Obesity SurgeryPub Date : 2026-10-21DOI: 10.1007/s11695-026-08904-x
Nayyera Tibi, Boris Kirshtein, Noam Peleg, Hila Shmilovich, Alex Tatarov, Nidal Issa, Eliahu Y Bekhor
{"title":"Does Ethnicity Influence the Long-Term Outcomes of Sleeve Gastrectomy? Results from a Prospectively Maintained Israeli Database.","authors":"Nayyera Tibi, Boris Kirshtein, Noam Peleg, Hila Shmilovich, Alex Tatarov, Nidal Issa, Eliahu Y Bekhor","doi":"10.1007/s11695-026-08904-x","DOIUrl":"https://doi.org/10.1007/s11695-026-08904-x","url":null,"abstract":"<p><strong>Background: </strong>Ethnic disparities often influence patient's outcomes. This study aimed to compare the weight loss and metabolic outcomes of laparoscopic sleeve gastrectomy (LSG) in Israeli-Arab and Israeli-Jewish patients.</p><p><strong>Methods: </strong>A prospectively maintained cohort of 892 patients (262 Arabs and 630 Jews) who underwent LSG between 2009 and 2022 at a single tertiary academic center was retrospectively analyzed. Demographic, peri-operative, and long-term outcome data were compared between the two groups.</p><p><strong>Results: </strong>Arabs were younger (35 vs. 44 years) and had a higher baseline BMI (45.1 vs. 42.9). Jews had more postoperative follow-ups (6.8 vs. 6.0). Despite these differences, long-term weight loss outcomes were broadly comparable between groups. %EWL outcomes did not differ significantly at 1- and 5-year follow-up. Although Arab patients demonstrated numerically higher %TWL at 1 year, this difference did not reach statistical significance and was not sustained at longer-term follow-up. Rates of comorbidity remission, including diabetes, hypertension, and dyslipidemia, were similarly high.</p><p><strong>Conclusion: </strong>Despite baseline ethnic disparities, LSG was associated with comparable long-term weight loss and comorbidity resolution among Israeli-Arab and Israeli-Jewish patients.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149238912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Obesity SurgeryPub Date : 2026-10-19DOI: 10.1007/s11695-026-08971-0
Jorge Febré Sánchez, Christian Esteo Verdú, Raul Cánovas de Lucas, Inmaculada Torrijo Gómez, Carla Leal Ferrandis, Maria Del Carmen Martínez Bagant
{"title":"Robotic Assisted SADI-S Using Hugo™<sup>-</sup>RAS: Step-by-Step Technique.","authors":"Jorge Febré Sánchez, Christian Esteo Verdú, Raul Cánovas de Lucas, Inmaculada Torrijo Gómez, Carla Leal Ferrandis, Maria Del Carmen Martínez Bagant","doi":"10.1007/s11695-026-08971-0","DOIUrl":"https://doi.org/10.1007/s11695-026-08971-0","url":null,"abstract":"","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Obesity SurgeryPub Date : 2026-10-16DOI: 10.1007/s11695-026-08982-x
Yanic Ammann, Rene Warschkow, Marie Klein, Romano Schneider, Beat Müller, Loriana Lisarelli, Ignazio Tarantino, Patrick Folie
{"title":"Linear versus Circular Stapled Gastrojejunostomy in Minimally Invasive Roux-en-Y Gastric Bypass: A Nationwide Swiss Administrative Database Study (2015-2022).","authors":"Yanic Ammann, Rene Warschkow, Marie Klein, Romano Schneider, Beat Müller, Loriana Lisarelli, Ignazio Tarantino, Patrick Folie","doi":"10.1007/s11695-026-08982-x","DOIUrl":"https://doi.org/10.1007/s11695-026-08982-x","url":null,"abstract":"<p><strong>Background: </strong>The impact of stapling technique on early postoperative outcomes after minimally invasive Roux-en-Y gastric bypass (RYGB) remains incompletely understood. This study compared short-term postoperative outcomes following linear versus circular gastrojejunostomy.</p><p><strong>Methods: </strong>This nationwide administrative database study included RYGB cases in Switzerland between 2015 and 2022. The primary endpoint was major in-hospital postoperative complication (composite of diagnoses and reoperation). Secondary endpoints included individual complications, length of hospital stay (LOS), and temporal trends in stapling technique. Associations were assessed using generalised additive regression models and propensity score matching (PSM).</p><p><strong>Results: </strong>Among 21,320 RYGB cases, 18,161 (85.2%) underwent linear and 3,159 (14.8%) circular gastrojejunostomy. Circular stapling was not associated with major complication in multivariable analysis (OR = 1.221, 95% CI 0.824-1.809), whereas higher odds were observed after PSM (OR = 2.464, 95% CI 1.225-4.956). Circular stapling was associated with both surgical site infection (SSI) and LOS exceeding the 50th percentile in both multivariable (SSI: OR = 2.251, 95% CI 1.331-3.809; LOS: RR = 1.136, 95% CI 1.047-1.232) and PSM analyses (SSI: OR = 7.647, 95% CI 2.885-20.271; LOS: RR = 1.318, 95% CI 1.218-1.426). For LOS exceeding the 90th percentile, an association was observed in multivariable analysis (RR = 1.209, 95% CI 1.014-1.441), but not after PSM (RR = 1.018, 95% CI 0.604-1.715). Circular stapling decreased overall during the study period (Τ=-0.714, p = 0.013), despite year-to-year variation.</p><p><strong>Conclusion: </strong>The association between circular stapling and major in-hospital postoperative complication differed across analytical approaches. Associations with SSI and prolonged LOS were more consistent. Linear stapling increasingly predominated over time. Registry: ClinicalTrials.gov, TRN: NCT07483957, Registration date: 17 March 2026.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149207478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Postoperative FIB-4 Trajectories by Biopsy-Confirmed Fibrosis Stage After Sleeve Gastrectomy: An Exploratory Biopsy-Based Cohort Study.","authors":"Hironobu Takano, Saseem Poudel, Hideyuki Wada, Takeo Nitta, Yuma Ebihara, Toshiaki Shichinohe, Satoshi Hirano","doi":"10.1007/s11695-026-08979-6","DOIUrl":"https://doi.org/10.1007/s11695-026-08979-6","url":null,"abstract":"<p><strong>Introduction: </strong>Whether advanced histological liver fibrosis limits postoperative improvement in fibrosis-related biomarkers after laparoscopic sleeve gastrectomy (LSG) remains unclear. We evaluated the fibrosis-related biomarker dynamics using biopsy-confirmed staging.</p><p><strong>Methods: </strong>This retrospective study included 74 patients who had undergone LSG with intraoperative liver biopsy. Fibrosis was staged using the Brunt classification and patients were stratified into the F0-2 (n = 64) and F3-4 (n = 10) groups. Changes in the Fibrosis-4 (FIB-4) index from baseline to 1 year postoperatively were assessed. The proportion of patients with FIB-4 ≥ 1.3 was analyzed. An exploratory analysis of covariance was performed among 41 patients with baseline diabetes to identify predictors of 1-year FIB-4.</p><p><strong>Results: </strong>The baseline FIB-4 was significantly higher in the F3-4 than in the F0-2 group (median 1.593 vs. 0.847, p = 0.026). At 1 year, the FIB-4 values did not differ significantly between the two groups (0.853 vs. 0.857, p = 0.433). The proportion of patients with FIB-4 ≥ 1.3 decreased from 60 to 20% in the F3-4 group and from 12.5 to 7.8% in the F0-2 group. Postoperative %total weight loss (%TWL), diabetes remission, HbA1c, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) levels did not differ between groups. In an exploratory multivariable analysis of 41 patients with baseline diabetes, baseline FIB-4 was significantly associated with 1-year FIB-4 (unstandardized β = 0.472, p < 0.001), whereas fibrosis stage was not statistically significant.</p><p><strong>Conclusions: </strong>These findings suggest that favorable changes in fibrosis-related biomarkers may occur after LSG even among patients with histologically advanced fibrosis. However, these observations should be considered exploratory and require confirmation in larger cohorts.</p><p><strong>Key points: </strong>• How severe liver fibrosis affects fibrosis-related risk after LSG remained unclear. • We evaluated the fibrosis-related biomarker dynamics using biopsy-confirmed staging. • The FIB-4 index decreased after LSG in patients with advanced fibrosis, and no significant difference in FIB-4 was detected between the fibrosis groups at 1 year. • The favorable changes in fibrosis-related risk markers may occur after LSG even among patients with histologically advanced fibrosis.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149183453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Obesity SurgeryPub Date : 2026-10-12DOI: 10.1007/s11695-026-08981-y
Tuna Bilecik
{"title":"Five-Year Outcomes of Sleeve Gastrectomy with Transit Bipartition in Women with Severe Obesity and Insulin-Treated Type 2 Diabetes: A Prospective Single-Center Cohort Study of 35 Women.","authors":"Tuna Bilecik","doi":"10.1007/s11695-026-08981-y","DOIUrl":"https://doi.org/10.1007/s11695-026-08981-y","url":null,"abstract":"<p><strong>Introduction: </strong>Five-year data on metabolic durability, nutritional outcomes, and late morbidity after sleeve gastrectomy with transit bipartition (SG + TB) remain limited. We evaluated glycemic, weight, nutritional, and safety outcomes in women with severe obesity and insulin-treated type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>This prospective single-center follow-up included 35 women who underwent laparoscopic SG + TB in 2016-2017. At 5 years, 30/35 (85.7%) retained SG + TB anatomy and had complete efficacy data; weight and HbA1c were available in one additional revised patient (31/35, 88.6%). T2DM remission was defined as HbA1c < 6.5% at least 3 months after stopping glucose-lowering pharmacotherapy. Nutritional assessment used a prespecified limited biochemical panel.</p><p><strong>Results: </strong>In the 30-patient anatomy-retained complete-case cohort, mean HbA1c decreased from 9.2 ± 1.0% to 5.5 ± 0.7%, body weight from 118.0 ± 10.6 to 75.6 ± 6.8 kg, and mean total weight loss was 35.7 ± 5.1%. Medication-free T2DM remission was 23/30 (76.7%; 95% CI, 59.1-88.2%); the conservative all-enrolled estimate was 23/35 (65.7%; 95% CI, 49.2-79.2%). At year 5, hypoalbuminemia was 20.0%, low serum iron 30.0%, vitamin B12 deficiency 13.3%, and vitamin D deficiency 73.3%; 27/30 (90.0%) had at least one predefined biochemical abnormality. Two patients required an SG + TB-related invasive intervention, including one revision; two additional patients underwent laparoscopic cholecystectomy.</p><p><strong>Conclusion: </strong>SG + TB was associated with substantial 5-year weight loss and glycemic improvement, but the lower all-enrolled remission estimate highlights attrition and revision-related exclusion. Biochemical abnormalities and clinically important gastrointestinal morbidity show that preserved duodenal continuity does not eliminate potential hypoabsorptive consequences. Lifelong metabolic and nutritional surveillance is warranted.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Obesity SurgeryPub Date : 2026-10-10DOI: 10.1007/s11695-026-08974-x
Rachael Caretti, Daniel Gomez-Carrillo, Emma Anne McKinley, Hameeda Arif Arain, Sophie Dream, Andrea Gillis, Brenessa Lindeman, Herbert Chen
{"title":"Implications of Roux-en-Y Gastric Bypass Surgery on Hypocalcemia in Total Thyroidectomy: A Narrative Review.","authors":"Rachael Caretti, Daniel Gomez-Carrillo, Emma Anne McKinley, Hameeda Arif Arain, Sophie Dream, Andrea Gillis, Brenessa Lindeman, Herbert Chen","doi":"10.1007/s11695-026-08974-x","DOIUrl":"https://doi.org/10.1007/s11695-026-08974-x","url":null,"abstract":"<p><p>Patients who undergo total thyroidectomy after Roux-en-Y gastric bypass are subject to higher risks of postoperative hypocalcemia due to altered gastrointestinal anatomy, but guidelines for management do not exist. Preoperative evaluation of patient's calcium and vitamin D levels should be performed to ensure that any baseline deficiencies are corrected. Postoperative management should include a step-up approach starting with oral calcium and vitamin D supplementation with IV supplementation when needed. In severe cases that progress to permanent hypoparathyroidism, consideration for surgical management to increase calcium absorption may be warranted.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Obesity SurgeryPub Date : 2026-10-08DOI: 10.1007/s11695-026-08972-z
Eduard Espinet-Coll, Manoel Galvao-Neto, Jonathan Jerez-Ortiz, Miguel Pérez-Ferrer, Jaime Bernabéu-López, Arnulfo Fernández-Zulueta, Javier Nebreda-Durán
{"title":"Persistent Abdominal Pain After Endoscopic Sleeve Gastroplasty: A Multicenter Case Series and Hypothesis-Generating Management Framework.","authors":"Eduard Espinet-Coll, Manoel Galvao-Neto, Jonathan Jerez-Ortiz, Miguel Pérez-Ferrer, Jaime Bernabéu-López, Arnulfo Fernández-Zulueta, Javier Nebreda-Durán","doi":"10.1007/s11695-026-08972-z","DOIUrl":"https://doi.org/10.1007/s11695-026-08972-z","url":null,"abstract":"<p><strong>Introduction: </strong>Endoscopic sleeve gastroplasty (ESG) is an established minimally invasive treatment for patients with obesity, with a favorable safety profile. Although transient abdominal pain is common in the early post-ESG period, persistent pain remains poorly characterized. We aimed to describe the clinical presentation, diagnostic evaluation, management strategies, and outcomes of patients with persistent abdominal pain after ESG, and to propose a pragmatic management pathway.</p><p><strong>Methods: </strong>We conducted a retrospective multicenter case series across six expert bariatric endoscopy centers. Patients with abdominal pain lasting more than 15 days after ESG were identified. Demographic, procedural, diagnostic, therapeutic, and follow-up data were collected.</p><p><strong>Results: </strong>Among 4,350 ESG procedures, nine patients developed persistent abdominal pain (0.21%; 95% CI, 0.09-0.39%). Mean baseline BMI was 33.7 ± 1.4 kg/m². The median interval from the 15-day post-ESG threshold to documented pain treatment was 21 days [IQR, 1-52.5]. Laboratory testing, radiologic evaluation, and endoscopy excluded major complications; one gastric wall hematoma was identified on CT. Suspected mechanisms included excessive plication-related tension (55.6%), possible extra-gastric tissue capture or adhesions (33.3%), and gastric wall hematoma (11.1%). Conservative management (mainly nutritional reset and conventional analgesia) improved symptoms in 77.8% of cases. Mean numerical pain score decreased from 4.9 ± 1.8 to 1.2 ± 1.2. Two refractory cases required complete and selective endoscopic suture release.</p><p><strong>Conclusions: </strong>Persistent abdominal pain after ESG is uncommon but clinically relevant. A stepwise strategy prioritizing exclusion of serious adverse events, conservative management, and selective endoscopic suture release in refractory cases may be appropriate. Prospective validation is required.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Obesity SurgeryPub Date : 2026-10-08DOI: 10.1007/s11695-026-08984-9
Alexandra Burtea, Jaime Almandoz, Marielle Nagele, Sunil Mathew, Luyu Xie, Kathleen Esselink, Jeffrey Schellinger, Sarah Messiah, Ildiko Lingvay
{"title":"Long-Term Satisfaction with the Choice to Complete Metabolic and Bariatric Surgery: The Hindsight 20/20 Study.","authors":"Alexandra Burtea, Jaime Almandoz, Marielle Nagele, Sunil Mathew, Luyu Xie, Kathleen Esselink, Jeffrey Schellinger, Sarah Messiah, Ildiko Lingvay","doi":"10.1007/s11695-026-08984-9","DOIUrl":"https://doi.org/10.1007/s11695-026-08984-9","url":null,"abstract":"<p><strong>Objective: </strong>Despite proven benefits, metabolic and bariatric surgery (MBS) remains underutilized. This study assessed long-term satisfaction among individuals after MBS and identified predictors of sustained satisfaction.</p><p><strong>Research design and methods: </strong>In this cross-sectional survey with retrospective EHR linkage, adults with prior MBS identified through electronic health records at a large academic medical center completed a satisfaction survey. LASSO regression was used for variable selection, followed by an exploratory multivariable logistic regression model.</p><p><strong>Results: </strong>Among 2,385 respondents (mean age 55.1 +/- 12.2 years; 84.7% female; mean 12.0 +/- 7.5 years post-MBS), 74.2% would choose MBS again, 7.3% were unsure, and 18.5% would not. Overall health benefit was the most commonly reported reason for willingness to choose MBS again, whereas weight recurrence was the most commonly reported reason for uncertainty or unwillingness. In the exploratory adjusted model, greater pre-MBS BMI and maximum percent total weight loss were associated with higher odds of choosing MBS again, whereas longer time since MBS and higher current BMI were associated with lower odds. Percent recurrence of lost weight was not independently associated with the outcome.</p><p><strong>Conclusions: </strong>Most respondents remained satisfied long-term with their decision to undergo MBS. Time since surgery and current and historical weight measures were associated with willingness to choose MBS again, although these exploratory, mutually adjusted associations should not be interpreted as independent causal effects. These findings may inform counseling about the long-term benefits and limitations of MBS.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Obesity SurgeryPub Date : 2026-10-08DOI: 10.1007/s11695-026-08968-9
Nahlah Fahad Alreshidi, Refaat A Eid, Rafika Harrabi, Waiel Sami Halabi, Abdullah M K Albloshi, Joud S Almutairi, Salah Alghamdi
{"title":"Correction: Time Trends in Thyroid Hormone Changes Following Bariatric Surgery: A Systematic Review and Meta-Analysis.","authors":"Nahlah Fahad Alreshidi, Refaat A Eid, Rafika Harrabi, Waiel Sami Halabi, Abdullah M K Albloshi, Joud S Almutairi, Salah Alghamdi","doi":"10.1007/s11695-026-08968-9","DOIUrl":"https://doi.org/10.1007/s11695-026-08968-9","url":null,"abstract":"","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Obesity SurgeryPub Date : 2026-10-07DOI: 10.1007/s11695-026-08903-y
Khaled Mosleh Torfa, George A Nashed, Stavro Paulo, Soha Hamed Ammar, Mohammed Elshwadfy Nageeb, Mohamed Yacoub
{"title":"Impact of Bariatric Surgery on Reproductive Hormones and Menstrual Regularity in Women with Obesity.","authors":"Khaled Mosleh Torfa, George A Nashed, Stavro Paulo, Soha Hamed Ammar, Mohammed Elshwadfy Nageeb, Mohamed Yacoub","doi":"10.1007/s11695-026-08903-y","DOIUrl":"https://doi.org/10.1007/s11695-026-08903-y","url":null,"abstract":"<p><strong>Background: </strong>Obesity affects 2.5 billion adults, disrupting the hypothalamic-pituitary-ovarian (HPO) axis through adipokine imbalance and aromatase activity. This causes hormonal dysregulation, infertility, and pregnancy risks. Bariatric surgery can restore hormonal balance and improve menstrual regularity. This study evaluates post-bariatric surgery changes in reproductive hormones and cycle regularity over six months in Egyptian women with obesity.</p><p><strong>Methods: </strong>This prospective cohort study included women aged 18-45 (BMI ≥ 35 kg/m²) undergoing laparoscopic bariatric surgery. Serum FSH, LH, estradiol, Progesterone, and AMH levels were measured at baseline, 3, and 6 months postoperatively. Secondary outcomes included menstrual regularity and hormonal correlations with weight loss.</p><p><strong>Results: </strong>Bariatric surgery resulted in a highly significant reduction in body weight and BMI over the six-month follow-up period (p < 0.001). Significant hormonal shifts were observed, including increased levels of FSH (p < 0.001) and LH (p = 0.001), a decreased LH/FSH ratio (p = 0.005), and marked reductions in estrogen and progesterone concentrations (p < 0.001). While AMH levels remained stable (p = 0.6), menstrual regularity improved significantly from 20% at baseline to 53.3% post-surgery (p = 0.001). Furthermore, the degree of weight loss was significantly and positively correlated with postoperative FSH and LH levels. The interventions were generally well-tolerated, with 82.4% of participants reporting no postoperative complications. No significant differences in the improvement of weight or hormonal profiles were noted between patients with and without PCOS.</p><p><strong>Conclusion: </strong>Bariatric surgery induces weight loss and restores reproductive hormonal balance in women with obesity by improving HPO axis regulation. Increased FSH and LH levels, resulting from reduced adiposity, might contribute to improved menstrual regularity.</p><p><strong>Key points: </strong>• Bariatric surgery resulted in a significant and progressive reduction in body weight and BMI over the six-month follow-up period (p < 0.001). • There was a significant postoperative increase in FSH and LH levels. Estrogen and progesterone concentrations demonstrated significant and sustained reductions post-surgery, whereas AMH levels remained stable throughout the study. • Menstrual regularity improved significantly, increasing from 20% of participants at baseline to 53.3% six months after surgery (p = 0.001). • The degree of weight loss was significantly and positively correlated with postoperative FSH and LH levels.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}