Oftalmologicheskii zhurnal最新文献

{"title":"Assessing quantitatively the state of the blood-aqueous barrier by laser flare photometry: a review","authors":"Олександра Зборовська, Олександра Дорохова, Андрій Король, Ксенія Трояновська, Олег Задорожний, Наталія Пасєчнікова, Вікторія Колесніченко","doi":"10.31288/oftalmolzh202346773","DOIUrl":"https://doi.org/10.31288/oftalmolzh202346773","url":null,"abstract":"This review discusses the experience in applying laser flare photometry, a non-invasive technique, in ophthalmology, to assess quantitatively the state of the blood-aqueous barrier (BAB) in patients with certain ocular and systemic disorders. The method allows reliable detection of such biomarkers of the state of the BAB as the intensity of the scattered light (flare) and number of cells in the aqueous of the anterior chamber, sometimes even at the subclinical level, which significantly improves the capability for early diagnosis and objective treatment monitoring.","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48818345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solitary occipital bone plasmacytoma with unusual ocular signs","authors":"Володимир Олегович Федірко, Катерина Єгорова, Дмитро Цюрупа, П. М. Оніщенко, Василь Шуст, Микола Єгоров","doi":"10.31288/oftalmolzh202347478","DOIUrl":"https://doi.org/10.31288/oftalmolzh202347478","url":null,"abstract":"Solitary occipital bone plasmacytoma at the level of the confluence of sinuses is a rare condition. We report a case of an unusual combination of occipital bone plasmacytoma, ocular motility abnormalities, and papilledema. To the best of our knowledge, no case has been reported in the literature on such a combination of nosology, location and clinical course.\u0000 ","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49153210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical treatment and survival of patients with invasive orbital tumors","authors":"Орест Ігорович Паламар, А. П. Гук, Б.О. Давиденко, Д. І. Оконський, О. С. Усатов","doi":"10.31288/oftalmolzh202343440","DOIUrl":"https://doi.org/10.31288/oftalmolzh202343440","url":null,"abstract":"Background: Intraorbital tumor invasion is not uncommon among craniofacial tumors, and is seen in 27% of cases. Craniofacial malignancies account for 3% of all head and neck tumors. Malignant tumors are more common than benign and comprise about 73% of all craniofacial tumors with intraorbital invasion. Their growth is aggressive and invasive, leading to early postoperative recurrence. The survival of patients with malignant craniofacial tumors depends largely on orbital invasion, and patients demonstrating orbital invasion had a 40% survival rate, while patients without had a survival rate of 72%. Patients with total resection of craniofacial tumors (including those with intraorbital extensions) show higher non-recurrence and survival rates than patients without total resection. Orbital exenteration does not provide patients with better survival rates and worsened the quality of life.\u0000\u0000Purpose: To assess the outcomes of surgical treatment for, and the survival of patients with, malignant craniofacial tumors growing into the orbit.\u0000\u0000Material and Methods: We reviewed the outcomes of surgical treatment for, and the survival of 94 patients with, malignant craniofacial tumors growing into the orbit.\u0000\u0000Results: Destruction of the bony orbital wall only (without periorbital adhesion), was seen in 27/94 cases (28.7%), whereas periorbital invasion, in 67/94 cases (71.3%). The tumor was excised completely with visually clear margins in all cases. Patient survival was affected by the degree of orbital invasion. The recurrence rate after surgery for malignant craniofacial tumors growing into the orbit was 44.7% (40/94 patients). Ten patients had a local intraorbital recurrence after surgery for malignant craniofacial tumors growing into the orbit.\u0000\u0000Conclusion: Periorbital invasion was seen in 71.3% of patients with malignant craniofacial tumors. There was no significant difference in the survival of patients with malignant craniofacial tumors of different histology. Orbital exenteration does not improve survival and recurrence in patients with malignant craniofacial tumors with orbital invasion. In patients with preoperative periorbital invasion and further intraorbital extension, the recurrence rate was more than three-fold higher than in those showing only destruction of the bony orbital wall preoperatively.","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49181232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunologic status and sensitivity of peripheral blood T cells to neurotransmitters in patients with optic neuritis","authors":"Наталя Храменко, Людмила Величко, Наталія Коновалова, Олександра Богданова, Тетяна Серебріна, Юлія Журавок","doi":"10.31288/oftalmolzh202341420","DOIUrl":"https://doi.org/10.31288/oftalmolzh202341420","url":null,"abstract":"Background: Optic neuritis (ON) is an optic nerve inflammation that can result in impairment of visual function. Studying expression patterns of immune cell subpopulations and genes is of importance for revealing the role and influence of each of them in the early ongoing ON pathological process.\u0000\u0000Purpose: To examine the immunologic status and sensitivity of peripheral blood T cells to adrenaline and acetylcholine neurotransmitters in patients with ON and its sequelae.\u0000\u0000Material and Methods: The study cohort included 45 patients with idiopathic ON who underwent an examination: group 1, 27 patients with primary acute ON; group 2, 9 patients with partial optic atrophy (POA) following ON; and group 3, 9 patients with loss of posterior pole structure following ON. Group 4 (controls) was composed of 27 healthy volunteers. The specific reactivity of lymphocytes to adrenaline and acetylcholine was assessed using our complex methodology (in conjunction with a parallel sampling method) for assessing the individual’s sensitivity to medicaments (biological regulators) which has been developed at Immunology laboratory, Filatov Institute of Eye Diseases and Tissue Therapy. The methodology involves obtaining lymphocytes from an individual, culturing lymphocytes with examined drugs immunohistochemically, and use of a peroxidase anti-peroxidase method with monoclonal antibodies\u0000\u0000Results: Patients with acute idiopathic ON showed increased cell immunity activity, with increased absolute numbers of CD3, CD4, and CD8 cells compared to the control group. The CD4:CD8 ratio for acute ON was not significantly different from the norm. We noted increased levels of activity of humoral immunity components (increased absolute numbers of B lymphocytes and increased IgA and IgM levels) in acute ON compared to the control group. A reduction in and normalization of absolute numbers of СD3 and СD4 T cells compared to acute ON were characteristic features of cell-mediated immunity in patients with POA following ON and those with loss of posterior pole structure following ON. The percentage of CD8 cells in patients with POA following ON was lower than in controls. It is these characteristic proportions of immunocompetent cell ratios that mirrored in increased CD4:CD8 ratios in ON groups, which is associated with a reduced level of cytotoxic T cells. Patients in groups 1, 2 and 3 had increased absolute numbers of peripheral blood T cells sensitive to adrenaline, being 3.4-fold, 2.4-fold, and 1.7-fold more than controls, respectively. In addition, patients in groups 1 and 2 had increased absolute numbers of peripheral blood T cells sensitive to acetylcholine, being 2.8-fold and 2.6-fold more than controls, respectively. We found significant direct correlations of the level of the T cells sensitive to adrenaline and acetylcholine with the leukocyte cell count and CD3, CD8, CD19 and CD16 lymphocyte subset counts in patients with ON and its sequelae.\u0000\u0000Conclusion: The levels of some cell","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41614959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a course of injections with melatonin on morphological and functional changes in the optic nerve in experimental animals with hypopinealism","authors":"Ольга Недзвецька, Уляна Пастух, Ольга Кузьмина де Гутврра, Ірина Пастух, Ірина Соболева, Наталія Сотник","doi":"10.31288/oftalmolzh202344854","DOIUrl":"https://doi.org/10.31288/oftalmolzh202344854","url":null,"abstract":"Background: Optic atrophy (OA) may be expected in hypopinealism, which is accompanied by degenerative changes in the retina.\u0000\u0000Purpose: To assess the impact of a course of injections with melatonin on the morphological and functional optic nerve (ON) changes in rabbits exposed to prolonged around-the-clock light (ATCL) leading to hypopinealism.\u0000\u0000Material and Methods: Eighty-four rabbits were used in this experimental study. Group 1 (an ATCL group) was composed of 32 animals exposed to ATCL to develop functional hypopinealism. Group 2 (an ATCL+M group) was composed of 29 animals exposed to ATCL but treated with intramuscular melatonin for 14 days. Group 3 (a control group or CG) was composed of 23 intact animals maintained under natural day/night cycle conditions. Groups were subdivided into subgroups based on experimental constructs (1-2 months, 3-5 months, 8-12 months, 18-19 months, 26-28 months). Blood melatonin levels were assessed by commercially available enzyme-linked immunosorbent assay kits. ON specimens were obtained and comprehensively assessed morphologically and morphometrically.\u0000\u0000Results: Night-time blood melatonin level in experimental groups was almost six-fold lower than that in controls. Signs of abnormal ON circulation were observed at ≤12 months of ATCL exposure. ON demyelination was observed from months 3-5 of the experiment. Sclerotic and atrophic processes in the ON were observed at 28 months of ATCL exposure. In ATCL26-28 and ATCL+M26-28 subgroups, the mean relative vascular area in the intraorbital ON was significantly reduced compared to CG26-28 (2.01 ± 0.15% and 1.93 ± 0.15%, respectively, versus 3.20 ± 0.13%, р less 0.05). In addition, the mean relative area of the perivascular connective tissue (4.80 ± 0.15% and 4.61 ± 0.17%, respectively) was significantly increased compared to CG26-28 (3.40 ± 0.14%, р less 0.05). Moreover, the mean diameter of the nerve fiber bundle (2.51 ± 0.09 ×10-6 m and 2.73±0.10×10-6 m, respectively) was significantly reduced compared to CG26-28 (3.85±0.14×10-6 m; р less 0.05).\u0000\u0000Conclusion: The morphological findings (like demyelination of nerve fibers and thinning of nerve fiber bundles of the ON), combined with low blood flow in ON vessels, vascular wall thickening and connective tissue growth, indicated the development of sclerotic atrophy of the ON, in the presence of marked melatonin deficiency, in rabbits exposed to ATCL. The 14-day course melatonin treatment of ATCI-exposed rabbits exerted anti-edematous effects at early time points (less 5 months), until obviously irreversible changes in the ON occurred. However, the course melatonin treatment exerted no impact on the development of OA in animals with persistent, marked hypopinealism developed in the presence of prolonged (28-month) exposure to ATCI.","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44848643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nasal septal deviation and olfactory dysfunction: septoplasty and autoplatelet mesoconcentrate","authors":"Олександра Цепколенко, С.М. Пухлік","doi":"10.31288/oftalmolzh202344147","DOIUrl":"https://doi.org/10.31288/oftalmolzh202344147","url":null,"abstract":"Background: Nasal septal deviation (NSD) prevalence rates in the general population range between 75% and 89.2%. The disease results in disorders of the ear, throat and nose, olfactory dysfunction (OD) in the form of hyposmia or anosmia, nasolacrimal duct obstruction, and, consequently, chronic dacryocystitis and low quality of life. Surgery for NSD (septoplasty) can be followed by postoperative anosmia. The three-year COVID-19 pandemic worsened the histories of candidates for septoplasty and the prognosis for surgical outcome in terms of restoration of smell. The methods available for the treatment of OD require close cooperation of specialties like ophthalmology, otorhinolaryngology and neuropathology. Cell-therapy technologies and application of platelet-reach plasma (PRP) seem to be promising in the treatment of NSD and OD.\u0000\u0000Purpose: To improve the efficacy of septoplasty for patients with NSD-associated OD through the use of autoplatelet mesoconcentrate (APMC).\u0000\u0000Material and Methods: One hundred and fifty-five individuals underwent examination and treatment. These included 22 apparently healthy volunteers aged 25 to 34 years (group 1 or control group), 47 patients with NSD-associated OD only aged 24 to 33 years (group 2 or archival group), 44 patients with NSD-associated OD only aged 23 to 35 years (group 3), and 42 patients with NSD-associated OD and a history of COVID-19 aged 23 to 36 years (group 4). Ten of the patients of group 4 had nasolacrimal duct obstruction.\u0000\u0000Results: Our magnetic resonance imaging (MRI) studies found that olfactory bulb volume was 27.2% and 54.5% decreased in groups 3 and 4, respectively, compared to healthy volunteers. A procedure for obtaining at least 24 ml of APMC was described. A 4–mm diameter endoscope (Karl Storz, Germany) was used to perform septoplasty under general endotracheal anesthesia in groups 2, 3 and 4. Application of APMC after endoscopic septoplasty in patients presenting with NSD-associated OD, a history of COVID-19 contributed to the normalization of olfactory bulb volume, reduction in postoperative complication rate, and restoration of the sense of smell and quality of life. Application of APMC after endoscopic septoplasty in patients presenting with NSD-associated OD, a history of COVID-19 and nasolacrimal duct obstruction, contributed to restoration of nasolacrimal duct patency, thus preventing chronic dacryocystitis.","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45110413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical treatment of idiopathic macular holes with a fovea-sparing technique and 20% SF6 gas tamponade","authors":"Інес Буаллагуі, Зоя Анатоліївна Розанова, Микола Уманець","doi":"10.31288/oftalmolzh202342125","DOIUrl":"https://doi.org/10.31288/oftalmolzh202342125","url":null,"abstract":"Purpose: To assess the macular hole (MH) closure rate and final visual acuity after idiopathic MH treatment with a modified fovea-sparing technique and 20% SF6 gas tamponade.\u0000\u0000Material and Methods: Fifteen patients (16 eyes; 12 women and 3 men; mean age (standard deviation or SD), 65.5 (5.90 years)) with Gass stage 2 to stage 4 MHs were involved in the study. Before surgery, mean best-corrected visual acuity (BCVA) (SD) was 0.15 (0.09), and mean MH diameter (SD), 437.2 (164.7) µm. Patients underwent surgical treatment with the modified fovea-sparing technique and 20% SF6 gas tamponade of two-week duration and were instructed to maintain a face-down position for a week after surgery.\u0000\u0000Results: At 1 month after the first surgery, MHs were closed in 11/16 eyes (68.75%). In addition, mean BCVA (SD) in eyes with closed MHs improved significantly from 0.15 (0.09) to 0.48 (0.16) (р = 0.000000). Of the five eyes in which the MH had failed to close after primary fovea-sparing surgery, two received a gas fluid exchange gas tamponade with 15% С3F8, and these patients were advised to maintain a face down position for 3 more weeks. In addition, in another two eyes, the vitreous cavity was revised, and the internal limiting membrane (ILM) was removed by a conventional technique with 15% С3F8 gas tamponade. Moreover, one patient rejected repeat intervention. In the four eyes in which the MH had failed to close after primary fovea-sparing surgery, after a repeat intervention, the MH was closed, and mean BCVA (SD) improved to 0.35 (0.04). There was no significant difference between the eyes in which the MH failed to close and the eyes in which the MH did close after primary surgery in terms of mean MH size (SD) (455 (203) µm versus 415 (155) µm, р = 0.66) or MH duration.\u0000\u0000Conclusion: A long gas tamponade (longer than 1 week) is required to improve the closure rate with the fovea-sparing ILM peeling technique for idiopathic MHs.","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42546703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idiopathic congenital Horner Syndrome. Presentation of a case","authors":"Leopoldo Garduño-Vieyra, Raúl Rúa Martínez, Natalia Rodriguez Mena, Isabel De la Fuente Batta","doi":"10.31288/oftalmolzh202347980","DOIUrl":"https://doi.org/10.31288/oftalmolzh202347980","url":null,"abstract":"Horner Syndrome results from an interruption of the sympathetic innervation of the eye. This pathway is a chain of three neurons which originate in the hypothalamus, travels down to spinal cord at the level of lower cervical and upper thoracic levels, then traverses the upper chest cavity traveling with the carotid artery, traverse the orbit to innervate pupillary sphincter and accessory muscles for eyelid retraction. The classic clinical triad is unilateral ptosis, miosis and anhidrosis.\u0000There are many causes of Horner Syndrome which can be congenital o acquired. During the first year of life is most often idiopathic in 70%, but the others can be related to neuroblastoma, that’s why it is so important to recognize the cause of the syndrome in each patient. In this paper we describe a case report of congenital Horner syndrome, how the diagnosis was made, identification of the causing injury and differential diagnosis.","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":"2004 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41331277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrastromal corneal ring segment implantation in pediatric patients with keratoconus: long-term follow-up","authors":"C. Castro, Nisa Silva, Ana Carolina Abreu, Saul Pires, Miguel Mesquita Neves, Miguel Gomes, Oliveira Luis, P. Menéres","doi":"10.31288/oftalmolzh20234913","DOIUrl":"https://doi.org/10.31288/oftalmolzh20234913","url":null,"abstract":"Purpose: To evaluate the long-term outcomes of Intrastromal Corneal Ring Segments (ICRS) implantation in pediatric patients with keratoconus. \u0000Methods: Retrospective analysis of eyes with ICRS implantation in pediatric age. Uncorrected (UCVA) and best-corrected (BCVA) visual acuity, maximum and minimum keratometry (Kmax and Kmin), and corneal thickness at the thinnest point (CTTP) were evaluated preoperatively, 6 to 12 months after surgery, 5 years after surgery, and at the last follow-up visit (>10 years after surgery). \u0000Results: Fourteen eyes (10 patients) were included. In 5 eyes all ICRS were explanted and in 1 eye, one of the segments was explanted. UCVA (p=0.028) and BCVA (p=0.028) improved 6 to 12 months after surgery and remained stable afterwards (p>0.999). There was a decrease in Kmax and Kmin 6 to 12 months after surgery (p<0.001 and p=0.012, respectively), with subsequent stability at the 5-year follow-up (p=0.736 and p=0.056, respectively). Kmax remained stable at the last follow-up (p>0.999) but there was an increase in Kmin (p=0.028). There were no changes in CTTP (p=0.097).\u0000Conclusion: ICRS implantation seems to be a minimally invasive, and reversible procedure that leads to improvement of BCVA and keratometry readings.  Despite this, the need for explantation increased overtime.","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43640049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurodegenrative changes in retina of rats with streptozotocin-induced diabetes under conditions of treatment with niacin-oxy-ethylidene-diphosphonate germanate (MIGU-4)","authors":"В.Й. Кресюн, Нора Джавад Аль-Надаві","doi":"10.31288/oftalmolzh202345560","DOIUrl":"https://doi.org/10.31288/oftalmolzh202345560","url":null,"abstract":"Background: Diabetes is accompanied by neurodegenerative changes in the retina. The determination of retinal function parameters under conditions of experimental diabetes may allow for the development of new approaches to pharmacological vision correction.\u0000\u0000Purpose: To assess changes in the metabolic (lipid peroxidation and antioxidant defence) and functional characteristics (electroretinography (ERG)) of the retina in the rat with streptozotocin (STZ)-induced diabetes, treated with niacin-oxy-ethylidene-diphosphonate germanate (MIGU-4) and a reference drug, diazepam.\u0000\u0000Material and Methods: Diabetes was induced intraperitoneally (i.p.) in Wistar male rats by streptozotocin (STZ 65 mg/kg). Four weeks thereafter, the rats received a two-week course of a daily dose of MIGU-4 (5.0 mg/kg or 25.0 mg/kg) or diazepam (0.5 mg/kg or 1.5 mg/kg). The electroretinogram (ERG) was obtained, the animals were euthanized and retinal malondialdehyde (MDA) levels and superoxide dismutase (SOD) and catalase (CAT) activity were determined.\u0000\u0000Results: In rats with untreated STZ-induced diabetes, the retinal MDA level was 3.71 times increased and CAT activity was 35% lower, compared to controls, whereas the SOD activity was half of the activity found in controls (р less 0.05). In diabetic animals treated with MIGU-4 i.p. at a 25.0-mg/kg daily dose, the retinal MDA level was 63.2% lower, whereas the CAT activity and SOD activity were 41.9% and 27.6%, respectively, higher, than in untreated diabetic rats (р less 0.05). In diabetic animals treated with diazepam i.p. at a 1.5-mg/kg daily dose, the retinal MDA level was 59.2% lower, whereas the CAT activity and SOD activity were 44.4% and 32.1%, respectively, higher, than in untreated diabetic rats (р less 0.05). In untreated diabetic rats, the ERG b-wave amplitude was 39.2% lower, ERG a-wave and b-wave latencies, 23.4% and 14.0%, respectively, higher, and the a-wave amplitude recovery rate, 38.8% lower than in controls (р less 0.05). The use of a 25.0-mg/kg daily dose of MIGU-4 resulted in a 29.7% and 33.9%, respectively, increase in the ERG b-wave amplitude and the a-wave amplitude recovery rate compared to untreated diabetic rats (р less 0.05). The use of a 1.5-mg/kg daily dose of diazepam resulted in a 25.0% and 30.0%, respectively, increase in the above ERG parameters compared to untreated diabetic rats (р less 0.05). In untreated diabetic rats, the number of squares crossed (SK) was 29.4% lower (р less 0.05); the number of central squares crossed (CSC), 52.1% lower (р less 0.05); the number of upright postures (UP), 34.2% lower; and the defecation bolus number, 32.4% higher than in controls (р less 0.05). After MIGU-4 (25-mg/kg) withdrawal, there were no more differences in SK, CSC, UP and defecation bolus numbers between treated diabetic rats and controls. In addition, the number of CSC was 4.27 times lower than in controls, and half of that in untreated diabetic animals (р less 0.05). In diabetic rats treated with dia","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43566724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}