Obesity Surgery最新文献

{"title":"Exploratory Assessment of Preoperative GLP-1 Receptor Agonists Before Sleeve Gastrectomy: A Retrospective Matched Analysis.","authors":"Guillaume Luc, Arnaud Dedieu, Guillaume Canard, Amélie Cesard, Amandine Brunet, Camille Furois, Angèle Leterrier, Barbara Daridon, Lea Mendes, Emilie Brighen, Lucie Fournet, Anaelle David, Ludivine Muzard","doi":"10.1007/s11695-025-08258-w","DOIUrl":"10.1007/s11695-025-08258-w","url":null,"abstract":"<p><strong>Background: </strong>Preoperative treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) before bariatric surgery has not been studied. Therefore, we investigated the impact of neoadjuvant treatment with GLP-1 RAs on weight loss and postoperative outcomes in patients who underwent sleeve gastrectomy for severe obesity.</p><p><strong>Method: </strong>A retrospective single-center study was conducted between January 2022 and December 2023. Patients with morbid obesity who were treated preoperatively with a GLP-1 RA (GLP-1 group) were matched with patients who were not preoperatively treated with a GLP-1 RA (No GLP-1 group) using propensity scores calculated according to age and body mass index (BMI). Between-group differences in demographics, comorbidities, surgical parameters, complications, weight loss, and comorbidity outcomes were analyzed.</p><p><strong>Results: </strong>Fourteen patients were included in the GLP-1 group and matched with 28 controls (1:2 ratio). Preoperative weight loss was significantly greater in the GLP-1 group (7.8 ± 6.8 kg) than in the control group (0.2 ± 4.5 kg), with a mean difference of + 7.54 kg (95% CI: [3.47;11.6], p = 0.001, Cohen's d = 1.41). Mixed-effects ANOVA revealed a significant effect of time, with progressive BMI reduction in both groups (p = 0.019), no main effect of group (p = 0.080), and no group-time interaction (p = 0.972), indicating similar BMI trajectories throughout the perioperative period and no between-group difference at 12 months. Postoperative vomiting occurred in 21.4% of patients in the GLP-1 group versus 0% in the No GLP-1 group (p = 0.031). No significant differences in surgical parameters or the comorbidity resolution rate at one year were found.</p><p><strong>Conclusion: </strong>Neoadjuvant GLP-1 RA treatment increased preoperative weight loss before sleeve gastrectomy, but the benefit was not sustained postoperatively. Preoperative GLP-1 RA use could be considered to optimize surgical preparation, but further data regarding postoperative outcomes and long-term weight benefits are needed.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":"4383-4392"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying Malabsorption After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy Using Near Infrared Spectroscopy.","authors":"Rutger Franken, Max Zwartjes, Ashley Senff, Barbara Hutten, Maurits de Rotte, Victor Gerdes, Arnold van de Laar, Max Nieuwdorp","doi":"10.1007/s11695-025-08244-2","DOIUrl":"10.1007/s11695-025-08244-2","url":null,"abstract":"<p><strong>Background: </strong>Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) are common bariatric procedures that lead to substantial and sustained weight loss. Although both procedures induce hormonal and physiological effects, RYGB includes both a restrictive and malabsorptive component due to anatomical rerouting, whereas SG is considered primarily restrictive. This study aimed to quantify differences in energy and fat absorption between both procedures using near-infrared spectroscopy (NIRS).</p><p><strong>Methods: </strong>Female patients, 12-24 months post-RYGB or SG, followed a strictly controlled, tailor-made diet for 6 days. Faecal samples collected over the final 3 days were analysed using NIRS to assess energy and fat malabsorption. Physical activity and stool consistency were also evaluated.</p><p><strong>Results: </strong>Twenty-nine patients were initially included; one RYGB patient was excluded due to implausibly high reported energy intake leaving 14 RYGB and 14 SG patients. We found higher (p = 0.03) malabsorption in patients after RYGB (194.8 malabsorbed kcal, 13.2%) as compared to patients after SG (111.7 malabsorbed kcal, 7.6%). Furthermore, in the RYGB group, malabsorbed fat was higher (p = 0.01) with 9.7 g (15.4%) malabsorbed as compared to 3.9 g (6.1%) malabsorbed in SG. Even when adjusting for percentage weight loss, both differences remained statistically significant.</p><p><strong>Conclusion: </strong>Fat and energy malabsorption are significantly higher following RYGB compared to SG, and NIRS proves to be a feasible method for assessing these differences. However, the differences are relatively modest and do not appear to be directly proportional to the reduction in functional intestinal length exposed to nutrients.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":"4048-4054"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective, Multicenter Clinical Trial to Evaluate the Safety of the Stella® Intragastric Balloon at 7 Months and the Balloon Delivery System.","authors":"Eduardo Espinet-Coll, Román Turró-Arau, Javier Nebreda-Durán, Ramón Abad-Belando, Óscar MartínezNúñez-Martínez, Fernando Saenger, Modesto Varas-Lorenzo, Franco Antonio Samaniego-Aquino, Patricia Díaz-Galán, Antonio Ortega-Sabater, Gerard Grau-Manrubia, Gonzalo López-Roldán, José María Alberdi-Alonso, Manoel Galvao Neto","doi":"10.1007/s11695-025-08264-y","DOIUrl":"10.1007/s11695-025-08264-y","url":null,"abstract":"<p><strong>Background: </strong>The intragastric balloon (IGB) is a well-established treatment for obesity. However, several models have been developed to optimize outcomes and procedural efficiency. The Stella®-IGB is a novel, double-lumen device, designed for guidewire-assisted placement to improve procedural safety and patient comfort.</p><p><strong>Methods: </strong>This is a prospective, multicenter, longitudinal, non-randomized study aimed to demonstrate the safety and feasibility of the Stella®-IGB system. Balloon insertion, delivery system, 6-month permanence integrity, 7-month adverse events (AEs) according to Clavien-Dindo AGREE classification, intolerance rate, weight loss and metabolic improvement were investigated.</p><p><strong>Results: </strong>Sixty-nine patients (72.46% females), median age of 42.0 years (IQR 34, 52) and BMI of 33.5 kg/m² (IQR 31.0, 36.1) were included. Adequate balloon insertion and 6-month good integrity permanence were obtained in 66/69 (95.65%). Three dysfunction cases were observed: one technical deploy difficulty (twisting of the feeding catheter), one device rupture due to extensive fungal colonization of the balloon and one partially deflated balloon. None presented clinical or endoscopic sequelae. The median balloon insertion time was 4.23 s (IQR 3.04, 5.0), with a first attempt rate of 97.1%. Balloon intolerance was detected in 5.8% of patients. At 6-month follow-up the mean %TWL was 15.39% (95%CI 13.77, 17.00%), with significant metabolic improvement. Globally, 211 grade I-II minor AEs were reported, with no serious AEs (95%CI 0.98, 1).</p><p><strong>Conclusion: </strong>Stella®-IGB uses a double-lumen probe and a guidewire for a more comfortable and safe placement procedure. No serious AEs were observed. Stella®-IGB could expand current indications to IGB placement for endoscopists-in-training and in case of pharyngo-esophageal anatomical alterations.</p><p><strong>Clinical trial number: </strong>NCT06744829.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":"4440-4451"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating National Trends in Bleeding Associated with Metabolic Bariatric Surgery over 7 Years.","authors":"Tina Bharani, Divyansh Agarwal, Abdelrahman Nimeri, Thomas Tsai, Neil Ghushe, Malcolm Robinson, Talar Tatarian, Ali Tavakkoli, Eric Sheu","doi":"10.1007/s11695-025-08231-7","DOIUrl":"10.1007/s11695-025-08231-7","url":null,"abstract":"<p><strong>Background: </strong>Post-operative bleeding is a known complication after metabolic bariatric surgery (MBS). This study evaluates the national trends in the rates of bleeding, factors associated with bleeding, and impact of bleeding complication on other outcomes.</p><p><strong>Methods: </strong>MBSAQIP database from 2015 to 2021 was utilized to perform multivariable regression analysis of pre-operative factors associated with bleeding for all MBS, as well as gastric bypass (RYGB) and sleeve gastrectomy (SG) subsets. Propensity matching using pre-operative factors was performed for patients with and without a bleeding complication to compare peri-operative outcomes.</p><p><strong>Results: </strong>Rates of post-operative bleeding decreased overall from 1.01% in 2015 to 0.69% in 2021. RYGB (OR 2.08, p < 0.01) had a higher risk of bleeding compared to SG. Open surgical approach (OR 2.33, p < 0.01), therapeutic anticoagulation (OR 2.49, p < 0.01), renal insufficiency (OR 1.61, p < 0.01), and history of MI (OR 1.26, p < 0.01) were highly associated with bleeding. Pre-operative demographics associated with increased bleeding risk included older age (OR 1.16-1.31, p < 0.01), male gender (OR 1.10, p < 0.01) and Asian race (OR 1.47, p < 0.01). Staple line reinforcement (OR 0.76, p < 0.01) and oversewing (OR 0.79, p < 0.01) were protective against bleeding after SG. Bleeding was associated with 18 times higher risk of major complications (42.57% vs 2.33%, p < 0.01) and 8 times higher risk of death (1.06% vs 0.13%, p < 0.01).</p><p><strong>Conclusions: </strong>The risk of bleeding after MBS has decreased over the past 7 years. Patients suffering a bleeding complication have a markedly higher risk of major complications and death. Therefore, identifying methods to reduce post-operative bleeding should be a priority.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":"4079-4086"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Elevated Interleukin-6 Is Associated with Successful Weight Loss 3 Months Postlaparoscopic Sleeve Gastrectomy.","authors":"Marietta Bracha, Alina Jaroch, Adrian Falkowski, Beata Zwierko, Magdalena Szwed, Maciej Michalik, Alina Borkowska, Krzysztof Szwed, Mariusz Kozakiewicz","doi":"10.1007/s11695-025-08260-2","DOIUrl":"10.1007/s11695-025-08260-2","url":null,"abstract":"","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":"4551"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in Adiposity, Body Fat Mobilization and Cardiometabolic Health Following Bariatric Surgery.","authors":"Lajeunesse-Trempe Fannie, Laurie Marchand, Maëlle Blais, Audrey Auclair, Simon Marceau, Samuel Alarie, Paul Poirier, Marie-Ève Piché","doi":"10.1007/s11695-025-08138-3","DOIUrl":"10.1007/s11695-025-08138-3","url":null,"abstract":"<p><strong>Background: </strong>Weight loss in light of various weight management strategies, including bariatric surgery, is recognized to vary according to sex.</p><p><strong>Objectives: </strong>This study aimed to compare sex differences in adiposity phenotypes, body fat mobilization, and obesity-associated comorbidities at baseline and after bariatric surgery.</p><p><strong>Methods: </strong>Ninety patients (26 men and 64 women) who underwent biliopancreatic diversion with duodenal switch surgery (BPD-DS) were included. Medical history, anthropometric, and bioelectrical impedance measurements as well as computed tomography scans (CT scan) were performed at baseline and at 12-month after BPD-DS. Sex differences in post-operative fat and muscle mobilization were assessed using one-way analysis of variance.</p><p><strong>Results: </strong>At baseline, men (mean age 44.5 ± 13.2 years) presented a higher global lean mass, abdominal muscle (estimated using CT scan), a higher volume of abdominal visceral fat, and a larger proportion of mid-thigh muscle infiltrated with lipids; a proxy for ectopic fat deposition in skeletal muscle compared to women (p < 0.05 for all). After BPD-DS, there were no differences in fat distribution between sexes, except for abdominal fat volume and muscle infiltrated with lipids which remained higher in men (p < 0.05). These differences translated into a numerically non-significant lower rate of remission of comorbidities in men.</p><p><strong>Conclusions: </strong>Our result reports on sex differences in body fat mobilization at 12 months post-BPD-DS. Despite comparable body mass index and overall lean and fat mass, men exhibit a higher volume of abdominal fat volume and greater ectopic fat deposition in skeletal muscles compared to women.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":"4216-4223"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145125335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Dual-Isotope Scintigraphy for Gastrointestinal Transit in Duodenal Switch: An Explorative Clinical Study\".","authors":"Anshu Kumar, Partha Sarothi Rakshit, Koyel Roy","doi":"10.1007/s11695-025-08200-0","DOIUrl":"10.1007/s11695-025-08200-0","url":null,"abstract":"","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":"4543-4544"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clarifying the 2022 IFSO/ASMBS Metabolic and Bariatric Surgery Guidelines for Asians: Safeguarding Against Misapplication.","authors":"Kuo-Feng Hsu","doi":"10.1007/s11695-025-08237-1","DOIUrl":"10.1007/s11695-025-08237-1","url":null,"abstract":"","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":"4023-4025"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Qualitative Study of Eating Behaviours and Weight Change After Metabolic Bariatric Surgery in Women.","authors":"Hilal Doğan Güney, Pınar Göbel","doi":"10.1007/s11695-025-08230-8","DOIUrl":"10.1007/s11695-025-08230-8","url":null,"abstract":"<p><strong>Background: </strong>Weight regain after metabolic bariatric surgery (MBS) poses a significant challenge to long-term treatment success. The experiences of individuals, especially in socioculturally distinct populations, remain underexplored.</p><p><strong>Methods: </strong>This qualitative study employed Interpretative Phenomenological Analysis (IPA) to examine the eating-related experiences of 20 Turkish women who had undergone MBS and regained at least 10% of their weight postoperatively. Participants were recruited from a private wellness center, and semi-structured interviews were conducted. Transcripts were coded and thematically analysed.</p><p><strong>Results: </strong>The following section presents five superordinate themes that emerged from the participants' narratives, each capturing a distinct yet interconnected aspect of their postoperative experiences. Five superordinate themes emerged: (1) food and nutrition; (2) eating habits and preferences; (3) changes in food tolerance; (4) emotional dimensions of weight; and (5) social and environmental influences. Participants reported profound shifts in their relationship with food, emotional regulation, and social dynamics. Although initial weight loss and physical health improvements were achieved, participants expressed distress over the recurrence of compulsive eating behaviours, cultural pressures, and lack of long-term psychosocial support. These findings reflect the multifaceted interplay of behavioural, emotional, and cultural factors that shape post-surgical weight trajectories.</p><p><strong>Conclusion: </strong>This study provides culturally contextualised insight into postoperative weight regain, an area often underrepresented in bariatric literature. Effective long-term outcomes may require not only surgical intervention but also sustained behavioural support and culturally sensitive dietary counselling. These findings underscore the need for multidisciplinary and culturally attuned post-bariatric care models.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":"4352-4361"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of Online Cognitive-behavioral Group Therapy Following Metabolic Bariatric Surgery: A Randomized Pilot Study.","authors":"Vanessa Ponstinnicoff de Almeida, Estela Kortchmar, Leorides Severo Duarte Guerra, Francisco Lotufo Neto, Marco Aurélio Santo, Yuan Pang Wang","doi":"10.1007/s11695-025-08066-2","DOIUrl":"10.1007/s11695-025-08066-2","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the applicability of group cognitive-behavioral therapy (CBT) delivered through an online intervention on mental health symptoms and weight change in patients who experienced recurrent weight gain four years after metabolic and bariatric surgery.</p><p><strong>Methods: </strong>Participants were recruited from a university bariatric center. Of the 142 postoperative patients assessed, 33 had regained 15% of the total weight lost from their lowest postoperative weight. After excluding 13 patients who declined to participate, 20 were randomly allocated into two groups: the intervention group, which received eight sessions of online group CBT, and the control group, which attended three psychoeducational lectures. The group CBT sessions included discussions on eating habits, anxiety, and sleep hygiene, with guidance from nutrition and physical education professionals. Homework assignments related to each topic were given to participants to reinforce cognitive and behavioral changes. Outcomes were assessed at baseline (T₀) and post-intervention (T₁) using the Beck Depression Inventory-II (BDI-II), the Generalized Anxiety Disorder-7 scale (GAD-7), the Binge Eating Scale (BES), and body weight.</p><p><strong>Results: </strong>A marginal reduction in depressive symptoms was observed across both groups (mean difference = -3.35, 95% CI: -6.80 to 0.09; p = 0.06), along with a statistically significant decrease in binge eating behaviors (mean difference = -3.36, 95% CI: -5.43 to -1.29; p = 0.004). However, no significant changes in body mass or anxiety symptoms were observed. In the group CBT condition, the mean attendance was 6.6 sessions; in the control group, it was 2.4 lectures.</p><p><strong>Conclusions: </strong>Findings from this pilot study suggest that both group CBT and psychoeducational lectures delivered as online interventions were feasible and beneficial for bariatric patients who experienced recurrent weight gain.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":"4183-4191"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}