醋酸介质中一锅顺序四组分反应合成新型二氢氧磷吡唑2-氧化物

IF 2 3区化学 Q2 CHEMISTRY, ORGANIC

Journal of Heterocyclic Chemistry Pub Date : 2024-12-29 DOI:10.1002/jhet.4946

Mingshu Wu, Zhengfan Sun, Rui Ning, Ziwen Yan, Junying Ma, Siqi Fan

{"title":"醋酸介质中一锅顺序四组分反应合成新型二氢氧磷吡唑2-氧化物","authors":"Mingshu Wu, Zhengfan Sun, Rui Ning, Ziwen Yan, Junying Ma, Siqi Fan","doi":"10.1002/jhet.4946","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>A four-component one-pot sequential approach to five-membered oxaphosphaheterocycles have developed. The method involves in situ generation of methylpyrazolin-5-one from ethyl acetoacetate and phenyl hydrazine. Further, a sequential reaction of methylpyrazolin-5-one with various aromatic aldehydes and phenyl dichloro phosphine afforded dihydro oxaphospholo pyrazole 2-oxide derivatives.</p>\n </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"62 3","pages":"316-321"},"PeriodicalIF":2.0000,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"One-Pot Sequential Four-Component Reaction for the Synthesis of Novel Dihydro Oxaphospholo Pyrazole 2-Oxides in Acetic Acid Medium\",\"authors\":\"Mingshu Wu, Zhengfan Sun, Rui Ning, Ziwen Yan, Junying Ma, Siqi Fan\",\"doi\":\"10.1002/jhet.4946\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>A four-component one-pot sequential approach to five-membered oxaphosphaheterocycles have developed. The method involves in situ generation of methylpyrazolin-5-one from ethyl acetoacetate and phenyl hydrazine. Further, a sequential reaction of methylpyrazolin-5-one with various aromatic aldehydes and phenyl dichloro phosphine afforded dihydro oxaphospholo pyrazole 2-oxide derivatives.</p>\\n </div>\",\"PeriodicalId\":194,\"journal\":{\"name\":\"Journal of Heterocyclic Chemistry\",\"volume\":\"62 3\",\"pages\":\"316-321\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2024-12-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Heterocyclic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/jhet.4946\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Heterocyclic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jhet.4946","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}

引用次数: 0

摘要

提出了一种四组分一锅序法合成五元磷杂环的方法。该方法涉及由乙酰乙酸乙酯和苯肼原位生成甲基吡唑啉-5- 1。此外，甲基吡唑啉-5- 1与各种芳香醛和苯基二氯膦的连续反应得到二氢氧磷吡唑2-氧化物衍生物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

One-Pot Sequential Four-Component Reaction for the Synthesis of Novel Dihydro Oxaphospholo Pyrazole 2-Oxides in Acetic Acid Medium

A four-component one-pot sequential approach to five-membered oxaphosphaheterocycles have developed. The method involves in situ generation of methylpyrazolin-5-one from ethyl acetoacetate and phenyl hydrazine. Further, a sequential reaction of methylpyrazolin-5-one with various aromatic aldehydes and phenyl dichloro phosphine afforded dihydro oxaphospholo pyrazole 2-oxide derivatives.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Heterocyclic Chemistry 化学-有机化学

CiteScore

5.20

自引率

4.20%

发文量

177

审稿时长

3.9 months

期刊介绍： The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.