ancestry populations. These findings raise a potential retinal safety signal requiring validation in clinical trials and longitudinal observational studies in clinical practice.</p>","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149081740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive Language in Ophthalmology Abstracts: A 30-Year Sentiment Analysis.","authors":"Eunoo Bak, Young Kook Kim","doi":"10.1016/j.ophtha.2026.09.025","DOIUrl":"https://doi.org/10.1016/j.ophtha.2026.09.025","url":null,"abstract":"<p><p>Positive language in ophthalmology abstracts increased 2.8-fold between 1996 and 2025, with acceleration after 2021. The trend persisted after adjustment for abstract length and study characteristics, suggesting a substantive shift in scientific language.</p>","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uveal Effusion in Mucopolysaccharidosis Type II.","authors":"Xinyu Liu, Rongping Dai","doi":"10.1016/j.ophtha.2026.08.032","DOIUrl":"https://doi.org/10.1016/j.ophtha.2026.08.032","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Encouraging Results Regarding the Risk of Systemic Complications of \"Biologic\" Therapy for Noninfectious Uveitis.","authors":"John H Kempen","doi":"10.1016/j.ophtha.2026.08.035","DOIUrl":"https://doi.org/10.1016/j.ophtha.2026.08.035","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bypassed, Not Treated: Dacryocystitis after Custom Gold Jones Tubes.","authors":"Qinghua Wang, Suming Wu, Zhengwei Zhang","doi":"10.1016/j.ophtha.2026.08.033","DOIUrl":"https://doi.org/10.1016/j.ophtha.2026.08.033","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}