Ophthalmology最新文献

{"title":"Re: Wang et al.: Myopia control efficacy of asymmetric multipoint defocus technique spectacle lenses: one-year double-masked randomized controlled trial (Ophthalmology. 2025;132:972-979).","authors":"Junyi Lou, Xuan Liao","doi":"10.1016/j.ophtha.2025.09.006","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.09.006","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":9.5,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Armbrust et al.: Preoperative glycemic control and acute endophthalmitis after cataract surgery in United States veterans with diabetes mellitus (Ophthalmology. 2025;132:903-910).","authors":"Kentaro Nishida, Naoto Katakami, Takatoshi Maeno, Kohji Nishida","doi":"10.1016/j.ophtha.2025.09.004","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.09.004","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":9.5,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145302409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply.","authors":"Karen R Armbrust, Meghan K Berkenstock","doi":"10.1016/j.ophtha.2025.09.005","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.09.005","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":9.5,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145302379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraocular pressure following phacoemulsification with retained lens fragments in the IRIS® Registry (Intelligent Research in Sight).","authors":"Adam L Rothman, Lomas S Persad, Vikram R Paranjpe, Ta Chen Chang, Flora Lum, Elizabeth A Vanner, Robert C O'Brien","doi":"10.1016/j.ophtha.2025.10.008","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.10.008","url":null,"abstract":"<p><strong>Purpose: </strong>To describe intraocular pressure (IOP) changes following cataract surgery resulting in retained lens fragments (RLF).</p><p><strong>Design: </strong>Retrospective clinical cohort study.</p><p><strong>Participants: </strong>Eyes in the IRIS® Registry (Intelligent Research in Sight) that underwent stand-alone phacoemulsification from 1/1/2013-9/30/2019 resulting in RLF.</p><p><strong>Methods: </strong>Daily mean IOP was calculated from postoperative day 1-90. IOP spike was defined as a daily mean IOP >30 mmHg and >10 mmHg above baseline IOP within the first postoperative week. A linear mixed model was used to determine when the postoperative daily mean IOP stabilized and a final mean IOP was calculated by averaging the final daily mean IOP for all eyes with data from that timepoint onward. Odds ratios (OR) with 95% confidence interval (CI) for demographic and clinical characteristics were calculated with univariate and multivariate logistic regression analyses. Eyes were censored upon additional intervention that could affect IOP such as secondary surgery or addition of IOP-lowering medication.</p><p><strong>Main outcome measures: </strong>Postoperative daily mean IOP; incidence and OR of IOP spike RESULTS: Retained lens fragments were noted in 6105 eyes with mean (standard deviation, SD) baseline IOP of 15.8 (3.6) mmHg. There was an initial elevation in daily mean (SD) IOP after cataract surgery to 21.2 (8.5) mmHg that gradually declined but remained greater than baseline IOP until postoperative day 14. The final mean (SD) IOP and weeks until IOP stabilization was 15.0 (4.1) mm Hg at 5 weeks. Intraocular pressure spike occurred in 766 (12.5%) eyes. Factors associated with IOP spike include male sex (OR 1.47, 95% CI 1.28-1.70), P<0.0001), higher baseline IOP (OR 1.24 per 3 mmHg, 95% CI 1.18-1.31, P<0.0001) and glaucoma diagnosis (OR 1.18, 95% CI 1.01-1.39, P=0.038).</p><p><strong>Conclusions: </strong>The initial IOP elevation after phacoemulsification resulting in RLF is higher than standard cataract surgery due to an increased incidence of IOP spike. Surgeons should be more vigilant for possible IOP spikes in eyes with higher baseline IOP, male sex, and glaucoma. Eyes without an indication for secondary intervention will have IOP gradually return to baseline level and stabilize after an average of five weeks.</p>","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":9.5,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scheimpflug Imaging in Isolated Ectopia Lentis.","authors":"Sanjeev Kumar Dhoot, Sahil Jain","doi":"10.1016/j.ophtha.2025.08.030","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.08.030","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":9.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atopic Dermatitis-Linked Intraocular Lens Deposits Resolved by Interleukin-4/13 Blockade.","authors":"Masahiro Akada, Yuki Muraoka, Akitaka Tsujikawa","doi":"10.1016/j.ophtha.2025.09.001","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.09.001","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":9.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orbital Follicular Lymphoma in a Child Masquerading as Dacryocystitis.","authors":"Marie Callet, Marc Putterman, Augustin Lecler","doi":"10.1016/j.ophtha.2025.09.003","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.09.003","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":9.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescent Malignant Uveal Melanoma with SMARCB1 Deficiency and Orbital Invasion.","authors":"Xiaotong Sha, Zhenguo Xiao, Lijun Shen","doi":"10.1016/j.ophtha.2025.08.029","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.08.029","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":9.5,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapidly Progressing Glaucoma: Clinical, Structural, and Socioeconomic Drivers of Treatment Escalation.","authors":"Lok Hin Lee, Yangyiran Xie, Annabelle Pan, Saeid Rasouli, Chris Bradley, Jithin Yohannan","doi":"10.1016/j.ophtha.2025.10.003","DOIUrl":"10.1016/j.ophtha.2025.10.003","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate clinical and sociodemographic factors associated with selecting treatments in glaucoma patients with rapid visual field (VF) progression.</p><p><strong>Design: </strong>Retrospective cohort study PARTICIPANTS: 2,782 eyes from 1,812 adults with 5 or more 24-2 visual fields over five years and at least one optical coherence tomography (OCT) scan at baseline.</p><p><strong>Methods: </strong>Rapid progressors were defined by mean deviation (MD) slopes worse than -1 dB/year. Demographic (age, gender, race), clinical (intraocular pressure (IOP), VF metrics, OCT measures), and socioeconomic (social vulnerability index, or SVI) variables were collected. Patients were categorized based on the most intensive treatment received in the first seven years: medical management, minimally invasive procedures (e.g., minimally invasive glaucoma surgery or laser), or aggressive procedures (e.g., filtering surgery or external ciliodestruction). Multinomial regression was performed to identify demographic, clinical, and socioeconomic factors associated with treatment intensity.</p><p><strong>Main outcome measures: </strong>Odds of treatment selection based on rapid VF progression RESULTS: Rapid progressors had significantly higher odds of receiving aggressive procedures (odds ratio [OR] 6.96, 95% confidence interval [CI] 2.61-18.55, p < 0.001), yet only 23% of rapid progressors underwent aggressive procedures in the first seven years. In a sample of rapid progressors who were managed with medical treatment alone, we found that 85% were conservatively managed due to clinician decision-making rather than patient preference. Worse MD, smaller rim area, and higher initial IOP were associated with more aggressive intervention. Functional decline (MD slope) was not associated with treatment selection in rapid progressors. We also found that higher (worse) SVI was associated with a reduced likelihood of receiving minimally invasive procedures among rapid progressors (OR 0.06, 95% CI 0.00-0.78, p = 0.032).</p><p><strong>Conclusion: </strong>Although rapid progression was a strong predictor of aggressive procedures, fewer than one in four underwent aggressive IOP-lowering interventions in the first seven years. Rate of functional decline did not play a role in treatment selection within rapid progressors. Rapidly progressing patients in areas of higher socioeconomic vulnerability were also less likely to receive less invasive procedures. Better integrating rates of functional decline and addressing socioeconomic barriers may help optimize care for rapidly progressing glaucoma patients.</p>","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":9.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adalimumab vs. Conventional Immunosuppression for Uveitis (ADVISE) Trial.","authors":"Douglas A Jabs, Elizabeth A Sugar, Alyce E Burke, Michael Altaweel, Jennifer E Thorne, Sheriza Baksh, Lyndell Lim, Akshay Thomas, Steven Yeh, Janet T Holbrook","doi":"10.1016/j.ophtha.2025.10.004","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.10.004","url":null,"abstract":"<p><strong>Objective: </strong>Patients with non-infectious intermediate, posterior, or panuveitides typically are treated with oral corticosteroids and immunosuppressive agents, such as antimetabolites and calcineurin inhibitors. Goals of treatment include suppression of ocular inflammation (inactive disease) and reduction of oral corticosteroids to a prednisone dose <7.5 mg/day (corticosteroid sparing) or, if possible, discontinuation of prednisone. The anti-tumor necrosis factor monoclonal antibody, adalimumab, also is used in the treatment of these diseases, but its comparative effectiveness to conventional agents is unknown. The purpose of this trial was to compare adalimumab treatment to that with conventional immunosuppressive drugs for uveitis.</p><p><strong>Design: </strong>Randomized, unmasked, comparative effectiveness trial conducted at uveitis clinics at academic medical centers and private practices in the United States and internationally PARTICIPANTS: Patients with active or recently active non-infectious intermediate, posterior, or panuveitides needing immunosuppression INTERVENTIONS: Adalimumab vs. conventional immunosuppressive drugs (antimetabolites and/or calcineurin inhibitors) MAIN OUTCOME MEASURES: The primary outcome was successful corticosteroid sparing, defined as inactive uveitis at a prednisone dose <7.5 mg/day (or its equivalent) for 2 consecutive study visits >28 days apart, at 6 months. Other outcomes included successful corticosteroid sparing at 1 year and successful corticosteroid discontinuation, defined as inactive uveitis and no oral corticosteroid therapy for 2 consecutive study visits >28 days apart RESULTS: 227 participants were randomized to either adalimumab (N=114) or conventional immunosuppression (N=113). By 6 months of follow-up successful corticosteroid sparing occurred in 69% of participants assigned to adalimumab vs. 54% assigned to conventional immunosuppression (odds ratio [OR] 1.86; 95% confidence interval [CI] 1.06, 3.25; P=0.029) and by 12 months in 86% of participants assigned to adalimumab vs. 77% assigned to conventional immunosuppression (OR 1.89; 95% CI 0.93, 3.83; P=0.077). By 12 months successful corticosteroid discontinuation occurred in 55% of participants assigned to adalimumab vs. 40% assigned to conventional immunosuppression (OR 1.85; 95% CI 1.06, 3.19: P=0.028).</p><p><strong>Conclusions: </strong>For patients with non-infectious intermediate, posterior, or panuveitides requiring immunosuppression, adalimumab treatment resulted in a greater proportion of participants with successful corticosteroid sparing at 6 months and successful corticosteroid discontinuation at 12 months compared to treatment with antimetabolites or calcineurin inhibitors.</p>","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":9.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}