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Outcomes After Perinatal Arterial Ischemic Stroke. 围产期动脉缺血性卒中后的预后。
NeoReviews Pub Date : 2025-05-01 DOI: 10.1542/neo.26-5-020
Daniel Davila-Williams, Dana Harrar
{"title":"Outcomes After Perinatal Arterial Ischemic Stroke.","authors":"Daniel Davila-Williams, Dana Harrar","doi":"10.1542/neo.26-5-020","DOIUrl":"https://doi.org/10.1542/neo.26-5-020","url":null,"abstract":"","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 5","pages":"e362-e371"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension: Screening and Management. 支气管肺发育不良相关的肺动脉高压：筛查和管理。
NeoReviews Pub Date : 2025-05-01 DOI: 10.1542/neo.26-5-013
Samuel F Schaeffer, Bwaar Omer, Akshaya Vachharajani, Chaitanya Panchangam
{"title":"Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension: Screening and Management.","authors":"Samuel F Schaeffer, Bwaar Omer, Akshaya Vachharajani, Chaitanya Panchangam","doi":"10.1542/neo.26-5-013","DOIUrl":"https://doi.org/10.1542/neo.26-5-013","url":null,"abstract":"<p><p>Screening for pulmonary hypertension (PH) in infants with bronchopulmonary dysplasia (BPD) was recommended by the American Thoracic Society in 2015. However, the definition of BPD has since changed. This review summarizes the current definition of BPD, the recommendations and tools for screening for PH in infants with BPD, and the various treatment options and outcomes in infants with BPD-PH.</p>","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 5","pages":"e316-e327"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic Disorders of Surfactant Metabolism. 表面活性剂代谢的遗传性疾病。
NeoReviews Pub Date : 2025-05-01 DOI: 10.1542/neo.26-5-014
Rebekah J Nevel, Steven K Brennan, Jennifer A Wambach
{"title":"Genetic Disorders of Surfactant Metabolism.","authors":"Rebekah J Nevel, Steven K Brennan, Jennifer A Wambach","doi":"10.1542/neo.26-5-014","DOIUrl":"https://doi.org/10.1542/neo.26-5-014","url":null,"abstract":"<p><p>Genetic disorders affecting surfactant protein production and function can result in respiratory distress and severe respiratory failure in late-preterm and term neonates. Pathogenic variants in surfactant pulmonary-associated protein B (SFTPB) are typically loss-of-function and disrupt surfactant protein B (SP-B) production and surfactant function. Dominant variants in surfactant pulmonary-associated protein C (SFTPC) generally result in a toxic gain-of-function with disruption of surfactant protein C (SP-C) processing and trafficking in the alveolar epithelial type 2 cells. Adenosine triphosphate binding cassette transporter A3 (ABCA3) variants include loss-of-function or \"null\" variants in which no ABCA3 protein is made or missense variants that disrupt intracellular trafficking of ABCA3 or impair phospholipid transport. Pathogenic variants and deletions of the NK2 homeobox 1 gene (NKX2-1) result in haploinsufficiency and alter transcription of surfactant-associated genes as well as genes for brain and thyroid development. Diagnosis of these disorders requires a high index of clinical suspicion because presentations may vary between and within diseases. Prognosis is highly variable, ranging from requiring supportive care with improvement in respiratory status over time to severe disease with early mortality without lung transplantation. Neonatologists and pulmonologists alike should recognize early presentations of these rare genetic disorders of surfactant metabolism to identify and care for affected infants and to counsel families regarding prognosis, treatment options, recurrence risk, and risk assessment for other family members.</p>","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 5","pages":"e328-e338"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neonate With a Scrotal Swelling. 新生儿阴囊肿胀。
NeoReviews Pub Date : 2025-05-01 DOI: 10.1542/neo.26-5-018
Muthu Vijayanathan, Sruthi Nair, Amey G Gore, Prashanth R Raghavendra, Anitha Haribalakrishna
{"title":"Neonate With a Scrotal Swelling.","authors":"Muthu Vijayanathan, Sruthi Nair, Amey G Gore, Prashanth R Raghavendra, Anitha Haribalakrishna","doi":"10.1542/neo.26-5-018","DOIUrl":"https://doi.org/10.1542/neo.26-5-018","url":null,"abstract":"","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 5","pages":"e353-e356"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Newborn Presenting with Alternating Bradycardia and Tachycardia. 新生儿表现为心动过缓和心动过速交替。
NeoReviews Pub Date : 2025-05-01 DOI: 10.1542/neo.26-5-016
Tiago Magalhães, Marisa Pereira, Renato Santos Silva, Luísa Sampaio, Ana Grangeia, João Antunes Sarmento, Ana Vilan
{"title":"A Newborn Presenting with Alternating Bradycardia and Tachycardia.","authors":"Tiago Magalhães, Marisa Pereira, Renato Santos Silva, Luísa Sampaio, Ana Grangeia, João Antunes Sarmento, Ana Vilan","doi":"10.1542/neo.26-5-016","DOIUrl":"https://doi.org/10.1542/neo.26-5-016","url":null,"abstract":"","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 5","pages":"e342-e347"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Neonate With Silent Expression. 新生儿沉默表达一例。
NeoReviews Pub Date : 2025-05-01 DOI: 10.1542/neo.26-5-015
Sunil Pawar, Oleti Tejopratap, Prabhjot Kaur, Kodumuru Suvarna Sindhu, Komaragiri Sai Sreevani, Arumulla Sailusha, Sakshi Chandra
{"title":"A Case of Neonate With Silent Expression.","authors":"Sunil Pawar, Oleti Tejopratap, Prabhjot Kaur, Kodumuru Suvarna Sindhu, Komaragiri Sai Sreevani, Arumulla Sailusha, Sakshi Chandra","doi":"10.1542/neo.26-5-015","DOIUrl":"https://doi.org/10.1542/neo.26-5-015","url":null,"abstract":"","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 5","pages":"e339-e341"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential Applications of Umbilical Cord Blood-Derived Cells in Neonatal Diseases. 脐带血来源细胞在新生儿疾病中的潜在应用
NeoReviews Pub Date : 2025-05-01 DOI: 10.1542/neo.26-5-011
Abdul Razak, Atul Malhotra
{"title":"Potential Applications of Umbilical Cord Blood-Derived Cells in Neonatal Diseases.","authors":"Abdul Razak, Atul Malhotra","doi":"10.1542/neo.26-5-011","DOIUrl":"https://doi.org/10.1542/neo.26-5-011","url":null,"abstract":"<p><p>Umbilical cord blood (UCB) has garnered attention as a potentially valuable resource in neonatal medicine. Blood from the cord contains a rich population of stem and progenitor cells, including hematopoietic stem cells, mesenchymal stromal cells, and endothelial progenitor cells, each offering unique therapeutic potential. Early clinical studies and preclinical trials have suggested that these cells may be able to promote tissue repair, provide neuroprotection, and modulate the immune system, potentially providing promising therapeutic avenues for neonates with limited treatment options. Current research has focused on the safety, feasibility, and preliminary efficacy of UCB-based therapies, particularly in neonates with brain injuries, lung diseases, and hematological disorders. Despite positive early results, the field is still evolving, and large-scale clinical trials are underway to further evaluate the potential of UCB-derived cells in neonates. In this review, we examine the diverse roles of UCB-derived cells in potentially treating neonatal diseases such as anemia, intraventricular hemorrhage, hypoxic-ischemic encephalopathy, and bronchopulmonary dysplasia. We also discuss future directions for the application of UCB-derived cells in transfusion and regenerative medicine.</p>","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 5","pages":"e297-e306"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selective Fetal Reduction for an Anomaly in a Twin Gestation. 选择性胎儿减少在双胎妊娠异常。
NeoReviews Pub Date : 2025-05-01 DOI: 10.1542/neo.26-5-017
Meagan Kline, Kisti Fuller, Michael Leovic
{"title":"Selective Fetal Reduction for an Anomaly in a Twin Gestation.","authors":"Meagan Kline, Kisti Fuller, Michael Leovic","doi":"10.1542/neo.26-5-017","DOIUrl":"https://doi.org/10.1542/neo.26-5-017","url":null,"abstract":"","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 5","pages":"e348-e352"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenatal Diagnosis of a Large Congenital Epulis. 先天性大瞳孔的产前诊断。
NeoReviews Pub Date : 2025-05-01 DOI: 10.1542/neo.26-5-019
Ritu Chitkara, Karthik Balakrishnan, Praveen Jayapal, Amy Judy, Serena Y Tan, Susan Hintz
{"title":"Prenatal Diagnosis of a Large Congenital Epulis.","authors":"Ritu Chitkara, Karthik Balakrishnan, Praveen Jayapal, Amy Judy, Serena Y Tan, Susan Hintz","doi":"10.1542/neo.26-5-019","DOIUrl":"https://doi.org/10.1542/neo.26-5-019","url":null,"abstract":"","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 5","pages":"e357-e361"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Esophageal Atresia and Tracheoesophageal Fistula: Diagnosis, Management, and Outcomes. 食管闭锁和气管食管瘘：诊断、处理和结果。
NeoReviews Pub Date : 2025-05-01 DOI: 10.1542/neo.26-5-012
Tara Kempker, Jessica Peuterbaugh
{"title":"Esophageal Atresia and Tracheoesophageal Fistula: Diagnosis, Management, and Outcomes.","authors":"Tara Kempker, Jessica Peuterbaugh","doi":"10.1542/neo.26-5-012","DOIUrl":"https://doi.org/10.1542/neo.26-5-012","url":null,"abstract":"<p><p>Esophageal atresia is a congenital disease that results in discontinuity of the esophagus and can occur with or without fistulous connections to the trachea. It is often associated with other anomalies and has multiple long-term health implications. Because of the complexity of care involved in affected children, it is important to diagnose this lesion as early as possible. Surgical repair via either anastomosis of the native esophagus or reconstruction using either the stomach or intestine if this is not possible remain the mainstays of therapy, although variations in technique prevail. In this review, we summarize the approach to diagnosis, preoperative management considerations, surgical approach, medical considerations, and long-term outcomes of infants with esophageal atresia.</p>","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 5","pages":"e307-e315"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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