5-芳基四氢苯卓类药物的合成

IF 2 3区化学 Q2 CHEMISTRY, ORGANIC

Journal of Heterocyclic Chemistry Pub Date : 2024-11-24 DOI:10.1002/jhet.4932

Naveenkumar Thoti, Deepika Gupta, Heera Lal, Indrapal Singh Aidhen

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引用次数: 0

摘要

设想5-芳基四氢苯甲酮和5-芳基四氢苯甲酮作为构象锁定的潜在B0AT1抑制剂，开发了一种方便的合成途径。该合成路线主要是利用Schmidt反应快速获得对称/不对称5-芳基四氢苯甲酮和5-芳基四氢苯甲酮。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthesis of 5-Aryltetrahydrobenzazepines

Envisaging 5-aryltetrahydrobenzazepinone and 5-aryltetrahydrobenzazepines as conformationally locked potential B⁰AT1 inhibitors, a convenient synthetic route has been developed for their access. The synthetic route banks on using the Schmidt reaction for quick access to symmetrical/unsymmetrical 5-aryltetrahydrobenzazepinone and 5-aryltetrahydrobenzazepines.

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来源期刊

Journal of Heterocyclic Chemistry 化学-有机化学

CiteScore

5.20

自引率

4.20%

发文量

177

审稿时长

3.9 months

期刊介绍： The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.