超声辅助cu催化n -羟基酰氯和2-碘酚分子间o -芳基化：新取代苯并[1,4,2]二恶嗪衍生物

IF 2 3区化学 Q2 CHEMISTRY, ORGANIC

Journal of Heterocyclic Chemistry Pub Date : 2024-11-17 DOI:10.1002/jhet.4930

Manijeh Nematpour

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引用次数: 0

摘要

研究了在乙腈溶剂中碘化铜催化n -羟基酰氯和2-碘酚分子间o -芳基化反应在超声辅助下快速、直接合成苯并[1,4,2]二恶嗪衍生物的方法。该方案的显著特点是使用廉价和可获得的原料和催化剂，无需柱层析，采用声化学方法，反应时间在40-45分钟，效率高（71%-93%）。本研究在苯并[1,4,2]二恶嗪衍生物的合成方面取得了重大进展。

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Ultrasonic Assisted Cu-Catalyzed Intermolecular O-Arylation of N-Hydroxyimidoyl Chloride and 2-Iodophenol: New Substituted Benzo[1,4,2]Dioxazine Derivatives

A rapid and direct route with the help of ultrasound for the synthesis of benzo[1,4,2]dioxazine derivatives through a copper iodide-catalyzed intermolecular O-arylation of N-hydroxyimidoyl chloride and 2-iodophenol in acetonitrile solvent has been investigated. The use of cheap and available raw materials and catalysts, without column chromatography, applying the sonochemical methodology, and performing the reaction in 40–45 min, with good efficiency (71%–93%) are notable features of this protocol. This research represents a significant advancement in the synthesis of benzo[1,4,2]dioxazine derivatives.

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来源期刊

Journal of Heterocyclic Chemistry 化学-有机化学

CiteScore

5.20

自引率

4.20%

发文量

177

审稿时长

3.9 months

期刊介绍： The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.