Obesity Science & Practice最新文献

{"title":"Exploring Expert Perspectives on Self-Monitoring Feedback Personalization, Content, Modality and Frequency: A Delphi Study.","authors":"Rebecca A Krukowski, Katherine Paulikonis, Theresa Markwalter, Simone Minor, Kathryn M Ross","doi":"10.1002/osp4.70104","DOIUrl":"10.1002/osp4.70104","url":null,"abstract":"<p><strong>Introduction: </strong>Participants in behavioral weight management programs are typically provided with weekly interventionist-crafted self-monitoring feedback; however, there is a lack of empirical evidence regarding optimal feedback construction.</p><p><strong>Methods: </strong>Using a Delphi method, experts (<i>N</i> = 67) provided perspectives regarding the optimal focus, frequency, interactivity, and modality of feedback messages. Directed content analyses were used to analyze qualitative data, and descriptive statistics were used to summarize quantitative data.</p><p><strong>Results: </strong>Experts' views on the modality (e.g., email, app notification) varied, and participant preference and practicality were noted as key considerations. Experts ranked 8 feedback components as most important: problem solving, goal setting prompts, calorie intake and physical activity goal attainment, diet tracking frequency, weight trajectory (since the last message and since the start of the program), and diet quality. More experts endorsed the \"sandwich\" approach (i.e., positive comments along with strategies for change) for those experiencing weight loss challenges (95%) than for those experiencing weight loss success (55%). Overall, 82% noted that personalized feedback was important, but they were not always able to provide it due to time restrictions/personnel cost (75% identified these as key barriers).</p><p><strong>Conclusions: </strong>Although most experts viewed personalized self-monitoring feedback as important, time/cost considerations in crafting this feedback are critical. Future experimental studies should be used to evaluate the expert recommendations gathered from this Delphi study.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"11 6","pages":"e70104"},"PeriodicalIF":2.5,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12676179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity and Early-Stage Breast Cancer: A Comprehensive Analysis of Tumor Biology, Staging Accuracy, and Long-Term Outcomes.","authors":"Marco Yusef, Augusto Lombardi, Valeria Vitale, Gianluca Stanzani, Niccolò Petrucciani, Francesco Maria Carrano, Francesco Spinelli, Danila Capoccia, Gianfranco Silecchia","doi":"10.1002/osp4.70098","DOIUrl":"10.1002/osp4.70098","url":null,"abstract":"<p><strong>Background: </strong>Obesity increases the risk of breast cancer by approximately 10% for every 5-unit increase in body mass index (BMI), underscoring its role as a key modifiable risk factor.</p><p><strong>Objective: </strong>To determine the prevalence of obesity among early-stage breast cancer patients at an academic breast unit and to evaluate its association with tumor characteristics, surgical outcomes, and survival, with a particular focus on premenopausal women.</p><p><strong>Methods: </strong>Prospectively collected data from patients treated between January 2005 and December 2023 were retrospectively analyzed. Statistical analyses, including chi-squared tests, ANOVA, Kaplan-Meier, and univariate regression analyses, were used to assess obesity prevalence, tumor size, axillary staging accuracy, molecular subtypes, surgical margins, recurrence, survival, and menopausal status.</p><p><strong>Results: </strong>Among 1187 patients, 55.6% were normal weight, 25.4% were overweight, and 19% were living with obesity (BMI > 30). Obesity was more common in patients > 50 years of age (22% vs. 10%; <i>p</i> = 0.001). Mean tumor size increased with BMI (13.8 vs. 15.4 mm vs. 17.6 mm; <i>p</i> = 0.001). Notably, in premenopausal patients, obesity correlated with a higher proportion of poorly differentiated (G3) tumors (50% vs. 27%; <i>p</i> < 0.05), while survival remained similar across BMI categories.</p><p><strong>Conclusion: </strong>Obesity is associated with larger tumors, poorer axillary staging, and a higher prevalence of aggressive histological subtypes among premenopausal patients. However, obesity did not significantly influence overall survival. Targeted screening and multidisciplinary management strategies are essential to improve early detection and individualize treatment for patients with obesity.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"11 6","pages":"e70098"},"PeriodicalIF":2.5,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12626897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145564844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Six Years of Genetic Diagnosis of Severe Early-Onset Obesity in a French Cohort.","authors":"M Rama, E Blond, A Janin, M Di-Filippo, C Cuerq, O Marmontel, P A Rollat-Farnier, E Dieterlen, B Segrestin, M Nicolino, E Disse, K Perge, D Collin-Chavagnac","doi":"10.1002/osp4.70100","DOIUrl":"10.1002/osp4.70100","url":null,"abstract":"<p><strong>Objective: </strong>Obesity is a multifactorial disease with a strong genetic component. It is imperative to enhance the identification of genetic variations in their early and severe manifestations in order to facilitate the development of personalized therapeutic strategies, informed clinical care, and the facilitation of genetic counseling. The objective of the study was to provide a comprehensive description of rare variations identified by next generation sequencing of a panel of genes.</p><p><strong>Methods: </strong>From 2018 to 2023, a panel of 22 genes was genotyped in 1066 probands (499 children and 567 adults) with severe early-onset obesity.</p><p><strong>Results: </strong>The genetic study led to a molecular diagnosis in 34 probands (3.2%) and revealed variants of unknown significance (VUS) in 10.3% of cases. In the pediatric cohort, a genetic diagnosis was established in 19 probands (3.8%) and a VUS was identified in 67 (13.4%). A total of 152 rare single-nucleotides variants (SNVs) were identified, of which 34 were classified as pathogenic, predominantly within the <i>MC4R</i> gene. Furthermore, 110 participants were carriers of one or two rare variants of uncertain significance (VUS). A total of three copy number variations (CNVs) were identified in the genes that were analyzed.</p><p><strong>Conclusion: </strong>Early genetic screening in severe obesity provides valuable diagnostic insights and identifies candidates for personalized treatment. The integration of genetics into clinical practice is imperative for the enhancement of care pathways and the facilitation of targeted therapeutic strategies.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"11 6","pages":"e70100"},"PeriodicalIF":2.5,"publicationDate":"2025-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12619922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145541655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of an MRI Body Fat Imaging Report on Obesity-Related Cardiometabolic Risk: Findings From the BODY-REAL Study, A Randomized Trial.","authors":"Shradha M Chhabria, Jaime A Pérez, Ian J Neeland","doi":"10.1002/osp4.70099","DOIUrl":"10.1002/osp4.70099","url":null,"abstract":"<p><strong>Objective: </strong>Advanced imaging can inform risk assessment and preventive/therapeutic decision-making to enhance care. It is not known how quantification of body fat distribution using advanced imaging and communication of the result through a graphic report may impact cardiometabolic risk factors and attitudes/behaviors among persons living with overweight or obesity. The BODY-REAL study assessed whether providing patients with (1) visual body fat MRI reports compared with the weight/body mass index (BMI) alone and (2) direct-to-patient reports versus through providers would improve cardiometabolic risk among individuals at elevated cardiometabolic risk.</p><p><strong>Methods: </strong>Participants were randomized in a 2 × 2 factorial design to receive a BMI or MRI body fat distribution report, provided direct-to-patient report or a report through their healthcare provider. Clinical and psychosocial outcomes were measured at 2 weeks, 3, and 6 months and compared using analysis of covariance and linear models with both fixed and random (time-updated) effects.</p><p><strong>Results: </strong>29 participants (31% female, mean BMI 33.6 kg/m²) were randomized. After 6 months of follow-up, MRI report recipients had lower fasting glucose and higher physical activity scores (<i>p</i> < 0.01). Provider-mediated reporting demonstrated greater medication adherence (<i>p</i> = 0.01) and greater perception of personal control of diabetes (<i>p</i> = 0.02) but lower perception of diabetes-related risk (<i>p</i> = 0.003). There were no significant differences in BMI, blood pressure, cholesterol, glycosylated hemoglobin, or other risk perception across study arms.</p><p><strong>Conclusions: </strong>This pilot feasibility study demonstrated potential for direct-to-patient visualization of body fat distribution to improve risk markers and preventive behaviors. Further investigation in a sufficiently powered study is warranted.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov NCT04763772.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"11 6","pages":"e70099"},"PeriodicalIF":2.5,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12612552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145541700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in the Association of Obesity With Prediabetes and Dyslipidemia Among Adolescents: A Cross-Sectional Study.","authors":"Ali H Ziyab, Aishah Saadallah, Zainab Almousa, Mohammad Almari, Thamer Alessa","doi":"10.1002/osp4.70096","DOIUrl":"10.1002/osp4.70096","url":null,"abstract":"<p><strong>Background: </strong>Limited knowledge exists on whether obesity during early life stages demonstrates sex-specific associations with cardiometabolic conditions. Therefore, this study aimed to determine if the association of obesity with prediabetes and dyslipidemia differs according to sex among adolescents.</p><p><strong>Methods: </strong>Adolescents aged 14-19 years were enrolled in a cross-sectional study. Capillary blood was used to measure glycated hemoglobin and lipids. Prediabetes and dyslipidemia were determined according to international guidelines. Associations and statistical interactions (body mass index-for-age × sex) were evaluated using multivariable logistic regression models.</p><p><strong>Results: </strong>Data from a total of 1584 adolescents (826 female participants) were analyzed in the current report. Obesity (38.6% vs. 24.4%) and dyslipidemia (54.2% vs. 36.7%) were more prevalent in male than female participants; however, prediabetes prevalence did not differ between male and female participants (34.8% vs. 33.8%). The association between obesity and prediabetes differed according to sex (<i>P</i> _interaction = 0.046), with obesity showing a stronger association among female participants (adjusted odds ratios [aOR]: 3.24; 95% confidence interval [CI]: 2.25, 4.66) compared with male participants (aOR: 1.64; 95% CI: 1.12, 2.39). However, obesity showed a stronger association with dyslipidemia among male participants (aOR: 2.74; 95% CI: 1.93, 3.90) compared with female participants (aOR: 1.49; 95% CI: 1.04, 2.13; <i>P</i> _interaction = 0.016).</p><p><strong>Conclusion: </strong>Obesity demonstrated sex-specific associations with cardiometabolic conditions in adolescents, showing a stronger association with prediabetes in females but with dyslipidemia in males.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"11 6","pages":"e70096"},"PeriodicalIF":2.5,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12605948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145513615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Naltrexone/Bupropion, Liraglutide, or Semaglutide as Adjuvant Therapy After Metabolic and Bariatric Surgery: An Observational Study.","authors":"Anthony Brancatisano, Brendan Ryan","doi":"10.1002/osp4.70097","DOIUrl":"10.1002/osp4.70097","url":null,"abstract":"<p><strong>Introduction: </strong>Obesity is a chronic and relapsing disease and metabolic and bariatric surgery (MBS) provides the greatest weight loss efficacy to improve obesity related complications. However, weight recurrence and suboptimal weight loss occur in some patients leading to a recurrence of disease. Obesity management medications (OMM) to prevent and manage excess weight after MBS are now being recommended. The aim of the study was to determine the efficacy of OMM prescribed for recurrent weight gain (RWG) or suboptimal weight loss (SWL) after primary and conversional bariatric metabolic surgery.</p><p><strong>Methods: </strong>Patients were prescribed either a fixed-dose extended-release combination of naltrexone and bupropion (NB-ER; 8 mg/90 mg), liraglutide (3.0 mg), or semaglutide (1.0 mg) for RWG and/or SWL following adjustable gastric banding (LAGB), sleeve gastrectomy (LSG), one anastomosis gastric bypass (OAGB), or conversional procedures. Data were reported as categorical values using either parametric or nonparametric statistics.</p><p><strong>Results: </strong>For the 121 patients analyzed, baseline characteristics were similar at initiation of OMM. Among these patients, 59.7% underwent LSG, 11.8% underwent OAGB, 6.7% underwent LAGB, and 21.8% underwent conversional procedures. Patients regained a median of 9.7 kg (IQR; 5-18.1) or 27.9% (IQR; 15.7-57.8) of total body weight previously lost following MBS. In total, 34 patients (28.1%) were prescribed NB-ER, 23 patients (19.1%) were prescribed liraglutide, and 64 patients (52.8%) were prescribed semaglutide post MBS. Overall, patients prescribed OMM treatment lost 8.8% (IQR; 5.7-14.1; median follow-up, 9 months [IQR; 5-12]) total body weight. Adverse effects were minor and reflected clinical trial nonsurgical cohorts.</p><p><strong>Conclusion: </strong>Adjuvant OMM conferred additional significant weight loss in patients with RWG or SWL in both primary and conversional surgical procedures and all three OMM studied should be considered as part of MBS aftercare.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"11 6","pages":"e70097"},"PeriodicalIF":2.5,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12606011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145513613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Identification of Potential Treatment Targets to Reduce the Risk of Obesity-Related Complications: A Step Toward a Treat-to-Target Approach in Obesity Management.","authors":"Luca Busetto, Volker Schnecke, Maria Overvad, Silvia Capucci, Ricardo Reynoso, Rafael Bravo, Abd A Tahrani, Camilla S Morgen","doi":"10.1002/osp4.70094","DOIUrl":"10.1002/osp4.70094","url":null,"abstract":"<p><strong>Aims: </strong>Obesity-related complications (ORCs) are associated with substantial health and economic burdens. Although treatment targets are routinely used for other chronic conditions, none currently exist in obesity management. We aimed to identify an adiposity measure that indicates a reduced risk of four ORCs.</p><p><strong>Materials and methods: </strong>This population-based cohort study of patients aged 18-60 years used data from the UK Clinical Practice Research Datalink Aurum. Associations between absolute 10-year ORC risk and baseline body mass index (BMI), waist-height ratio (WHtR), and changes in adiposity measures after weight loss were calculated. Absolute values and changes in adiposity measures were evaluated as a proxy for achieving an absolute 10-year ORC risk similar to that of people without obesity, and optimal cut-offs were identified based on the balance between true positive and true negative rates for achieving the treatment goal.</p><p><strong>Results: </strong>Absolute values of BMI and WHtR post-weight change were more strongly associated with 10-year ORC risk than relative changes; WHtR was the best proxy for a low absolute risk for type 2 diabetes, hypertension, and atherosclerotic cardiovascular disease, and BMI for hip/knee osteoarthritis. Based on the balance between true negative and true positive rates of multiple cut-offs, a BMI ≤ 27 kg/m² and WHtR ≤ 0.53 are proposed as potential treatment targets for obesity.</p><p><strong>Conclusions: </strong>These findings suggest that treatment goals for obesity management may be considered on post-weight-change absolute adiposity measures, rather than relative changes. Both weight and WHtR may be considered when defining treatment targets for ORC risk reduction.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"11 6","pages":"e70094"},"PeriodicalIF":2.5,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12589817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145481574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Weight Stigma Experiences in Healthcare and Self-Reported Healthcare Avoidance in a National Sample.","authors":"Kathleen M Robinson, Aaron M Scherer, Alithea N Zorn, Michelle A Mengeling, Helena H Laroche","doi":"10.1002/osp4.70095","DOIUrl":"10.1002/osp4.70095","url":null,"abstract":"<p><strong>Objectives: </strong>Although weight stigma in healthcare is common, existing measures may not capture the full range of patients' weight stigma experiences in clinical practice. We aimed to examine how physical examination by healthcare providers, communication, and the built environment perpetuate weight stigma and impact healthcare avoidance. Items from the previously developed Weight Stigma in Healthcare Inventory (WSHCI) were tested to assess weight stigma experiences and assess association with healthcare avoidance.</p><p><strong>Methods: </strong>Two sample groups, identified through ResearchMatch and a Qualtrics survey panel, completed the WSHCI online. We analyzed the association between individual items and healthcare avoidance, and between a summation of weight stigma experiences and healthcare avoidance, adjusting for demographics.</p><p><strong>Results: </strong>Five-hundred twenty four surveys were received. All weight stigma items were associated with healthcare avoidance, with the strongest associations found for items related to experiencing stigma during physical examination. Greater numbers of stigmatizing experiences were associated with healthcare avoidance (OR 1.31, 95% CI [1.26, 1.37]).</p><p><strong>Conclusions: </strong>To reduce healthcare avoidance due to weight stigma, all aspects-the physical examination, communication, overall experiences and the built environment-need to be addressed. Reducing the overall number of negative experiences and reducing weight stigma experiences during physical examination may be especially important to reduce healthcare avoidance.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"11 5","pages":"e70095"},"PeriodicalIF":2.5,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12550863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145372902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postpartum Body Composition in Women With Overweight: Associations With Diet During Pregnancy.","authors":"Ella Muhli, Tero Vahlberg, Lotta Saros, Noora Houttu, Outi Pellonperä, Kristiina Tertti, Kirsi Laitinen","doi":"10.1002/osp4.70093","DOIUrl":"10.1002/osp4.70093","url":null,"abstract":"<p><strong>Objective: </strong>Weight management during the first few years postpartum is considered important for the prevention of future metabolic disturbances. Body fat percentage measured using air displacement plethysmography is an accurate marker of body adiposity. In this secondary analysis of a randomized controlled trial, the aims were to identify distinctive body fat percentage trajectories up to 2 years postpartum in women with overweight and to investigate whether fish oil and/or probiotic supplements, diet, gestational diabetes, or gestational weight gain influenced the body composition.</p><p><strong>Methods: </strong>Women with overweight or obesity (<i>n</i> = 439) were randomized to receive fish oil (1.9 g docosahexaenoic acid and 0.22 g eicosapentaenoic acid) and/or probiotics (<i>Lacticaseibacillus rhamnosus</i> HN001 and <i>Bifidobacterium animalis</i> ssp. <i>lactis</i> 420, 10¹⁰ CFU each) in a double-blind manner from early pregnancy until 6 months postpartum. Body composition (<i>n</i> = 329) was measured using air displacement plethysmography, at three, six, 12, and 24 months postpartum. Diet in early pregnancy was evaluated using nutrient intakes, dietary patterns, and the Index of Diet Quality (IDQ) questionnaire.</p><p><strong>Results: </strong>Three postpartum body fat percentage trajectories were identified, but none displayed a sustained decrease in adiposity. A healthy dietary pattern (adjusted OR 5.8 [95% CI 2.5-13.5], <i>p</i> < 0.001) and high IDQ score (adjusted OR 2.5 [95% CI 1.1-5.5], <i>p</i> = 0.023) in early pregnancy increased the odds of a decreasing trend during the first postpartum year. The fish oil and/or probiotic intervention did not impact the body composition.</p><p><strong>Conclusion: </strong>Good overall dietary quality during pregnancy may benefit the body composition of women with overweight or obesity at postpartum.</p><p><strong>Trial registration: </strong>NCT01922791, ClinicalTrials.gov.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"11 5","pages":"e70093"},"PeriodicalIF":2.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12518782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145302527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifestyle Change Interventions: Effectiveness of REWIND, a Virtual, Community-Based Weight Management Program.","authors":"Amy E Rothberg, Wen Ye, Nicole Miller, Robert A Rizza","doi":"10.1002/osp4.70092","DOIUrl":"10.1002/osp4.70092","url":null,"abstract":"<p><strong>Importance: </strong>Despite the current enthusiasm for anti-obesity medications, there is a critical need for effective lifestyle interventions that can be broadly implemented.</p><p><strong>Objective: </strong>To assess the effectiveness of REWIND, an obesity and diabetes treatment program.</p><p><strong>Design: </strong>Prospective cohort study.</p><p><strong>Setting: </strong>Virtual, community-based weight management program.</p><p><strong>Participants: </strong>Two-hundred and nineteen participants, BMI ≥ 30 kg/m², with and without type 2 diabetes (T2D).</p><p><strong>Intervention: </strong>Three phases: \"induction\" with meal replacement diet to promote ≥ 15% weight loss; \"transition\" to everyday foods; and \"maintenance\" to prevent weight regain. REWIND leveraged teams including community leaders, media personalities, nationally recognized athletes and participants, to disseminate information, and foster belonging, commitment, and resilience.</p><p><strong>Main outcomes: </strong>The co-primary outcomes were the change in weight at 6-, 12-, and 18 months. Secondary outcomes were the proportion of patients achieving ≥ 5%, 10%, 15%, and 20% weight loss at 6, 12, and 18 months, and remission rates in T2D at 6-, 12-, and 18-month, respectively.</p><p><strong>Results: </strong>Two hundred and nineteen participants (mean age 49.1 [SD 10.5] years), 37% men, 12% Black, 26% with T2D. Weight decreased from: 114.4 (20.8) kg to 96.1 (18.4) kg at 6 months, to 98.5 (18.1) kg at 12 months, and to 101.1 (20.5) kg at 18 months. Weight loss percentages at 6, 12, and 18 months were ≥ 5%: 95%, 91%, 84%; ≥ 10%: 79%, 72%, 67%; ≥ 15%: 58%, 46%, 47%; and ≥ 20%: 24%, 25%, 22%. Diabetes remission was achieved by 52% and 43% of participants with T2D at 12- and 18-month, respectively.</p><p><strong>Limitations: </strong>Single geographic region. Weight was self-reported.</p><p><strong>Conclusion: </strong>A virtual community-based program for individuals with obesity and T2D facilitated substantial weight loss and T2D remission. This model has the potential for wide-scale implementation in diverse settings.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"11 5","pages":"e70092"},"PeriodicalIF":2.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12507722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}