The genome in space and time comes of age

IF 2.7 3区生物学 Q3 CELL BIOLOGY

Nucleus Pub Date : 2024-02-01 DOI:10.1080/19491034.2024.2307665

Martin Rey-Millet, Kerstin Bystricky, the International Nucleome Consortium

引用次数: 0

Abstract

DNA sequencing is not enough to grasp the complexity of genome organization and function. The four-dimensional (three in space, one in time) configuration of the eukaryotic nucleus varies with cell...

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时空基因组时代来临

要了解基因组组织和功能的复杂性，仅靠DNA测序是不够的。真核生物细胞核的四维（空间三维，时间一维）构型随细胞的不同而变化...

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nucleus CELL BIOLOGY-

CiteScore

5.60

自引率

5.40%

发文量

审稿时长

13 weeks

期刊介绍： Nucleus is a fully open access peer-reviewed journal. All articles will (if accepted) be available for anyone to read anywhere, at any time immediately on publication. Aims & Scope: The eukaryotic cell nucleus is more than a storage organelle for genomic DNA. It is involved in critical steps of cell signaling and gene regulation, as well as the maintenance of genome stability, including DNA replication and DNA damage repair. These activities heavily depend on the spatial and temporal “functional” organization of the nucleus and its integration into the complex meshwork of cellular scaffolding. Nucleus provides a platform for presenting and discussing cutting-edge research on all aspects of biology of the cell nucleus. It brings together a multidisciplinary community of scientists working in the areas of: • Nuclear structure and dynamics • Subnuclear organelles • Chromatin organization • Nuclear transport • DNA replication and DNA damage repair • Gene expression and RNA processing • Nucleus in signaling and development Nucleus offers a variety of paper formats including: • Original Research articles • Short Reports • Reviews • Commentaries • Extra Views • Methods manuscripts.