Ophthalmic and Physiological Optics最新文献

{"title":"The repeatability of macular and peripapillary vessel density in participants with different severities of glaucoma.","authors":"Yun Hsia, Tsing-Hong Wang, Jehn-Yu Huang, Chien-Chia Su","doi":"10.1111/opo.13448","DOIUrl":"10.1111/opo.13448","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the repeatability of optical coherence tomography angiography (OCTA) parameters in participants with different severities of glaucoma.</p><p><strong>Methods: </strong>Subjects with open-angle glaucoma were enrolled prospectively and categorised into mild (mean deviation [MD] of 24-2 visual field test ≥ -6 dB), moderate to advanced (-6 > MD ≥ -20 dB) and severe glaucoma groups (MD < -20 dB). OCTA was performed three times within a single visit to obtain superficial and deep macular vessel density (VD) and peripapillary vessel and capillary density. The association between the coefficient of variation (CoV) and intraclass correlation coefficient (ICC) of these OCTA parameters and glaucoma severity (MD, the thickness of the retinal nerve fibre layer and the ganglion cell complex) was analysed, along with factors associated with the CoV of OCTA parameters.</p><p><strong>Results: </strong>A total of 57 mild, 92 moderate to advanced and 39 severe glaucomatous eyes were included. CoV for superficial (p < 0.001) and deep macular VD (p < 0.001) and peripapillary VD (p = 0.004) increased with glaucoma severity. Greater CoV for superficial and deep macular VD and peripapillary VD was associated with worse MD and scan quality index in multivariable analysis. The association between a higher CoV of superficial and deep macular VD and worse MD was only noticeable in participants with a scan quality index <7. The relationship between the CoV of peripapillary VD and MD was consistent across varying image qualities.</p><p><strong>Conclusion: </strong>The intrasession variability of OCTA parameters was greater in glaucoma participants with advanced disease, especially in those with suboptimal scan quality.</p>","PeriodicalId":19522,"journal":{"name":"Ophthalmic and Physiological Optics","volume":" ","pages":"689-698"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal development of ocular biometric components and refractive error in hyperopic children with infantile versus late-onset accommodative esotropia.","authors":"Jingyun Wang, Reed M Jost, Brooke A Koritala, Eileen E Birch","doi":"10.1111/opo.13468","DOIUrl":"10.1111/opo.13468","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the developmental patterns of refractive error and optical components in hyperopic children with infantile (onset ≤12 months of age) accommodative or late-onset (18-48 months of age) accommodative esotropia.</p><p><strong>Methods: </strong>This prospective longitudinal study included children with infantile (n = 34) or late-onset (n = 63) accommodative esotropia. Axial length (AL), anterior chamber depth (ACD), lens thickness (LT) and keratometry (K1, K2) were obtained with a Lenstar LS 900. Lenstar measures were recorded <6 months after cycloplegic spherical equivalent refraction (SER) was derived. An initial examination was conducted at 5.8 ± 1.5 years of age, with a follow-up duration of 4.8 ± 0.8 years. A linear mixed-effects model was used to estimate the rate of individual development for each ocular component and SER, and to compare the two groups.</p><p><strong>Results: </strong>All biometric components changed with age. The rates of change with age for SER and AL were significantly different between the infantile and late-onset groups (SER: -0.18 vs. -0.12D/year, p < 0.001; AL: 0.16 vs. 0.14 mm/year, p < 0.01). The rate of change with age of the AL/CR ratio was significantly different between the infantile and late-onset groups (0.019 vs. 0.016, p < 0.001). No significant differences in the rates of change in ACD, LT, K1 or K2 were identified.</p><p><strong>Conclusions: </strong>Major ocular biometric components in children continue to mature in both infantile and late-onset accommodative esotropia. Annual change in axial length is smaller in late-onset accommodative esotropia than for infantile accommodative esotropia, consistent with less change in the SER with age.</p>","PeriodicalId":19522,"journal":{"name":"Ophthalmic and Physiological Optics","volume":" ","pages":"810-819"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of 0.025% atropine on ocular biometry changes during accommodation.","authors":"Rohan P J Hughes, Emily C Woodman-Pieterse, Scott A Read, Stephen J Vincent, Michael J Collins","doi":"10.1111/opo.13485","DOIUrl":"10.1111/opo.13485","url":null,"abstract":"<p><strong>Purpose: </strong>Low concentration atropine is an effective treatment to slow myopia progression and axial elongation and also reduces accommodation. On-axis ocular dimensions of the eye change during accommodation; hence, this study aimed to quantify the effect of 0.025% atropine eye drops on accommodation-induced changes in ocular biometry.</p><p><strong>Methods: </strong>Twenty-eight myopic participants with a mean (SD) age of 17.0 (6.0) years (range: 8.0-25.5 years) and spherical equivalent refraction (SER) of -2.03 (1.05) D (range: -0.75 to -4.38 D) were enrolled. Baseline ocular biometry measurements of the left eye were captured using an optical biometer (Zeiss IOLMaster 700) for 0, 2, 4 and 6 D accommodation stimuli, presented via a Badal optometer. The accommodation response (AR) was determined using wavefront aberrometry (Imagine Eyes irx3) for the same accommodation stimuli and following cycloplegia using 1% tropicamide. Participants instilled 0.025% atropine eye drops nightly for 1 week in both eyes, and ocular biometry measurements were repeated on the day after the final atropine dose.</p><p><strong>Results: </strong>Anterior chamber depth (ACD) and corrected vitreous chamber depth (cVCD) decreased, and crystalline lens thickness (LT), anterior segment length (ASL), crystalline lens centre position (LCP) and the AR increased significantly during accommodation (all p ≤ 0.009). Accommodation-induced changes in ACD and LT were reduced following 0.025% atropine use (both p ≤ 0.01), with significant pre- and post-atropine differences for the 4 and 6 D stimuli (all pairwise comparisons, p ≤ 0.004). On average, ACD, ASL and LCP increased, while cVCD, corrected axial length (cAL), and the AR decreased following 1 week of 0.025% atropine use (all p ≤ 0.002).</p><p><strong>Conclusions: </strong>The AR and on-axis ocular biometric changes during accommodation were reduced following 1 week of 0.025% atropine use. These findings may have implications for the association between near work and myopia, and atropine's mechanism of action in humans.</p>","PeriodicalId":19522,"journal":{"name":"Ophthalmic and Physiological Optics","volume":" ","pages":"865-876"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11976513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to 'Reliability and agreement of subjective and objective non-invasive break-up time measurements in contact lens wearers'.","authors":"","doi":"10.1111/opo.13470","DOIUrl":"10.1111/opo.13470","url":null,"abstract":"","PeriodicalId":19522,"journal":{"name":"Ophthalmic and Physiological Optics","volume":" ","pages":"895"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMC 60th Anniversary Lifetime Achievement Awards.","authors":"Weizhong Lan, Frank Schaeffel","doi":"10.1111/opo.13512","DOIUrl":"https://doi.org/10.1111/opo.13512","url":null,"abstract":"","PeriodicalId":19522,"journal":{"name":"Ophthalmic and Physiological Optics","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The case for treating all children with myopia control interventions.","authors":"Xiangui He, Nicola S Logan, James S Wolffsohn","doi":"10.1111/opo.13492","DOIUrl":"10.1111/opo.13492","url":null,"abstract":"","PeriodicalId":19522,"journal":{"name":"Ophthalmic and Physiological Optics","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should combination treatments be the standard of care to maximise efficacy for myopia treatment?","authors":"Padmaja Sankaridurg, Audrey Chia, Pauline Kang","doi":"10.1111/opo.13474","DOIUrl":"https://doi.org/10.1111/opo.13474","url":null,"abstract":"","PeriodicalId":19522,"journal":{"name":"Ophthalmic and Physiological Optics","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can short-term changes in the choroid in humans predict long-term eye growth?","authors":"Pavan K Verkicharla, Ranjay Chakraborty, Lisa A Ostrin","doi":"10.1111/opo.13478","DOIUrl":"https://doi.org/10.1111/opo.13478","url":null,"abstract":"","PeriodicalId":19522,"journal":{"name":"Ophthalmic and Physiological Optics","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can we predict which high myopes will develop pathological myopia?","authors":"Nicola Rizzieri, Quan V Hoang, Ian Flitcroft","doi":"10.1111/opo.13462","DOIUrl":"10.1111/opo.13462","url":null,"abstract":"","PeriodicalId":19522,"journal":{"name":"Ophthalmic and Physiological Optics","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modelling the thermal effects of stimulus airflow from the Dolphin aesthesiometer on a model eye surface.","authors":"Melanie A Mungalsingh, Benjamin Thompson, Sean D Peterson, Paul J Murphy","doi":"10.1111/opo.13436","DOIUrl":"10.1111/opo.13436","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the ability of the Dolphin air-pulse aesthesiometer to present multiple stimuli, which are separated temporally (in sequence) or spatially (simultaneously).</p><p><strong>Methods: </strong>Two studies were performed to explore the cooling effects induced by double air-puff stimuli generated by a novel aesthesiometer composed of two micro-blower integrated units. The stimuli were delivered sequentially or simultaneously at the same or different spatial locations to an in vitro eye model monitored using thermography. The model eye was based on a 2-cm LED dome light mounted on a circuit board with an 8-V supply producing a baseline 32°C temperature. Single and repeated air-pulse stimuli varying in intensity, duration, inter-stimulus delay and stimulus location were presented to the model. The cooling effect produced was observed using a thermal camera and quantified using image analysis software.</p><p><strong>Results: </strong>The instrument can deliver single stimuli, repeated single stimuli with a variable time delay or multiple stimuli either simultaneously or with a time delay between them. The thermal effects of stimuli were evaluated by measuring (relative to pre-stimulus baseline) the local temperature change and the diameter of the model eye surface region with ≥1°C reduction. Repeated stimuli at the same location produced a significantly greater effect than a single stimulus of the same intensity (larger area of cooling after the second stimulus compared to the first [|M|{SE} = 1.48 mm {0.06}, p < 0.001]). Spatially separated stimuli produced separate cooling zones, with the amount of cooling relative to stimulus intensity (rm-ANOVA, F_2,8 = 276.01, p < 0.001, <math> <semantics><mrow><mi>ω</mi></mrow> </semantics> </math> ² = 0.96).</p><p><strong>Conclusions: </strong>The combined use of two micro-blower units allows increased options for modification of stimulus intensity and timing of delivery that enables the production of alternative stimulus presentations and intensity compared to a single stimulus. This adaptability may enable future in vivo study of corneal sensory nerve summation.</p>","PeriodicalId":19522,"journal":{"name":"Ophthalmic and Physiological Optics","volume":" ","pages":"361-371"},"PeriodicalIF":2.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11823302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}