Obesity Science & Practice最新文献

{"title":"Changes in glomerular filtration rate in patients with body mass index ≥35 kg/m² treated with metabolic and bariatric surgery versus GLP-1 agonist at 1-year follow-up.","authors":"Diana Cristina Henao-Carrillo, Mayra Alejandra Jurado-Florez, Óscar Mauricio Muñoz","doi":"10.1002/osp4.782","DOIUrl":"10.1002/osp4.782","url":null,"abstract":"<p><strong>Background: </strong>Metabolic and bariatric surgery (MBS) reduces glomerular hyperfiltration. The renoprotective effects of GLP-1 analogs were derived from clinical studies in type 2 diabetes (T2D). The objective of this study was to evaluate the changes in glomerular filtration rate (GFR) over time associated with weight loss in patients with a BMI ≥ 35 kg/m² treated with liraglutide compared with patients treated with MBS.</p><p><strong>Methods: </strong>A longitudinal study derived from a retrospective cohort of patients with BMI ≥ 35 kg/m² treated with either MBS or liraglutide 3 mg/day, with follow-up ≥1 year. Clinical variables, baseline GFR, and 1-year GFR were analyzed. A generalized estimating equation (GEE) model was used to compare changes in GFR between both groups while controlling for confounding variables.</p><p><strong>Results: </strong>A total of 159 patients were included in the analysis. Of these, 129 patients underwent MBS (median age 60.5 years [IQR 51.8-66.6], body mass index (BMI) 40.9 kg/m2 [IQR 0.68-0.89]), and 30 patients were treated with liraglutide (median age 56 years [IQR 46-62], BMI 37.4 kg/m² [IQR 0.69-0.93]). No difference in baseline GFR or at 12 months of follow-up was found between the two interventions. GEE analysis revealed an increase of 0.32 mL/min/1.73 m² per month of follow-up. Factors associated with a greater increase in GFR were the percentage total weight loss (%TWL) (0.12 mL/min/1.73 m², <i>p</i> = 0.023) and baseline GFR (0.69 mL/min/1.73 m², <i>p</i> > 0.001) for both interventions, independent of a history of T2D.</p><p><strong>Conclusion: </strong>In patients with BMI ≥ 35 kg/m², changes in GFR are related to %TWL and baseline GFR, regardless of the presence of diabetes or the type of intervention used.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"10 4","pages":"e782"},"PeriodicalIF":1.9,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11316517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of socioecological factors on health behaviors and weight change during major life event: A cross-sectional study using data collected during the COVID-19 pandemic.","authors":"Tsz Kiu Chui, Yenni E Cedillo, Assil El Zein, Gregory Pavela, Ann E Caldwell, John C Peters, James E Friedman, Swati DebRoy, Jennifer L Oslund, Sai Krupa Das, Susan B Roberts, James O Hill, R Drew Sayer","doi":"10.1002/osp4.785","DOIUrl":"10.1002/osp4.785","url":null,"abstract":"<p><strong>Background: </strong>Socioecological factors are associated with key health behaviors that are critical for weight management, and major life events may disrupt engagement in these behaviors. However, the influence of socioecological factors on health behaviors in the midst of major life events is not clear and is difficult to study due to the random and sporadic nature of their occurrence. The COVID-19 pandemic provided a unique opportunity to study a major life event and its impacts on diet, physical activity, and body weight.</p><p><strong>Objective: </strong>This cross-sectional study aimed to investigate associations between socioecological factors (environmental, interpersonal, and individual) and self-reported weight change during a major life event using data collected during the COVID-19 pandemic, and whether the associations were mediated through self-reported changes in eating and physical activity behaviors.</p><p><strong>Methods: </strong>Participants self-reported socioecological factors, weight change, and changes in eating behaviors (EB) and physical activity (PA) via online questionnaires between December 2020 and October 2021. Changes in EB and PA were measured using scales with higher scores reflecting more positive changes during the COVID-19 pandemic.</p><p><strong>Results: </strong>Participants (<i>n</i> = 1283) were mostly female (84.9%) with age 52.1 ± 14.1 years (mean ± SD) and BMI of 32.9 ± 8.2 kg/m². Stronger healthy eater and exercise identities (individual factors) were associated with higher EB scores (EBS) and PA scores (PAS), respectively (<i>p</i>'s < 0.00001). Less discouragement for healthy eating by family/friends (interpersonal factor) was associated with higher EBS (<i>p</i> = 0.002). Higher EBS and PAS were associated with weight loss. The indirect effect of healthy eater identity (-0.72; 95% CI: -0.90, -0.55) and discouragement for diet (0.07; 95% CI: 0.03, 0.12) on weight change through EBS were significant, as was the indirect effect of exercise identity (-0.25; 95% CI: -0.35, -0.15) on weight change through PAS.</p><p><strong>Conclusions: </strong>Stronger identities and less discouragement from family/friends may support health promoting behaviors and weight loss during a major life event, as well as identify additional behavioral targets for lifestyle interventions.</p><p><strong>Clinical trial registration: </strong>IWCR was registered at ClinicalTrials.gov (NCT04907396).</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"10 4","pages":"e785"},"PeriodicalIF":1.9,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11316523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The intricate relationship between obesity, type 2 diabetes and female breast cancer: A retrospective study of 335 women.","authors":"Ilaria Milani, Chiara Gaita, Gloria Guarisco, Marianna Chinucci, Roberta Parisella, Silvia Piroli, Eleonora Bruno, Annunziata Martellucci, Elena De Falco, Fabio Ricci, Antonella Calogero, Frida Leonetti, Danila Capoccia","doi":"10.1002/osp4.786","DOIUrl":"10.1002/osp4.786","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes (T2D) is a risk factor for female breast cancer (FBC). Obesity has also been associated with FBC, also depending on menopausal status. This study aimed to evaluate the impact of obesity and T2D on the development, aggressiveness, and invasiveness of FBC.</p><p><strong>Methods: </strong>Demographic, clinical, and histopathological data from 335 women with FBC were collected, and analyzed according to weight category (102 normal weight, 117 overweight, and 116 living with obesity) and the presence/absence of T2D.</p><p><strong>Results: </strong>Age at oncologic diagnosis was not statistically significantly different for body weight; women with overweight or obesity were more likely to have an oncologic diagnosis after menopause than normal weight (<i>p</i> < 0.001). The presence of overweight/obesity and T2D seemed to be associated with a higher incidence of metastasis, recurrence, and triple-negative breast cancer (TNBC) subtype (<i>p</i> < 0.001). Excess body weight was also associated with high histologic grade (G3) (<i>p</i> < 0.005).</p><p><strong>Conclusions: </strong>These results confirm excess body weight and T2D as unfavorable prognostic factors in terms of the presence of the TNBC subtype, tumor metastasis, recurrence, and aggressiveness (G3 and Ki-67 > 20%). This study highlights the importance of prevention in all women, with early screening, and adequate nutritional programs.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"10 4","pages":"e786"},"PeriodicalIF":1.9,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11310762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient perspectives on incretin-based weight loss medications and relationship with demographic factors.","authors":"Megan A McVay, Wendy S Moore, Francesca L Wilkins, Jalen R Jackson, Michael D Robinson","doi":"10.1002/osp4.783","DOIUrl":"10.1002/osp4.783","url":null,"abstract":"<p><strong>Objective: </strong>Treatment of obesity has been transformed by the recent approval of incretin-based therapies for weight loss (e.g., glucagon-like peptide 1 agonist semaglutide), but little is known about patient perspectives on these medications.</p><p><strong>Methods: </strong>Between December 2023 and March 2024, healthcare patients from an academic medical center in the Southeast United States with Body Mass Index ≥30 kg/m² completed a cross-sectional online survey on attitudes toward incretin-based medications.</p><p><strong>Results: </strong>Compared to patients with a bachelor's degree, those without a degree were less likely to be aware of incretin-based pharmacotherapies (96% vs. 78%) and to have discussed pharmacotherapies with a doctor (43% vs. 27%) but had greater interest in using these pharmacotherapies (4.3 vs. 4.7). These pharmacotherapy-related variables did not differ significantly according to gender, race, or financial security. Concerns about side effects, long-term health risks, and potential for weight regain were highly endorsed and were associated with lower interest in using incretin-based therapies and with some demographic factors. Patients reported high interest in lifestyle programs designed for individuals taking anti-obesity medications.</p><p><strong>Conclusion: </strong>Demographic considerations, notably education level, should be factored into the strategy to promote equitable utilization of incretin-based therapies, particularly as their accessibility expands.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"10 4","pages":"e783"},"PeriodicalIF":1.9,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11302371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of probiotics in preventing and treating excess weight and obesity. A systematic review.","authors":"Belén Torres, María C Sánchez, Leire Virto, Arancha Llama-Palacios, María J Ciudad, Luis Collado","doi":"10.1002/osp4.759","DOIUrl":"10.1002/osp4.759","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of excess weight and obesity is increasing in an extremely concerning manner worldwide, with highly diverse therapies for current treatment. This review evaluated the scientific evidence of the past 10 years on the use of probiotics in treating excess weight and obesity in the absence of dieting.</p><p><strong>Materials: </strong>A systematic review was conducted by searching for clinical trials on humans published in English in the PubMed, Scopus and Cochrane Central databases, using the combination of keywords \"Overweight\", \"Probiotics\" and \"Obesity\", and published between 2012 and 2022.</p><p><strong>Results: </strong>Six published studies met the inclusion criteria. The review showed that, although there is a lack of consensus in the literature, the use of probiotics in the absence of dieting produced a significant reduction in body weight and body mass index in 66.6% of the reviewed studies, a significant reduction in waist circumference in 80.0% of the reviewed studies, and an improvement in total body fat mass and waist circumference.</p><p><strong>Conclusions: </strong>This review showed evidence of a trend in preventing body weight gain and reducing weight through the use of probiotics in individuals with excess weight or obesity. A combination of various strains of the genera <i>Bifidobacterium</i> and <i>Lactobacillus</i> was the most effective.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"10 3","pages":"e759"},"PeriodicalIF":1.9,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11187407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141432460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using the behavior change wheel to design a novel home-based exercise program for adults living with overweight and obesity: Comprehensive reporting of intervention development.","authors":"Sofie Power, David Broom, Michael Duncan, Stuart Biddle, Nikita Rowley","doi":"10.1002/osp4.774","DOIUrl":"10.1002/osp4.774","url":null,"abstract":"<p><strong>Introduction: </strong>Physical activity and exercise are movement behaviors that support the lifestyle management of overweight and obesity. However, home-based exercise programs are commonly generic, and inconsistently undertake a holistic approach to program design.</p><p><strong>Methods: </strong>This work applied the Behavior Change Wheel, supplemented with previously conducted interviews, to the development of a home-based exercise program, specifically for people living with overweight and obesity. This provided an understanding of the target behavior and identified a behavioral diagnosis. These findings were mapped onto the Capability, Opportunity, Motivation-Behavior model and Theoretical Domains Framework, identifying changes needed and corresponding intervention functions.</p><p><strong>Results: </strong>Suitable Behavior Change Techniques were identified, alongside Capability Opportunity Motivation-Behavior components needed to facilitate an increase in exercise behaviors, and five key intervention functions. This housed the delivery of 24 Behavior Change Techniques, including goal setting, feedback, monitoring and repetition.</p><p><strong>Conclusion: </strong>Applying the Behavior Change Wheel has enabled detailed development of a home-based exercise program for adults living with overweight and obesity.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"10 3","pages":"e774"},"PeriodicalIF":1.9,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11187404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141432461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of traditional Chinese medicines on weight management among adults with overweight or obesity: A systematic review and network meta-analysis.","authors":"Meifang Chen, Jiaqi Liu","doi":"10.1002/osp4.763","DOIUrl":"10.1002/osp4.763","url":null,"abstract":"<p><p>Increasing evidence has reported the anti-obesity effects of traditional Chinese medicines (TCMs) and their potential advantages in weight loss, such as fewer side effects and lower costs compared to the current recommended treatments like Western medicines. Previous review studies have examined the effects of a few commonly used TCM therapies such as acupuncture and herbal medicines on weight loss. This network meta-analysis (NMA) study aims to review and rank the effects of currently available TCMs on weight loss and to compare the effects of TCMs with different intervention durations. Eligible Randomized controlled trials (RCTs) conducted among Chinese adults with overweight or obesity were searched on electronic databases (PubMed, Embase, CNKI, WanFang, VIP, and SinoMed) up to 1 March 2023. Pairwise meta-analysis was performed to examine the pooled effects of TCMs on weight loss, and NMA was conducted to rank different types of TCMs. Subgroup analysis stratified by intervention duration was performed. Forty-six RCTs were eligible for inclusion in the review. The results showed that TCMs, especially when the treatment duration was ≤6 months, were more effective in both body weight and Body Mass Index (BMI) reduction than non-pharmacological interventions and placebo/no treatment. Acupotomy was ranked as the most effective TCM treatment in reducing both body weight and BMI. Traditional Chinese medicines have promising potential for weight loss and could be included in future clinical guidance as a standalone or supplementary treatment for obesity. Future studies need to further investigate under-researched TCMs, examine the long-term effects and safety of TCMs in obesity treatment, and validate the findings from this study among other ethnic populations.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"10 3","pages":"e763"},"PeriodicalIF":2.2,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11164975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short sleep duration is associated with higher risk of central obesity in adults: A systematic review and meta-analysis of prospective cohort studies.","authors":"Ali Kohanmoo, Masoumeh Akhlaghi, Najmeh Sasani, Fatemeh Nouripour, Caterina Lombardo, Asma Kazemi","doi":"10.1002/osp4.772","DOIUrl":"10.1002/osp4.772","url":null,"abstract":"<p><strong>Background and objective: </strong>The relationship between sleep duration and obesity has been the focus of numerous investigations. This systematic review and meta-analysis of prospective cohort studies aimed to assess the relationship between sleep duration, abdominal obesity, and body composition.</p><p><strong>Methods: </strong>PubMed, Scopus, and Web of Science were searched until February 2024. Cohort studies that assessed the relationship between sleep duration at night and central obesity measures or body composition indices in adults were included. The quality of studies was assessed using the Newcastle-Ottawa scale. Random-effects meta-analysis was conducted on studies that reported risk ratio (RR) and 95% confidence intervals (CIs).</p><p><strong>Results: </strong>Eighteen studies were eligible to be included. Eleven out of the 18 studies were not included in the analysis as 10 studies did not report RR, and in one study, the definition of short and normal sleep duration was different from others. The results of the meta-analysis indicated that short sleep duration was significantly associated with abdominal obesity (RR = 1.08; 95% CI: 1.04-1.12; <i>I</i> ² = 49.1%, n = 7), but long sleep duration was not (RR = 1.02; 95% CI: 0.83-1.24; <i>I</i> ² = 98.2%, n = 6).</p><p><strong>Conclusions: </strong>Short sleep duration was associated with a slightly higher risk of central obesity, while long sleep duration was not.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"10 3","pages":"e772"},"PeriodicalIF":2.2,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11149606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful dietary changes correlate with weight-loss outcomes in a new dietary weight-loss program.","authors":"Mindy H Lee, Annabelle Shaffer, Nouf W Alfouzan, Catherine C Applegate, Jennie C Hsu, John W Erdman, Manabu T Nakamura","doi":"10.1002/osp4.764","DOIUrl":"10.1002/osp4.764","url":null,"abstract":"<p><strong>Background: </strong>Currently available behavioral and dietary weight-loss programs lack magnitude and sustainability compared with bariatric surgery. A novel dietary weight-loss program was developed to assist participants in achieving sustainable diet changes by building knowledge and skills in food self-selection. Although the approach worked, a large variation was observed in outcome among participants.</p><p><strong>Objective: </strong>Determine factors affecting weight-loss outcomes among participants to further improve the efficacy of the program.</p><p><strong>Methods: </strong>Participants attended 19 dietary educational sessions during a 1-year intervention which included prescribed homework. Changes in weight, diet, and body composition were assessed.</p><p><strong>Results: </strong>Participants (<i>n</i> = 22) achieved mean body weight loss of -6.49(8.37%, <i>p</i> < 0.001) from baseline at 12 months. Nine participants (41%) achieved weight loss >5% of initial bodyweight; two reached a Body Mass Index 25 kg/m². A large divergence in weight loss among participants was observed; successful (<i>n</i> = 9) achieved -12.9(9.6)% while unsuccessful achieved -2.03(2.78)%. Dietary protein and fiber density by 24-h records showed a significant and inverse correlation with weight loss (%) throughout the program. Weight loss at 3 months and 12 months showed a strong correlation (<i>r</i> = 0.84). Participants with self-reported depression lost significantly less weight than those without depression at 12 months (<i>p</i> < 0.03).</p><p><strong>Conclusions: </strong>Divergence in weight-loss outcomes among the participants is likely due to a difference in successful dietary implementation. Intra-cohort analysis indicates early weight-loss success and early dietary implementation was predictive of long-term success.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"10 3","pages":"e764"},"PeriodicalIF":1.9,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11129620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141157458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of mobile app usage in facilitating weight loss: An observational study.","authors":"Rosemary Huntriss, Rodion Salimgaraev, Dimitri Nikogosov, John Powell, Krista A Varady","doi":"10.1002/osp4.757","DOIUrl":"10.1002/osp4.757","url":null,"abstract":"<p><strong>Aim: </strong>With increasing rates of global obesity and associated health issues, there is an ever-increasing need for weight management solutions to be more accessible. Mobile applications offer accessible support systems and have the potential to offer a viable and effective weight management solution as an alternative to traditional healthcare models.</p><p><strong>Objective: </strong>To evaluate the effectiveness of the SIMPLE mobile application for time-restricted eating in achieving weight loss (WL).</p><p><strong>Methods: </strong>User data were analyzed between January 2021 and January 2023. In-app activity was calculated as the proportion of active days over 12, 26 and 52 weeks. A day is considered active if it contains at least one in-app action (e.g., logging weight, food, fasting, or physical activity). Users were categorized into four in-app activity levels: inactive (in-app activity <33%), medium activity (33%-66%), high activity (66%-99%), and maximal activity (100%). Weight change among in-app activity groups was assessed at 12, 26, and 52 weeks.</p><p><strong>Results: </strong>Out of 53,482 users, a positive association was found between the use of the SIMPLE app and WL. Active app users lost more weight than their less active counterparts. Active users had a median WL of 4.20%, 5.04%, and 3.86% at 12, 26, and 52 weeks, respectively. A larger percentage of active users-up to 50.26%-achieved clinically significant WL (≥5%) when compared to inactive users. A dose-response relationship between WL and app usage was found after adjusting for gender, age, and initial Body Mass Index; a 10% increase in app activity correlated with increased WL by 0.43, 0.66 and 0.69 kg at 12, 26, and 52 weeks, respectively.</p><p><strong>Conclusions: </strong>The study demonstrates that the SIMPLE app enables effective WL directly associated with the level of app engagement. Mobile health applications offer an accessible and effective weight management solution and should be considered when supporting adults to lose weight.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"10 3","pages":"e757"},"PeriodicalIF":1.9,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11091450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140922727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}