Oncology Reviews最新文献_第9页

Recent trends in predictive biomarkers for determining malignant potential of oral potentially malignant disorders 预测口腔潜在恶性疾病的恶性潜能的生物标志物的最新趋势

IF 3.6

Oncology Reviews Pub Date : 2019-07-22 DOI: 10.4081/oncol.2019.424

G. Sarode, S. Sarode, Nikunj Maniyar, N. Sharma, Sujata Yerwadekar, S. Patil

{"title":"Recent trends in predictive biomarkers for determining malignant potential of oral potentially malignant disorders","authors":"G. Sarode, S. Sarode, Nikunj Maniyar, N. Sharma, Sujata Yerwadekar, S. Patil","doi":"10.4081/oncol.2019.424","DOIUrl":"https://doi.org/10.4081/oncol.2019.424","url":null,"abstract":"Despite of the tremendous advancements in the field of cancer prevention, detection and treatment, the overall prognosis of oral squamous cell carcinoma (OSCC) still remains poor. This can be partly imparted to the lack of early detection of oral potentially malignant disorders (OPMDs), especially those at a higher risk of progression into OSCC. Over years, various specific and non-specific markers have been introduced that could predict the malignant transformation of OPMDs; however detail information on these OPMD markers in a concise manner is lacking. Moreover, their use on daily clinical basis still remains questionable. With continuous research in the field of cytology and genomics, several contemporary biomarkers have been discovered that are not yet foregrounded and proved to be more promising than those used conventionally. Here, in the present paper, we overview several recently concluded predictive biomarkers with special emphasis on their role in molecular pathogenesis of OSCC transformation. These markers can be used for risk assessment of malignant transformation in patients with OPMDs as well as for prophylactic conciliation and fair management of the high-risk OPMD patient group.","PeriodicalId":19487,"journal":{"name":"Oncology Reviews","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2019-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4081/oncol.2019.424","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42567484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Potential effect of probiotics in the treatment of breast cancer 益生菌治疗癌症的潜在疗效

IF 3.6

Oncology Reviews Pub Date : 2019-07-22 DOI: 10.4081/oncol.2019.422

L. Mendoza

引用次数: 50

Therapeutic options for ampullary carcinomas. A review 壶腹癌的治疗选择。回顾

IF 3.6

Oncology Reviews Pub Date : 2019-07-22 DOI: 10.4081/oncol.2019.440

Dileep Kumar Reddy Regalla, R. Jacob, A. Manne, R. Paluri

{"title":"Therapeutic options for ampullary carcinomas. A review","authors":"Dileep Kumar Reddy Regalla, R. Jacob, A. Manne, R. Paluri","doi":"10.4081/oncol.2019.440","DOIUrl":"https://doi.org/10.4081/oncol.2019.440","url":null,"abstract":"Ampullary Carcinoma arises from a histologically heterogeneous region where three different epithelia converge. Even though Ampullary Carcinoma has a superior prognosis compared to pancreatic and biliary ductal neoplasms, at least half of the patients turn up at an advanced stage that limits the treatment prospects. In addition to surgery for early-stage disease, several studies have shown that chemoradiotherapy confers additional benefits in the management of Ampullary Carcinoma. Analogously, chemotherapy plays a crucial role in treating advanced Ampullary Carcinoma with distant metastasis/recurrences. Although, stage of the disease, lymph node status, and histo-morphology are three critical prognostic variables, recently much attention is being placed on the genetic landscape of Ampullary Carcinoma. In this review, we have discussed various studies describing the role of chemoradiation and chemotherapy in the treatment of early and advanced stage Ampullary Carcinoma. Also, we have summarized the molecular landscape of Ampullary Carcinoma and the novel therapeutic strategies which could possibly target the genetic alterations involving the tumor cells.","PeriodicalId":19487,"journal":{"name":"Oncology Reviews","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2019-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4081/oncol.2019.440","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42228429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Omics-based insights into therapy failure of pediatric B-lineage acute lymphoblastic leukemia 儿童b系急性淋巴细胞白血病治疗失败的组学分析

IF 3.6

Oncology Reviews Pub Date : 2019-07-22 DOI: 10.4081/oncol.2019.435

S. Alsagaby

引用次数: 5

Epigenetic modification in the expression of p73 p73 - epigenetic target for anticancer therapy 表观遗传修饰p73 -抗肿瘤表观遗传靶点的表达

IF 3.6

Oncology Reviews Pub Date : 2019-07-22 DOI: 10.4081/oncol.2019.421

Faiza Naseer, M. Saleem

引用次数: 0

Genomics meets immunity in pancreatic cancer: Current research and future directions for pancreatic adenocarcinoma immunotherapy 癌症基因组学与免疫的结合：胰腺癌免疫治疗的研究现状和未来方向

IF 3.6

Oncology Reviews Pub Date : 2019-07-22 DOI: 10.4081/oncol.2019.430

Jacob S. Bowers, Stefanie R. Bailey, M. Rubinstein, C. Paulos, E. Camp

{"title":"Genomics meets immunity in pancreatic cancer: Current research and future directions for pancreatic adenocarcinoma immunotherapy","authors":"Jacob S. Bowers, Stefanie R. Bailey, M. Rubinstein, C. Paulos, E. Camp","doi":"10.4081/oncol.2019.430","DOIUrl":"https://doi.org/10.4081/oncol.2019.430","url":null,"abstract":"Pancreatic adenocarcinoma (PDAC) remains a formidable disease that needs improved therapeutic strategies. Even though immunotherapy has revolutionized treatment for various solid tumor types, it remains largely ineffective in treating individuals with PDAC. This review describes how the application of genome-wide analysis is revitalizing the field of PDAC immunotherapy. Major themes include new insights into the body’s immune response to the cancer, and key immunosuppressive elements that blunt that antitumor immunity. In particular, new evidence indicates that T cell-based antitumor immunity against PDAC is more common, and more easily generated, than previously thought. However, equally common are an array of cellular and molecular defenses employed by the tumor against those T cells. These discoveries have changed how current immunotherapies are deployed and have directed development of novel strategies to better treat this disease. Thus, the impact of genomic analysis has been two-fold: both in demonstrating the heterogeneity of immune targets and defenses in this disease, as well as providing a powerful tool for designing and identifying personalized therapies that exploit each tumor’s unique phenotype. Such personalized treatment combinations may be the key to developing successful immunotherapies for pancreatic adenocarcinoma.","PeriodicalId":19487,"journal":{"name":"Oncology Reviews","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2019-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4081/oncol.2019.430","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46867961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Prognostic significance of mutated genes in megakaryocytic disorders 突变基因在巨核细胞疾病中的预后意义

IF 3.6

Oncology Reviews Pub Date : 2019-07-22 DOI: 10.4081/oncol.2019.408

A. Asnafi, M. Mohammadi, Hadi Rezaeeyan, Nader Davari, N. Saki

{"title":"Prognostic significance of mutated genes in megakaryocytic disorders","authors":"A. Asnafi, M. Mohammadi, Hadi Rezaeeyan, Nader Davari, N. Saki","doi":"10.4081/oncol.2019.408","DOIUrl":"https://doi.org/10.4081/oncol.2019.408","url":null,"abstract":"Megakaryopoiesis is a process during which platelets that play a major role in hemostasis are produced due to differentiation and maturation of megakaryocytic precursors. Several genes, including oncogenes and tumor suppressor genes, play a role in the regulation of this process. This study was conducted to investigate the oncogenes and tumor suppressor genes as well as their mutations during the megakaryopoiesis process, which can lead to megakaryocytic disorders. Relevant literature was identified by a PubMed search (1998-2019) of English language papers using the terms ‘Megakaryopoiesis’, ‘Mutation’, ‘oncogenes’, and ‘Tumor Suppressor’. According to investigations, several mutations occur in the genes implicated in megakaryopoiesis, which abnormally induce or inhibit megakaryocyte production, differentiation, and maturation, leading to platelet disorders. GATA-1 is one of the important genes in megakaryopoiesis and its mutations can be considered among the factors involved in the incidence of these disorders. Considering the essential role of these genes (such as GATA- 1) in megakaryopoiesis and the involvement of their mutations in platelet disorders, study and examination of these changes can be a positive step in the diagnosis and prognosis of these diseases.","PeriodicalId":19487,"journal":{"name":"Oncology Reviews","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2019-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4081/oncol.2019.408","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45253034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

CDK4/6 inhibitors in advanced breast cancer, what is beyond? CDK4/6抑制剂在晚期乳腺癌中的作用?

IF 3.6

Oncology Reviews Pub Date : 2019-07-22 DOI: 10.4081/oncol.2019.416

Amrallah A. Mohammed, Hanaa Rashied, F. M. Elsayed

引用次数: 8

Thrombocytopenia in solid tumors: Prognostic significance. 实体瘤中的血小板减少症：预后意义。

IF 3.1

Oncology Reviews Pub Date : 2019-05-14 eCollection Date: 2019-01-14 DOI: 10.4081/oncol.2019.413

Majid Ghanavat, Mina Ebrahimi, Hassan Rafieemehr, Mahmood Maniati, Masumeh Maleki Behzad, Saeid Shahrabi

引用次数: 0

Prognostic significance of aberrant CD5 expression in B-cell leukemia. CD5异常表达在b细胞白血病中的预后意义。

IF 3.6

Oncology Reviews Pub Date : 2019-04-18 eCollection Date: 2019-01-14 DOI: 10.4081/oncol.2019.400

Kaveh Jaseb, Daryush Purrahman, Saeid Shahrabi, Majid Ghanavat, Hadi Rezaeean, Najmaldin Saki

{"title":"Prognostic significance of aberrant CD5 expression in B-cell leukemia.","authors":"Kaveh Jaseb, Daryush Purrahman, Saeid Shahrabi, Majid Ghanavat, Hadi Rezaeean, Najmaldin Saki","doi":"10.4081/oncol.2019.400","DOIUrl":"https://doi.org/10.4081/oncol.2019.400","url":null,"abstract":"Aberrant expression of CD5 (as a T-cell marker) is seen in some leukemia and lymphoma of B lineage origin. Given that the signaling resulting from the expression of this marker plays an essential role in the development of leukemia and lymphoma, evaluating the expression of this marker is of paramount importance. Therefore, our goal in this study was to investigate the prognostic importance of CD5 expression in B-cell leukemia and lymphoma. We evaluate CD5 expression in normal and leukemic B-cells by identifying relevant literature through a PubMed search (1998-2018) of English language papers using the terms: 'CD5,' 'B-cell,' 'Leukemia,' and 'Lymphoma.' We are doing this thorough comparison of results from CD5 positive and negative cases to make a correct decision about prognostic importance of CD5 expression in these malignancies. In a number of B-cell malignancies, CD5 is expressed in varying degrees. Due to the different origins and characteristics of these malignancies, the results of CD5 expression evaluations are heterogeneous and impossible to generalize. However, CD5 expression is sometimes associated with clinicopathologic findings, more invasive clinical course, and even resistance to treatment (specifically in DLBCL) among CD5- positive patients, which appears to be a function of CD5 signaling and its downstream factors such as STAT3. Depending on the type of malignancy, CD5 expression is associated with good or bad prognosis, which can be used as an auxiliary prognostic factor to assess the clinical course of B-cell malignancies. Moreover, the difference in expression levels of CD5 in a variety of B-cell malignancies allows for differential diagnosis of these malignancies, which can be helpful when diagnosis is difficult.","PeriodicalId":19487,"journal":{"name":"Oncology Reviews","volume":"13 1","pages":"400"},"PeriodicalIF":3.6,"publicationDate":"2019-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4081/oncol.2019.400","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37204652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9