Obesity Surgery最新文献

{"title":"Endoscopic Band Ligation for Weight Loss: Exploring the Gastric Antrum as a Promising Target.","authors":"Mohamed A Abeid","doi":"10.1007/s11695-025-07937-y","DOIUrl":"https://doi.org/10.1007/s11695-025-07937-y","url":null,"abstract":"","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Sleeve Gastroplasty: A Retrospective Cohort Study of 90 Patients in Colombia.","authors":"Camilo Ortiz Silva, Maria Pamela Delgado Mosquera, Julio Ricardo Zuluaga Peña, Valeria Atenea Costa Barney","doi":"10.1007/s11695-025-07945-y","DOIUrl":"https://doi.org/10.1007/s11695-025-07945-y","url":null,"abstract":"<p><strong>Introduction: </strong>Endoscopic sleeve gastroplasty (ESG) is a minimally invasive weight loss procedure that reduces stomach volume and length using an endoscope suturing device, creating a sleeve-like shape to limit food intake and promote weight loss. ESG has been proven to be more effective in promoting weight loss than dietary and lifestyle changes, with a low incidence of complications. In Colombia, data regarding the effectiveness and safety of this procedure are lacking.</p><p><strong>Methods: </strong>This descriptive, retrospective cohort study included patients who underwent ESG between January 2022 and July 2023. Demographic and clinical characteristics were descriptively analyzed. Changes in weight, Body Mass Index (BMI), and percentage of Total Body Weight Loss (%TBWL) at 1, 3, and 6 months were assessed.</p><p><strong>Results: </strong>Ninety patients were included in this study. The median baseline weight was 85.5 kg, and the median BMI was 33 kg/m². Weight reduction was observed after 3 and 6 months, with weights of 73 kg and 69.5 kg, respectively (p < 0.001). %TBWL increased to 8.3%, 15.5%, and 20.0% at 1, 3, and 6 months (p < 0.001). BMI decreased to 27.4 kg/m² at the third month and 25.9 kg/m² in the sixth month, respectively (p < 0.001). Complications were mostly minor, occurring within the first month of follow-up, and included abdominal pain (21.1%), nausea (28.9%), vomiting (14.4%) and gastroesophageal reflux disease (GERD) symptoms including heartburn and regurgitation (10%). Gastrointestinal bleeding (3.3%) was less common.</p><p><strong>Conclusions: </strong>ESG is a safe and effective adjuvant treatment for obesity. This study showed significant BMI and %TBWL reduction at the 3- and 6-months post-procedure follow-ups, with a low incidence of minor complications.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Sleeve Gastrectomy on Ectopic Fat Deposition and Skeletal Muscle Composition Across Glucose Metabolic States.","authors":"Xiang Gao, Junhong Duan, Beibei Cui, Pengzhou Li, Zhihong Su, Weizheng Li, Zhi Song, Shaihong Zhu, Pengfei Rong, Liyong Zhu","doi":"10.1007/s11695-025-07940-3","DOIUrl":"https://doi.org/10.1007/s11695-025-07940-3","url":null,"abstract":"<p><strong>Background: </strong>Differences in abdominal fat and muscle composition among patients with obesity across glycemic statuses-and the modulatory role of metabolic bariatric surgery (MBS) on these interrelationships-remain unclear. This study thus aims to elucidate the interplay between body composition and glycemic status, and to assess how MBS differentially impacts metabolic parameters and body composition outcomes in these patient groups.</p><p><strong>Methods: </strong>In this single-center prospective study, 49 patients with obesity (31 with impaired glucose metabolism [IGM], 18 with normal glucose tolerance [NGT]) underwent Dixon MRI for fat/water separation to assess pancreatic, hepatic, and muscle fat. Measurements were taken preoperatively and 3 months post-laparoscopic sleeve gastrectomy.</p><p><strong>Results: </strong>The study included 18 patients with NGT (2 male/16 female; mean age 26.22 ± 7.17 years) and 31 with IGM (16 male/15 female; mean age 33.52 ± 10.65years). Both groups showed significant postoperative reductions in all measured parameters (P < 0.0001). The IGM group demonstrated greater decreases in visceral fat (88.33 ± 38.33 vs. 54.68 ± 25.91 cm², P = 0.001), hepatic fat (13.27 ± 7.00% vs. 8.93 ± 6.69%, P = 0.039), pancreatic fat (13.27 ± 7.00% vs. 8.93 ± 6.69%, P = 0.021), and psoas area (6.13 ± 4.82 vs. 2.18 ± 6.00 cm², P = 0.015) compared to the NGT group. Liver fat correlated positively with HOMA-IR, fasting glucose, and HbA1c (P < 0.05).</p><p><strong>Conclusions: </strong>Patients with obesity and IGM have higher visceral fat, pancreatic fat, and erector spinae mass than their NGT counterparts. Following bariatric surgery, they experience greater reductions in liver fat, pancreatic fat, and muscle areas. These findings suggest differential metabolic effects based on preoperative glucose status. However, further large-scale studies are needed to confirm.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Horizons in GIQoL Assessment: Commendation and Considerations for a Culturally Adaptable Tool Post-MBS.","authors":"Yi Ding, Shuying Wang","doi":"10.1007/s11695-025-07948-9","DOIUrl":"https://doi.org/10.1007/s11695-025-07948-9","url":null,"abstract":"","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bariatric Surgery and Lung Transplant Outcomes: Case Series and Insights from a Propensity-Matched Analysis at a High-Volume Transplant Center.","authors":"Andrés Latorre-Rodriguez, Mark Shacker, Hesham Mohamed, Ross M Bremner, Sumeet K Mittal","doi":"10.1007/s11695-025-07932-3","DOIUrl":"https://doi.org/10.1007/s11695-025-07932-3","url":null,"abstract":"<p><strong>Background: </strong>An increasing number of patients with a history of bariatric surgery and advanced respiratory disease are presenting for lung transplantation (LTx). We aimed to describe and compare LTx outcomes between recipients with prior bariatric surgery and a matched control group at a high-volume lung transplant center.</p><p><strong>Methods: </strong>After IRB approval, we identified bilateral LTx recipients with a pre-LTx history of bariatric surgery (Roux-en-Y gastric bypass [RYGB], sleeve gastrectomy [SG], or laparoscopic adjustable gastric band [LAGB]). The institutional experience is reported as a case series. Furthermore, perioperative and mid-term transplant outcomes such primary graft dysfunction (PGD), antibody-mediated rejection (AMR), acute cellular rejection (ACR), chronic lung allograft dysfunction (CLAD)-free survival, and overall survival (OS) were compared to a 1-to-2 propensity score-matched control group.</p><p><strong>Results: </strong>Nine patients (median age: 65 years; 77.8% female) with a history of bariatric surgery (RYGB = 4, SG = 4, LAGB = 1) a median of 76 months before LTx were included. The median hospital length of stay (LOS) and ICU-LOS were similar to the control group (n = 18). Moreover, 1-, 2-, and 3-year OS in bariatric and control groups were similar (88.9%, 88.9%, and 66.7% vs. 100%, 86.7%, and 78%, respectively; p = 0.27). CLAD-free survival and rates of PGD, AMR, and ACR were also similar.</p><p><strong>Conclusions: </strong>Prior bariatric surgery may not affect overall or CLAD-free survival after bilateral LTx. Bariatric surgery for obesity treatment in patients with advanced lung diseases may improve their LTx candidacy without compromising early and mid-term transplant outcomes.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Evidence for Preoperative Multivitamin Use: Insights into Efficacy, Safety, and Study Design.","authors":"Yi Ding, Shuying Wang","doi":"10.1007/s11695-025-07949-8","DOIUrl":"https://doi.org/10.1007/s11695-025-07949-8","url":null,"abstract":"","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic Single Anastomosis Sleeve Ileal Bypass Versus Laparoscopic Roux-en-Y Gastric Bypass as Single Stage Procedure for Management of Patients with Class V Obesity (BMI ≥ 60 kg/m²): Short-Term Follow-Up.","authors":"Mohamed Wael, Mohamed Mosaad Kandel, Hashem Altabbaa, Mostafa Refaie Elkeleny","doi":"10.1007/s11695-025-07930-5","DOIUrl":"https://doi.org/10.1007/s11695-025-07930-5","url":null,"abstract":"<p><strong>Background: </strong>Individuals with clinically severe obesity and a BMI ≥ 60 kg/m² (class V obesity) have a higher incidence of both obesity-related comorbidities and anticipated operative difficulty, with a subsequent higher risk of perioperative morbidity and mortality and a longer hospital stay. In patients with class V obesity, the definitive bariatric procedure is still a matter of debate. This study compared surgical procedures (SASI vs. RYGB) in people with class V obesity. The primary objective was to compare weight loss after both procedures over a 1-year follow-up. Secondary outcomes included the evaluation of the incidence of the operative time (skin-to-skin), postoperative complications, duration of hospital stay, rate of conversion to the open technique, and quality of life, as well as amelioration of obesity-related comorbidities.</p><p><strong>Methods: </strong>From January 2019 to December 2022, the data of 73 consecutive patients with class V obesity was collected, who underwent either standard RYGB (n = 40) or SASI (n = 33) at the General Surgery Department of Alexandria University Hospital and some non-governmental hospitals.</p><p><strong>Results: </strong>There was no statistically significant difference between both groups as regards mean age (p = 0.012), sex (p = 0.250), preoperative BMI (p = 0.754), or preoperative incidence of obesity-related co-morbidities. The SASI procedure showed a statistically shorter operative time (p < 0.001). There was no significant difference between the two groups as regards the incidence of postoperative surgical complications, either early cmplications (21.1% and 20% in both SASI and RYGB, respectively, p = 0.770) or late (beyond 30 days) complications (15.2% and 15% in SASI and RYGB, respectively, p = 1.000), with neither conversion nor intra-operative mortality in both groups. However, the SASI group showed a significant shorter postoperative hospital stay (p < 0.001). During the follow-up period, both operations demonstrated a significant overall resolution of pre-operative obesity-related comorbidities, a significant increase in postprandial 6 weeks postoperative GLP-1 with statistically more rise in the SASI group in the postprandial GLP-1 compared to the RYGB group (p < 0.001). There was no mortalities in both group during the follow up duration.</p><p><strong>Conclusion: </strong>In patients with class V obesity, the SASI procedure had a statistically shorter operative time (skin-to-skin) and a shorter hospital stay compared to RYGB. Both procedures resulted in satisfactory weight loss, as well as comparable improvements in obesity-related comorbidities.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast Cancer Characteristics after Metabolic and Bariatric Surgery: A Matched Comparison to Patients with Severe Obesity.","authors":"Jawad Tome, Marian Khatib, Eran Nizri, Lilah Margalit Grigg, Lior Orbach, Guy Lahat, Shai Meron Eldar, Adam Abu-Abeid","doi":"10.1007/s11695-025-07916-3","DOIUrl":"https://doi.org/10.1007/s11695-025-07916-3","url":null,"abstract":"<p><strong>Background: </strong>Severe obesity increases breast cancer (BC) risk and progression. Metabolic and Bariatric Surgery (MBS) modulates metabolic and hormonal pathways, potentially influencing cancer biology. This study evaluates BC patients after MBS. The aim of this study is to assess the impact of MBS on BC, focusing on disease-free survival (DFS), presentation, subtypes, and oncologic outcomes.</p><p><strong>Methods: </strong>A retrospective analysis of a single-center database included patients undergoing BC surgery after MBS (2012-2020), matched (1:4) to patients with severe obesity undergoing BC surgery.</p><p><strong>Results: </strong>Among 696 patients, 29 (4%) had BC post-MBS. Sleeve gastrectomy was the most common procedure (48.2%). Mean age at BC surgery was 60.7 ± 10 years. BMI prior to BC surgery was lower in the MBS-group (32.4 vs. 38.3 kg/m², p < 0.0001). Disease-free survival (114 vs. 146 months, p = 0.75) and recurrence rates were similar. The MBS-group had lower luminal-A subtype rates (34.4% vs. 59.5%, p = 0.01) and higher luminal-B subtype rates (58.6% vs. 27.6%, p = 0.001). No patients in the MBS-group had ductal carcinoma in situ (DCIS) (0% vs. 20%, p = 0.03). Other subtypes showed no differences.</p><p><strong>Conclusion: </strong>MBS may influence BC pathogenesis, with lower DCIS and luminal-A rates. These findings suggest a potential reduction in overall BC incidence due to metabolic and hormonal changes after MBS. Oncologic outcomes remained comparable.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Inflammatory Markers Following Bariatric Surgery and the Impact of the Surgical Procedure: A 12-Month Longitudinal Study.","authors":"Rasmus Tanderup Jensen, Anne Cathrine Baun Thuesen, Yun Huang, Sara Elizabeth Stinson, Helene Bæk Juel, Sten Madsbad, Flemming Bendtsen, Torben Hansen, Julie Steen Pedersen","doi":"10.1007/s11695-024-07629-z","DOIUrl":"https://doi.org/10.1007/s11695-024-07629-z","url":null,"abstract":"<p><strong>Background: </strong>Obesity is associated with an increased risk of cardiometabolic morbidity and mortality, which may be attributable to systemic low-grade inflammation. The impact of bariatric surgery-induced weight loss on low-grade inflammation has not yet thoroughly been described. We investigated the effect of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) on the plasma levels of cytokines, chemokines, and cytokine receptors prior to surgery (baseline), and then three and 12 months after surgery.</p><p><strong>Methods: </strong>We recruited 68 individuals (41 females, 27 males) with severe obesity (42.84 ± 6.28) who had been referred for bariatric surgery (RYGB: n = 29, SG: n = 39). Blood samples were collected after an overnight fast at baseline (immediately before surgery), 3 and 12 months after surgery. Eleven patients without obesity or cardiometabolic disease served as controls at baseline. Ninety-two plasma proteins were measured using an Olink Target 96 inflammation panel.</p><p><strong>Results: </strong>We used a linear mixed model to test differences in inflammatory markers at baseline, across time points and between groups. At baseline, 36 cytokines were found to be differentially expressed between the bariatric surgery patients and controls. Of these cytokines, 13 had significantly decreased three months after bariatric surgery and 27 had significantly decreased 12 months after surgery, compared with baseline. Two cytokines (CCL25 and CCL28) increased markedly after 12 months. Only one cytokine (CCL25) was significantly different between the procedures performed, where it increased in the RYGB group 12 months after surgery.</p><p><strong>Conclusion: </strong>Individuals with severe obesity have increased expression of plasma inflammatory cytokines compared to controls, but low-grade inflammation improves following bariatric surgery, regardless of whether it is RYGB or SG.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor Regarding \"The Relationship and Mechanisms Between Body Mass Index and Autoimmune Hypothyroidism: Insights from Mendelian Randomization\".","authors":"Ping Zhao, Qiuwan Han, Xu Qiu, Jian Zhao","doi":"10.1007/s11695-025-07938-x","DOIUrl":"https://doi.org/10.1007/s11695-025-07938-x","url":null,"abstract":"","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}