Obesity Science & Practice最新文献

{"title":"Body Weight Changes and Associated Social Factors in Newly Recruited Students at a Mexican Public University.","authors":"Wendy Paola Gastélum Espinoza, Alma Marlene Guadrón Llanos, Gisela Duarte de la Peña, Francisco Castro Apodaca, Loranda Calderón Zamora, Dalia Magaña Ordorica, Yuridia Chaidez Fernández, Javier Abednego Magaña Gómez","doi":"10.1002/osp4.70102","DOIUrl":"https://doi.org/10.1002/osp4.70102","url":null,"abstract":"<p><strong>Introduction: </strong>The transition from high school to college involves lifestyle changes that can lead to increased body weight, a phenomenon commonly referred to as the Freshman 15. Although educational settings may differ across countries, this period could also present a risk of weight gain.</p><p><strong>Objective: </strong>To determine the weight gain in Mexican students during the transition from high school to a public university and identify the primary associated modifiable factors.</p><p><strong>Methods: </strong>Two hundred twenty-six students of both sexes, aged 17-21 years, were evaluated at the beginning and end of the first semester. Anthropometric characteristics, lifestyle habits, and self-perceived stress were analyzed. Intra-subject differences were assessed using the general linear model with repeated measures, and categorical variables were evaluated using non-parametric tests.</p><p><strong>Results: </strong>A significant weight increase of 0.8 kg was observed regardless of sex. Adolescents who ate under 20 min or lived in a rooming house without appliances exhibited the highest weight gain. Regression analyses revealed that female sex (<i>β</i> = -0.929, <i>p</i> = 0.008) and eating time of 21 min or more (<i>β</i> = 0.756, <i>p</i> = 0.050) were significantly associated with body weight change. In the multiple regression model, only sex remained a significant factor (<i>p</i> = 0.018).</p><p><strong>Conclusions: </strong>Weight gain in university students, especially in men, highlights this stage as a vulnerable period. It is essential to study habits and behaviors according to gender to design interventions that promote healthy eating. Further research is needed to identify modifiable factors associated with weight gain.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"12 2","pages":"e70102"},"PeriodicalIF":1.9,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secular Trends and Prognostic Value of the Body Shape Index in U.S. Adults.","authors":"Shuang Li, Yuchen Zhong, Yan Liu, Meixia Xiao, Shengming Shi","doi":"10.1002/osp4.70148","DOIUrl":"https://doi.org/10.1002/osp4.70148","url":null,"abstract":"<p><strong>Objective: </strong>A Body Shape Index (BSI), previously developed and evaluated as an improvement over traditional adiposity measures for predicting health risks, has not been comprehensively characterized with respect to its temporal trends, population disparities, and prognostic value in the United States.</p><p><strong>Methods: </strong>This analysis examined data from 47,762 adults across 10 NHANES cycles (1999-2018). BSI trends were assessed across demographic and health-related subgroups. All-cause mortality risk was evaluated using Cox regression, with adjustment for multiple confounders. Interaction and restricted cubic spline analyses explored effect modification and nonlinearity.</p><p><strong>Results: </strong>Mean BSI increased significantly over the two decades. Disparities persisted or widened over time. Elevated BSI was independently associated with higher mortality risk, particularly above the median, with a nonlinear escalation in risk at higher BSI levels. The impact of high BSI on all-cause mortality was stronger in males and varied by race/ethnicity, while lower BSI showed no protective effect.</p><p><strong>Conclusions: </strong>BSI demonstrates a rising trend and persistent disparities among U.S. adults, with high BSI independently predicting adverse all-cause mortality in a nonlinear manner. These findings from the analyzed data supported the utility of BSI in risk stratification and highlighted the need for targeted interventions. Future research should explore BSI's role in public health strategies.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"12 ","pages":"e70148"},"PeriodicalIF":1.9,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity Treatment Pathways and Implementation in Health Systems.","authors":"Ariana M Chao, Stephanie Walsh, Pamela R Rama, Jason M Samuels","doi":"10.1002/osp4.70142","DOIUrl":"https://doi.org/10.1002/osp4.70142","url":null,"abstract":"<p><strong>Background: </strong>Although clinical practice guidelines are valuable for managing obesity and should be the foundation for health system protocols for screening, diagnosis, and treatment, these guidelines need to be translated and implemented within clinical care pathways that account for organizations' processes, structures, and cultures. Variation in resources across systems is another challenge.</p><p><strong>Methods: </strong>A narrative review was undertaken to assess how obesity treatment pathways can support health systems and HCPs in informed decision-making for obesity management, and to offer practical considerations for developing and implementing health care system treatment pathways.</p><p><strong>Findings: </strong>Little publicly available information exists on developing and implementing obesity treatment pathways in clinical practice within health systems. This review discusses the key elements of obesity care, including screening, diagnosis, treatment, and monitoring, and outlines the roles and responsibilities of health care professionals within each step of the pathway.</p><p><strong>Conclusion: </strong>This review offers resources and considerations for developing and implementing obesity care pathways in primary care, specialty care, and various other settings to assist health systems and health care professionals in making informed, evidence-based decisions in obesity management.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"12 ","pages":"e70142"},"PeriodicalIF":1.9,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Economic Evaluation of the Metabolic and Bariatric Surgery Initiative for Patients With Obesity and Comorbid Diabetes in Queensland.","authors":"Paul Scuffham, Katie Wykes, Jody Paxton","doi":"10.1002/osp4.70144","DOIUrl":"https://doi.org/10.1002/osp4.70144","url":null,"abstract":"<p><strong>Background: </strong>Metabolic and bariatric surgery is the most effective long-term treatment for patients with obesity; however, access to publicly funded surgery in Australia has been limited despite strong evidence of clinical benefit. The Bariatric Surgery Initiative (BSI) was established to improve equitable access for people with obesity and type 2 diabetes, but its long-term economic value has not been evaluated. This study assessed the cost-effectiveness of metabolic and bariatric surgery compared with usual medical care to inform health-system decision-making.</p><p><strong>Methods: </strong>A Markov model was developed to simulate health outcomes and costs over the rest of life for patients with BSI. The model had five health states representing BMI classes. Costs obtained from the BSI for the surgical procedure were used and long-term costs for BMI classes were drawn from the literature. Quality of life (utility) weights were obtained from the BSI as were outcomes at 12 months following surgery. A Usual Care comparison group was developed from the literature and long-term costs were applied to both groups depending on the BMI class. Incremental cost-effectiveness ratios were estimated and sensitivity analyses were undertaken from the perspective of the Australian public health system.</p><p><strong>Results: </strong>The base-case analysis demonstrated that MBS was the preferred strategy that is, better health outcomes (2.5 QALYs gained) and lower costs (cost-savings of $67,000). Scenario analyses identified that younger age groups have greater health benefits and higher BMI classes have greater cost-savings.</p><p><strong>Conclusions: </strong>MBS is a cost-effective intervention for patients with obesity class 2 and diabetes. The BSI was an efficient service that provided the necessary information to develop the local evidence.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"12 ","pages":"e70144"},"PeriodicalIF":1.9,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13093609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Health-Related Quality of Life After Metabolic and Bariatric Surgery: A Prospective Single-Center Cohort Study.","authors":"Camilla Thorbøll Wæhrens, Ingrid Poulsen, Thomas Kallemose, Bodil Just Christensen, Inge Marie Poulsen, Julie Jacoby Petersen, Dorthe Greve Jørgensen, Carsten Dirksen","doi":"10.1002/osp4.70145","DOIUrl":"10.1002/osp4.70145","url":null,"abstract":"<p><strong>Objective: </strong>Obesity impairs health-related quality-of-life (HRQoL). Substantial weight loss following metabolic and bariatric surgery improves HRQoL, but there is a need for larger long-term studies. This study aimed to examine changes in HRQoL at 2 and 5 years, comparing outcomes between Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), and to evaluate associations with pre-operative patient characteristics.</p><p><strong>Methods: </strong>HRQoL was assessed using the Short Form-36 (SF-36) questionnaire before surgery and at 2- and 5-year follow-up. Physical and Mental Component Scores (PCS and MCS) were calculated, and associations between baseline characteristics and changes in HRQoL were analyzed.</p><p><strong>Results: </strong>Of 2031 patients, 1285 completed at least one postoperative SF-36. PCS improved significantly at 2 years (mean 9.4, 95% CI 8.7-10.0) and was maintained at 5 years. MCS showed an improvement at 2 years (1.5, 95% CI 0.8-2.2) but not at 5 years. No major differences were found between RYGB and SG, except for lower MCS at 5 years in SG patients (5.2, <i>p</i> = 0.009). Preoperative type 2 diabetes and osteoarthritis were associated with improved HRQoL, whereas psychiatric and gastrointestinal disorders predicted poorer results.</p><p><strong>Conclusions: </strong>Metabolic and bariatric surgery leads to sustained improvements in physical HRQoL, but the response is influenced by preoperative comorbidity.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"12 2","pages":"e70145"},"PeriodicalIF":1.9,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and Disparities in Obesity-Related Mortality Among U.S. Adults: A CDC WONDER Analysis (1968-2025).","authors":"Faizan Ahmed, Husnain Ahmed, Ayesha Ishtiaq, Najam Gohar, Anika Goel, Abdul Waheed, Tehmasp Rehman Mirza, Haris Bin Tahir, Fatima Saleemi, Tallal Mushtaq Hashmi, Ramsha Ali, Hritvik Jain, Mushood Ahmed, Farah Deshmukh, Mohamed Bakr, Swapnil Patel, Mohammad Hossain, Ameer Haider Cheema","doi":"10.1002/osp4.70146","DOIUrl":"https://doi.org/10.1002/osp4.70146","url":null,"abstract":"<p><strong>Context: </strong>Obesity-related mortality in the United States has increased substantially over recent decades, yet long-term national trends and demographic disparities remain incompletely characterized.</p><p><strong>Objective: </strong>To evaluate nationwide trends in obesity-related mortality among U.S. adults and identify disparities by age, sex, race, and geographic region from <i>1968 to 2025</i>.</p><p><strong>Methods: </strong>We performed a retrospective analysis using CDC WONDER mortality data from 1968 to 2025 (nearly six decades). Adults aged ≥ 25 years with obesity identified using International Classification of Diseases (ICD) codes listed as an underlying or contributing cause of death were included. Age-adjusted mortality rates (AAMRs) per 100,000 population were calculated using the 2000 U.S. standard population, and temporal trends were evaluated using Joinpoint regression to estimate annual percent change (APC) and average annual percent change (AAPC).</p><p><strong>Results: </strong>From 1968 to 2025, a total of 211,479 obesity-related deaths were recorded among U.S. adults aged ≥ 25 years. AAMRs increased from 1.15 to 3.32 per 100,000, peaking in 2021 (4.54 per 100,000). Mortality rates were consistently higher among males, older adults, Black populations, and residents of the Southern United States, while younger adults (25-44 years) experienced the most rapid rise in mortality.</p><p><strong>Conclusion: </strong>Obesity-related mortality in the United States has more than tripled over nearly six decades, with substantial demographic and geographic disparities. These findings highlight the urgent need for targeted, culturally tailored, and age-specific public health interventions to address the growing burden of obesity.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"12 2","pages":"e70146"},"PeriodicalIF":1.9,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13080113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Human Monoacylglycerol Acyltransferase 2 Inhibitor VB-85387 Is Associated With Weight Loss in Mice With Obesity.","authors":"J Jose Corbalan, Pranavi Jagadeesan, Chia-Yu Huang, James R Beasley, Joseph T Nickels","doi":"10.1002/osp4.70131","DOIUrl":"https://doi.org/10.1002/osp4.70131","url":null,"abstract":"<p><strong>Background: </strong>GLP-1 therapies for obesity are limited by side effects and weight regain is common after treatment ends. Therefore, alternative treatments with new mechanisms are needed for sustained weight loss. Human MOGAT2 regulates triglyceride metabolism and its inhibition reduces weight in people with obesity, making MOGAT2 a promising target for obesity therapy.</p><p><strong>Objective: </strong>This study evaluated the therapeutic potential of the VB-85387 MOGAT2 inhibitor for weight loss.</p><p><strong>Methods: </strong>High throughput screening was used to identify human MOGAT2 inhibitors. Diet-induced mice with obesity were treated with VB-85387 for 7 days. Body weight, food intake, blood and liver lipid and hormone levels were assessed. Glucose tolerance and insulin sensitivity were evaluated via oral glucose tolerance and hyperinsulaemic-euglycaemic clamp tests. Gene expression of PPARα and SREBP target genes was measured using <i>q</i>RT-PCR.</p><p><strong>Results: </strong>High throughput screening identified VB-85387 as a highly potent and selective human MOGAT2 inhibitor. Mice with obesity treated with VB-85387 experienced weight loss, reduced food intake, improved glucose tolerance, and enhanced insulin sensitivity. Treatment decreased liver triglyceride levels and increased GLP-1 concentrations. <i>β</i>-hydroxybutyrate levels were elevated, PPARα-dependent fatty acid <i>β</i>-oxidation gene expression was increased, and SREBP-dependent gene expression was reduced.</p><p><strong>Conclusion: </strong>VB-85387 serves as a starting point for medicinal chemistry lead optimization. Weight loss may be attributed to PPARα activation and a sustained elevation in GLP-1 levels.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"12 2","pages":"e70131"},"PeriodicalIF":1.9,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13066718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting Multiple Gut-Brain Pathways in Obesity: Rationale for Combination Pharmacotherapy.","authors":"Alexander D Miras, Muzamil Hussain","doi":"10.1002/osp4.70141","DOIUrl":"https://doi.org/10.1002/osp4.70141","url":null,"abstract":"<p><strong>Background: </strong>As a disease of energy dysregulation, obesity involves metabolic, hormonal, and neural factors, the interconnection of which is referred to as the \"gut-brain axis.\"</p><p><strong>Objective: </strong>This review aimed to provide an overview of the clinical evidence of physiological and objective or subjective changes in eating behavior with gut hormone analogs and NB-ER, as well as a mechanistic rationale for the combined use of these medications to target multiple pathways along the gut-brain axis, particularly for patients who have not achieved their health goals with a single medication.</p><p><strong>Findings: </strong>Peripheral hormones such as glucagon-like peptide-1 (GLP-1) are released in response to food consumption. Peripheral signals are integrated in the hypothalamus and hindbrain to promote energy homeostasis. These brain regions also interact with other systems such as the mesolimbic dopamine system, which promotes food intake for its rewarding properties. Thus, medical interventions for obesity, such as pharmacotherapy and bariatric surgery, aim to regulate various components of this gut hormone-hedonic brain axis. Gut hormone analog medications such as liraglutide, semaglutide, and tirzepatide target the GLP-1 receptor, with tirzepatide also targeting the glucose-dependent insulinotropic polypeptide receptor. These gut hormone analog medications primarily exert their effects on the hypothalamus and brainstem to reduce energy intake. Evidence on their effects on the reward system and reward-based eating is inconsistent. The fixed-dose, extended-release combination of naltrexone and bupropion (NB-ER) acts via the hypothalamic and mesolimbic systems to reduce food intake and reward-based eating.</p><p><strong>Conclusion: </strong>The distinct yet complementary effects of gut hormone analog medications and NB-ER on gut-brain pathways regulating satiety, hunger, and reward provide a mechanistic rationale for their combination in obesity treatment.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"12 2","pages":"e70141"},"PeriodicalIF":1.9,"publicationDate":"2026-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13052175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Obesity Management With GLP-1 Agonist Medication Through Mobile Health Technology, Nutrition Therapy, and Progressive Strength Training: A Retrospective Program Review.","authors":"Elizabeth Sharp Edens, Heather Falise, Rebecca Smith, Elle Bernardo","doi":"10.1002/osp4.70140","DOIUrl":"https://doi.org/10.1002/osp4.70140","url":null,"abstract":"<p><strong>Background: </strong>GLP-1 RAs are effective in treating obesity; however, they typically result in significant loss of skeletal muscle mass. Real-world evidence to inform systematic guidelines and clinical implementation for preserving skeletal muscle mass and reducing cardiometabolic risk with lifestyle modifications on GLP-1 RAs remains limited.</p><p><strong>Objective: </strong>This study evaluated the effectiveness of the TouchCare Method, a lifestyle intervention incorporating nutrition and exercise with GLP-1 RAs, for improving body composition and cardiometabolic risk.</p><p><strong>Methods: </strong>A retrospective chart review included patients enrolled in Bucks Health and Wellness between February 2024 and September 2025, for at least 12 month (<i>n</i> = 187). The TouchCare Method incorporates registered dietitian counseling, progressive exercise programming, mobile self monitoring, and body composition analysis during visits. Primary outcomes included: clinically significant weight loss (> 10% of body weight), proportion of weight loss from skeletal muscle mass, and changes in total-C, LDL-C, Apolipoprotein B, Triglycerides, HbA1c, and blood pressure at 12 months.</p><p><strong>Results: </strong>Patients adherent to the TouchCare Method for 12 months were included in the final analysis (<i>n</i> = 171). Clinically significant weight loss (≥ 10%) was achieved by 69.56% (<i>n</i> = 139) of patients. Skeletal muscle mass accounted for 12.22% ± 8.73% of total weight loss. Among prediabetic patients (<i>n</i> = 95), 74.7% (<i>n</i> = 71) reached euglycemia by 12 months. Patients with Stage II hypertension or higher (77% of the cohort) demonstrated improved blood pressure control, with most reaching < 140/90 mmHg. Patients with HLD experienced significant reductions in Total-C (24.71 ± 23.31 mg/dL), LDL-C (-13.75 ± 21.51 mg/dL), and ApoB (-14.24 ± 16.19 mg/dL). All lipid and HgA1c changes were statistically significant (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>The TouchCare Method may improve GLP-1 RA treatment outcomes by providing comprehensive structured lifestyle interventions supporting clinically significant weight loss while preserving skeletal muscle mass and improving cardiometabolic risk factors.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"12 2","pages":"e70140"},"PeriodicalIF":1.9,"publicationDate":"2026-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13052065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bariatric Surgery and Gender Differences in Depressive Symptoms-A 5-Year Prospective Study of Preoperative Predictors.","authors":"Liliana Buer, Ingela Lundin Kvalem, Tom Mala","doi":"10.1002/osp4.70120","DOIUrl":"https://doi.org/10.1002/osp4.70120","url":null,"abstract":"<p><strong>Objective: </strong>Candidates for metabolic bariatric surgery (MBS) often exhibit a higher prevalence of depressive symptoms compared with the general population. Studies have shown improvements in depressive symptoms and a reduction in depression prevalence during the initial years following MBS. However, reports on the long-term maintenance of these improvements are conflicting, and factors such as preoperative predictors and gender differences remain poorly understood.</p><p><strong>Methods: </strong>Data were collected from 210 subjects pre-MBS and at 1- and 5-years post-MBS. Health care providers measured Body Mass Index (BMI). All other data were collected via self-report (questionnaires). Pre-MBS factors assumed associated with depressive symptoms at 5 years included BMI, body dissatisfaction, appearance orientation, resilience, and outcome expectancies.</p><p><strong>Results: </strong>The sample comprised 77.6% women. Pre-MBS there were no significant gender differences in depressive symptomatology or the likelihood of being depressed. At both one and 5 years post-MBS, a higher proportion of men were categorized as probably depressed. From baseline to 5 years post-MBS, depressive symptoms declined among women, whereas there was no change among men. Regardless of gender, preoperative depressive symptoms and resilience predicted postoperative depression. Among women, preoperative body dissatisfaction and expectations regarding weight change and appearance were initially associated with postoperative levels of depression.</p><p><strong>Conclusions: </strong>Contrasting common findings, this study identified higher rates of post-surgery depression in men than in women. Furthermore, the results indicate that post-surgery depression may be bivariately associated with different factors depending on gender, although resilience predicted depressive symptoms irrespective of gender.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"12 2","pages":"e70120"},"PeriodicalIF":1.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13042490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}