Oftalmologicheskii zhurnal最新文献

{"title":"Detecting diabetic retinopathy using an artificial intelligence-based software platform: a pilot study","authors":"A. Nevska, O. A. Pohosian, K. O. Goncharuk, D. F. Sofyna, O. O. Chernenko, K. M. Tronko, N. I. Kozhan, A. Korol","doi":"10.31288/oftalmolzh202412731","DOIUrl":"https://doi.org/10.31288/oftalmolzh202412731","url":null,"abstract":"","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":"190 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140437788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tear lactoferrin and ceruloplasmin levels in patients with traumatic and recurrent corneal erosions","authors":"I. Gavrylyak, Dmytro Zhaboiedov, N. Greben, Artem Tykhomyrov","doi":"10.31288/oftalmolzh20241814","DOIUrl":"https://doi.org/10.31288/oftalmolzh20241814","url":null,"abstract":"level increased and the tear Cp level decreased to the levels in controls, and there was a negative correlation between the tear Lf level and the tear Cp level (r = -0.491, p < 0.001). Conclusion: The results confirmed the feasibility of utlizing Lf-containing eye drops as an adjunct in the treatment of TCE and RCE. This approach contributed to the restoration of ocular surface homeostasis, thus promoting corneal epithelialization and enabling a reduction in treatment duration.","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140436834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of TLR4 rs1927911 polymorphism with diabetic retinopathy and diabetic macular edema in type 2 diabetic patients","authors":"S. Rykov, Ie. P. Galytska, D. V. Zhmuryk, V. A. Dufynets","doi":"10.31288/oftalmolzh202412026","DOIUrl":"https://doi.org/10.31288/oftalmolzh202412026","url":null,"abstract":"","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":"2 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140436993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in visual abnormalities after endonasal endoscopic surgery for giant pituitary adenoma with extension to the ventricular system","authors":"K. Iegorova, O.V. Ukrainets, Mykola O. Guk","doi":"10.31288/oftalmolzh202416166","DOIUrl":"https://doi.org/10.31288/oftalmolzh202416166","url":null,"abstract":"","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":"33 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140435755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal changes as evidenced by fundoscopy and their frequencies in patients with COVID-19 with different variants of the angiotensin-converting enzyme gene","authors":"K. M. Hutsaliuk, Z. I. Rossokha, N. Skalska, N. Ulianova","doi":"10.31288/oftalmolzh202415460","DOIUrl":"https://doi.org/10.31288/oftalmolzh202415460","url":null,"abstract":"","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":"16 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140435355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for the progression of age-related macular degeneration in patients of the Ukrainian population","authors":"Sergiy Mogilevskyy, Tetiana Zavgorodnia","doi":"10.31288/oftalmolzh202413743","DOIUrl":"https://doi.org/10.31288/oftalmolzh202413743","url":null,"abstract":"","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":"59 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140436935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of vitreous angiopoietin-2 levels in rhegmatogenous retinal detachment on the macular microvascular bed","authors":"I. Bezkorovaina, A. Ivanchenko","doi":"10.31288/oftalmolzh202413236","DOIUrl":"https://doi.org/10.31288/oftalmolzh202413236","url":null,"abstract":"Background: Our previous optical coherent tomography angiography (OCTA) study of rhegmatogenous retinal detachment (RRD) treatment has found an impaired retinal microvascular bed over a 12-month postoperative follow-up and warranted for the study of vitreous angiopoietin (Ang)-2 levels as a vascular destabilizing factor in patients treated for RRD. Purpose: To assess vitreous Ang-2 levels in patients with primary RRD and their association with OCTA-based changes in the macular microvascular bed in patients with RRD. Material and Methods: Eighty-seven patients with primary RRD were involved in the study and divided into two groups depending of the state of the macula: patients that underwent surgery for macular-on RRD (group 1) and those that underwent surgery for macular-off RRD (group 2). All patients had their vitreous samples taken and underwent subtotal posterior vitrectomy. Concentrations of Ang-2 in these samples were measured by an enzyme-linked immunosorbent assay (ELISA) kit (Human Angiopoietin-2 ELISA Kit, Thermo Fisher SCIENTIFIC, Rockford, IL, USA) in accordance with the manufacturer’s protocol. We assessed correlations of vitreous Ang-2 levels and OCTA-based parameters in patients. Results: At the preoperative vitreous Ang-2 level of 129.7 ± 51.99 pg/ml in group 1, there was a strong correlation of preoperative OCTA-based foveal avascular zone (FAZ) area, parafoveal deep capillary plexus density (PDCPD) and foveal deep capillary plexus density (FDCPD) with vitreous Ang-2 levels over the study period for group 1. At the preoperative vitreous Ang-2 level of 693.8 ± 634.7 pg/ml in group 2, there was a strong correlation of OCTA-based FAZ area, FDCPD, and PDCPD with vitreous Ang-2 levels at baseline and 12 months, and a moderate direct correlation of OCTA-based FAZ area, FDCPD, and PDCPD with vitreous Ang-2 levels at months 3 and 6. Conclusion: Vitreous Ang-2 levels were significantly lower in macula-on RRD eyes than in macula-off RRD eyes (129.7 ± 51.99 pg/ml versus 693.8 ± 634.7 pg/ml, p < 0.001). There was a strong direct correlation (p < 0.05) of Ang-2 with OCTA-based characteristics of the retinal microvascular bed (FAZ area, PDCPD and FDCPD) for both groups, which indirectly indicates the effect of the vascular destabilizing factor on the postoperative best-corrected visual acuity.","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":"34 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140435262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil activation marker CD15+ as a prognostic factor of ocular surface damage in type 2 diabetics","authors":"T. Zhmud, G. Drozhzhyna, L. Velychko","doi":"10.31288/oftalmolzh202411519","DOIUrl":"https://doi.org/10.31288/oftalmolzh202411519","url":null,"abstract":"Purpose: To evaluate the prognostic value of the neutrophil activation marker CD15+ in ocular surface damage in type 2 diabetics. Material and Methods: This study was conducted from January 2021 to January 2021 at the Pirogov Vinnytsia Regional Clinical Hospital, the clinical site of the Medical University. A total of 60 type 2 diabetics (120 eyes) were enrolled, with an average age of 62.1 ± 5.24 years. Results: The prognostic value of the percentage expression of CD15+ in ocular surface damage in type 2 diabetics was for the first time evaluated. A rather high sensitivity of the percentage expression of CD15 (88.3%) allows using it as a parameter for screening for the presence of ocular surface damage in type 2 diabetics. Type 2 diabetics with a percentage of >27% of CD15+ cells had 10.52 times increased odds of ocular surface damage (95%CI, 4.34–25.50; p < 0.0001), and this value of the percentage of CD15+ cells can be used for the purpose of screening for ocular surface damage with a sensitivity of 88.3% (95% СІ, 77.8-94.2) and specificity of 63.3% (95% СІ, 50.7-74","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":"23 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140435386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytologic features of the bulbar conjunctiva in patients with primary open-angle glaucoma-associated dry eye disease","authors":"Т.М. Жмудь, Владислав Тетарчук, Ольга Олександрівна Андрушкова, Алла Василівна Демчук, Катерина Юріївна Гріжимальська, Світлана Петрівна Веретельник","doi":"10.31288/oftalmolzh2023438","DOIUrl":"https://doi.org/10.31288/oftalmolzh2023438","url":null,"abstract":"Purpose: To examine the features of the bulbar conjunctiva in patients who developed dry-eye disease (DED) after drug treatment for primary open-angle glaucoma (POAG).\u0000\u0000Methods: Impression cytology was performed by applying twice a strip of cellulose acetate filter to the ocular surface to remove the superficial epithelial layers of the temporal bulbar conjunctiva. The strips were removed with a peeling motion in a few seconds, and the samples were immediately fixed in 95% ethyl alcohol, stained with hematoxylin and eosin, mounted on glass slides and coverslipped for light microscopy. Squamous metaplasia was graded according to Nelson’s grading system on the basis of cell morphology, staining and integrity as well as the nucleus-to-cytoplasm ratio. This study included a case group of 80 patients (mean age, 63.8 +- 6.7 years) with POAG-associated DED, with the group being divided into four subgroups. Subgroups 1 and 2 were composed of 40 patients each, with glaucoma duration of less or more than 5 years, respectively. Subgroups a and b were composed of 40 patients each, with a number of topical ocular hypotensive drugs used equal to one or at least two, respectively. The control group was composed of 20 apparently healthy volunteers (mean age, 67.9 +- 8.9 years). All patients underwent a routine eye examination.\u0000\u0000Results: All patients with glaucoma had symptoms of DED with Ocular Surface Disease Index (OSDI) scores of at least 15. In subgroup 1, 60% had Nelson’s grade 1 and 40%, Nelson’s grade 2 squamous metaplasia. In subgroup 2, 10% had Nelson’s grade 1; 60%, Nelson’s grade 2 and 30%, Nelson’s grade 3 squamous metaplasia. In subgroup a, 20% had Nelson’s grade 1; 60%, Nelson’s grade 2 and 30%, Nelson’s grade 3 squamous metaplasia. In subgroup b, 10% had Nelson’s grade 1; 60%, Nelson’s grade 2 and 30%, Nelson’s grade 3 squamous metaplasia.\u0000\u0000Conclusion: Changes in the bulbar conjunctival epithelium corresponded to Nelson’s grade 2 or 3 squamous metaplasia in 80% of patients who developed DED after drug treatment for POAG. The severity of squamous metaplasia correlated with the duration of glaucoma and, consequently, longer use of hypotensive eye drops (r1 = 0.15, p1 = 0.02, p2 = 0.01). Findings of the current study and international guidelines argue for the use of the medications containing no preservatives or potentially toxic components in long-term therapy against glaucoma.","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48510714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal energy state in rats with experimental diabetes and axial myopia","authors":"І.М. Михейцева, Ахмед Амаієд, Сергій Коломійчук","doi":"10.31288/oftalmolzh202346166","DOIUrl":"https://doi.org/10.31288/oftalmolzh202346166","url":null,"abstract":"Background: Elucidating the pathogenesis of diabetic retinopathy (DR) for further development of methods of treatment and prevention of the disease is an important medical and social task for ophthalmologists. The development of DR in the presence of myopia has some special features. In the presence of myopia, the diabetic complications in the retina are less severe than in emmetropia. The mechanisms of this paradoxical impact of eye myopization on the severity of these complications are, however, still unknown.\u0000\u0000Purpose: To examine the state of retinal energy metabolism based on evaluation of biochemical markers of mitochondrial function (lactate, pyruvate, adenosine triphosphate (ATP) and adenosine diphosphate (ADP) levels and succinate dehydrogenase activity) in rats with streptozotocin (STZ)-induced diabetes that developed in the presence of axial myopia, compared to rats with diabetes alone and those with myopia alone.\u0000\u0000Material and Methods: High axial myopia was produced in two-week animals by surgically fusing the eyelids of both eyes and maintaining these animals under conditions of reduced illumination for two weeks. A 15 mg/kg intraperitoneal streptozotocin injection for 5 days was used for inducing diabetes mellitus in rats with induced axial myopia and intact rats. Animals in the control group were maintained under conditions of natural illumination. In two months, all rats were euthanized under anesthesia, and their eyes were enucleated. ATP, ADP, lactate, and pyruvate levels were measured in blood and retinal specimens and ATP/ADP ratio and lactate/pyruvate ratio were determined. Succinate dehydrogenase activity was determined in isolated retinal mitochondria. For statistical analysis of biochemical results, Student’s t-test was conducted (Statistica software).\u0000\u0000Results: Rats with diabetes alone exhibited lower retinal and plasma energy metabolism characteristics (ATP, ADP, and succinate dehydrogenase activity), and developed retinal hypoxia, with retinal lactate and pyruvate levels being 1.838-fold and 1.455-fold higher, respectively, and their ratio, 26.5% higher, compared to controls. In animals with STZ-induced diabetes in the presence of axial hypoxia, retinal lactate and pyruvate levels were 20.2% and 15.5% lower, respectively, and their ratio was lower (36.5 versus 38.7), compared to rats with diabetes alone, indicating lower hypoxia in the setting of eye myopization. In addition, in rats with diabetes in the presence of axial hypoxia, plasma and retinal ATP levels were 21.8% and 21.2% higher, respectively, and retinal succinate dehydrogenase activity, 20.8% higher, compared to rats with diabetes alone.\u0000\u0000Conclusion: In experimental diabetes, an increase in the axial length of the eye (i.e., eye myopization) is accompanied by activation of energy processes and the development of hypoxia adaptation in retinal cells.","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45153253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}