NeoReviews Pub Date : 2025-10-01 DOI: 10.1542/neo.26-10-063

Jennifer Teng, Shane Blunk, Bryan Williams, Theresa Urbina

引用次数: 0

Advances in RSV Immunoprophylaxis: Evolution, Efficacy, and Implementation Challenges. RSV免疫预防的进展：演变、疗效和实施挑战。

NeoReviews Pub Date : 2025-10-01 DOI: 10.1542/neo.26-10-062

Faris Al Gharaibeh, Ved Deshmukh, Hitesh Deshmukh

{"title":"Advances in RSV Immunoprophylaxis: Evolution, Efficacy, and Implementation Challenges.","authors":"Faris Al Gharaibeh, Ved Deshmukh, Hitesh Deshmukh","doi":"10.1542/neo.26-10-062","DOIUrl":"https://doi.org/10.1542/neo.26-10-062","url":null,"abstract":"Respiratory syncytial virus (RSV) poses a critical global health challenge, causing more than 33.1 million acute lower respiratory tract infections and more than 118 000 deaths annually in children younger than 5 years of age. The burden falls disproportionately on infants younger than 12 months of age, with devastating impacts on health care systems worldwide. Prevention strategies have evolved from early vaccine attempts through first-generation monoclonal antibodies to current next-generation antibodies with extended half-lives and novel vaccination approaches in pregnant persons. These recent advances demonstrate unprecedented efficacy, with clinical trials showing reduction rates exceeding 70% in RSV-associated hospitalizations across diverse infant populations. Although economic analyses suggest favorable cost-benefit ratios, implementation raises important considerations regarding health care delivery systems and global access equity. This comprehensive review synthesizes evidence-based guidelines, evaluates implementation challenges, and explores future directions for RSV prevention, with particular attention to regional variations in health care delivery and emerging challenges from changing climate patterns affecting RSV seasonality.","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 10","pages":"e704-e711"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145200457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacology in Congenital Diaphragmatic Hernia: A Focus on Cardiovascular Management. 先天性膈疝的药理学：心血管治疗的焦点。

NeoReviews Pub Date : 2025-10-01 DOI: 10.1542/neo.26-10-060

Anie Lapointe, Florian Kipfmueller, Neil Patel, Gabriel Altit

{"title":"Pharmacology in Congenital Diaphragmatic Hernia: A Focus on Cardiovascular Management.","authors":"Anie Lapointe, Florian Kipfmueller, Neil Patel, Gabriel Altit","doi":"10.1542/neo.26-10-060","DOIUrl":"https://doi.org/10.1542/neo.26-10-060","url":null,"abstract":"Congenital diaphragmatic hernia (CDH) presents a complex challenge in neonatal care, requiring tailored pharmacological strategies to manage its distinct cardiorespiratory pathophysiology. CDH is commonly associated with pulmonary hypertension, impaired myocardial function, and adverse cardiorespiratory interactions, contributing to significant morbidity and mortality. Effective pharmacotherapy must address these interconnected factors while minimizing complications or side effects. Despite limited randomized controlled trial data specific to CDH, recent reports highlight the benefits of a precision medicine approach, focusing on individualized treatments based on evolving pathophysiology. Therapeutic interventions primarily involve pulmonary vasodilators, inotropes and vasopressors, prostaglandins, and corticosteroids; each agent has a distinct physiologic effect, and use needs to be tailored to the specific patient pathophysiology. Targeted neonatal echocardiography has emerged as a valuable tool for optimizing treatment decisions by providing real-time insights into ventricular performance and hemodynamic status. In this review, we explore the shift from a generalized pharmacological approach to targeted interventions based on evolving patient physiology. We discuss key therapeutic principles and the role of different drug classes in optimizing the management of infants with CDH throughout their intensive care journey.","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 10","pages":"e660-e678"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145200522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Follow-Up of an Infant With Posterior Cerebral Artery Stroke. 1例婴儿脑后动脉卒中的随访。

NeoReviews Pub Date : 2025-10-01 DOI: 10.1542/neo.26-10-066

Emma E Williams, Nomazulu Dlamini, Amr El Shahed, Linh G Ly, Mehmet N Cizmeci

引用次数: 0

Cardiac Arrest in a Newborn. 新生儿心脏骤停。

NeoReviews Pub Date : 2025-10-01 DOI: 10.1542/neo.26-10-064

Inês Mazeda, Tiago Magalhães, João Antunes Sarmento, Ana Vilan

引用次数: 0

A NeoReviews Milestone: Our 25th Anniversary. 一个新评论的里程碑：我们的25周年纪念。

NeoReviews Pub Date : 2025-10-01 DOI: 10.1542/neo.26-10-059

Dara Brodsky