Oncology ReviewsPub Date : 2020-04-27eCollection Date: 2020-02-18DOI: 10.4081/oncol.2020.493
Camillo Porta
{"title":"RETRACTION: The biological mechanism involved in anticancer properties of amniotic membrane.","authors":"Camillo Porta","doi":"10.4081/oncol.2020.493","DOIUrl":"https://doi.org/10.4081/oncol.2020.493","url":null,"abstract":"To our readers: \u0000With deep regrets, we inform our Readers that the article The biological mechanism involved in anticancer properties of amniotic membrane (DOI: https://doi.org/10.4081/oncol.2020.429), which has been published in the current issue of Oncology Reviews (2020-1), contains verbatim text plagiarized from another paper.1 The manuscript must be considered as retracted. On behalf of the Editorial Board of Oncology Reviews, I apologize to the Author of the manuscript whose text was plagiarized by Ameneh Jafari, Hassan Niknejad, Mostafa Rezaei-Tavirani, Caitlin D’Amico, Hakimeh Zali that this was not picked up in the peer review process. I also apologize to the affected journal for the violation of copyright due to plagiarism. Unfortunately we were not able to detect it before publication due to the language of the original paper (Slovenian). Oncology Reviews is uncompromising in its commitment to scientific integrity. When credible evidence of misconduct is brought to our attention, our commitment to the scientific record and to our readership requires immediate notification. Oncology Reviews is increasingly employing sophisticated software to detect plagiarism. Other journals use similar tools. Authors should be aware that most journals routinely employ plagiarism detection software, and that any plagiarism is likely to be detected. \u0000Camillo Porta, Editor-in-Chief Oncology Reviews \u0000 \u0000Reference1. Ramuta TZ, Cirman T, Erdani Kreft M. Celicno-bioloski mehanizmi delovanja amnijske membrane proti raku in možnosti za njeno uporabo pri zdravljenju raka [Cell-biological mechanisms of amniotic membrane anticancer activity and the possibilities of its use in anticancer therapy]. Slovenian Medical Journal (Zdravniski vestnik) 2018;87(9-10):483-92. (DOI: 10.6016/ZdravVestn.2674).","PeriodicalId":19487,"journal":{"name":"Oncology Reviews","volume":"14 1","pages":"493"},"PeriodicalIF":3.6,"publicationDate":"2020-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4081/oncol.2020.493","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37921624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oncology ReviewsPub Date : 2020-03-18eCollection Date: 2020-02-18DOI: 10.4081/oncol.2020.465
Soussan Irani, Iman Barati, Mohammadreza Badiei
{"title":"Periodontitis and oral cancer - current concepts of the etiopathogenesis.","authors":"Soussan Irani, Iman Barati, Mohammadreza Badiei","doi":"10.4081/oncol.2020.465","DOIUrl":"10.4081/oncol.2020.465","url":null,"abstract":"<p><p>Gingival tissues are attacked by oral pathogens which can induce inflammatory reactions. The immune-inflammatory responses play essential roles in the patient susceptibility to periodontal diseases. There is a wealth of evidence indicating a link between chronic inflammation and risk of malignant transformation of the affected oral epithelium. Periodontitis is associated with an increased risk of developing chronic systemic conditions including autoimmune diseases and different types of cancers. Besides, some risk factors such as smoking, alcohol consumption and human papilloma virus have been found to be associated with both periodontitis and oral cancer. This review article aimed to study the current concepts in pathogenesis of chronic periodontitis and oral cancer by reviewing the related articles.</p>","PeriodicalId":19487,"journal":{"name":"Oncology Reviews","volume":"14 1","pages":"465"},"PeriodicalIF":3.6,"publicationDate":"2020-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/95/48/onco-14-1-465.PMC7097927.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37787512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The impact of extended adjuvant temozolomide in newly diagnosed glioblastoma multiforme: a meta-analysis and systematic review.","authors":"Ehsan Alimohammadi, Seyed Reza Bagheri, Shahram Taheri, Maliheh Dayani, Alireza Abdi","doi":"10.4081/oncol.2020.461","DOIUrl":"https://doi.org/10.4081/oncol.2020.461","url":null,"abstract":"<p><p>Surgical resection followed by concurrent radiation therapy and temozolomide (TMZ) chemotherapy is the current standard treatment for glioblastoma multiforme (GBM). The present metaanalysis investigated the impact of prolonged TMZ maintenance therapy (more than 6 cycles) in comparison with standard TMZ maintenance therapy (exactly six cycles) on overall survival (OS) and progression-free survival (PFS) of patients with GBM. A meta-analysis of the literature was conducted using Medline, PubMed, EMBASE and the Cochrane Library in accordance with PRISMA guidelines. Seven articles involving 1018 patients were included. The overall survival was higher in the case group (>6 cycles TMZ) compared to the control group (6 cycles TMZ) (Z=2.375, P=0.018). The lower and upper limits were between 1.002-10.467 months. The case group had higher progression-free survival compared with the control group (Z=3.84; P<0.001). The lower and upper limits were between 2.559-7.894 months. Evidence from this meta-analysis suggests that prolonged TMZ therapy compared to the standard 6-cycle TMZ therapy was associated with higher survival in patients with glioblastoma.</p>","PeriodicalId":19487,"journal":{"name":"Oncology Reviews","volume":"14 1","pages":"461"},"PeriodicalIF":3.6,"publicationDate":"2020-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4081/oncol.2020.461","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37721399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The biological mechanism involved in anticancer properties of amniotic membrane.","authors":"Ameneh Jafari, Hassan Niknejad, Mostafa Rezaei-Tavirani, Hakimeh Zali","doi":"10.4081/oncol.2020.429","DOIUrl":"10.4081/oncol.2020.429","url":null,"abstract":"<p><p>The main role of amniotic membrane (AM), or amnion, is to protect the fetus from drying out and create an appropriate environment for its growth. AM is also a suitable candidate for the treatment of various diseases due to its unique characteristics. In recent years, a new line of research has focused on the anticancer properties of amnion and its potential use in cancer treatment. The <i>in vitro</i> and <i>in vivo</i> studies indicate the anti-proliferative and proapoptotic activities, as well as the angioregulatory and immunomodulatory properties of the amniotic membrane. However, the exact mechanism and molecular basis of these anticancer effects of AM are not fully elucidated. This paper presents an overview of the latest findings and knowledge about the anticancer effects of AM and its underlying molecular mechanisms, which is crucial for the application of amnion in cancer therapy.</p>","PeriodicalId":19487,"journal":{"name":"Oncology Reviews","volume":"14 1","pages":"429"},"PeriodicalIF":3.6,"publicationDate":"2020-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4081/oncol.2020.429","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37721397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oncology ReviewsPub Date : 2020-02-18DOI: 10.4081/oncol.2020.452
Kandasamy Ashokachakkaravarthy, Biju Pottakkat
{"title":"Mitotic quiescence in hepatic cancer stem cells: An incognito mode.","authors":"Kandasamy Ashokachakkaravarthy, Biju Pottakkat","doi":"10.4081/oncol.2020.452","DOIUrl":"https://doi.org/10.4081/oncol.2020.452","url":null,"abstract":"<p><p>Hepatocellular carcinoma represents one of the most aggressive cancers with high recurrence rates. The high recurrence is a major problem in the management of this disease. Cancer stem cells (CSCs) are often regarded as the basis of cancer recurrence. The anti-proliferative therapy kills the proliferating cells but induces mitotic quiescence in CSCs which remain as residual dormant CSCs. Later on, withdrawal of treatment reactivates the residual CSCs from dormancy to produce new cancer cells. The proliferation of these newly formed cancer cells initiates new tumor formation in the liver leading to tumor recurrence. HCC cells evade the immune surveillance via modulating the key immune cells by alpha feto-protein (AFP) secreted from CSCs or hepatic progenitor cells. This AFP mediated immune evasion assists in establishing new tumors by cancer cells in the liver. In this review, we will summarise the CSC mechanisms of recurrence, mitotic quiescence, dormancy and reactivation of CSCs, metastasis and immune evasion of hepatocellular carcinoma.</p>","PeriodicalId":19487,"journal":{"name":"Oncology Reviews","volume":"14 1","pages":"452"},"PeriodicalIF":3.6,"publicationDate":"2020-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4081/oncol.2020.452","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37721398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oncology ReviewsPub Date : 2019-11-28eCollection Date: 2019-07-22DOI: 10.4081/oncol.2019.433
Rachel A Fayne, Francisco I Macedo, Steven E Rodgers, Mecker G Möller
{"title":"Evolving management of positive regional lymph nodes in melanoma: Past, present and future directions.","authors":"Rachel A Fayne, Francisco I Macedo, Steven E Rodgers, Mecker G Möller","doi":"10.4081/oncol.2019.433","DOIUrl":"https://doi.org/10.4081/oncol.2019.433","url":null,"abstract":"<p><p>Sentinel lymph node (SLN) biopsy has become the standard of care for lymph node staging in melanoma and the most important predictor of survival in clinically node-negative disease. Previous guidelines recommend completion lymph node dissection (CLND) in cases of positive SLN; however, the lymph nodes recovered during CLND are only positive in a minority of these cases. Recent evidence suggests that conservative management (<i>i.e.</i> observation) has similar outcomes compared to CLND. We sought to review the most current literature regarding the management of SLN in metastatic melanoma and to discuss potential future directions.</p>","PeriodicalId":19487,"journal":{"name":"Oncology Reviews","volume":"13 2","pages":"433"},"PeriodicalIF":3.6,"publicationDate":"2019-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4081/oncol.2019.433","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37475358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oncology ReviewsPub Date : 2019-11-25eCollection Date: 2019-07-22DOI: 10.4081/oncol.2019.455
Ravi K Paluri, Guru Sonpavde, Charity Morgan, Jacob Rojymon, Anastasia Hartzes Mar, Radhika Gangaraju
{"title":"Renal toxicity with mammalian target of rapamycin inhibitors: A meta-analysis of randomized clinical trials.","authors":"Ravi K Paluri, Guru Sonpavde, Charity Morgan, Jacob Rojymon, Anastasia Hartzes Mar, Radhika Gangaraju","doi":"10.4081/oncol.2019.455","DOIUrl":"https://doi.org/10.4081/oncol.2019.455","url":null,"abstract":"<p><p>A meta-analysis of randomized clinical trials (RCT) was done to determine the relative risk (RR) of acute kidney injury (AKI) with the use of mammalian target of rapamycin (mTOR) inhibitors. Citations from PubMed/Medline, clinical trials.gov, package inserts and abstracts from major conferences were reviewed to include RCTs comparing arms with or without mTOR inhibitors. The RR of all grade AKI in patients taking mTOR inhibitors compared to patients not on mTOR inhibitors was 1.55 (95% CI: 1.11 to 2.16, P=0.010). There was no significant difference in the risk of high-grade AKI for the two groups (RR=1.29, P=0.118, 95% CI: 0.94 to 1.77). There was no significant difference in the incidence rates for either all grade or high-grade AKI between the two groups. There was no publication bias and the trials were of high quality per Jadad scoring.</p>","PeriodicalId":19487,"journal":{"name":"Oncology Reviews","volume":"13 2","pages":"455"},"PeriodicalIF":3.6,"publicationDate":"2019-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4081/oncol.2019.455","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37475359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oncology ReviewsPub Date : 2019-10-10eCollection Date: 2019-07-22DOI: 10.4081/oncol.2019.425
Gilbert Lazarus, Jessica Audrey, Anthony William Brian Iskandar
{"title":"Efficacy and safety profiles of programmed cell death-1/programmed cell death ligand-1 inhibitors in the treatment of triple-negative breast cancer: A comprehensive systematic review.","authors":"Gilbert Lazarus, Jessica Audrey, Anthony William Brian Iskandar","doi":"10.4081/oncol.2019.425","DOIUrl":"10.4081/oncol.2019.425","url":null,"abstract":"<p><p>Triple-negative breast cancer (TNBC) is associated with worse prognosis, with limited treatment regiments available and higher mortality rate. Immune checkpoint inhibitors targeting programmed cell death-1 (PD-1) or programmed cell death-ligand 1 (PD-L1) showed great potentials in treating malignancies and may serve as potential therapies for TNBC. This systematic review aims to evaluate the efficacy and safety profiles of PD-1/PD-L1 inhibitors in the treatment of TNBC. Literature search was performed via PubMed, EBSCOhost, Scopus, and CENTRAL databases, selecting studies which evaluated the use of anti-PD-1/PDL1 for TNBC from inception until February 2019. Risk of bias was assessed by the Newcastle-Ottawa Scale (NOS). Overall, 7 studies evaluating outcomes of 1395 patients with TNBC were included in this systematic review. Anti-PD-1/PD-L1 showed significant antitumor effect, proven by their promising response (objective response rate (ORR), 18.5-39.4%) and survival rates (median overall survival (OS), 9.2-21.3 months). Moreover, anti- PD-1/PD-L1 yielded better outcomes when given as first-line therapy, and overexpression of PD-L1 in tumors showed better therapeutic effects. On the other hands, safety profiles were similar across agents and generally acceptable, with grade ≥3 treatment- related adverse effects (AEs) ranging from 9.5% to 15.6% and no new AEs were experienced by TNBC patients. Most grade ≥3 AEs are immune-mediated, which are manifested as neutropenia, fatigue, peripheral neuropathy, and anemia. PD-1/PD-L1 inhibitors showed promising efficacy and tolerable AEs, and thus may benefit TNBC patients. Further studies of randomized controlled trials with larger populations are needed to better confirm the potential of these agents.</p>","PeriodicalId":19487,"journal":{"name":"Oncology Reviews","volume":"13 2","pages":"425"},"PeriodicalIF":3.6,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4081/oncol.2019.425","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37475357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oncology ReviewsPub Date : 2019-07-25eCollection Date: 2019-07-22DOI: 10.4081/oncol.2019.417
Sanjib Bahadur, Arvind Kumar Sahu, Pragya Baghel, Suman Saha
{"title":"Current promising treatment strategy for glioblastoma multiform: A review.","authors":"Sanjib Bahadur, Arvind Kumar Sahu, Pragya Baghel, Suman Saha","doi":"10.4081/oncol.2019.417","DOIUrl":"10.4081/oncol.2019.417","url":null,"abstract":"<p><p>Glioblastoma multiform (GBM) is a heterogeneous group of primary neoplasm resistant to conventional therapies. Due to their infiltrative nature it not fully isolated by aggressive surgery, radiation and chemotherapy showing poor prognosis in glioma patients. Unfortunately, diagnosed patients die within 1.5-2 year treatment schedule. Currently temozolomide (TMZ) is the first choice for the prognosis of GBM patients. TMZ metabolites methyl triazen imidazol carboxamide form complex with alkyl guanine alkyl transferase (O6 MGMT- DNA repair protein) induced DNA damage following resistance properties of TMZ and inhibit the overall survival of the patients. Last few decades different TMZ conjugated strategy is developed to overcome the resistance and enhance the chemotherapy efficacy. The main aim of this review is to introduce the new promising pharmaceutical candidates that significantly influence the therapeutic response of the TMZ in context of targeted therapy of glioblastoma patients. It is hoped that this proposed strategy are highly effective to overcome the current resistance limitations of TMZ in GBM patients and enhance the survival rate of the patients.</p>","PeriodicalId":19487,"journal":{"name":"Oncology Reviews","volume":"13 2","pages":"417"},"PeriodicalIF":3.1,"publicationDate":"2019-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/df/85/onco-13-2-417.PMC6661528.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41207882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oncology ReviewsPub Date : 2019-07-22DOI: 10.4081/oncol.2019.403
Arslaan Javaeed, S. Ghauri
{"title":"MCT4 has a potential to be used as a prognostic biomarker - a systematic review and meta-analysis","authors":"Arslaan Javaeed, S. Ghauri","doi":"10.4081/oncol.2019.403","DOIUrl":"https://doi.org/10.4081/oncol.2019.403","url":null,"abstract":"The role of several metabolic changes, such as hypoxia and acidosis, in the tumour environment has caught the attention of researchers in cancer progression and invasion. Lactate transport is one of the acidosis-enhancing processes that are mediated via monocarboxylate transporters (MCTs). We conducted a systematic review and meta-analysis to investigate the expression of two cancer-relevant MCTs (MCT1 and MCT4) and their potential prognostic significance in patients with metastasis of different types of cancer. Studies were included if they reported the number of metastatic tissue samples expressing either low or high levels of MCT1 and/or MCT4 or those revealing the hazard ratios (HRs) of the overall survival (OS) or disease-free survival (DFS) as prognostic indicators. During the period between 2010 and 2018, a total of 20 articles including 3831 patients (56.3% males) were identified. There was a significant association between MCT4 expression (high versus low) and lymph node metastasis [odds ratio (OR)=1.87, 95% confidence interval (CI)=1.10-3.17, P=0.02] and distant metastasis (OR=2.18, 95%CI=1.65-2.86, P<0.001) and the correlation remained significant for colorectal and hepatic cancer in subgroup analysis. For survival analysis, patients with shorter OS periods exhibited a higher MCT4 expression [hazard ratio (HR)=1.78, 95%CI=1.49-2.13, P<0.001], while DFS was shorter in patients with high MCT1 (HR=1.48, 95%CI=1.04-2.10, P=0.03) and MCT4 expression (HR=1.70, 95%CI=1.19-2.42, P=0.003) when compared to their counterparts with low expression levels. Future research studies should consider the pharmacologic inhibition of MCT4 to effectively inhibit cancer progression to metastasis.","PeriodicalId":19487,"journal":{"name":"Oncology Reviews","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2019-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4081/oncol.2019.403","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41966914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}