Ophthalmology最新文献

{"title":"OCT Angiography of Retinal Capillary Hamartoma","authors":"Zhenlong Ran MD , Jiayue Wang MD , Jingxue Ma MD, PhD","doi":"10.1016/j.ophtha.2024.01.031","DOIUrl":"10.1016/j.ophtha.2024.01.031","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 1","pages":"Page e15"},"PeriodicalIF":13.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139983443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Glaucoma Severity and Progression in Individuals with Asymmetric Axial Length","authors":"Min Gu Huh MD ,&nbsp;Yoon Jeong MD ,&nbsp;Young In Shin MD ,&nbsp;Young Kook Kim MD, PhD ,&nbsp;Jin Wook Jeoung MD, PhD ,&nbsp;Ki Ho Park MD, PhD","doi":"10.1016/j.ophtha.2024.07.013","DOIUrl":"10.1016/j.ophtha.2024.07.013","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate whether a difference exists in intereye glaucoma severity and progression in patients with asymmetric axial length.</div></div><div><h3>Design</h3><div>Long-term observational study.</div></div><div><h3>Participants</h3><div>Patients older than 20 years with a diagnosis of glaucoma at Seoul National University Hospital, Seoul, Korea, between 2010 and 2020.</div></div><div><h3>Methods</h3><div>Patients with a diagnosis of glaucoma in both eyes with an axial length difference of more than 1.0 mm were included. Each individual’s eyes were classified into longer eye and shorter eye, and the baseline and follow-up clinical data were analyzed using the paired T-test and McNemar test.</div></div><div><h3>Main Outcome Measures</h3><div>Differences in clinical characteristics in patients with asymmetric axial length.</div></div><div><h3>Results</h3><div>A total of 190 eyes of 95 patients with glaucoma with asymmetric axial length were included in the study. The patients’ mean age was 51.2 ± 12.3 years, and the mean follow-up period was 10.1 ± 3.9 years. No difference was found in baseline intraocular pressure (IOP) or central corneal thickness between longer eyes and shorter eyes. Among the baseline disc parameters, ovality index, β-zone and γ-zone parapapillary atrophy (PPA) area were larger (<em>P</em> &lt; 0.001) in the longer eyes. In the baseline OCT data, the retinal nerve fiber layer (RNFL) thickness (<em>P</em> = 0.009) and ganglion cell–inner plexiform layer (GCIPL) thickness (<em>P</em> &lt; 0.001) were thinner in the longer eyes. According to a baseline visual field (VF) test, the mean deviation and VF index (VFI) values were significantly lower (<em>P</em> &lt; 0.001, <em>P</em> = 0.034) in the longer eyes. Based on an analysis of glaucoma progression, the rate of change of superior GCIPL (longer eyes, –0.65 μm/year; shorter eyes, –0.40 μm/year), mean deviation (longer eyes, –0.40 dB/year; shorter eyes, –0.21 dB/year), and VFI (longer eyes, –0.92%/year; shorter eyes, –0.46%/year) were larger (<em>P</em> = 0.006, <em>P</em> = 0.005, <em>P</em> &lt; 0.001) in the longer eyes. Additionally, the greater the difference in IOP fluctuation, the greater the difference in the rate of change between mean deviation and VFI.</div></div><div><h3>Conclusions</h3><div>When an axial length difference of more than 1.0 mm was present, glaucoma tended to be more severe and to progress faster in the longer eyes.</div></div><div><h3>Financial Disclosure(s)</h3><div>The author(s) have no proprietary or commercial interest in any materials discussed in this article.</div></div>","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 1","pages":"Pages 39-51"},"PeriodicalIF":13.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141634161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Potter et al.: Concordance between self-reported visual difficulty and objective visual impairment: The National Health and Aging Trends Study (Ophthalmology. 2024;131:1447-1456)","authors":"Yating Zhou MD,&nbsp;Fei Xue MD","doi":"10.1016/j.ophtha.2024.09.018","DOIUrl":"10.1016/j.ophtha.2024.09.018","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 1","pages":"Pages e4-e5"},"PeriodicalIF":13.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Antioxidant and Lutein/Zeaxanthin Supplements Slow Geographic Atrophy Progression to the Fovea in Age-Related Macular Degeneration","authors":"Tiarnán D.L. Keenan BM BCh, PhD ,&nbsp;Elvira Agrón MA ,&nbsp;Pearse A. Keane MD ,&nbsp;Amitha Domalpally MD, PhD ,&nbsp;Emily Y. Chew MD ,&nbsp;Age-Related Eye Disease Study Research Group,&nbsp;Age-Related Eye Disease Study 2 Research Group","doi":"10.1016/j.ophtha.2024.07.014","DOIUrl":"10.1016/j.ophtha.2024.07.014","url":null,"abstract":"<div><h3>Purpose</h3><div>To determine whether oral micronutrient supplementation slows geographic atrophy (GA) progression in age-related macular degeneration (AMD).</div></div><div><h3>Design</h3><div>Post hoc analysis of Age-Related Eye Disease Study (AREDS) and AREDS2, multicenter randomized placebo-controlled trials of oral micronutrient supplementation, each with 2 × 2 factorial design.</div></div><div><h3>Participants</h3><div>A total of 392 eyes (318 participants) with GA in AREDS and 1210 eyes (891 participants) with GA in AREDS2.</div></div><div><h3>Methods</h3><div>The AREDS participants were randomly assigned to oral antioxidants (500 mg vitamin C, 400 IU vitamin E, 15 mg β-carotene), 80 mg zinc, combination, or placebo. The AREDS2 participants were randomly assigned to 10 mg lutein/2 mg zeaxanthin, 350 mg docosahexaenoic acid/650 mg eicosapentaenoic acid, combination, or placebo. Consenting AREDS2 participants were also randomly assigned to alternative AREDS formulations: original; no beta-carotene; 25 mg zinc instead of 80 mg; both.</div></div><div><h3>Main Outcome Measures</h3><div>(1) Change in GA proximity to central macula over time and (2) change in square root GA area over time, each measured from color fundus photographs at annual visits and analyzed by mixed-model regression according to randomized assignments.</div></div><div><h3>Results</h3><div>In AREDS eyes with noncentral GA (n = 208), proximity-based progression toward the central macula was significantly slower with randomization to antioxidants versus none, at 50.7 μm/year (95% confidence interval [CI], 38.0–63.4 μm/year) versus 72.9 μm/year (95% CI, 61.3–84.5 μm/year; <em>P =</em> 0.012), respectively. In AREDS2 eyes with noncentral GA, in participants assigned to AREDS antioxidants without β-carotene (n = 325 eyes), proximity-based progression was significantly slower with randomization to lutein/zeaxanthin versus none, at 80.1 μm/year (95% CI, 60.9–99.3 μm/year) versus 114.4 μm/year (95% CI, 96.2–132.7 μm/year; <em>P =</em> 0.011), respectively. In AREDS eyes with any GA (n = 392), area-based progression was not significantly different with randomization to antioxidants versus none (<em>P =</em> 0.63). In AREDS2 eyes with any GA, in participants assigned to AREDS antioxidants without β-carotene (n = 505 eyes), area-based progression was not significantly different with randomization to lutein/zeaxanthin versus none (<em>P =</em> 0.64).</div></div><div><h3>Conclusions</h3><div>Oral micronutrient supplementation slowed GA progression toward the central macula, likely by augmenting the natural phenomenon of foveal sparing.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found after the references.</div></div>","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 1","pages":"Pages 14-29"},"PeriodicalIF":13.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141698679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Racial, Ethnic, and Socioeconomic Differences on Visual Impairment before Cataract Surgery","authors":"Abdelhalim A. Awidi MD ,&nbsp;Fasika A. Woreta MD, MPH ,&nbsp;Ahmed Sabit MS ,&nbsp;Haihong Hu MS ,&nbsp;Niteesh Potu MS ,&nbsp;Eva Devience MD ,&nbsp;Jiangxia Wang MA, MS ,&nbsp;Suma Vupputuri PhD, MPH","doi":"10.1016/j.ophtha.2024.07.021","DOIUrl":"10.1016/j.ophtha.2024.07.021","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare the associations of race, ethnicity, and socioeconomic status (SES) with visual impairment (VI) before surgical removal of cataracts across 2 health systems in the United States Mid-Atlantic region.</div></div><div><h3>Design</h3><div>Multi-institutional cross-sectional study.</div></div><div><h3>Participants</h3><div>Patients ≥ 65 years of age who underwent cataract surgery at Johns Hopkins Hospital (JHH) and Kaiser Permanente (KP) between January 1, 2017, and December 31, 2019.</div></div><div><h3>Methods</h3><div>Covariates included patient age, sex, smoking status, surgery laterality, Charlson comorbidity index, and ocular comorbidities. Multivariable generalized estimating equation models were used to examine the association of race, ethnicity, and area deprivation index (ADI) with visual acuity.</div></div><div><h3>Main Outcome Measures</h3><div>Visual acuity before cataract surgery was assessed using logarithm of minimum angle of resolution values. Race, ethnicity, and ADI were the main exposures of interest.</div></div><div><h3>Results</h3><div>At JHH, 11 509 patients (17 731 eyes) were included, whereas KP included 7143 patients (10 542 eyes). After adjusting for covariates, Black patients (β = 0.49), Asian patients (β = 0.83), and Hispanic patients (β = 0.95) were more likely to have worse visual acuity at JHH (<em>P</em> &lt; 0.001 for all) compared with White patients. Similarly, at KP, Black patients (β = 0.56), Asian patients (β = 0.70), and Hispanic patients (β = 0.89) were more likely to have worse visual acuity (<em>P</em> &lt; 0.001 for all) compared with White patients. Compared with those living in the least disadvantaged neighborhoods at JHH, higher ADI quartiles (more deprived) were more likely to have worse visual acuity (β = 0.27 [<em>P</em> &lt; 0.001] for quartile 2; β = 0.40 [<em>P</em> = 0.001] for quartile 3; β = 0.95 [<em>P</em> &lt; 0.001] for quartile 4). No significant association was found between ADI and VI at KP.</div></div><div><h3>Conclusions</h3><div>Among older adults, non-White race or ethnicity was associated independently with VI secondary to cataracts in 2 large health systems in the United States Mid-Atlantic region, after adjustment for ADI. Area deprivation also was associated with VI but only in the JHH system. Our study suggests that non-White patients and those with lower SES are at greater risk of VI secondary to cataracts possibly because of social, structural, and institutional barriers.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 1","pages":"Pages 98-107"},"PeriodicalIF":13.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optic Disc Melanocytoma: Apparent Shrinkage after Posterior Vitreous Detachment","authors":"Michael Balas BHSc ,&nbsp;Mark Mandell MD, FRCSC ,&nbsp;Parnian Arjmand MD, FRCSC","doi":"10.1016/j.ophtha.2024.01.021","DOIUrl":"10.1016/j.ophtha.2024.01.021","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 1","pages":"Page e11"},"PeriodicalIF":13.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139741640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orbital Inflammation Prompted by Endovascular Mechanical Thrombectomy","authors":"Mattan Arazi MD ,&nbsp;Gal Yaniv MD ,&nbsp;Guy Ben-Simon MD, MPH","doi":"10.1016/j.ophtha.2024.01.034","DOIUrl":"10.1016/j.ophtha.2024.01.034","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 1","pages":"Page e16"},"PeriodicalIF":13.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140013109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anterior Segment OCT Image of Vitreous Hernia","authors":"Ce Shi MD, PhD ,&nbsp;Zhe Xu MD, PhD ,&nbsp;Wen Xu MD, PhD","doi":"10.1016/j.ophtha.2024.02.001","DOIUrl":"10.1016/j.ophtha.2024.02.001","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 1","pages":"Page e17"},"PeriodicalIF":13.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140013108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal Opacity in the United States","authors":"Rohan Bir Singh MD ,&nbsp;Thomas H. Dohlman MD ,&nbsp;Alexander Ivanov MS,&nbsp;Nathan Hall MS,&nbsp;Connor Ross MS,&nbsp;Tobias Elze PhD,&nbsp;Joan W. Miller MD,&nbsp;Alice Lorch MD, MPH,&nbsp;Erdem Yuksel MD,&nbsp;Jia Yin MD, PhD,&nbsp;Reza Dana MD, MPH,&nbsp;IRIS Registry Data Analytic Center Consortium","doi":"10.1016/j.ophtha.2024.07.005","DOIUrl":"10.1016/j.ophtha.2024.07.005","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Purpose&lt;/h3&gt;&lt;div&gt;This study assesses the case frequencies, underlying causes, and vision outcomes in patients with a diagnosis of corneal opacity in the United States.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Design&lt;/h3&gt;&lt;div&gt;Retrospective cohort study.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Participants&lt;/h3&gt;&lt;div&gt;Patients in the IRIS® Registry (Intelligent Research in Sight) who received a diagnosis of corneal opacity between January 1, 2013, and November 30, 2020.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;The IRIS Registry contains demographic and clinical data of 79 887 324 patients who sought treatment at eye clinics during the study period. We identified patients with corneal opacity using &lt;em&gt;International Classification of Diseases&lt;/em&gt; (ICD), &lt;em&gt;Ninth and Tenth&lt;/em&gt; Revisions, codes of 371 (corneal scar) and H17 (corneal opacity), respectively. The analyzed data comprised demographic parameters including age, sex, race, ethnicity, and geographical location. We evaluated clinical data including laterality, cause, disease descriptors, and best-corrected visual acuity (VA) up to 1 year before the onset (± 30 days), at the time of diagnosis, and at 1 year after diagnosis (± 30 days).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Main Outcome Measures&lt;/h3&gt;&lt;div&gt;Case frequencies, causes, and vision outcomes in patients with a diagnosis of corneal opacity.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;We identified 5 220 382 patients who received a diagnosis of corneal opacity and scars using H17 (ICD, Tenth Revision) and 371.0 (ICD, Ninth Revision) codes over 7 years. The case frequency of corneal opacity during the study period was 6535 cases per 100 000 patients (6.5%). The mean age of the patients was 63.36 ± 18.14 years, and most were female (57.6%). In the cohort, 38.39% and 30.00% of patients had bilateral and unilateral corneal opacity, respectively. Most of the patients affected by corneal opacity were White (69.13%), followed by Black or African American (6.84%). Corneal dystrophies (64.66%) were the most common cause of corneal opacity in the study cohort. Visual acuity of the patients worsened significantly because of corneal opacity (0.46 ± 0.74 logarithm of the minimum angle of resolution [logMAR]) and did not improve to the baseline (0.37 ± 0.68 logMAR) after management (0.43 ± 0.77 logMAR). The multiple linear regression analysis showed worse vision outcomes in female patients (compared with male patients), and Asian, Black or African American, and American Indian or Alaska Native (compared with White) patients. Additionally, worse vision outcomes were observed in patients with opacity associated with corneal malformation, degenerative disorders, edema, injury, and ulcer compared with those with hereditary corneal dystrophy.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;Our study showed that corneal opacity was diagnosed in 6.5% of patients in the IRIS Registry and primarily associated with corneal dystrophies. The final vision outcomes in patients with corneal opacity were significantly worse compared wit","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 1","pages":"Pages 52-61"},"PeriodicalIF":13.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pleomorphic Adenoma Misdiagnosed as Chalazion","authors":"Ruimiao Li M Med,&nbsp;Mingyu Ren M Med,&nbsp;Limin Liu M Med","doi":"10.1016/j.ophtha.2024.01.025","DOIUrl":"10.1016/j.ophtha.2024.01.025","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 1","pages":"Page e12"},"PeriodicalIF":13.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139900252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}