NeoReviewsPub Date : 2025-03-01DOI: 10.1542/neo.26-3-019
Lina Diaz-Calderon, Runa Watkins, Atiye N Aktay
{"title":"Congenital Diarrhea and Enteropathies.","authors":"Lina Diaz-Calderon, Runa Watkins, Atiye N Aktay","doi":"10.1542/neo.26-3-019","DOIUrl":"10.1542/neo.26-3-019","url":null,"abstract":"<p><p>Diarrhea in neonates is usually secondary to an infectious process or a food protein allergy. Once the infection is treated or the allergen is removed, the diarrhea resolves without lifelong sequelae. On the contrary, infants with anatomical disorders such as intestinal atresia, gastroschisis, malrotation with volvulus, or necrotizing enterocolitis can present with protracted diarrhea secondary to poor gut motility and short bowel syndrome. A small group of infants who present with severe diarrhea shortly after birth can have a congenital enteropathy resulting from a monogenic disorder. This group poses clinical challenges that require intensive resuscitation and meticulous diagnostic evaluation aimed at optimizing interventions and outcomes. In this review, we will provide a diagnostic and management approach for infants with congenital enteropathies.</p>","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 3","pages":"e154-e162"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeoReviewsPub Date : 2025-03-01DOI: 10.1542/neo.26-3-023
Anisha Gopu-Gilboy, Joshua R Sheak, Nagendra Monangi, Andreas Damianos, Lauren Pommert
{"title":"Shining a TORCH on a Case of Blueberry Muffin Rash in a Newborn Infant.","authors":"Anisha Gopu-Gilboy, Joshua R Sheak, Nagendra Monangi, Andreas Damianos, Lauren Pommert","doi":"10.1542/neo.26-3-023","DOIUrl":"https://doi.org/10.1542/neo.26-3-023","url":null,"abstract":"","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 3","pages":"e191-e196"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeoReviewsPub Date : 2025-03-01DOI: 10.1542/neo.26-3-022
Callie Marshall, Ekta Shah, Liza Siegel, Melissa Riley, Leo Shmuylovich, Ali Mian, Christopher D Smyser, Lindsay Peglar Marsala
{"title":"Unilateral Facial Lesion in an Infant With Known Vermian Hypoplasia.","authors":"Callie Marshall, Ekta Shah, Liza Siegel, Melissa Riley, Leo Shmuylovich, Ali Mian, Christopher D Smyser, Lindsay Peglar Marsala","doi":"10.1542/neo.26-3-022","DOIUrl":"https://doi.org/10.1542/neo.26-3-022","url":null,"abstract":"","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 3","pages":"e186-e190"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeoReviewsPub Date : 2025-03-01DOI: 10.1542/neo.26-3-020
Kanika Puri, Courtney Svenstrup, Charles Vanderpool
{"title":"Functional Infant Formula Additives.","authors":"Kanika Puri, Courtney Svenstrup, Charles Vanderpool","doi":"10.1542/neo.26-3-020","DOIUrl":"10.1542/neo.26-3-020","url":null,"abstract":"<p><p>Breastfeeding is the ideal initial feeding method for providing nutrition to full-term infants and is recommended by major health organizations, including the American Academy of Pediatrics and the World Health Organization. Despite improvements in global breastfeeding rates, many infants still receive formula. Significant advancements have been achieved in the safety and nutritional content of modern formulas. Various functional additives, such as human milk oligosaccharides, milk fat globule membrane, docosahexaenoic acid, and lactoferrin, are used with the aim to replicate some of the benefits of breast milk. These additives enhance formula by providing benefits beyond basic nutrition. The aim of this review is to summarize these additives and their impact on infant nutrition and development.</p>","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 3","pages":"e163-e171"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeoReviewsPub Date : 2025-03-01DOI: 10.1542/neo.26-3-021
Tony H Tzeng, Sujir Pritha Nayak, Katie A Huff
{"title":"Nutritional Considerations in Neonates Requiring Gastrointestinal Surgery.","authors":"Tony H Tzeng, Sujir Pritha Nayak, Katie A Huff","doi":"10.1542/neo.26-3-021","DOIUrl":"10.1542/neo.26-3-021","url":null,"abstract":"<p><p>Neonates who require gastrointestinal surgery are a complex group of patients that require special consideration with regard to nutritional supplementation and growth. During the acute postoperative phase, a major stress response causes catabolism with degradation of the body's nutrient stores leading to poor growth. Following surgery, parenteral nutrition is often required to support the surgical neonate; although, enteral nutrition, if feasible, is critical because it helps improve intestinal adaptation. However, the best type, mode, and duration of feeding is not established in the current literature. It is important to factor in the individual patient anatomy and site of intestinal resection when considering intestinal absorptive ability because these patients are at high risk for nutrient malabsorption, with the risk persisting even when enteral autonomy is achieved. The neonate undergoing gastrointestinal surgery requires close growth and nutritional monitoring both during the neonatal period but also into later life because risks of abnormalities persist. In this review, we summarize the impact of gastrointestinal surgery and postoperative intestinal changes on infant growth and nutrition.</p>","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 3","pages":"e172-e185"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeoReviewsPub Date : 2025-03-01DOI: 10.1542/neo.26-3-024
Alexander Guh-Siesel, Elizabeth Oh
{"title":"Term Infant With a Large Red-Purple Mass in the Upper Thigh.","authors":"Alexander Guh-Siesel, Elizabeth Oh","doi":"10.1542/neo.26-3-024","DOIUrl":"https://doi.org/10.1542/neo.26-3-024","url":null,"abstract":"","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 3","pages":"e197-e200"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeoReviewsPub Date : 2025-03-01DOI: 10.1542/neo.26-3-026
Keadrea Wilson, Bhuvaneshwari Jagadesan, Karis Browder, Jennifer M Davidson, Joni Rose, Michelle-Marie Peña
{"title":"Fostering Breastfeeding Equity in the Neonatal Intensive Care Unit.","authors":"Keadrea Wilson, Bhuvaneshwari Jagadesan, Karis Browder, Jennifer M Davidson, Joni Rose, Michelle-Marie Peña","doi":"10.1542/neo.26-3-026","DOIUrl":"10.1542/neo.26-3-026","url":null,"abstract":"<p><p>The benefits of mother's milk are abundant and well known for both term and preterm infants (Note: Not everyone who provides human milk identifies as a woman or relates to the term \"breastfeeding,\" but because this accompanies the majority of infant feeding experiences, we have made the decision to phrase it this way while also acknowledging that this language can be exclusionary). The American Academy of Pediatrics now supports longer breastfeeding duration through the first 2 years of age.1 United States legislation in the last 2 decades has made progress in supporting breastfeeding, with policies such as improved access to antenatal and postpartum lactation support, some improvements in double electric breast pump access, and protected time and private spaces to pump at work for many employees.2,3 Despite this progress, sustained breastfeeding beyond the early postpartum period remains challenging. Among all infants born in 2021, 84.1% received breast milk for some time after birth, but this rate fell to 59.8% by 6 months and 39.5% at 1 year.4 There are also striking disparities in which infants receive mother's milk, with fewer non-Hispanic Black infants (75.4%) ever breastfeeding compared with Asian infants (92.7%), non-Hispanic white infants (86.2%) and Hispanic infants (83.4%).4 Young mothers aged 20 to 29 years were also less likely to ever breastfeed than mothers 30 years and older.4 Similar disparities have been shown among racial and ethnic groups who have been marginalized, with lower prevalences of any human milk at discharge for non-Hispanic Black and Native American very low birth weight (VLBW) infants compared with white VLBW infants.5,67Through the case reviews we present, we will discuss the underlying drivers of these breastfeeding inequities in neonatal intensive care units (NICUs) by understanding the inherent costs of breastfeeding as well as the individual and institutional level factors that impact mother's milk provision.</p>","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 3","pages":"e207-e214"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeoReviewsPub Date : 2025-03-01DOI: 10.1542/neo.26-3-025
Kelly S Sulo, Megan Kraemer, Mindy Li, Anatoli F Karas, Xavier Pombar, Esther Lee
{"title":"Navigating Prenatal Diagnosis of Fetal Agnathia: A Complex Case and Diagnostic Journey.","authors":"Kelly S Sulo, Megan Kraemer, Mindy Li, Anatoli F Karas, Xavier Pombar, Esther Lee","doi":"10.1542/neo.26-3-025","DOIUrl":"https://doi.org/10.1542/neo.26-3-025","url":null,"abstract":"","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 3","pages":"e201-e206"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeoReviewsPub Date : 2025-03-01DOI: 10.1542/neo.26-3-018
Kathryn Hawa, Shamaila Waseem, Joseph Croffie
{"title":"Gastrointestinal Motility Disorders in the Neonate.","authors":"Kathryn Hawa, Shamaila Waseem, Joseph Croffie","doi":"10.1542/neo.26-3-018","DOIUrl":"10.1542/neo.26-3-018","url":null,"abstract":"<p><p>Gastrointestinal (GI) motility disorders in term and premature infants may occur at different times of gestation. Knowledge of normal neuromuscular development can help clinicians determine the cause of GI dysmotility and prognosis in infants born with congenital anomalies. Various developmental abnormalities and premature gestational age can alter normal GI motility, requiring further advanced testing and management. A multidisciplinary approach is often needed to care for these patients.</p>","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 3","pages":"e141-e153"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeoReviewsPub Date : 2025-02-01DOI: 10.1542/neo.26-2-010
Christopher M Stark, Brian N Hughes, John Paul Schacht, Theresa M Urbina
{"title":"Decoding Hearts: Genetic Insights and Clinical Strategies in Congenital Heart Disease.","authors":"Christopher M Stark, Brian N Hughes, John Paul Schacht, Theresa M Urbina","doi":"10.1542/neo.26-2-010","DOIUrl":"10.1542/neo.26-2-010","url":null,"abstract":"<p><p>Structural congenital heart disease (CHD) represents a heterogeneous group of cardiac anomalies of variable embryologic and molecular origins. A basic understanding of the genetics implicated in nonsyndromic (isolated) and syndromic structural CHD can better inform management decisions and family counseling. When a fetus or neonate develops CHD as a result of a genetic cause, it can be due to a mutation or a monogenic, oligogenic, or polygenic pathogenic variant. In this review, we summarize basic cardiac embryology in the context of genetic signaling pathways and proteins that are commonly implicated in syndromic and nonsyndromic structural CHD. We also provide an overview of the basic genetic evaluation in infants with common syndromic structural CHD.</p>","PeriodicalId":19465,"journal":{"name":"NeoReviews","volume":"26 2","pages":"e73-e88"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}