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Mechanical determinants of chromatin topology and gene expression 染色质拓扑结构和基因表达的机械决定因素
IF 3.7 3区 生物学
Nucleus Pub Date : 2022-02-27 DOI: 10.1080/19491034.2022.2038868
R. Jha, D. Levens, Fedor Kouzine
{"title":"Mechanical determinants of chromatin topology and gene expression","authors":"R. Jha, D. Levens, Fedor Kouzine","doi":"10.1080/19491034.2022.2038868","DOIUrl":"https://doi.org/10.1080/19491034.2022.2038868","url":null,"abstract":"ABSTRACT The compaction of linear DNA into micrometer-sized nuclear boundaries involves the establishment of specific three-dimensional (3D) DNA structures complexed with histone proteins that form chromatin. The resulting structures modulate essential nuclear processes such as transcription, replication, and repair to facilitate or impede their multi-step progression and these contribute to dynamic modification of the 3D-genome organization. It is generally accepted that protein–protein and protein–DNA interactions form the basis of 3D-genome organization. However, the constant generation of mechanical forces, torques, and other stresses produced by various proteins translocating along DNA could be playing a larger role in genome organization than currently appreciated. Clearly, a thorough understanding of the mechanical determinants imposed by DNA transactions on the 3D organization of the genome is required. We provide here an overview of our current knowledge and highlight the importance of DNA and chromatin mechanics in gene expression.","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2022-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74343377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Development of Predict-Observe-Explain (POE)-Based Physics Module by Utilizing QR Code and YouTube Learning Videos 利用二维码和YouTube学习视频开发基于预测-观察-解释(POE)的物理模块
IF 3.7 3区 生物学
Nucleus Pub Date : 2021-11-30 DOI: 10.37010/nuc.v2i2.447
Rahman Sidik, N. N. Mulyaningsih, I. A. D. Astuti
{"title":"Development of Predict-Observe-Explain (POE)-Based Physics Module by Utilizing QR Code and YouTube Learning Videos","authors":"Rahman Sidik, N. N. Mulyaningsih, I. A. D. Astuti","doi":"10.37010/nuc.v2i2.447","DOIUrl":"https://doi.org/10.37010/nuc.v2i2.447","url":null,"abstract":"Most of the students stated that studying Physics using relatively thick textbooks tended to be boring. This has an impact on unsatisfactory learning outcomes. The purpose of this research is to develop a product in the form of a module that is compiled using the Predict-Observe-Explain (POE) learning model with a combination of learning videos from YouTube, and analyze the feasibility level. The research method used is by making a module on temperature and heat material, which includes learning videos in the form of a QR code that can be scanned via a smartphone. The parameters analyzed include the results of the validation of experts who include material experts, media experts, and linguists. Another parameter that was measured as the level of student interest in the module, with a sample of 10 students from SMAN 1 Dramaga, SMA Bumi Sejahtera, and SMA Hanura. The results showed that the assessments of material experts, media experts, and linguists respectively were 3.83, 3.32, and 3.47 with the criteria of \"very decent\". The attractiveness test results for SMAN 1 Dramaga, SMA Bumi Sejahtera, and SMA Hanura were 3.57, 3.36 with the criteria of \"very interesting\" and 3.03 with the criteria of \"attractive\". Thus, it is concluded that the POE-based physics module by utilizing the QR code and YouTube learning videos is very feasible to be used as a learning medium.","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78903145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Proposed Repair of Queues for Trucks Transporting TBS at PT Nirmala Agro Lestari's Weight Bridge with Promodel Software 使用Promodel软件修复PT Nirmala Agro Lestari重量桥运输TBS的卡车队列
IF 3.7 3区 生物学
Nucleus Pub Date : 2021-11-30 DOI: 10.37010/nuc.v2i2.629
Riri Cornellia
{"title":"Proposed Repair of Queues for Trucks Transporting TBS at PT Nirmala Agro Lestari's Weight Bridge with Promodel Software","authors":"Riri Cornellia","doi":"10.37010/nuc.v2i2.629","DOIUrl":"https://doi.org/10.37010/nuc.v2i2.629","url":null,"abstract":"Queue often causes some problems, one of which is inefficiency in time and expense. PT Nirmala Agro Lestari is endeavoring to optimize the line of TBS truck transports on weight bridge. If the queue at weight bridge PT Nirmala Agro Lestari is going on constantly will result in its slow delivery of TBS to the production area and affect the quality of production. To avoid this, companies conduct queue simulations in order to determine whether the queue system is efficient or should be implemented as an adjustment. PT Nirmala Agro Lestari has always been trying to reach consumer demand targets, with production capacity of 60 tons/hour. The study used the method of queue theory by creating a model of queue simulations based on actual conditions using the promodel. The data on this study is from the TBS transport queue to the weight bridge of PT Nirmala Agro Lestari. The simulation steps on this research was to design an optimum model of line simulation with promodel and test the proposed model for a line model by calculating the workload of TBS trucks. Model modifications are needed because there is still a queue of buildup in the TBS weight bridge loading process. At weight bridge at 90,95%, there is high activity at weight bridge because of the time of service and the frequency of trucks over at the high harvest time that gives trucks a long line of time to enter the production process. The addition of weight bridge to two units shows a utilisation drop on the entry road to the weight bridge from 71.34% to 22.82%, and 90,95% to 62.30%.","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82978392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rainfall Prediction Using Fuzzy Time Series 基于模糊时间序列的降雨预测
IF 3.7 3区 生物学
Nucleus Pub Date : 2021-11-30 DOI: 10.37010/nuc.v2i2.619
Adhi Susano, Wulan Anggraeni
{"title":"Rainfall Prediction Using Fuzzy Time Series","authors":"Adhi Susano, Wulan Anggraeni","doi":"10.37010/nuc.v2i2.619","DOIUrl":"https://doi.org/10.37010/nuc.v2i2.619","url":null,"abstract":"Flood is one of the problems faced by DKI Jakarta Province. To be able to reduce losses caused by flooding is to predict rainfall. The type of research is quantitative research using rainfall prediction method using Fuzzy Time Series (FTS) which was developed by Stevenson & Porter (2009). The data used is rainfall data at Kemayoran Station in the period January 2018 to December 2020. The prediction accuracy results state that the FTS method has poor accuracy so that improvements are needed in the formation of interval intervals.","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82717771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Implementation of a Filter Kalman Method Forecasting Rainfall Obtained Through Model ARIMA in Kota Jambi 基于滤波卡尔曼法预测ARIMA模式在哥打占比地区降雨的实现
IF 3.7 3区 生物学
Nucleus Pub Date : 2021-11-30 DOI: 10.37010/nuc.v2i2.607
Mellyani Aprilia, Nayla Desviona
{"title":"The Implementation of a Filter Kalman Method Forecasting Rainfall Obtained Through Model ARIMA in Kota Jambi","authors":"Mellyani Aprilia, Nayla Desviona","doi":"10.37010/nuc.v2i2.607","DOIUrl":"https://doi.org/10.37010/nuc.v2i2.607","url":null,"abstract":"In the last three years the climatic conditions in Jambi City have experienced erratic weather conditions. One way to predict rainfall is using the Kalman Filter approach. However, in this case, the Kalman Filter method is implemented on the forecasting results from ARIMA (Autoregressive Integrated Moving Average) because there has been rainfall measurement data from 2008 to 2017 at the BMKG Muaro Jambi Climatology Station which is also a function of time and the existing pattern will be described with using Time Series Analysis. Time series data is data that has a time series of more than one year on one object or data collected from time to time on one object. ARIMA model will be used to predict the next data. Kalman filter is a model part of state space that can be applied in forecasting models. The Kalman filter consists of a prediction stage and a correction stage. This method uses a recursive technique to integrate the latest observational data into the model to correct previous predictions and make further predictions. This study aims to determine the implementation of the kalman filter method in predicting rainfall obtained through the ARIMA model in Jambi City. The results of the 2018 Jambi City rainfall prediction research show that the best ARIMA model formed is the ARIMA model (1,0,1). In the Kalman Filter model, a MAPE value of 24.92% is obtained, which indicates that the Kalman Filter has a fairly good predictive ability.","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72482965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of the Success of the Personnel Management Information System at the Purwakarta District Attorney with the Delone and Mclean Method Delone和Mclean方法在普瓦卡塔地方检察官人事管理信息系统中的成功分析
IF 3.7 3区 生物学
Nucleus Pub Date : 2021-11-28 DOI: 10.37010/nuc.v2i2.442
D. Anggraeni, Rangga Sanjaya
{"title":"Analysis of the Success of the Personnel Management Information System at the Purwakarta District Attorney with the Delone and Mclean Method","authors":"D. Anggraeni, Rangga Sanjaya","doi":"10.37010/nuc.v2i2.442","DOIUrl":"https://doi.org/10.37010/nuc.v2i2.442","url":null,"abstract":"Management information system is an information provider system that is used to support the operating system in the process of returning certain decisions within an institution/organization. The application of technology in government agencies is needed to create an accountable, transparent and trustworthy government. The personnel management information system is a useful application for managing administrative data, based on the Decree of the Attorney General of the Republic of Indonesia Number: KEP-155/J.A/12/1997 concerning the operational organization of the management information system of the Indonesian Attorney General's Office. This study aims to determine the success rate of the personnel management system at the Purwakarta District Attorney's Office using the Delone and McLean information system success model. The variables used in this research are system quality, information quality, service quality and user satisfaction. This research is a type of descriptive analysis research that is used to interpret the data that has been processed quantitatively. Based on the results of the study, there is a successful implementation of the Personnel Management Information System (SIMPEG) using the Delone and Mclean method, the quality of information has a positive and significant impact on user satisfaction of the Personnel Management System (SIMPEG), with a significance value of 0.007 <0.05 and a t value of 2,838 > t table 2,021.","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2021-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76717817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analisis Perhitungan Metode MOORA dalam Pemilihan Lokasi Kedai Kopi 莫拉方法计算分析咖啡地点地点
IF 3.7 3区 生物学
Nucleus Pub Date : 2021-11-24 DOI: 10.37010/nuc.v2i2.448
Hamzah Robbani
{"title":"Analisis Perhitungan Metode MOORA dalam Pemilihan Lokasi Kedai Kopi","authors":"Hamzah Robbani","doi":"10.37010/nuc.v2i2.448","DOIUrl":"https://doi.org/10.37010/nuc.v2i2.448","url":null,"abstract":"Tujuan penelitian ini adalah untuk menentukan lokasi kedai kopi dengan metode MOORA. Desain penelitian yang digunakan adalah kuantitatif dengan pendekatan deskriptif, yaitu menganalisis satu variabel untuk dideskripsikan tanpa melakukan perbandingan dan mencarikan pengaruh dengan variabel lainya. teknik pengumpulan data yang dilakukan peneliti menggunakan pengukuran jarak antar pilihan lokasi, harga tanah, luas tanah, kepadatan lalu lintas, dan jalur angkutan. Hasil penelitian menunjukkan bahwa lokasi A3 menjadi pilihan paling efektif untuk membuka cabang baru.","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2021-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89339596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Production Chain of Black Pepper in Brazil 巴西黑胡椒生产链
IF 3.7 3区 生物学
Nucleus Pub Date : 2021-10-29 DOI: 10.3738/1982.2278.3826
W. K. O. Moreira, H. M. Beneduzzi, F. D. Alves, Silvia Renata Coelho Machado, Adriane Silva de Mendonça, Raimundo Thiago Lima da Silva
{"title":"Production Chain of Black Pepper in Brazil","authors":"W. K. O. Moreira, H. M. Beneduzzi, F. D. Alves, Silvia Renata Coelho Machado, Adriane Silva de Mendonça, Raimundo Thiago Lima da Silva","doi":"10.3738/1982.2278.3826","DOIUrl":"https://doi.org/10.3738/1982.2278.3826","url":null,"abstract":"The Brazilian trade balance shows positive surpluses every year, due to the strong performance of the Brazilian agribusiness, which has played a fundamental role in the country's economy. In view of the economic scenario the peppercorn culture has shown great importance in the Brazilian export market. Considered a commodity this has its transaction carried out through the stock exchange and oscillate through the world market. The present research aims to characterize the chain of black pepper production in the Brazilian scenario. The dynamics of pepper production chain in Brazil is established by its high added value in the product, basically its production is developed by family agriculture, where it shows its strong impact on the maintenance of labor in the field. The Brazilian productivity of black pepper is higher than the world average. However, the initial exploitation of black pepper requires high capital, besides presenting great variability in prices, even though it is a commodity. Being a demanding crop in nutrients and highly susceptible to fusariosis, it is essential to develop alternative exploitation, which can be consortium exploitation, in SAF, besides the technical assistance and organization of producers, to realize sales with volumes and quality in the processing (drying and cleaning) and production of differentiated products, such as white pepper, which has the highest final product value.","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77902605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PONTAS DE PULVERIZAÇÃO E DIFERENTES HORÁRIOS NOS PARÂMETROS TÉCNICOS DA TECNOLOGIA DE APLICAÇÃO 喷头和不同时间的技术参数的应用工艺
IF 3.7 3区 生物学
Nucleus Pub Date : 2021-10-29 DOI: 10.3738/1982.2278.3817
Gabriela Rodrigues Monteiro, Lucas Bernardino Martins Sales Brito, Jackeline Matos Nascimento, Sálvio Napoleão Soares Arcoverde
{"title":"PONTAS DE PULVERIZAÇÃO E DIFERENTES HORÁRIOS NOS PARÂMETROS TÉCNICOS DA TECNOLOGIA DE APLICAÇÃO","authors":"Gabriela Rodrigues Monteiro, Lucas Bernardino Martins Sales Brito, Jackeline Matos Nascimento, Sálvio Napoleão Soares Arcoverde","doi":"10.3738/1982.2278.3817","DOIUrl":"https://doi.org/10.3738/1982.2278.3817","url":null,"abstract":"Este trabalho teve como objetivo avaliar a eficiencia de aplicacao em quatro horarios do dia e dois modelos de pontas de pulverizacao. O ensaio foi conduzido em Dourados-MS, avaliando duas diferentes pontas de pulverizacao (Leque Simples -JSF 110.02, Leque Duplo - JTT 110.02) em quatro horarios (13:00, 14:00, 15:00 e 17:00 h) com pulverizador tratorizado Modelo PJ 401. Para avaliacao de parâmetros de tecnologia de aplicacao foram utilizados papeis hidrosensiveis, apos as aplicacoes os papeis foram armazenados e posteriormente digitalizados com resolucao de 300 dpi com o programa DropScan, determinando-se o diâmetro da mediana volumetrica (DMV), a porcentagem de cobertura (%), a densidade de gotas, o coeficiente de dispersao, a amplitude e o diâmetro da mediana numerica (DMN). Os melhores resultados para estes parâmetros ocorreram quando a aplicacao foi realizada as 17:00 h, enquanto a ponta Leque Duplo (JTTT 110.02) mostrou-se mais eficiente nos parâmetros de amplitude, coeficiente de dispersao e diâmetro da mediana volumetrica, em contrapartida a ponta leque simples (JSF-110.02) mostrou desempenho superior nos parâmetros de porcentagem de cobertura, amplitude e diâmetro da mediana numerica.","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84908871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DIAGNÓSTICO AMBIENTAL DE UMA INDÚSTRIA DE GRANDE PORTE DE PRODUTOS DE LIMPEZA E HIGIENE 大型清洁卫生产品行业的环境诊断
IF 3.7 3区 生物学
Nucleus Pub Date : 2021-10-29 DOI: 10.3738/1982.2278.3943
Lucas Araújo De Almeida, Wyara Cordeiro Valença Herculano, Camila Campêlo de Sousa
{"title":"DIAGNÓSTICO AMBIENTAL DE UMA INDÚSTRIA DE GRANDE PORTE DE PRODUTOS DE LIMPEZA E HIGIENE","authors":"Lucas Araújo De Almeida, Wyara Cordeiro Valença Herculano, Camila Campêlo de Sousa","doi":"10.3738/1982.2278.3943","DOIUrl":"https://doi.org/10.3738/1982.2278.3943","url":null,"abstract":"As atividades industriais realizadas pelo homem para desenvolvimento de tecnologias que supram suas necessidades produzem impactos positivos e/ou negativos no ambiente. Considerando os possiveis riscos e prejuizos a natureza ocasionados pelo processo industrial, o objetivo geral do presente estudo foi realizar um diagnostico ambiental em uma industria de grande porte de produtos de limpeza e higiene, localizada na cidade de Codo (MA). Para a realizacao deste estudo, visitou-se o empreendimento a fim de conhecer seu sistema produtivo, os principais residuos gerados, as medidas compensatorias e mitigadoras e o setor onde e realizada a reciclagem. Com os dados obtidos, elaborou-se uma matriz de atividade-aspecto-impacto ambiental. O empreendimento estudado tem como atividade economica a fabricacao de produtos de limpeza, higiene, materiais descartaveis, oleo lubrificante e velas. Os resultados encontrados foram: i) quanto a poluicao do solo: nao possui aterro industrial adequado, realizando-se o despejo de residuos em aterro controlado e como principal mitigacao realiza o processo de reciclagem do polietileno de alta densidade; ii) quanto aos recursos hidricos: sao utilizados em abundância e como medida compensatoria a empresa possui uma estacao de tratamento de efluentes, realizando o reciclo da agua; iii) quanto a poluicao atmosferica: apresenta tecnologias de controle e filtracao dos gases gerados e iv) quanto aos impactos sociais: tem-se a geracao de renda e emprego no municipio. Pode-se constatar que mesmo com algumas limitacoes, o empreendimento atende as exigencias de mitigacoes propostas pelos orgaos competentes.","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77678187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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