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Neonatal Hearing Loss: Mechanisms, Clinical Implications, and Global Perspectives. 新生儿听力损失：机制、临床意义和全球视角。
NeoReviews Pub Date : 2026-05-01 DOI: 10.1542/neo.27-5-009
Namit Kant Singh, Naina Kumar, Neemu Hage, Balaji Ramamourthy, Divya Nayani, Deepashree Srinivasan, Mercy Haokip
{"title":"Neonatal Hearing Loss: Mechanisms, Clinical Implications, and Global Perspectives.","authors":"Namit Kant Singh, Naina Kumar, Neemu Hage, Balaji Ramamourthy, Divya Nayani, Deepashree Srinivasan, Mercy Haokip","doi":"10.1542/neo.27-5-009","DOIUrl":"https://doi.org/10.1542/neo.27-5-009","url":null,"abstract":"<p><p>Neonatal hearing loss remains a significant global health concern, contributing substantially to long-term communication difficulties, language delays, and social impairment. Neonatal hearing loss arises from a multifactorial interplay of infectious, genetic, and acquired etiologies, each contributing distinctly to auditory impairment. Genetic factors account for a substantial proportion of sensorineural hearing loss, influencing susceptibility and severity. Congenital and perinatal infections are preventable causes that can induce cochlear injury through cytotoxicity, inflammation, ischemia, and disruption of auditory development. Acquired conditions, including hyperbilirubinemia, kernicterus, aminoglycoside and loop-diuretic ototoxicity, hypoxic-ischemic injury, and other neonatal intensive care unit-related exposures, further contribute through mechanisms involving neurotoxicity, oxidative stress, and impaired neural transmission. Understanding this broad etiological spectrum is essential for early risk identification, targeted prevention, and timely auditory intervention. Early detection through newborn hearing screening, TORCH surveillance, and pharmacogenomic approaches offers an opportunity for timely interventions that may preserve auditory and developmental outcomes. This review provides a comprehensive synthesis of the epidemiology, pathophysiology, diagnostic approaches, and evidence-based management strategies for neonatal hearing loss, with particular attention to recent advances published within the last decade.</p>","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"27 5","pages":"e263-e278"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Life Course Approach to Health Equity: Lessons From Medical-Legal Collaborations. 健康公平的生命历程方法：来自医疗-法律合作的教训。
NeoReviews Pub Date : 2026-05-01 DOI: 10.1542/neo.27-5-017
Samantha L Simpson, John Feister, Adrienne W Henize, Rachel E Barr, Andrew F Beck, Emily F Gregory, Diana Montoya-Williams
{"title":"A Life Course Approach to Health Equity: Lessons From Medical-Legal Collaborations.","authors":"Samantha L Simpson, John Feister, Adrienne W Henize, Rachel E Barr, Andrew F Beck, Emily F Gregory, Diana Montoya-Williams","doi":"10.1542/neo.27-5-017","DOIUrl":"https://doi.org/10.1542/neo.27-5-017","url":null,"abstract":"","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"27 5","pages":"e322-e330"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternity Care Deserts: Disparities in Maternal and Infant Access to Care and Potential Solutions. 产妇护理沙漠：产妇和婴儿获得护理的差异和潜在的解决方案。
NeoReviews Pub Date : 2026-05-01 DOI: 10.1542/neo.27-5-011
Anjali P Anders, Sarah E Cammack
{"title":"Maternity Care Deserts: Disparities in Maternal and Infant Access to Care and Potential Solutions.","authors":"Anjali P Anders, Sarah E Cammack","doi":"10.1542/neo.27-5-011","DOIUrl":"https://doi.org/10.1542/neo.27-5-011","url":null,"abstract":"<p><p>Access to maternity care in the United States is becoming more disparate, leading to worsening maternal and infant outcomes in rural communities. Increases in maternal and infant morbidity and mortality are especially prominent in maternity care deserts (MCDs). These MCDs are counties that lack obstetric-specific clinicians such as obstetricians, family physicians, or certified nurse midwives and also lack birth centers or hospitals with obstetric units. This has led to an increase in out-of-hospital births, deliveries in emergency departments, or births at hospitals that are not equipped to manage obstetric and neonatal emergencies. Obstetric unit closures are driven by multiple factors, including reduced clinician staffing, declining birth volumes, and counties with limited income. Potential solutions include changes in policy, growth and diversification of the workforce, and use of telemedicine to improve access to maternity care.</p>","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"27 5","pages":"e287-e295"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Term Infant With Multiple Ulcerative Lesions. 足月婴儿多发溃疡性病变。
NeoReviews Pub Date : 2026-05-01 DOI: 10.1542/neo.27-5-013
Michelle A McCloud, Elizabeth K Oh, Jennifer Tan, Yarden S Fraiman
{"title":"Term Infant With Multiple Ulcerative Lesions.","authors":"Michelle A McCloud, Elizabeth K Oh, Jennifer Tan, Yarden S Fraiman","doi":"10.1542/neo.27-5-013","DOIUrl":"https://doi.org/10.1542/neo.27-5-013","url":null,"abstract":"","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"27 5","pages":"e305-e308"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Wink or a Blink? 眨眼还是眨眼？
NeoReviews Pub Date : 2026-05-01 DOI: 10.1542/neo.27-5-016
Madison Granberry, Jennifer Hanford, Kelsey Davis, Akshaya Vachharajani
{"title":"A Wink or a Blink?","authors":"Madison Granberry, Jennifer Hanford, Kelsey Davis, Akshaya Vachharajani","doi":"10.1542/neo.27-5-016","DOIUrl":"https://doi.org/10.1542/neo.27-5-016","url":null,"abstract":"","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"27 5","pages":"e318-e321"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obstetric Management and Neonatal Implications of Higher-Order Multiple Pregnancies. 高阶多胎妊娠的产科管理和新生儿影响。
NeoReviews Pub Date : 2026-05-01 DOI: 10.1542/neo.27-5-014
Elliana Gianacopoulos, Nina K Ayala
{"title":"Obstetric Management and Neonatal Implications of Higher-Order Multiple Pregnancies.","authors":"Elliana Gianacopoulos, Nina K Ayala","doi":"10.1542/neo.27-5-014","DOIUrl":"https://doi.org/10.1542/neo.27-5-014","url":null,"abstract":"<p><p>Triplet and higher-order multifetal pregnancies are associated with significant obstetric complexity and neonatal morbidity. The rise of multifetal gestations is mostly attributed to advances in assisted reproductive technology; however, more recent practice changes aim to reduce the incidence given the associated risks. Recommendations for enhanced antepartum care include additional screening for obstetric complications, tailored ultrasonography surveillance, and counseling regarding interventions for risk reduction, including multifetal pregnancy reduction. Chorionicity remains the primary determinant of risk of perinatal mortality, with additional surveillance required for monochorionic twin pairs because of the complexity of shared placentation. Neonatal outcomes are largely driven by complications associated with prematurity, including respiratory distress syndrome, intraventricular hemorrhage, necrotizing enterocolitis, feeding immaturity, and prolonged neonatal intensive care unit hospitalization. Infants from monochorionic pairs within higher-order gestations may require specialized evaluation for cardiovascular compromise, anemia, and other sequelae of shared placentation. Delivery planning requires coordination across obstetric, neonatal, and other indicated specialty teams, with anticipation of simultaneous resuscitation and stabilization of multiple preterm infants. This review summarizes current evidence and consensus recommendations from the American College of Obstetricians and Gynecologists, Society for Maternal-Fetal Medicine, and American Academy of Pediatrics to guide the comprehensive management of higher-order multifetal pregnancies and optimize neonatal outcomes.</p>","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"27 5","pages":"e309-e313"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Out-of-Hospital and Emergency Department Births: A Review of Preparedness and Management. 院外和急诊分娩：准备和管理综述。
NeoReviews Pub Date : 2026-05-01 DOI: 10.1542/neo.27-5-012
Chelsea A Broomhead
{"title":"Out-of-Hospital and Emergency Department Births: A Review of Preparedness and Management.","authors":"Chelsea A Broomhead","doi":"10.1542/neo.27-5-012","DOIUrl":"https://doi.org/10.1542/neo.27-5-012","url":null,"abstract":"<p><p>Out-of-hospital births represent a small but growing proportion of deliveries in the United States. Although many of these births are planned and supervised by a midwife, deliveries that occur outside the labor and delivery suite present risks to both the birthing person and newborn. National organizations such as the American College of Obstetrics and Gynecology and the American Academy of Pediatrics generally caution against planned home births, but they do provide recommendations to reduce risk, including careful selection of appropriate candidates, presence of qualified clinical practitioners, and quick and reliable access to a higher level of care. Unplanned births in the community requiring responses from emergency personnel or emergency department births also present challenges for health care practitioners and departments that have limited experience with such cases. This review summarizes strategies to prepare for and manage these births, emphasizing care of the neonate.</p>","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"27 5","pages":"e296-e304"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiple Well-Circumscribed Cutaneous Lesions in a 6-Day-Old Neonate Born Extremely Preterm. 6天大的极早产新生儿多发界限明确的皮肤病变。
NeoReviews Pub Date : 2026-05-01 DOI: 10.1542/neo.27-5-015
Yashaswini Kelagere, Susanna Pappas, Shakuntala N Chandra, Sabah Kalyoussef
{"title":"Multiple Well-Circumscribed Cutaneous Lesions in a 6-Day-Old Neonate Born Extremely Preterm.","authors":"Yashaswini Kelagere, Susanna Pappas, Shakuntala N Chandra, Sabah Kalyoussef","doi":"10.1542/neo.27-5-015","DOIUrl":"https://doi.org/10.1542/neo.27-5-015","url":null,"abstract":"","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"27 5","pages":"e314-e317"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychosocial Impact of Parental Presence During Neonatal Resuscitation. 新生儿复苏期间父母在场的心理社会影响。
NeoReviews Pub Date : 2026-05-01 DOI: 10.1542/neo.27-5-010
Lacey Prater, Jennifer Hanford
{"title":"Psychosocial Impact of Parental Presence During Neonatal Resuscitation.","authors":"Lacey Prater, Jennifer Hanford","doi":"10.1542/neo.27-5-010","DOIUrl":"https://doi.org/10.1542/neo.27-5-010","url":null,"abstract":"<p><p>There has been a recent shift toward allowing parents to remain during resuscitation of their newborn because studies have found that parents generally prefer to be present during this time. However, questions remain about the psychosocial impact of parental presence during resuscitation on both parents and health care professionals. This review summarizes the current literature on the impact of this practice and outlines best practices for its implementation.</p>","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"27 5","pages":"e279-e286"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Newborn With Cyanosis. 新生儿发绀。
NeoReviews Pub Date : 2026-04-01 DOI: 10.1542/neo.27-4-004
Neha Dalal, Kirti M Naranje, Anita Singh
{"title":"A Newborn With Cyanosis.","authors":"Neha Dalal, Kirti M Naranje, Anita Singh","doi":"10.1542/neo.27-4-004","DOIUrl":"https://doi.org/10.1542/neo.27-4-004","url":null,"abstract":"","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"27 4","pages":"e235-e238"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147593740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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