Prospective Associations Between Salivary Biomarkers of Inflammation and Body Mass Index in Adolescents.

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM

Obesity Science & Practice Pub Date : 2025-06-21 eCollection Date: 2025-06-01 DOI:10.1002/osp4.70081

Keri M Kemp, Catheryn A Orihuela, Douglas A Granger, Retta R Evans, Sylvie Mrug

{"title":"Prospective Associations Between Salivary Biomarkers of Inflammation and Body Mass Index in Adolescents.","authors":"Keri M Kemp, Catheryn A Orihuela, Douglas A Granger, Retta R Evans, Sylvie Mrug","doi":"10.1002/osp4.70081","DOIUrl":null,"url":null,"abstract":"Background: Childhood and adolescent obesity, which affects nearly 1 in 5 youth in the US, presents a pressing public health concern. Obesity is linked to chronic low-grade inflammation, which exacerbates comorbidities. Noninvasive tools are needed to monitor obesity-related inflammation and assess weight-management interventions in children and adolescents.Objective: This study investigated the associations between Body Mass Index z-score (BMIz) and salivary biomarkers: C-reactive protein (CRP), cytokines interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α.Methods: A sample of 280 adolescents (Mage = 12.1 years, SD = 0.44) was followed for 2 years (3 time points) from 2019 to 2021. An autoregressive cross-lagged path model was used to examine the prospective relationships between BMIz and salivary biomarkers.Results: Findings indicated a bidirectional relationship between BMIz and salivary CRP levels, suggesting a feed-forward cycle in which excessive weight gain and inflammation mutually amplify each other. Salivary cytokines were not associated with BMIz.Conclusions: This study underscores the utility of salivary CRP as a noninvasive biomarker for obesity-related inflammation. Monitoring salivary CRP levels could aid in targeting interventions to prevent obesity-related complications early in life.","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"11 3","pages":"e70081"},"PeriodicalIF":1.9000,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181989/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obesity Science & Practice","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/osp4.70081","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Childhood and adolescent obesity, which affects nearly 1 in 5 youth in the US, presents a pressing public health concern. Obesity is linked to chronic low-grade inflammation, which exacerbates comorbidities. Noninvasive tools are needed to monitor obesity-related inflammation and assess weight-management interventions in children and adolescents.

Objective: This study investigated the associations between Body Mass Index z-score (BMIz) and salivary biomarkers: C-reactive protein (CRP), cytokines interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α.

Methods: A sample of 280 adolescents (Mage = 12.1 years, SD = 0.44) was followed for 2 years (3 time points) from 2019 to 2021. An autoregressive cross-lagged path model was used to examine the prospective relationships between BMIz and salivary biomarkers.

Results: Findings indicated a bidirectional relationship between BMIz and salivary CRP levels, suggesting a feed-forward cycle in which excessive weight gain and inflammation mutually amplify each other. Salivary cytokines were not associated with BMIz.

Conclusions: This study underscores the utility of salivary CRP as a noninvasive biomarker for obesity-related inflammation. Monitoring salivary CRP levels could aid in targeting interventions to prevent obesity-related complications early in life.

查看原文本刊更多论文

青少年唾液炎症生物标志物与体重指数的前瞻性关联。

背景：儿童和青少年肥胖影响着美国近五分之一的青少年，是一个紧迫的公共卫生问题。肥胖与慢性低度炎症有关，这会加剧合并症。需要无创工具来监测肥胖相关炎症并评估儿童和青少年的体重管理干预措施。目的：本研究探讨体重指数z-评分（BMIz）与唾液生物标志物：c反应蛋白（CRP）、细胞因子白介素(IL)-1β、IL-6、IL-8和肿瘤坏死因子(TNF)-α的关系。方法：从2019年至2021年，对280名青少年（年龄为12.1岁，SD = 0.44）进行为期2年（3个时间点）的随访。一个自回归的交叉滞后路径模型被用来检验BMIz和唾液生物标志物之间的潜在关系。结果：研究结果表明BMIz与唾液CRP水平之间存在双向关系，提示体重过度增加和炎症相互放大的前馈循环。唾液细胞因子与BMIz无关。结论：本研究强调了唾液CRP作为肥胖相关炎症的非侵入性生物标志物的实用性。监测唾液c反应蛋白水平有助于有针对性地干预，预防生命早期与肥胖相关的并发症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊