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Journal of Heterocyclic Chemistry最新文献

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An approach for the diastereoselective synthesis of (R)-(+)-methyl pipecolate and (+)-dextro-erythrophacetoperane from (S)-(−)-methylbenzylamine 从(S)-(-)-甲基苄胺非对映选择性合成(R)-(+)-甲基哌啶酮和(+)-右旋赤式乙酰哌啶的方法
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2024-07-23 DOI: 10.1002/jhet.4878
Alan Aguilar-Aguilar, Alan Carrasco-Carballo, Dino Gnecco, Hisami Rodríguez-Matsui, David Aparicio-Solano, Joel L. Terán
{"title":"An approach for the diastereoselective synthesis of (R)-(+)-methyl pipecolate and (+)-dextro-erythrophacetoperane from (S)-(−)-methylbenzylamine","authors":"Alan Aguilar-Aguilar,&nbsp;Alan Carrasco-Carballo,&nbsp;Dino Gnecco,&nbsp;Hisami Rodríguez-Matsui,&nbsp;David Aparicio-Solano,&nbsp;Joel L. Terán","doi":"10.1002/jhet.4878","DOIUrl":"10.1002/jhet.4878","url":null,"abstract":"<p>A diastereoselective synthesis for the preparation of (<i>R</i>)-methyl pipecolate and dextro-erythrophacetoperane, analogs of methylphenidate, drugs used to treat attention deficit hyperactivity disorder, is reported. The key steps involve a high diastereoselective ring-closing reaction via enolate formation and a diastereoselective ketone reduction reaction. The total synthesis of these valuable drugs could be obtained in only 5 and 8 steps, respectively, starting from (<i>S</i>)-(−)-methyl benzylamine.</p>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 10","pages":"1571-1579"},"PeriodicalIF":2.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141776931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel and convenient method for the synthesis of 1,2,4-oxadiazole-5-thiones 合成 1,2,4-噁二唑-5-硫酮的新颖简便方法
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2024-07-23 DOI: 10.1002/jhet.4874
Babak Kaboudin, Saman Soleymanie, Ali Sabzalipour, Foad Kazemi, Haruhiko Fukaya
{"title":"A novel and convenient method for the synthesis of 1,2,4-oxadiazole-5-thiones","authors":"Babak Kaboudin,&nbsp;Saman Soleymanie,&nbsp;Ali Sabzalipour,&nbsp;Foad Kazemi,&nbsp;Haruhiko Fukaya","doi":"10.1002/jhet.4874","DOIUrl":"10.1002/jhet.4874","url":null,"abstract":"<p>A novel and convenient method for the synthesis of 1,2,4-oxadiazole-5-thiones with carbon disulfide as effective C=S source has been developed in a super basic condition. The presented method has a broad substrate scope, and various corresponding 1,2,4-oxadiazole-5-thiones have been obtained in good to excellent yields. This method allows to the gram-scale synthesis of products. Under similar conditions, synthesis of diazole thione benzothioamide derivative from <i>p-</i>cyanobenzamidoxime with CS<sub>2</sub> has been successfully achieved.</p>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 10","pages":"1564-1570"},"PeriodicalIF":2.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141785668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential synthesis of nitrated products from 2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazaisowurtzitane derivatives with linear substituents 从具有线性取代基的 2,6,8,12-四乙酰基-2,4,6,8,10,12-六氮杂昭乌齐坦衍生物合成硝化产品的可能性
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2024-07-23 DOI: 10.1002/jhet.4879
Daria A. Kulagina, Sergey V. Sysolyatin, Yuri A. Balakhnin, Valeria V. Eremina, Natalia A. Alekseeva
{"title":"Potential synthesis of nitrated products from 2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazaisowurtzitane derivatives with linear substituents","authors":"Daria A. Kulagina,&nbsp;Sergey V. Sysolyatin,&nbsp;Yuri A. Balakhnin,&nbsp;Valeria V. Eremina,&nbsp;Natalia A. Alekseeva","doi":"10.1002/jhet.4879","DOIUrl":"10.1002/jhet.4879","url":null,"abstract":"<p>The compact, nitrogen-rich structure of 2,4,6,8,10,12-hexaazaisowurtzitanes calls attention among researchers worldwide. These compounds have found the greatest utility as substrates for nitration to obtain the caged polynitramine, 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane, which possesses a high-energy performance. All new derivatives of hexaazaisowurtzitane are nitratable. The present study examined the nitration process of 2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazaisowurtzitane derivatives obtained through the condensation reaction with aldehydes under various conditions to yield CL-20. The yield of CL-20, a well-known nitration product of hexaazaisowurtzitane compounds, was found to depend on the substrate structure and the nitrating mixture composition. The revealed dependence of the synthesis of various nitrated compounds on the holding time enables the synthesis of products with different physicochemical properties in a single process.</p>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 10","pages":"1580-1585"},"PeriodicalIF":2.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141776932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of substituted 5,6,7,8-tetrafluoro-1H-benzo[f]indol-4,9-diones based on the reaction of hexafluoro-1,4-napthoquinone with methyl 3-aminocrotonates 基于六氟-1,4-萘醌与 3-氨基巴豆酸甲酯反应合成取代的 5,6,7,8-四氟-1H-苯并[f]吲哚-4,9-二酮
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2024-07-23 DOI: 10.1002/jhet.4872
Ekaterina N. Kudryavtseva, Boris V. Lichitsky, Andrey N. Komogortsev, Constantine V. Milyutin, Evgeny V. Tretyakov
{"title":"Synthesis of substituted 5,6,7,8-tetrafluoro-1H-benzo[f]indol-4,9-diones based on the reaction of hexafluoro-1,4-napthoquinone with methyl 3-aminocrotonates","authors":"Ekaterina N. Kudryavtseva,&nbsp;Boris V. Lichitsky,&nbsp;Andrey N. Komogortsev,&nbsp;Constantine V. Milyutin,&nbsp;Evgeny V. Tretyakov","doi":"10.1002/jhet.4872","DOIUrl":"10.1002/jhet.4872","url":null,"abstract":"<p>For the first time, the possibility of using hexafluoro-1,4-naphthoquinone for the construction of condensed heterocyclic system was demonstrated. As a result, two-step synthesis of previously unknown 5,6,7,8-tetrafluoro-1<i>H</i>-benzo[<i>f</i>]indol-4,9-dione derivatives was elaborated. The suggested method includes initial interaction of hexafluoro-1,4-naphthoquinone with various methyl 3-aminocrotonates and subsequent intramolecular cyclization into the target fluorinated benzo[<i>f</i>]indole-4,9-diones. The distinctive feature of considered protocol is regiospecific reaction of fluorine atoms in quinone fragment. Advantages of the presented approach are simple synthetic procedure avoiding chromatographic purification, atom economy and readily available starting materials. The structure of one of the synthesized compounds was established by x-ray analysis.</p>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 10","pages":"1554-1563"},"PeriodicalIF":2.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141776989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design, synthesis, biological evaluation of a new tricyclicthiazolopy-rimidinone derivatives as acetylcholinesterase inhibitors 作为乙酰胆碱酯酶抑制剂的新型三环噻唑并嘧啶酮衍生物的设计、合成和生物学评价
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2024-07-19 DOI: 10.1002/jhet.4863
Yan Zeng, Lifei Nie, Liu Liu, Khurshed Bozorov, Jiangyu Zhao
{"title":"Design, synthesis, biological evaluation of a new tricyclicthiazolopy-rimidinone derivatives as acetylcholinesterase inhibitors","authors":"Yan Zeng,&nbsp;Lifei Nie,&nbsp;Liu Liu,&nbsp;Khurshed Bozorov,&nbsp;Jiangyu Zhao","doi":"10.1002/jhet.4863","DOIUrl":"10.1002/jhet.4863","url":null,"abstract":"<p>The novel serious of tricyclicthiazolo[5,4-<i>d</i>]pyrimidinone were designed and synthesized as acetylcholinesterase (AChE) inhibitor agents. The main factors affecting the reactions of syntheses and the structure–activity relationships (SARs) were investigated as well. All compounds were confirmed by <sup>1</sup>H NMR, <sup>13</sup>C NMR, and HRMS. The in vitro enzyme assays proved that most of the compounds effectively inhibited AChE in the micromolar range with little cytotoxicity. Especially the compound <b>G15</b> exhibited the best inhibitory activity against AChE with IC<sub>50</sub> values of 4.41 ± 0.46 μM. Furthermore, kinetic analysis and molecular modeling studies pointed out the competitive inhibition manner of <b>G15</b> on AChE. Thus, the derivative <b>G15</b> can be considered a promising leading compound on AChE.</p>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 10","pages":"1542-1553"},"PeriodicalIF":2.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141740493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microwave assisted synthesis, acetylcholinesterase inhibition and molecular docking studies of furo[2,3-d]pyrido[1,2-a]pyrimidin-4-one derivatives 呋喃并[2,3-d]吡啶并[1,2-a]嘧啶-4-酮衍生物的微波辅助合成、乙酰胆碱酯酶抑制作用和分子对接研究
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2024-07-17 DOI: 10.1002/jhet.4875
Sümeyye Yalduz, Sait Sarı, Mehmet Yılmaz
{"title":"Microwave assisted synthesis, acetylcholinesterase inhibition and molecular docking studies of furo[2,3-d]pyrido[1,2-a]pyrimidin-4-one derivatives","authors":"Sümeyye Yalduz,&nbsp;Sait Sarı,&nbsp;Mehmet Yılmaz","doi":"10.1002/jhet.4875","DOIUrl":"10.1002/jhet.4875","url":null,"abstract":"<p>A series of phenyl, substituted phenyl and thiophene bearing dihydrofuropyrimidin-4-ones <b>(3a-p)</b> were synthesized by Mn(OAc)<sub>3</sub> mediated, microwave irradiated radical cyclizations of 2-hydroxy-pyridopyrimidin-4-one derivatives (<b>1a-j</b>) with substituted phenylvinylthiophenes (<b>2a-c</b>) at 70°C in 2 min. Compounds <b>3a-j</b> was obtained between 28% and 66% yields. Molecular structures of <b>3a-p</b> were determined by <sup>1</sup>H NMR, <sup>13</sup>C NMR, <sup>19</sup>F NMR, FTIR and HRMS techniques. Inhibitory activity of <b>3a-p</b> were evaluated against Acetylcholinesterase (AChE) and inhibition results of these compounds showed that the compounds had good inhibition with IC<sub>50</sub> values between 0.52 and 3.77 μM. In addition, molecular docking studies were carried out on the most potent inhibitory compounds <b>3d</b> (IC<sub>50</sub> = 0.64 μM), <b>3p</b> (IC<sub>50</sub> = 0.52 μM) and standart drug Donepezil. The binding energies for <b>3d</b>, <b>3p</b> and Donepezil are −9.12, −10.08 and −12.65 Kcal/mol, respectively. Based on these results, it was determined that, compounds <b>3d</b> and <b>3p</b> are promising AChE inhibitors.</p>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 10","pages":"1517-1530"},"PeriodicalIF":2.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141740495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of 2-aminothiazoles containing 3-hydroxypyran-4-one fragment based on condensation of substituted α-arylaminoketones with thiourea 基于取代的 α-芳基氨基酮与硫脲的缩合合成含有 3- 羟基吡喃-4-酮片段的 2-氨基噻唑
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2024-07-17 DOI: 10.1002/jhet.4876
Andrey N. Komogortsev, Valeriya G. Melekhina, Constantine V. Milyutin, Boris V. Lichitsky
{"title":"Synthesis of 2-aminothiazoles containing 3-hydroxypyran-4-one fragment based on condensation of substituted α-arylaminoketones with thiourea","authors":"Andrey N. Komogortsev,&nbsp;Valeriya G. Melekhina,&nbsp;Constantine V. Milyutin,&nbsp;Boris V. Lichitsky","doi":"10.1002/jhet.4876","DOIUrl":"10.1002/jhet.4876","url":null,"abstract":"<p>Condensation of α-arylaminoketones bearing 3-hydroxypyran-4-one fragment with thiourea was studied. Based on considered investigation, the method for the synthesis of terarylenes with 2-aminothiazole bridge was elaborated. The presented process is the first example of construction of thiazole core starting from α-aminoketone precursor. The advantages of developed approach are easily available starting materials and convenient isolation of target products avoiding chromatographic purification. The structure of one of prepared products was confirmed by x-ray analysis. The synthetic utility of obtained 2-aminothiazoles with allomaltol substituent was demonstrated by reaction at amino and hydroxyl groups.</p>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 10","pages":"1531-1541"},"PeriodicalIF":2.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141740494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficient synthetic strategies for fused pyrimidine and pyridine derivatives: A review 融合嘧啶和吡啶衍生物的高效合成策略：综述
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2024-07-17 DOI: 10.1002/jhet.4871
Sharmil N. Anjirwala, Saurabh K. Patel
{"title":"Efficient synthetic strategies for fused pyrimidine and pyridine derivatives: A review","authors":"Sharmil N. Anjirwala,&nbsp;Saurabh K. Patel","doi":"10.1002/jhet.4871","DOIUrl":"10.1002/jhet.4871","url":null,"abstract":"<p>Pyrimidine and its derivatives play a paramount role in drug discovery as privileged pharmacophores with considerable chemical and biological significance and its presence in genes. This review aims to assemble a systematic evaluation of synthetic tactics of various fused pyrimidine derivatives containing nitrogen heterocycles such as pyridopyridines, pyridopyrimidines, and pyrimidopyrimidine from a pharmacological point of view and deliver an overview of methodologies presenting the chemistry of fused pyrimidine derivatives. The review details the importance of various catalysts and ring substitution using various electrophilic and nucleophilic reagents. These synthetic strategies were elaborated based on the different synthetic routes that lead to the specific type of pyrimidine and pyridine fused derivatives. The literature accumulates various developments in one-pot condensation, the Knoevenagel–Michael addition mechanism, microwave and ultrasound irradiation, intramolecular cyclization, nano-catalytic reactions, and so forth. Short reaction times, catalyst reusability, solvent-free conditions, excellent yields, and stereo-selectivity are some of the benefits of certain synthetic approaches.</p>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 10","pages":"1481-1516"},"PeriodicalIF":2.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141740496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DABCO-catalyzed highly regioselective synthesis of novel 4H-pyrano[2,3-b]quinoline derivatives: One-pot three-component reaction DABCO 催化的新型 4H-吡喃并[2,3-b]喹啉衍生物的高区域选择性合成：一锅三组份反应
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2024-07-10 DOI: 10.1002/jhet.4862
Masumeh Heydari, Ali A. Mohammadi, Mohammad R. Mosleh
{"title":"DABCO-catalyzed highly regioselective synthesis of novel 4H-pyrano[2,3-b]quinoline derivatives: One-pot three-component reaction","authors":"Masumeh Heydari,&nbsp;Ali A. Mohammadi,&nbsp;Mohammad R. Mosleh","doi":"10.1002/jhet.4862","DOIUrl":"10.1002/jhet.4862","url":null,"abstract":"<p>A regioselective synthesis of 4<i>H</i>-pyrano[2,3-b]quinoline derivatives via DABCO-mediated Knoevenagel condensation/heterocyclization sequence has been executed. In this way some new fused heterocyclic compounds were synthesized from 2-chloroquinoline-3-carbaldehyde as a versatile and efficient synthetic building block. The one-pot three-component reaction of 2-chloroquinoline-3-carbaldehyde and diverse cyclic active methylenes for construction of highly substituted quinolines scaffold has been accomplished under mild condition. The strategy included herein shows significant advantages, including a facile process with easy purification, excellent yields, wide applicability, available substrates, and cost-effective/eco-friendly solvent and catalyst.</p>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 9","pages":"1446-1454"},"PeriodicalIF":2.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141585828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of 6-R-N-aryl-4-(trichloromethyl)-4H-1,3,5-oxadiazin-2-amines based on N-(2,2,2-trichloro-1-(3-R-thioureido)ethyl)carboxamides: Their spectral characteristics and molecular structure 基于 N-(2,2,2-三氯-1-(3-R-硫脲基)乙基)羧酰胺合成 6-R-N-芳基-4-(三氯甲基)-4H-1,3,5-恶二嗪-2-胺：其光谱特征和分子结构
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2024-07-10 DOI: 10.1002/jhet.4870
Yelyzaveta R. Lomynoha, Pavlo V. Zadorozhnii, Vadym V. Kiselev, Aleksandr V. Kharchenko
{"title":"Synthesis of 6-R-N-aryl-4-(trichloromethyl)-4H-1,3,5-oxadiazin-2-amines based on N-(2,2,2-trichloro-1-(3-R-thioureido)ethyl)carboxamides: Their spectral characteristics and molecular structure","authors":"Yelyzaveta R. Lomynoha,&nbsp;Pavlo V. Zadorozhnii,&nbsp;Vadym V. Kiselev,&nbsp;Aleksandr V. Kharchenko","doi":"10.1002/jhet.4870","DOIUrl":"10.1002/jhet.4870","url":null,"abstract":"<p>In this work, we report the synthesis of a series of new 4<i>H</i>-1,3,5-oxadiazine derivatives. The method of their production is based on the dehydrosulfurization reaction of <i>N</i>-(2,2,2-trichloro-1-(3-<i>R</i>-thioureido)ethyl)carboxamides under the action of a mixture of iodine and triethylamine in DMF. A possible reaction mechanism has been proposed. The target products have been obtained in 58%–75% yield. The structure of the obtained compounds has been confirmed by <sup>1</sup>H, <sup>13</sup>C NMR, IR spectroscopy data, and x-ray diffraction analysis carried out for 6-(<i>tert</i>-butyl)-<i>N</i>-phenyl-4-(trichloromethyl)-4<i>H</i>-1,3,5-oxadiazin-2-amine.</p>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 10","pages":"1467-1480"},"PeriodicalIF":2.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141611572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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