NeoReviews最新文献_第5页

Once Bitten, Twice Prepared: Managing Subsequent Pregnancy After Neonatal Alloimmune Thrombocytopenia. 一次被咬，两次准备：处理新生儿同种免疫性血小板减少症后的后续妊娠。

NeoReviews Pub Date : 2026-06-01 DOI: 10.1542/neo.27-6-023

Avery Cox, Melissa Spiel

引用次数: 0

Risk Stratification and Fetal Therapies for Congenital Diaphragmatic Hernia. 先天性膈疝的风险分层和胎儿治疗。

NeoReviews Pub Date : 2026-06-01 DOI: 10.1542/neo.27-6-021

Connor V Haynes, David H Stitelman

{"title":"Risk Stratification and Fetal Therapies for Congenital Diaphragmatic Hernia.","authors":"Connor V Haynes, David H Stitelman","doi":"10.1542/neo.27-6-021","DOIUrl":"10.1542/neo.27-6-021","url":null,"abstract":"Congenital diaphragmatic hernia (CDH) remains one of the most challenging congenital anomalies encountered by neonatologists and pediatric surgeons, with outcomes largely determined before birth. Although surgical repair of the diaphragmatic defect is essential, postnatal morbidity and mortality are primarily driven by antenatal pulmonary hypoplasia, abnormal pulmonary vascular development, and associated cardiac dysfunction that culminate in respiratory failure and pulmonary hypertension. Advances in prenatal imaging have enabled increasingly refined risk stratification, allowing for the identification of fetuses who are at highest risk for postnatal cardiopulmonary failure. Within this framework, fetal therapies, most notably fetoscopic endoluminal tracheal occlusion, have emerged as the first interventions shown to improve survival in carefully selected cases of severe CDH. However, uncertainty persists regarding optimal patient selection, timing, complications, and the generalizability of outcomes across health care systems. In this review, we examine the pathophysiologic rationale for fetal lung recruitment therapies, contemporary approaches to prenatal diagnosis and severity stratification, and the evidence supporting current fetal interventions. We also discuss how fetal therapy alters postnatal surgical and extracorporeal membrane oxygenation decision-making and highlight emerging prenatal strategies aimed at modifying lung and vascular development before birth. By framing CDH as a prenatal cardiopulmonary disease with postnatal surgical manifestations, we aim to provide a cohesive framework for multidisciplinary counseling, referral, and perioperative planning in the evolving era of fetal therapy.","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"27 6","pages":"e369-e381"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antenatal and Postnatal Management of Sacrococcygeal Teratoma. 骶尾骨畸胎瘤的产前和产后处理。

NeoReviews Pub Date : 2026-06-01 DOI: 10.1542/neo.27-6-020

William G Lee, Eveline H Shue

{"title":"Antenatal and Postnatal Management of Sacrococcygeal Teratoma.","authors":"William G Lee, Eveline H Shue","doi":"10.1542/neo.27-6-020","DOIUrl":"10.1542/neo.27-6-020","url":null,"abstract":"Sacrococcygeal teratoma (SCT) is the most common congenital germ cell tumor and is often detected antenatally. Advances in routine obstetric ultrasonography now allow for earlier risk stratification and identification of tumors that may precipitate potentially lethal conditions such as high-output cardiac failure, nonimmune hydrops, and maternal mirror syndrome. Antenatal risk assessment integrates tumor morphology, growth kinetics, and fetal cardiovascular status to determine the optimal management strategy for both the fetus and the pregnant patient. Surgical management relies on multidisciplinary perinatal planning and includes complete oncologic resection with coccygectomy. Incomplete resection, tumor spillage, failure to remove the coccyx, and immature/malignant tumor elements are the primary drivers of recurrence. Survival is generally favorable for resectable tumors, but long-term surveillance is important in order to monitor for recurrence and bladder and/or bowel dysfunction. Surveillance with serial clinical examination, alpha-fetoprotein monitoring, and cross-sectional imaging is effective in identifying early recurrence. This review synthesizes the epidemiology, pathogenesis, antenatal and postnatal management, outcomes, and postoperative surveillance for SCTs.","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"27 6","pages":"e355-e368"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Life Course Approach to Health Equity: Lessons From Medical-Legal Collaborations. 健康公平的生命历程方法：来自医疗-法律合作的教训。

NeoReviews Pub Date : 2026-05-01 DOI: 10.1542/neo.27-5-017

Samantha L Simpson, John Feister, Adrienne W Henize, Rachel E Barr, Andrew F Beck, Emily F Gregory, Diana Montoya-Williams

引用次数: 0

Neonatal Hearing Loss: Mechanisms, Clinical Implications, and Global Perspectives. 新生儿听力损失：机制、临床意义和全球视角。

NeoReviews Pub Date : 2026-05-01 DOI: 10.1542/neo.27-5-009

Namit Kant Singh, Naina Kumar, Neemu Hage, Balaji Ramamourthy, Divya Nayani, Deepashree Srinivasan, Mercy Haokip

{"title":"Neonatal Hearing Loss: Mechanisms, Clinical Implications, and Global Perspectives.","authors":"Namit Kant Singh, Naina Kumar, Neemu Hage, Balaji Ramamourthy, Divya Nayani, Deepashree Srinivasan, Mercy Haokip","doi":"10.1542/neo.27-5-009","DOIUrl":"10.1542/neo.27-5-009","url":null,"abstract":"Neonatal hearing loss remains a significant global health concern, contributing substantially to long-term communication difficulties, language delays, and social impairment. Neonatal hearing loss arises from a multifactorial interplay of infectious, genetic, and acquired etiologies, each contributing distinctly to auditory impairment. Genetic factors account for a substantial proportion of sensorineural hearing loss, influencing susceptibility and severity. Congenital and perinatal infections are preventable causes that can induce cochlear injury through cytotoxicity, inflammation, ischemia, and disruption of auditory development. Acquired conditions, including hyperbilirubinemia, kernicterus, aminoglycoside and loop-diuretic ototoxicity, hypoxic-ischemic injury, and other neonatal intensive care unit-related exposures, further contribute through mechanisms involving neurotoxicity, oxidative stress, and impaired neural transmission. Understanding this broad etiological spectrum is essential for early risk identification, targeted prevention, and timely auditory intervention. Early detection through newborn hearing screening, TORCH surveillance, and pharmacogenomic approaches offers an opportunity for timely interventions that may preserve auditory and developmental outcomes. This review provides a comprehensive synthesis of the epidemiology, pathophysiology, diagnostic approaches, and evidence-based management strategies for neonatal hearing loss, with particular attention to recent advances published within the last decade.","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"27 5","pages":"e263-e278"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Term Infant With Multiple Ulcerative Lesions. 足月婴儿多发溃疡性病变。

NeoReviews Pub Date : 2026-05-01 DOI: 10.1542/neo.27-5-013

Michelle A McCloud, Elizabeth K Oh, Jennifer Tan, Yarden S Fraiman

引用次数: 0

A Wink or a Blink? 眨眼还是眨眼？

NeoReviews Pub Date : 2026-05-01 DOI: 10.1542/neo.27-5-016

Madison Granberry, Jennifer Hanford, Kelsey Davis, Akshaya Vachharajani

引用次数: 0

Maternity Care Deserts: Disparities in Maternal and Infant Access to Care and Potential Solutions. 产妇护理沙漠：产妇和婴儿获得护理的差异和潜在的解决方案。

NeoReviews Pub Date : 2026-05-01 DOI: 10.1542/neo.27-5-011

Anjali P Anders, Sarah E Cammack

引用次数: 0

Obstetric Management and Neonatal Implications of Higher-Order Multiple Pregnancies. 高阶多胎妊娠的产科管理和新生儿影响。

NeoReviews Pub Date : 2026-05-01 DOI: 10.1542/neo.27-5-014

Elliana Gianacopoulos, Nina K Ayala

{"title":"Obstetric Management and Neonatal Implications of Higher-Order Multiple Pregnancies.","authors":"Elliana Gianacopoulos, Nina K Ayala","doi":"10.1542/neo.27-5-014","DOIUrl":"10.1542/neo.27-5-014","url":null,"abstract":"Triplet and higher-order multifetal pregnancies are associated with significant obstetric complexity and neonatal morbidity. The rise of multifetal gestations is mostly attributed to advances in assisted reproductive technology; however, more recent practice changes aim to reduce the incidence given the associated risks. Recommendations for enhanced antepartum care include additional screening for obstetric complications, tailored ultrasonography surveillance, and counseling regarding interventions for risk reduction, including multifetal pregnancy reduction. Chorionicity remains the primary determinant of risk of perinatal mortality, with additional surveillance required for monochorionic twin pairs because of the complexity of shared placentation. Neonatal outcomes are largely driven by complications associated with prematurity, including respiratory distress syndrome, intraventricular hemorrhage, necrotizing enterocolitis, feeding immaturity, and prolonged neonatal intensive care unit hospitalization. Infants from monochorionic pairs within higher-order gestations may require specialized evaluation for cardiovascular compromise, anemia, and other sequelae of shared placentation. Delivery planning requires coordination across obstetric, neonatal, and other indicated specialty teams, with anticipation of simultaneous resuscitation and stabilization of multiple preterm infants. This review summarizes current evidence and consensus recommendations from the American College of Obstetricians and Gynecologists, Society for Maternal-Fetal Medicine, and American Academy of Pediatrics to guide the comprehensive management of higher-order multifetal pregnancies and optimize neonatal outcomes.","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"27 5","pages":"e309-e313"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Out-of-Hospital and Emergency Department Births: A Review of Preparedness and Management. 院外和急诊分娩：准备和管理综述。

NeoReviews Pub Date : 2026-05-01 DOI: 10.1542/neo.27-5-012

Chelsea A Broomhead

引用次数: 0