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Journal of Heterocyclic Chemistry最新文献

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Microwave-Assisted Hantzsch, Biginelli, and GBB Reactions: Eco-Efficient Synthesis of N-Heterocycles 微波辅助Hantzsch， Biginelli和GBB反应：n -杂环的生态高效合成
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2026-03-01 Epub Date: 2025-12-02 DOI: 10.1002/jhet.70139
Divyani P. Patel, Satish Kumar Singh
{"title":"Microwave-Assisted Hantzsch, Biginelli, and GBB Reactions: Eco-Efficient Synthesis of N-Heterocycles","authors":"Divyani P. Patel,&nbsp;Satish Kumar Singh","doi":"10.1002/jhet.70139","DOIUrl":"https://doi.org/10.1002/jhet.70139","url":null,"abstract":"<div>\u0000 \u0000 <p>As we look to the future, it is important to remember the significance of assessing the efficiency of multicomponent reactions (MCRs) of green chemistry principles. These reactions have a favorable compatibility with environmentally friendly organic synthesis. N-heterocyclic moieties are highly regarded and play a crucial role in modern organic chemistry. Looking ahead, Hantzsch, Biginelli, and GBB MCRs with microwave-assisted chemistry approaches promise to significantly reduce chemical waste and reaction times. These methods quickly and effectively incorporate numerous structurally diverse aspects into heterocyclic compounds, all accomplished in a single synthetic step. Anticipating the need to produce biologically active heterocyclic compounds in the future, MW-assisted MCRs (Hantzsch, Biginelli, and GBB) could become important green synthesis methods.</p>\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"63 3","pages":"432-453"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147562267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Catalyst-Free and Visible Light-Promoted Perfluoroalkylation of Indoles 无催化剂和可见光促进的吲哚全氟烷基化
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2026-03-01 Epub Date: 2025-12-18 DOI: 10.1002/jhet.70154
Jing Wang, Xun Sun, Jialuo Zou, Xiaojing Su, Yin Lin, Fan Zhou, Lei Zhang
{"title":"Catalyst-Free and Visible Light-Promoted Perfluoroalkylation of Indoles","authors":"Jing Wang,&nbsp;Xun Sun,&nbsp;Jialuo Zou,&nbsp;Xiaojing Su,&nbsp;Yin Lin,&nbsp;Fan Zhou,&nbsp;Lei Zhang","doi":"10.1002/jhet.70154","DOIUrl":"https://doi.org/10.1002/jhet.70154","url":null,"abstract":"<div>\u0000 \u0000 <p>In this study, we report a catalyst-free and photoinduced strategy for the direct perfluoroalkylation of heterocyclic indoles. This method demonstrates synthetic simplicity, mild reaction conditions, and eliminates the need for any catalyst, yielding perfluoroalkylated products in moderate to excellent yields. A diverse range of substrates, including various biologically relevant molecules, exhibited excellent compatibility with the reaction system, highlighting its potential for late-stage functionalization of pharmaceutical analogues.</p>\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"63 3","pages":"512-525"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147566812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of Novel Benzimidazole Derivatives as a Carbonic Anhydrase IX (Ca IX) Inhibitor With Anticancer Potential 具有抗癌潜力的新型苯并咪唑类碳酸酐酶IX （Ca IX）抑制剂的合成
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2026-03-01 Epub Date: 2025-12-02 DOI: 10.1002/jhet.70138
Zeynep Deniz Şahin Inan, Hayrani Eren Bostancı, Serkan Kapancık, Ayşen Işık, Hacı Ahmet Kılıç, Ulviye Acar Çevik, Özen Özensoy Güler, Yusuf Özkay, Zafer Asım Kaplancıklı
{"title":"Synthesis of Novel Benzimidazole Derivatives as a Carbonic Anhydrase IX (Ca IX) Inhibitor With Anticancer Potential","authors":"Zeynep Deniz Şahin Inan,&nbsp;Hayrani Eren Bostancı,&nbsp;Serkan Kapancık,&nbsp;Ayşen Işık,&nbsp;Hacı Ahmet Kılıç,&nbsp;Ulviye Acar Çevik,&nbsp;Özen Özensoy Güler,&nbsp;Yusuf Özkay,&nbsp;Zafer Asım Kaplancıklı","doi":"10.1002/jhet.70138","DOIUrl":"https://doi.org/10.1002/jhet.70138","url":null,"abstract":"<div>\u0000 \u0000 <p>In the present study, a series of benzimidazole-thiazole derivatives (<b>4a</b>–<b>4k</b>) were rationally designed and synthesized to evaluate their potential inhibitory effects on carbonic anhydrase IX (CA IX) and anticancer properties. The structural elucidation of the compounds was performed using spectroscopic techniques including <sup>1</sup>H NMR, <sup>13</sup>C NMR, and HRMS. Their cytotoxic activities were assessed on L929, HT29, MCF7, and C6 cell lines through MTT assays. Following the MTT assay, compound <b>4h</b> was identified as exhibiting notable cytotoxicity against HT29, MCF7, and C6 cell lines, with IC<sub>50</sub> values measured at 36.6 ± 11.98, 22.8 ± 5.18, and 42.06 ± 6.58 μM, respectively. Moreover, compound <b>4h</b> exhibited lower toxicity toward the L929 healthy mouse fibroblast cell line compared to the reference drug cisplatin. Flow cytometry analysis demonstrated that in cancer cell lines treated with compound <b>4h</b>, the proportion of apoptotic cells was markedly higher than that of necrotic (non-programmed dead) cells. Immunofluorescence microscopy analysis also confirmed that compound <b>4h</b> had cytotoxic effects on cancer cells. According to the carbonic anhydrase IX activity results, compound <b>4h</b> was found to have the highest activity.</p>\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"63 3","pages":"418-431"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147562266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Protocol for the Synthesis of Substituted 1,4-Dihydroquinoxalin-2-Amine Derivatives From CN Cross-Coupling Reactions of Carbodiimides, Nitro Compounds, and Various 2-Iodoanilines 由碳二亚胺、硝基化合物和各种2-碘苯胺的C - N交叉偶联反应合成取代的1,4-二氢喹啉-2-胺衍生物的新方法
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2026-03-01 Epub Date: 2025-12-28 DOI: 10.1002/jhet.70140
Manijeh Nematpour
{"title":"A Novel Protocol for the Synthesis of Substituted 1,4-Dihydroquinoxalin-2-Amine Derivatives From CN Cross-Coupling Reactions of Carbodiimides, Nitro Compounds, and Various 2-Iodoanilines","authors":"Manijeh Nematpour","doi":"10.1002/jhet.70140","DOIUrl":"https://doi.org/10.1002/jhet.70140","url":null,"abstract":"<div>\u0000 \u0000 <p>A simple, rapid, and efficient ultrasonic-assisted protocol is reported for the synthesis of 1,4-dihydroquinoxalin-2-amine from the one-pot C<span></span>N cross-coupling reactions of carbodiimides, nitro compounds, and various 2-iodoanilines in THF solvent, CuI (10 mol%) as catalyst, and KO<i>t</i>-Bu as an active base under ultrasonic conditions in 45 min with optimal efficiency. The role of ultrasound is to reduce the reaction time, increase the efficiency of product preparation, and make the work-up easier. Finally, 15 new heterocyclic compounds from the 1,4-dihydroquinoxalin-2-amine family have been synthesized in this project using a simple, rapid, and efficient ultrasonic method.</p>\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"63 3","pages":"548-556"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147569834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2026-02-27
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引用次数: 0
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2026-02-24
{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"63 5","pages":"877-882"},"PeriodicalIF":2.0,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148091603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2026-02-24
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引用次数: 0
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2026-02-19
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引用次数: 0
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2026-02-18
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引用次数: 0
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2026-02-17
{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"63 5","pages":"809-817"},"PeriodicalIF":2.0,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148079548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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