Ophthalmology最新文献

{"title":"US Incidence and Demographics of Ocular Surface Squamous Neoplasia in the IRIS® Registry 2014-2021.","authors":"Elise V H Meide, Tanner J Ferguson, Carol L Karp, Flora Lum, Daniel C Terveen","doi":"10.1016/j.ophtha.2025.04.014","DOIUrl":"10.1016/j.ophtha.2025.04.014","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the incidence and demographics of ocular surface squamous neoplasia (OSSN) in the United States using the IRIS® Registry (Intelligence Research in Sight).</p><p><strong>Design: </strong>Retrospective analysis of all patients with OSSN International Classification of Diseases (ICD) 9^th and 10^th Revision codes.</p><p><strong>Participants: </strong>A total of 13 924 unique eyes from 13 383 patients.</p><p><strong>Methods: </strong>The ICD 9^th and 10^th revision codes were used to identify eyes with OSSN.</p><p><strong>Main outcome measures: </strong>Incidence of OSSN, demographic information, diagnosis, risk factors, and frequency of use for current treatments.</p><p><strong>Results: </strong>The annual incidence from 2014 to 2021 in the IRIS Registry was 3.4 per 100 00 patient-years. The incidence within the registry of OSSN increased 2.9 times from 2014 to 2021. The average age was 67 years, with 88% of patients older than 50 years and 62% older than 65 years. Demographics of the affected cohort were 63.8% male, 65% White, and 10% Hispanic. Forty percent of patients with OSSN had a history of smoking, and 39% of patients were in southern US states based on US Census classification. Surgical excision was performed on 44% of OSSN eyes. Of the patients with primary topical therapy, 62% were treated with interferon (IFN) alfa-2b.</p><p><strong>Conclusions: </strong>This study used the IRIS Registry as a database for the incidence and demographics of OSSN. Our demographic results are consistent with other studies showing a higher incidence in older, White, and male patients. This study demonstrated that as of 2021 there are at least 2100 new OSSN cases per year in the United States and that incidence increased from 2014 to 2021. The use of the topical immuno-chemotherapy IFN remained a popular treatment modality for OSSN from 2014 to 2021.</p><p><strong>Financial disclosure(s): </strong>Proprietary or commercial disclosure may be found after the references.</p>","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Lema et al.: A remote consult retinal artery occlusion diagnostic protocol (Ophthalmology. 2024;131:724–730)","authors":"Cecilia C. Canizela BS ,&nbsp;Pranesh Ravichandran BS ,&nbsp;Kamal Kishore MD, FASRS","doi":"10.1016/j.ophtha.2025.03.014","DOIUrl":"10.1016/j.ophtha.2025.03.014","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 7","pages":"Pages e118-e119"},"PeriodicalIF":13.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disciplinary Revocation of American Board of Ophthalmology Certification: 2005-2024.","authors":"George B Bartley, Gabriel Watkins, Ann Acers-Warn, Tamara R Fountain","doi":"10.1016/j.ophtha.2025.04.013","DOIUrl":"10.1016/j.ophtha.2025.04.013","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unusual Epibulbar Complex Choristoma.","authors":"Maneesh Kumar, Ritu Arora, Smrithi Krishna C","doi":"10.1016/j.ophtha.2025.03.020","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.03.020","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual Outcomes of Limbal Stem Cell Transplantation in the IRIS® Registry","authors":"Jennifer A. Tran MD ,&nbsp;Thomas H. Dohlman MD ,&nbsp;Lyvia J. Zhang BA ,&nbsp;Alice Lorch MD, MPH ,&nbsp;Tobias Elze PhD ,&nbsp;Joan W. Miller MD ,&nbsp;Jia Yin MD, PhD ,&nbsp;Isdin Oke MD, MPH ,&nbsp;Reza Dana MD, MPH","doi":"10.1016/j.ophtha.2025.04.009","DOIUrl":"10.1016/j.ophtha.2025.04.009","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 8","pages":"Pages 954-957"},"PeriodicalIF":13.1,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caruncle Sebaceous Carcinoma.","authors":"Miriam-Benigna C Amobi, Tatyana Milman, Carol L Shields","doi":"10.1016/j.ophtha.2025.01.025","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.01.025","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Chou et al.: Association between semaglutide and nonarteritic anterior ischemic optic neuropathy: a multinational population-based study (Ophthalmology. 2025;132:381-388)","authors":"Flora Lum MD","doi":"10.1016/j.ophtha.2025.03.011","DOIUrl":"10.1016/j.ophtha.2025.03.011","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 7","pages":"Pages e121-e122"},"PeriodicalIF":13.1,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Risk for Open-Angle Glaucoma Subtypes Is Associated with Specific Visual Field Defect Classes.","authors":"Sayuri Sekimitsu, Kavin Selvan, Yan Zhao, Saber Kazeminasab Hashemabad, Mohammad Eslami, Mengyu Wang, Tobias Elze, Ayellet V Segrè, Joni A Turunen, Aarno Palotie, Joel Rämō, Janey L Wiggs, Louis R Pasquale, Jae H Kang, Nazlee Zebardast","doi":"10.1016/j.ophtha.2025.04.008","DOIUrl":"10.1016/j.ophtha.2025.04.008","url":null,"abstract":"<p><strong>Purpose: </strong>We investigated visual field (VF) archetype-genotype associations for open-angle glaucoma (OAG) and its subtypes, high-tension glaucoma (HTG) and normal-tension glaucoma (NTG).</p><p><strong>Design: </strong>Cross-sectional, population-based study.</p><p><strong>Participants: </strong>A total of 79 357 VF results from 11 572 patients with OAG at Massachusetts Eye and Ear (2012-2022) were used to identify VF archetypes. Archetype-genotype correlations were performed on participants with genotyping data, VF results, and OAG codes (H40.1x) from the Mass General Brigham Biobank, and 3 Health Professional Cohorts (n = 1517) with primary open-angle glaucoma (POAG) and reproducible VF loss.</p><p><strong>Methods: </strong>Primary open-angle glaucoma polygenic risk score (PRS), NTG PRS, and weighted HTG genetic risk score (GRS) from genome-wide association studies were calculated for 1517 participants (2408 eyes). Logistic regression assessed VF archetype-genotype associations.</p><p><strong>Main outcome measures: </strong>Associations between PRS or GRS and VF archetypes.</p><p><strong>Results: </strong>Nine archetypes were identified, including normal and various paracentral, peripheral, and total loss patterns. In a logistic regression model adjusted for age, sex, and ancestry, a 1-standard deviation (SD) increase in POAG PRS was linked to 1.65-times higher odds of paracentral defects (adjusted odds ratio [aOR], 1.65; 95% confidence interval [CI], 1.32-2.08) and 1.30-times higher odds of peripheral defects (aOR, 1.3; 95% CI, 1.14-1.48). A 1-SD increase in NTG PRS was associated with 1.69-times higher odds of paracentral defects (aOR, 1.69; 95% CI, 1.23-2.3) and 1.28-times higher odds of peripheral defects (aOR, 1.28; 95% CI, 1.06-1.54). A 1-SD increase in HTG GRS was linked to 0.68-times lower odds of both paracentral defects (aOR, 0.68; 95% CI, 0.57-0.82) and peripheral defects (aOR, 0.68; 95% CI, 0.62-0.76). A 1-SD increase in HTG GRS also was associated with 1.31-times higher odds of total loss (OR, 1.31; 95% CI, 1.01-1.77) in an unadjusted model, but was not significant in the adjusted model.</p><p><strong>Conclusions: </strong>Higher POAG PRSs and NTG PRSs were associated with paracentral VF loss, whereas higher HTG GRS was linked to total VF loss, but not paracentral defects. Genetic risk for glaucoma subtypes is associated with specific VF defects, which may affect disease diagnosis and prognostication.</p><p><strong>Financial disclosure(s): </strong>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</p>","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiorgan Cysticercosis.","authors":"Anirudh Kapoor, Baijukumar R Virani, Rishav Raj","doi":"10.1016/j.ophtha.2025.02.022","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.02.022","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Junctional Scotoma of Traquair Caused by an Intracranial Mass.","authors":"Jo-Hsuan Wu, Tal Paz, Meital Ben Dov","doi":"10.1016/j.ophtha.2025.02.021","DOIUrl":"https://doi.org/10.1016/j.ophtha.2025.02.021","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}