NeoReviewsPub Date : 2025-02-01DOI: 10.1542/neo.26-2-017
Lateia Taylor, Alexis Hood, Francesca Mancuso, Sofia Horan, Zachary Walker
{"title":"Effects of Assisted Reproductive Technology on Genetics, Obstetrics, and Neonatal Outcomes.","authors":"Lateia Taylor, Alexis Hood, Francesca Mancuso, Sofia Horan, Zachary Walker","doi":"10.1542/neo.26-2-017","DOIUrl":"https://doi.org/10.1542/neo.26-2-017","url":null,"abstract":"<p><p>The prevalence of infertility has increased in the United States over the past decade with 1 in 5 reproductive-aged women suffering from this diagnosis. The use of assisted reproductive technology (ART) to achieve pregnancy has correspondingly steadily increased. After examining the outcomes of ART births, clear trends of increased preterm birth rate, higher-order multiples, and imprinting disorders have been established among ART-related outcomes. However, the relationship between ART and birth defects, abnormal placentation, and stillbirth require further investigation. This review aims to highlight current literature surrounding ART and its relationship with key obstetrical outcomes, neonatal outcomes, and medical genetics.</p>","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 2","pages":"e89-e99"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeoReviewsPub Date : 2025-02-01DOI: 10.1542/neo.26-2-010
Christopher M Stark, Brian N Hughes, John Paul Schacht, Theresa M Urbina
{"title":"Decoding Hearts: Genetic Insights and Clinical Strategies in Congenital Heart Disease.","authors":"Christopher M Stark, Brian N Hughes, John Paul Schacht, Theresa M Urbina","doi":"10.1542/neo.26-2-010","DOIUrl":"10.1542/neo.26-2-010","url":null,"abstract":"<p><p>Structural congenital heart disease (CHD) represents a heterogeneous group of cardiac anomalies of variable embryologic and molecular origins. A basic understanding of the genetics implicated in nonsyndromic (isolated) and syndromic structural CHD can better inform management decisions and family counseling. When a fetus or neonate develops CHD as a result of a genetic cause, it can be due to a mutation or a monogenic, oligogenic, or polygenic pathogenic variant. In this review, we summarize basic cardiac embryology in the context of genetic signaling pathways and proteins that are commonly implicated in syndromic and nonsyndromic structural CHD. We also provide an overview of the basic genetic evaluation in infants with common syndromic structural CHD.</p>","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 2","pages":"e73-e88"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeoReviewsPub Date : 2025-02-01DOI: 10.1542/neo.26-2-016
Rodolfo Fernandez Criado, Stephanie Ros Saposnik
{"title":"Managing Fetal Anemia: A Case of Parvovirus Infection in Pregnancy.","authors":"Rodolfo Fernandez Criado, Stephanie Ros Saposnik","doi":"10.1542/neo.26-2-016","DOIUrl":"https://doi.org/10.1542/neo.26-2-016","url":null,"abstract":"","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 2","pages":"e123-e126"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeoReviewsPub Date : 2025-02-01DOI: 10.1542/neo.26-2-013
Ina A Lee, Erin Von Klein, Laura Petrauskas, Gabriella L Crane, Kevin Louie, Lyndy Wilcox
{"title":"Term Infant With Apnea and Seizure-Like Activity.","authors":"Ina A Lee, Erin Von Klein, Laura Petrauskas, Gabriella L Crane, Kevin Louie, Lyndy Wilcox","doi":"10.1542/neo.26-2-013","DOIUrl":"https://doi.org/10.1542/neo.26-2-013","url":null,"abstract":"","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 2","pages":"e119-e122"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeoReviewsPub Date : 2025-02-01DOI: 10.1542/neo.26-2-011
Jonathan D Reiss, Samson J Mataraso, Lindsay F Holzapfel, Ivana Marić, Maya M Kasowski, Camilia R Martin, Jonathan Z Long, David K Stevenson, Gary M Shaw
{"title":"Applications of Metabolomics and Lipidomics in the Neonatal Intensive Care Unit.","authors":"Jonathan D Reiss, Samson J Mataraso, Lindsay F Holzapfel, Ivana Marić, Maya M Kasowski, Camilia R Martin, Jonathan Z Long, David K Stevenson, Gary M Shaw","doi":"10.1542/neo.26-2-011","DOIUrl":"https://doi.org/10.1542/neo.26-2-011","url":null,"abstract":"<p><p>The metabolome and lipidome comprise the thousands of molecular compounds in an organism. Molecular compounds consist of the upstream metabolic components of intracellular reactions or the byproducts of cellular pathways. Molecular and biochemical perturbations are associated with disorders in newborns and infants. The diagnosis of inborn errors of metabolism has relied on targeted metabolomics for several decades. Newer approaches offer the potential to identify novel biomarkers for common diseases of the newborn and infant. They may also elucidate novel predictive or diagnostic measures for a variety of health trajectories. Here, we review the relevance of the metabolome and lipidome for common disorders and highlight challenges and opportunities for future investigations.</p>","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 2","pages":"e100-e114"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeoReviewsPub Date : 2025-02-01DOI: 10.1542/neo.26-2-015
Kathryn Hasselfeld, Erik Hysinger, Melissa House
{"title":"Preterm Infants With Bronchopulmonary Dysplasia and Pulmonary Hypertension.","authors":"Kathryn Hasselfeld, Erik Hysinger, Melissa House","doi":"10.1542/neo.26-2-015","DOIUrl":"https://doi.org/10.1542/neo.26-2-015","url":null,"abstract":"","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 2","pages":"e132-e140"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Late Preterm Neonate With a Small Chest.","authors":"Abhilasha Gupta, Prashanth Ranya Raghavendra, Sruthi Nair, Anitha Haribalakrishna","doi":"10.1542/neo.26-2-014","DOIUrl":"https://doi.org/10.1542/neo.26-2-014","url":null,"abstract":"","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 2","pages":"e127-e131"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeoReviewsPub Date : 2025-01-01DOI: 10.1542/neo.26-1-005
Samantha L Simpson, Patrick D Smith, William Adams, Thomas Nienaber
{"title":"Hypoxia, Poor Lower Extremity Perfusion, and Metabolic Acidosis in the First Day of Life.","authors":"Samantha L Simpson, Patrick D Smith, William Adams, Thomas Nienaber","doi":"10.1542/neo.26-1-005","DOIUrl":"https://doi.org/10.1542/neo.26-1-005","url":null,"abstract":"","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 1","pages":"e50-e52"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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