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Multifaceted roles of SUMO in DNA metabolism SUMO 在 DNA 代谢中的多方面作用
IF 3.7 3区 生物学
Nucleus Pub Date : 2024-09-17 DOI: 10.1080/19491034.2024.2398450
Yee Mon Thu
{"title":"Multifaceted roles of SUMO in DNA metabolism","authors":"Yee Mon Thu","doi":"10.1080/19491034.2024.2398450","DOIUrl":"https://doi.org/10.1080/19491034.2024.2398450","url":null,"abstract":"Sumoylation, a process in which SUMO (small ubiquitin like modifier) is conjugated to target proteins, emerges as a post-translational modification that mediates protein−protein interactions, prote...","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":"47 1","pages":"2398450"},"PeriodicalIF":3.7,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142261520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deciphering the intrinsically disordered characteristics of the FG-Nups through the lens of polymer physics. 从聚合物物理学的角度解读 FG-Nups 固有的无序特性。
IF 3.7 3区 生物学
Nucleus Pub Date : 2024-09-16 DOI: 10.1080/19491034.2024.2399247
Atsushi Matsuda,Abdullah Mansour,Mohammad R K Mofrad
{"title":"Deciphering the intrinsically disordered characteristics of the FG-Nups through the lens of polymer physics.","authors":"Atsushi Matsuda,Abdullah Mansour,Mohammad R K Mofrad","doi":"10.1080/19491034.2024.2399247","DOIUrl":"https://doi.org/10.1080/19491034.2024.2399247","url":null,"abstract":"The nuclear pore complex (NPC) is a critical gateway regulating molecular transport between the nucleus and cytoplasm. It allows small molecules to pass freely, while larger molecules require nuclear transport receptors to traverse the barrier. This selective permeability is maintained by phenylalanine-glycine-rich nucleoporins (FG-Nups), intrinsically disordered proteins that fill the NPC's central channel. The disordered and flexible nature of FG-Nups complicates their spatial characterization with conventional structural biology techniques. To address this challenge, polymer physics offers a valuable framework for describing FG-Nup behavior, reducing their complex structures to a few key parameters. In this review, we explore how polymer physics models FG-Nups using these parameters and discuss experimental efforts to quantify them in various contexts, providing insights into the conformational properties of FG-Nups.","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":"10 1","pages":"2399247"},"PeriodicalIF":3.7,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142261523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nuclear bodies: concentrating at an aqueous site, with momentum. 核体：在水体中集中，具有动量。
IF 3.7 3区 生物学
Nucleus Pub Date : 2024-09-16 DOI: 10.1080/19491034.2024.2404677
Ling-Ling Chen,Erica Larschan,A Gregory Matera,Amy Strom,Thoru Pederson
{"title":"Nuclear bodies: concentrating at an aqueous site, with momentum.","authors":"Ling-Ling Chen,Erica Larschan,A Gregory Matera,Amy Strom,Thoru Pederson","doi":"10.1080/19491034.2024.2404677","DOIUrl":"https://doi.org/10.1080/19491034.2024.2404677","url":null,"abstract":"The second FASEB conference on Nuclear Bodies: Hubs of Genome Activity was held June 2-7, 2024, at Niagara Falls, NY. The central theme was how these protein and RNA-protein complexes that are situated in the nucleus outside the genome support and regulate gene expression. Topics included their relevance to disease, especially cancer, their molecular dynamics, and their phase separation transition properties. The meeting included numerous trainees as speakers and session chairs, hosted a memorable Keynote talk on diversity, and a vibrant career development session.","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":"18 1","pages":"2404677"},"PeriodicalIF":3.7,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142261521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nuclear bodies: a gene expression collection for our time 核体：我们时代的基因表达集
IF 3.7 3区 生物学
Nucleus Pub Date : 2024-04-14 DOI: 10.1080/19491034.2024.2339580
Thoru Pederson
{"title":"Nuclear bodies: a gene expression collection for our time","authors":"Thoru Pederson","doi":"10.1080/19491034.2024.2339580","DOIUrl":"https://doi.org/10.1080/19491034.2024.2339580","url":null,"abstract":"Published in Nucleus (Vol. 15, No. 1, 2024)","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":"301 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140603409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A lineage-specific protein network at the trypanosome nuclear envelope 锥虫核膜上的品系特异性蛋白质网络
IF 3.7 3区 生物学
Nucleus Pub Date : 2024-04-11 DOI: 10.1080/19491034.2024.2310452
Erin R. Butterfield, Samson O. Obado, Simon R. Scutts, Wenzhu Zhang, Brian T. Chait, Michael P. Rout, Mark C. Field
{"title":"A lineage-specific protein network at the trypanosome nuclear envelope","authors":"Erin R. Butterfield, Samson O. Obado, Simon R. Scutts, Wenzhu Zhang, Brian T. Chait, Michael P. Rout, Mark C. Field","doi":"10.1080/19491034.2024.2310452","DOIUrl":"https://doi.org/10.1080/19491034.2024.2310452","url":null,"abstract":"The nuclear envelope (NE) separates translation and transcription and is the location of multiple functions, including chromatin organization and nucleocytoplasmic transport. The molecular basis fo...","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":"164 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140589161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developmental changes in nuclear lamina components during germ cell differentiation 生殖细胞分化过程中核薄层成分的发育变化
IF 3.7 3区 生物学
Nucleus Pub Date : 2024-04-10 DOI: 10.1080/19491034.2024.2339214
Isabella E. Perales, Samuel D. Jones, Katherine M. Piaszynski, Pamela K. Geyer
{"title":"Developmental changes in nuclear lamina components during germ cell differentiation","authors":"Isabella E. Perales, Samuel D. Jones, Katherine M. Piaszynski, Pamela K. Geyer","doi":"10.1080/19491034.2024.2339214","DOIUrl":"https://doi.org/10.1080/19491034.2024.2339214","url":null,"abstract":"The nuclear lamina (NL) changes composition for regulation of nuclear events. We investigated changes that occur in Drosophila oogenesis, revealing switches in NL composition during germ cell diffe...","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":"51 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140602752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Running the gauntlet: challenges to genome integrity in spermiogenesis 精子发生过程中基因组完整性面临的挑战
IF 3.7 3区 生物学
Nucleus Pub Date : 2024-04-09 DOI: 10.1080/19491034.2024.2339220
Maiko Kitaoka, Yukiko M. Yamashita
{"title":"Running the gauntlet: challenges to genome integrity in spermiogenesis","authors":"Maiko Kitaoka, Yukiko M. Yamashita","doi":"10.1080/19491034.2024.2339220","DOIUrl":"https://doi.org/10.1080/19491034.2024.2339220","url":null,"abstract":"Species’ continuity depends on gametogenesis to produce the only cell types that can transmit genetic information across generations. Spermiogenesis, which encompasses post-meiotic, haploid stages ...","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":"5 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140589581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nuclear actin filaments – a historical perspective 核肌动蛋白丝--历史视角
IF 3.7 3区 生物学
Nucleus Pub Date : 2024-02-21 DOI: 10.1080/19491034.2024.2320656
Maria Kristha Fernandez, Molika Sinha, Mia Zidan, Malte Renz
{"title":"Nuclear actin filaments – a historical perspective","authors":"Maria Kristha Fernandez, Molika Sinha, Mia Zidan, Malte Renz","doi":"10.1080/19491034.2024.2320656","DOIUrl":"https://doi.org/10.1080/19491034.2024.2320656","url":null,"abstract":"The view on nuclear filaments formed by non-skeletal β-actin has significantly changed over the decades. Initially, filamentous actin was observed in amphibian oocyte nuclei and only under specific...","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":"72 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139922420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The genome in space and time comes of age 时空基因组时代来临
IF 3.7 3区 生物学
Nucleus Pub Date : 2024-02-01 DOI: 10.1080/19491034.2024.2307665
Martin Rey-Millet, Kerstin Bystricky, the International Nucleome Consortium
{"title":"The genome in space and time comes of age","authors":"Martin Rey-Millet, Kerstin Bystricky, the International Nucleome Consortium","doi":"10.1080/19491034.2024.2307665","DOIUrl":"https://doi.org/10.1080/19491034.2024.2307665","url":null,"abstract":"DNA sequencing is not enough to grasp the complexity of genome organization and function. The four-dimensional (three in space, one in time) configuration of the eukaryotic nucleus varies with cell...","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":"37 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139668942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histone locus bodies: a paradigm for how nuclear biomolecular condensates control cell cycle regulated gene expression 组蛋白基因座体：核生物分子凝聚体控制细胞周期调控基因表达的范例
IF 3.7 3区 生物学
Nucleus Pub Date : 2023-12-14 DOI: 10.1080/19491034.2023.2293604
Mark S. Geisler, James P. Kemp Jr., Robert J. Duronio
{"title":"Histone locus bodies: a paradigm for how nuclear biomolecular condensates control cell cycle regulated gene expression","authors":"Mark S. Geisler, James P. Kemp Jr., Robert J. Duronio","doi":"10.1080/19491034.2023.2293604","DOIUrl":"https://doi.org/10.1080/19491034.2023.2293604","url":null,"abstract":"Histone locus bodies (HLBs) are biomolecular condensates that assemble at replication-dependent (RD) histone genes in animal cells. These genes produce unique mRNAs that are not polyadenylated and ...","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":"9 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138629326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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