Obesity Surgery最新文献

{"title":"Publisher Correction: Machine Learning Models for Predicting Significant Liver Fibrosis in Patients with Severe Obesity and Nonalcoholic Fatty Liver Disease.","authors":"Chien-Hung Lu, Weu Wang, Yu-Chuan Jack Li, I-Wei Chang, Chi-Long Chen, Chien-Wei Su, Chun-Chao Chang, Wei-Yu Kao","doi":"10.1007/s11695-026-08668-4","DOIUrl":"https://doi.org/10.1007/s11695-026-08668-4","url":null,"abstract":"","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Metabolic Bariatric Surgery on Inflammatory Bowel Disease Risk and Outcomes in Adults With Obesity: a Propensity-matched, Nationwide, Analysis.","authors":"Antoinette Pusateri, Yevgeniya Gokun, Kenneth Allen, ChienWei Chang, Adeeti Chiplunker, Madalina Butnariu, Hisham Hussan","doi":"10.1007/s11695-026-08714-1","DOIUrl":"https://doi.org/10.1007/s11695-026-08714-1","url":null,"abstract":"<p><strong>Introduction: </strong>The risk of de novo inflammatory bowel disease (IBD) after metabolic bariatric surgery (MBS) has been described, but the timing and severity of de novo IBD is unclear.</p><p><strong>Methods: </strong>Using MarketScan Databases, patients with severe obesity undergoing Roux-en-Y-gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) were propensity-matched with patients with severe obesity without MBS (controls). Adjusted hazard ratio (aHR) assessed ulcerative colitis (UC) or Crohn's disease (CD) hazard <3 or ≥3 years from surgery or severe obesity. IBD severity was assessed using healthcare utilization-based proxies including medication exposure, IBD-related hospitalizations, and surgical interventions.</p><p><strong>Results: </strong>The cohort included 100,832 adults with MBS versus 376,855 controls (76.0% females, median age of 44 years). The incidence of IBD was higher in MBS cohort versus controls (61.2 vs. 44.4 per 100,000 adults/year). Within 3 years, patients with MBS had a 24% lower risk of de novo IBD versus controls (aHR: 0.76, 95% CI: 0.60-0.95). When stratified by surgery and IBD type, VSG had reduction in CD risk (aHR=0.46, 95% CI:0.22-0.96), while RYGB had reduction in UC risk (aHR=0.22, 95% CI:0.06-0.75). After 3 years, patients with MBS, particularly VSG, had greater than 2-fold increased risk of IBD (aHR=2.28, 95%CI: 1.02-5.06). Markers of treatment intensity and healthcare utilization did not significantly differ between groups overall; however, a higher proportion of UC patients in the MBS cohort underwent colectomy, though absolute event numbers were small. (8.70% vs 1.57%, p=0.03).</p><p><strong>Conclusion: </strong>While MBS may lower IBD risk initially, IBD risk increases after 3 years, especially UC after VSG, and may be more severe as indicated by the higher proportion of colectomies for patients in the MBS cohort versus controls. Findings regarding treatment intensity should be interpreted cautiously, as objective measures of disease activity were not available in claims data.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Future of Obesity Care: Exploring Synergies Between Metabolic Bariatric Surgery, Interventional Endoscopy and Pharmacotherapy.","authors":"Wendy A Brown, Priya Sumithran, Michael Cowley, Ricardo Cohen, Carel Le Roux, Philip Schauer, Santosh Agarwal, Jamie Ard, Camilo Boza, Jenny Lynn Cargiuolo, Letizia Ceccarelli, Jake Coverdale, Brian Dunkin, Francis Finucane, Kapil Gupta, Lee M Kaplan, Marina Kurian, Ildiko Lingvay, Alex Miras, Chuck Pearlman, Terissa Petry, Dimitri Pournaras, Jonthan Purnell, Roxana Ruiz, Carlos Schiavon, Abd Tahrani, Hanan Tarek, Jorg Tomaszewski, Sascha Tumik, Ramy Younes","doi":"10.1007/s11695-026-08692-4","DOIUrl":"https://doi.org/10.1007/s11695-026-08692-4","url":null,"abstract":"<p><p>With the advent of new effective treatments for obesity, the field is rapidly changing creating an urgent need for evidence to guide best patient management. To help prioritise and plan for future trials, a meeting of experts was convened with the aim of reviewing the current literature to identify and prioritise current knowledge gaps; identify relevant research questions, and discuss appropriate trial methodologies that could be utilised to address the identified gaps in a timely and pragmatic manner. Participants included research-active academic surgeons and physicians, and industry representatives from various pharmaceutical and device companies. This report summarizes the key outcomes from this meeting.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Weight Bias, Stigma and Discrimination on Physical, Mental, and Quality of Life Outcomes of Metabolic and Bariatric Surgery: A Systematic Review.","authors":"Eugenia Romano, Ximena Ramos Salas, Lucia Alonso Diez, Ida Camperchioli, Chiara Gerardi, Violeta Moize, Ken Clare, Silvia Frusone, Francesco Maria Carrano","doi":"10.1007/s11695-026-08696-0","DOIUrl":"https://doi.org/10.1007/s11695-026-08696-0","url":null,"abstract":"<p><strong>Background: </strong>Weight-related bias, stigma, and discrimination significantly affect quality of life and health in persons with obesity. Their influence on post-operative outcomes following metabolic surgery and bariatric remains underexplored.</p><p><strong>Objectives: </strong>This systematic review aimed to evaluate any impact of pre- and post-operative weight bias, stigma, and discrimination on post-metabolic and bariatric surgery outcomes, specifically physical health and mental health, including quality of life.</p><p><strong>Methods: </strong>This review was conducted in accordance with the PRISMA 2020 guidelines, with the protocol registered on PROSPERO. Comprehensive searches were performed across MEDLINE, PsycINFO, Embase, Web of Science, PEDro, CINAHL, ISRCTN, and CENTRA. Eligible studies included randomized controlled trials, clinical trials, longitudinal studies, cross-sectional studies, and qualitative research involving patients who underwent metabolic and bariatric surgery. Risk of bias was assessed using validated tools tailored to study design.</p><p><strong>Results: </strong>Eleven studies met the inclusion criteria, examining the influence of weight bias, stigma, and discrimination on post-surgical outcomes. Physical health outcomes included weight loss and BMI. Mental health outcomes included depressive symptoms, disordered eating behaviours, and quality of life domains such as social interactions, occupational settings, sexual health, educational experiences, and post-surgical health management. Findings suggest that weight bias negatively influences mental health and quality of life, associating with depressive symptoms, problematic eating, and lower adherence to nutritional instructions and exercise, potentially impeding optimal physical outcomes.</p><p><strong>Conclusions: </strong>Despite some studies suggesting its negative impact on postoperative outcomes, current evidence on the impact of weight bias, stigma, and discrimination on post-metabolic and bariatric surgery outcomes is limited. Critical gaps remain in understanding how these psychosocial factors affect long-term disease management, self-care, and overall quality of life.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Acute Aerobic Exercise On the Time Spent in Hypoglycaemia After Bariatric Surgery (The BariEX Study).","authors":"Israel Podesta-Donoso, Dimitris Papamargaritis, Joe Henson, Stanislava Katsarova-Harrison, Aikaterina Tziannou, Helen Waller, Alex V Rowlands, David Bowrey, Oluwaseun Anyiam, Iskandar Idris, David J Stensel, David R Webb, Anjali Zalin, Tom Yates, Pratik Choudhary, Melanie J Davies, Louisa Y Herring","doi":"10.1007/s11695-026-08712-3","DOIUrl":"https://doi.org/10.1007/s11695-026-08712-3","url":null,"abstract":"<p><strong>Objective: </strong>To determine whether a pre-lunch single bout of moderate-intensity aerobic exercise (AEX) alters time spent in hypoglycaemia (<3.0 mmol/L) during the subsequent 24 hours (24-h) and parameters of glucose homeostasis in individuals without diabetes after metabolic/bariatric surgery (MBS).</p><p><strong>Methods: </strong>In a randomised crossover study, 15 participants completed two conditions: 30min treadmill walking at 60% V̇O₂peak (AEX) and time-matched sitting (CON). After an overnight fast and a standardised breakfast, participants performed AEX or CON, and both conditions were followed by an identical lunch administered as a mixed-meal tolerance test (MMTT). Continuous glucose monitoring (CGM) assessed glucose levels for 24-h post-intervention, during which participants consumed standardised meals. CGM data were available for analysis in 11 participants. The primary outcome was time spent with glucose <3.0 mmol/L during the 24-h post-intervention. Secondary outcomes included other CGM-derived glucose metrics and plasma glucose and insulin responses during the 3-h MMTT.</p><p><strong>Results: </strong>Only one isolated hypoglycaemic event (<3.0 mmol/L) occurred, precluding statistical analysis of the primary outcome. Mean 24-h glucose (AEX: 6.4 (1.0); CON: 6.5 (0.9) mmol/L; p = 0.57) and time <3.9 mmol/L (AEX 0 (0.0, 0.5); CON 0 (0.0, 0.5) %; p = 0.68) did not differ between conditions. AEX reduced glucose coefficient of variation (p < 0.01). During the MMTT, nadir, peak, and AUC_0-180 glucose, as well as pre-MMTT insulin concentrations, were higher following AEX (all p < 0.05).</p><p><strong>Conclusions: </strong>A pre-lunch 30-min bout of AEX did not increase the 24-h risk of hypoglycaemia post-MBS but elevated post-MMTT glucose levels.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictability of Same-Day Discharge Candidacy After Bariatric Surgery with Machine Learning.","authors":"Jia-Ling Wu, Che-Chen Lin, Hsiu-Yin Chiang, Chin-Chi Kuo, Lucian Panait, Peter Billing, Yen-Yi Juo","doi":"10.1007/s11695-026-08699-x","DOIUrl":"https://doi.org/10.1007/s11695-026-08699-x","url":null,"abstract":"<p><strong>Introduction: </strong>Despite growing interest, same-day discharge (SDD) after bariatric surgery remains uncommon due to challenges with patient selection. In this study, we seek to evaluate whether Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) database provides sufficient information for predicting SDD candidacy METHODS: In this retrospective cohort study, we identified average-risk patients who underwent gastric bypass or sleeve gastrectomy in the 2023 MBSAQIP database. We assigned SDD candidacy to patients who were discharged home within a day and experienced no 30-day readmission. We used five predictive modeling approaches: logistic regression, random forest, gradient boosting, extreme gradient boosting (XGBoost), and light gradient boosting machine. Hyperparameter optimization was conducted with a Bayesian optimization framework.</p><p><strong>Results: </strong>Among the 47,071 included patients, about 70.1% of gastric bypasses and 80.4% of sleeve gastrectomies were deemed SDD candidates. SDD candidates were more commonly males and had less comorbidities. Despite extensive tuning and optimization, all five models performed poorly in predicting SDD candidacy. For gastric bypass, XGBoost performed the best, with an Area Under ROC curve (AUROC) of 0.519, sensitivity/specificity of 0.690/0.329, and Kappa of 0.018. For sleeve gastrectomy, logistic regression performed the best, with an AUROC of 0.538, sensitivity/specificity of 0.609/0.451 and Kappa of 0.042.</p><p><strong>Conclusions: </strong>As of 2023, more than half of average-risk bariatric patients may be safe for SDD. However, predictive artificial intelligence could not reliably identify SDD candidacy using MBSAQIP data.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Machine Learning Prediction Models for Weight Loss Outcomes after Metabolic and Bariatric Surgery: a Systematic Review and Meta-Analysis.","authors":"Jinkun Wang, Jiarun Zhang, Xiaoyun Zhu, Zhaoyi Chen, Jun Zhou, Lu Liu, Bin Li","doi":"10.1007/s11695-026-08710-5","DOIUrl":"https://doi.org/10.1007/s11695-026-08710-5","url":null,"abstract":"","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roux-en-Y Gastric Bypass versus Sleeve Gastrectomy for Cardiometabolic Outcomes: A Systematic Review and Meta-analysis of Randomized Controlled Trials.","authors":"Felipe Pereira Garrido Pazos, Rafael Matos Vieira Gordilho, Eduardo de Oliveira Novelli, Luiz Guilherme Lima Santana, Maria da Conceição Cavalcanti de Figueiredo Vilaboim, Breno Santos Matos de Magalhães, Maria Luisa França Lessa, Pedro Henrique Matos Oliveira, Marcelo Falcão","doi":"10.1007/s11695-026-08664-8","DOIUrl":"https://doi.org/10.1007/s11695-026-08664-8","url":null,"abstract":"","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food Consumption by Processing Levels in Adults Two or More Years After Sleeve Gastrectomy: Associations with Surgical Outcomes and Eating Behaviors.","authors":"Nazanin Moslehi, Zahra Kamali, Mahdieh Golzarand, Maryam Barzin, Alireza Khalaj, Parvin Mirmiran","doi":"10.1007/s11695-026-08582-9","DOIUrl":"https://doi.org/10.1007/s11695-026-08582-9","url":null,"abstract":"","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Animal Study of the Performance of Two Endoscopic Sleeve Gastroplasty Devices.","authors":"Sohaïb Ouazzani, Arnaud Lemmers, Ivo Boskoski, Marc Barthet","doi":"10.1007/s11695-026-08701-6","DOIUrl":"https://doi.org/10.1007/s11695-026-08701-6","url":null,"abstract":"<p><strong>Background: </strong>Endoscopic sleeve gastroplasty (ESG) is an established endoscopic bariatric therapy. Two main platforms are currently used in clinical practice: the OverStitch Endoscopic Suturing System (OESS) and the triangulation Endomina System (ES). Comparative data regarding their technical performance and suture durability remain limited. This experimental study aimed to compare both systems in terms of usability, safety, and durability of full-thickness sutures.</p><p><strong>Methods: </strong>In this prospective comparative animal study, six adult minipigs were randomized to ESG using either OESS or ES (three animals per group; five sutures per animal). Primary outcomes included ease of use, tissue apposition (TA) tightness assessed at index procedure, day 15 endoscopy, and day 30 necropsy, as well as histological evaluation of serosal fusion and bite size.</p><p><strong>Results: </strong>All procedures were successfully completed without intra-procedural adverse events. Overall ease-of-use scores were higher with ES compared to OESS (median 6 vs 5; p=0.047). Immediate post-procedural TA scores were similar between groups (both tight; p=1). However, at day 15, ES demonstrated significantly higher TA scores than OESS (OR=29.1; 95% CI 4.3-200.3; p=0.026). At day 30 necropsy, TA remained significantly tighter with ES (OR=199.9; 95% CI 2.5-16245; p=0.029). No leaks or abscesses were observed. Histologically, serosal fusion was observed only in the ES group, although differences did not reach statistical significance.</p><p><strong>Conclusion: </strong>Both ESG platforms were safe and feasible in this animal model. While immediate suture performance was comparable, the Endomina System demonstrated superior mid-term durability and tighter tissue apposition compared with OverStitch. The clinical relevance of these findings warrants further investigation.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}