Ophthalmology最新文献

{"title":"Central Clearing of Epipapillary Infiltrates in Varicella-Zoster Virus Optic Nerve Infiltration.","authors":"Anamika Patel, Anup Kelgaonkar, Avinash Pathengay","doi":"10.1016/j.ophtha.2025.02.015","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.02.015","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-Operative Glycemic Control and Acute Endophthalmitis after Cataract Surgery in US Veterans with Diabetes Mellitus.","authors":"Karen R Armbrust, Sanya Ailani, Meghan K Berkenstock","doi":"10.1016/j.ophtha.2025.03.023","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.03.023","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate whether pre-operative glycemic control is predictive of acute endophthalmitis after cataract surgery.</p><p><strong>Design: </strong>Retrospective case-control study.</p><p><strong>Subjects: </strong>Patients with diabetes mellitus (DM) who underwent cataract surgery in 2010-2022 in the US Veterans Affairs (VA) Health Care System.</p><p><strong>Methods: </strong>Data extracted from the VA Corporate Data Warehouse included patient demographics, clinical features, timing of DM diagnosis, and pre-operative hemoglobin A1c (HbA1c) levels drawn 0-6 months before surgery. Acute post-operative endophthalmitis cases were identified using Current Procedural Terminology and International Classification of Diseases codes, then confirmed by chart review. Univariable and multivariable analyses were used to test for an association between pre-operative HbA1c and the development of post-operative endophthalmitis.</p><p><strong>Main outcome measures: </strong>Development of post-operative endophthalmitis within 42 days after cataract surgery.</p><p><strong>Results: </strong>Of 190 393 patients with a diagnosis of DM at the time of cataract surgery and HbA1c recorded 0-6 months prior to surgery, 157 (0.08%) developed acute post-operative endophthalmitis. Mean ± standard deviation pre-operative HbA1c was lower in patients with acute post-operative endophthalmitis (7.1 ± 1.4%) than in controls without endophthalmitis (7.3 ± 1.5%) but this difference was not significant (P = 0.14). Similarly, subanalysis of the cohort with HbA1c levels drawn 0-2 months before surgery showed no association between pre-operative HbA1c and endophthalmitis (P = 0.31). Multiple logistic regression analysis also showed no association between pre-operative glycemic control as measured by HbA1c and post-operative endophthalmitis (adjusted odds ratio, 0.89; 95% confidence interval, 0.79 - 1.01; P = 0.08).</p><p><strong>Conclusions: </strong>Pre-operative HbA1c level was not associated with the development of acute post-operative endophthalmitis in patients with DM undergoing cataract surgery. These findings suggest that pre-operative HbA1c guidelines based on infection rates after non-ophthalmic surgery may not apply to cataract surgery.</p>","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"期刊一览","authors":"Sandeep Ravindran PhD","doi":"10.1016/j.ophtha.2025.02.003","DOIUrl":"10.1016/j.ophtha.2025.02.003","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 4","pages":"Page e3"},"PeriodicalIF":13.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"En Breve","authors":"Sandeep Ravindran PhD","doi":"10.1016/j.ophtha.2025.02.001","DOIUrl":"10.1016/j.ophtha.2025.02.001","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 4","pages":"Pages e1-e2"},"PeriodicalIF":13.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"This Issue at a Glance","authors":"Sandeep Ravindran PhD","doi":"10.1016/j.ophtha.2025.02.002","DOIUrl":"10.1016/j.ophtha.2025.02.002","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 4","pages":"Page 375"},"PeriodicalIF":13.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caruncular Dacryops Arising from Lacrimal Gland of Popoff.","authors":"Matthew E Wei, Tatyana Milman, Carol L Shields","doi":"10.1016/j.ophtha.2025.02.008","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.02.008","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Safety Assessment of Aqueous Humor Liquid Biopsy in Retinoblastoma: A Multicenter Study of 1,203 Procedures\".","authors":"Douglas Chigane, Drishti Pandya, Muskaan Singh, Brianne Brown, Michelle Lin, Liya Xu, Andrew W Stacey, Alyssa C Bonnell, G Baker Hubbard, Hans Grossniklaus, Alison H Skalet, Kellyn N Bellsmith, Sara E Lally, Margarida Simão-Rafael, Cristina Jou Muñoz, Jaume Català-Mora, Denis Malaise, Livia Lumbroso-Le Rouic, Alexandre Matet, Guillermo L Chantada, Nathalie Cassoux, Carol L Shields, Jesse L Berry","doi":"10.1016/j.ophtha.2025.03.018","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.03.018","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the safety profile of aqueous humor (AH) liquid biopsy in pediatric patients with retinoblastoma (RB) and RB-simulating lesions through a multicenter analysis of paracentesis procedures.</p><p><strong>Design: </strong>Retrospective multicenter study.</p><p><strong>Subjects: </strong>A total of 1,203 paracentesis procedures were performed on 484 eyes of 425 pediatric patients, including 352 patients with RB and 73 with RB-simulating lesions.</p><p><strong>Methods: </strong>Medical records were reviewed retrospectively to identify complications from anterior chamber paracentesis performed to obtain AH for liquid biopsy. Procedures were conducted during routine examination under anesthesia (EUA). AH samples were extracted using a 32-gauge needle and underwent cell-free DNA analysis. Complications were classified as mild, moderate, or severe based on clinical impact and required interventions.</p><p><strong>Main outcome measures: </strong>Incidence and severity of complications related to the paracentesis procedure.</p><p><strong>Results: </strong>Among 1,203 procedures, 1 mild complication was identified, representing an overall complication rate of 0.08%. No moderate or severe complications, including vision, eye loss, extraocular tumor spread, or death were observed at a median follow-up of 16 months. The procedure demonstrated an excellent safety profile across multiple centers, with no permanent adverse outcomes.</p><p><strong>Conclusion: </strong>AH liquid biopsy via anterior chamber paracentesis is a safe and well-tolerated procedure in pediatric patients with RB when performed by trained ocular surgeons under general anesthesia. This large-scale analysis supports the procedure's use as a minimally invasive diagnostic tool with minimal risk, providing valuable molecular insights for RB management. These findings offer reassurance to clinicians and parents regarding the safety of AH liquid biopsy for RB.</p>","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surveillance for Metastasis in Low-Risk Uveal Melanoma Patients: Need for Optimization.","authors":"Adrienne Delaney, Yağmur Seda Yeşiltaş, Emily C Zabor, Arun D Singh","doi":"10.1016/j.ophtha.2025.03.019","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.03.019","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effectiveness of surveillance protocols utilizing hepatic ultrasonography (US) at 6-month intervals to detect metastasis and determine its impact on overall survival (OS) in low-risk uveal melanoma (UM) patients.</p><p><strong>Design: </strong>Retrospective Cohort Study SUBJECTS: 144 consecutive patients with Class 1 (low risk) primary UM were enrolled.</p><p><strong>Methods: </strong>All patients had negative baseline systemic staging following which they underwent systemic surveillance either with hepatic US at 6-month intervals (standard protocol, SP) or enhanced protocol (EP) utilizing high frequency (US every 3 months) or enhanced modality (EM, hepatic computed tomography/magnetic resonance imaging).</p><p><strong>Main outcome measures: </strong>Largest diameter of largest hepatic metastasis (LDLM), number of hepatic metastatic lesions, time to detection of metastasis (TDM), and OS.</p><p><strong>Results: </strong>Median follow-up time for those still alive (134, 10 patients died from any cause) was 50.6 months (IQR: 28.6-76.1). Surveillance was done with SP in the majority (101 [70%]) and EP in 43[30%]). A total of 834 US scans were performed (median 5.0 [IQR: 3.0, 8.0])) that led to detection of metastasis in 6 patients by SP in the majority (5/6) and EP in 1/6. The median LDLM at detection was 2.8 cm. Only tumor largest basal diameter was significantly associated with increased hazard of metastasis (HR 1.33 [95% CI, 1.04-1.70]; p= 0.022) whereas age, tumor thickness, and PRAME status were not. All patients were treated for metastasis (liver directed 1 [17%], systemic therapy 5 [83%]).</p><p><strong>Conclusions: </strong>The vast majority of patients with UM predicted to have low risk of metastasis do not develop metastasis by 5 years (96%). Surveillance protocols in such patients have very low yield and their impact on survival cannot be assessed. Our study demonstrates the need for further risk refinement of low-risk UM patients to better identify at-risk individuals. Currently used surveillance protocols need to be optimized.</p>","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply.","authors":"Alan Y Hsu, Chun-Ju Lin, Yi-Yu Tsai","doi":"10.1016/j.ophtha.2025.01.027","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.01.027","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrawidefield Imaging of Choroidal Abnormalities in Neurofibromatosis Type 1.","authors":"Alessandro Feo, Arash Omidtabrizi, David Sarraf","doi":"10.1016/j.ophtha.2025.01.009","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.01.009","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}