Nouvelle revue francaise d'hematologie最新文献_第3页

St14 (DXS52) VNTR in the Chinese population and its application to genetic diagnosis of haemophilia A. 中国人群St14 (DXS52) VNTR及其在血友病A遗传诊断中的应用

Nouvelle revue francaise d'hematologie Pub Date : 1995-01-01

X Wang, X Chu, C Ruan

引用次数: 0

Cardiac localization of non-Hodgkin's lymphoma: two case reports and review of the literature. 非霍奇金淋巴瘤的心脏定位:两例报告和文献回顾。

Nouvelle revue francaise d'hematologie Pub Date : 1995-01-01

B Delmas-Marsalet, V Molinie, L Jary, F Teillet-Thiebaud, P Estagnasie, J Barge, F Teillet

{"title":"Cardiac localization of non-Hodgkin's lymphoma: two case reports and review of the literature.","authors":"B Delmas-Marsalet, V Molinie, L Jary, F Teillet-Thiebaud, P Estagnasie, J Barge, F Teillet","doi":"","DOIUrl":"","url":null,"abstract":"Secondary non-Hodgkin's lymphoma of the heart (SNHLH) are more frequent than primitive non-Hodgkin's lymphoma and represent the third most common malignant tumour of the heart in autopsy studies. Cardiac involvement usually occurs as a late manifestation in patients with disseminated disease. Initial cardiac lymphoma, defined as cardiac involvement at initial diagnosis with concomitant extracardiac localizations, have nevertheless been reported in approximately 42 cases. The present paper concerns two patients with non-Hodgkin's B-cell lymphoma where cardiac involvement occurring 3 and 6 years after initial diagnosis constituted the unique site of relapse. These cases differ from previous reports of the literature by the predominance of extranodal localizations at initial diagnosis and the late onset of cardiac involvement. Clinical and radiological findings were otherwise in accordance with those usually described in such patients. Transthoracic echocardiography revealed the cardiac tumour in the first case, but in the second case transoesophageal echocardiography and magnetic resonance imaging (MRI) were required to demonstrate its presence. As in most reports, the site of tumour involvement was the right cardiac cavity and histology showed high grade B-cell non-Hodgkin's lymphoma. Polychemotherapy, associated with radiotherapy in the second case, led to partial or complete remission of the cardiac tumour without recurrence within the months of follow-up, although both patients died of their disease within one year.","PeriodicalId":19366,"journal":{"name":"Nouvelle revue francaise d'hematologie","volume":"37 4","pages":"223-30"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19868439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abnormal chromatin clumping in granulocytes in a case of Ph1-negative, BCR-ABL rearrangement positive, haematologically atypical chronic myeloid leukaemia (CML). 1例ph1阴性，BCR-ABL重排阳性，血液学不典型慢性髓性白血病(CML)的粒细胞异常染色质聚集。

Nouvelle revue francaise d'hematologie Pub Date : 1995-01-01

G Tertian, M Misrahi, D Diallo, F Mielot, C Leonard, S Salmeron, G Tchernia

引用次数: 0

[Delayed autologous transfusion and erythropoietin]. 延迟自体输血和促红细胞生成素。

Nouvelle revue francaise d'hematologie Pub Date : 1995-01-01

J F Baron

引用次数: 0

[Definition of a target population for utilization of recombinant erythropoietin with a view to taking of delayed autologous blood]. [利用重组红细胞生成素以取延迟自体血的目标人群的定义]。

Nouvelle revue francaise d'hematologie Pub Date : 1995-01-01

J J Fournel

引用次数: 0

[Role of autologous transfusion in economy measures for blood in surgery]. 外科手术中自体输血在节约用血措施中的作用。

Nouvelle revue francaise d'hematologie Pub Date : 1995-01-01

G Janvier, N Bénillan, C Roth

引用次数: 0

Biochemical and molecular basis of Bernard-Soulier syndrome: a review. Bernard-Soulier综合征的生化和分子基础研究进展。

Nouvelle revue francaise d'hematologie Pub Date : 1995-01-01

C de la Salle, F Lanza, J P Cazenave

{"title":"Biochemical and molecular basis of Bernard-Soulier syndrome: a review.","authors":"C de la Salle, F Lanza, J P Cazenave","doi":"","DOIUrl":"","url":null,"abstract":"Bernard-Soulier syndrome (BSS) is a rare hereditary recessive autosomal bleeding disorder characterized by a prolonged bleeding time, giant platelets, thrombocytopenia, normal platelet aggregation in response to ADP and no agglutination in response to ristocetin. This disease is due to absence or abnormality of the platelet membrane glycoprotein GPIb-IX-V, the receptor for von Willebrand factor. All four genes encoding the complex have been cloned and 17 forms of BSS have to date been characterized at the functional, immunological and molecular levels. The mutations can be divided into two main groups. Firstly, mutations located in leucine rich repeats (LRR), responsible for conformational modifications of the molecule, in some cases higher sensitivity to proteases and loss of adhesive function of the receptor, which is expressed at lower than normal levels at the platelet membrane. When mutations affect the LRR of GPIbalpha, the presence of the other chains varies from normal to residual amounts. When mutations affect the LRR of GPIX, expression of the other chains is strongly diminished, suggesting that GPIX plays a major role in the stability of the complex. A second type of mutations leads to synthesis of a truncated molecule lacking the transmembrane domain and absence of its expression at the platelet surface, while the other chains are present in residual amounts. Expression of recombinant proteins in eukaryotic cells has recently confirmed the results derived from studies of natural mutations. Separate expression of each chain can be obtained, although the presence of all subunits is required for full expression.","PeriodicalId":19366,"journal":{"name":"Nouvelle revue francaise d'hematologie","volume":"37 4","pages":"215-22"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19869086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nouvelle revue francaise d'hematologie Pub Date : 1995-01-01

A Brion, J Y Cahn, C Mougin, R Angonin, M Flesch, M L Deschaseaux, E Plouvier, E Deconinck, L Voillat, E Racadot

引用次数: 0

Expansion of blood CD34 positive cells: committed precursors expansion does not affect immature hematopoietic progenitors. 血液CD34阳性细胞的扩增:承诺的前体扩增不影响未成熟的造血祖细胞。

Nouvelle revue francaise d'hematologie Pub Date : 1995-01-01

S David, A Rice, I Vianes, V Duperray, M Dupouy, J Reiffers

{"title":"Expansion of blood CD34 positive cells: committed precursors expansion does not affect immature hematopoietic progenitors.","authors":"S David, A Rice, I Vianes, V Duperray, M Dupouy, J Reiffers","doi":"","DOIUrl":"","url":null,"abstract":"CD34 positive (CD34+) cells contain all hematopoietic progenitors from stem cells to committed precursors. Therefore the transplantation of purified bone marrow or blood CD34+ cells is sufficient for hematopoietic recovery after a myeloablative radiochemotherapy. Using different techniques, CD34+ progenitors can be induced to undergo terminal differentiation in a stroma-free liquid culture system in the presence of cytokines. In the present study, we have evaluated the functional potential of CD34+ blood progenitors after ex-vivo expansion cultures. CD34+ cells were isolated from 16 samples (PBSC n = 8 and Cord Blood (CB) n = 8) using either ISOLEX 50 (n=6), CEPRATE LC CD34 kit (n = 6) or MICROCELLECTOR T-25 Stem Cell kit (n = 4). CD34+ cells were cultured for seven days in the presence of 500 UI/ML of IL-1, 10 ng/ml of IL-3 and 10 ng/ml of SCF. We obtained an 8-fold expansion of nucleated cells. We observed a 59-fold expansion of GM-CSF responsive committed precursors, a 4.4-fold expansion of IL-1+IL-3+SCF+Epo responsive multilineage progenitors and a 2.2-fold expansion of the 5-FU resistant quiescent progenitors. We did not observe any significant difference in the amplification/expansion parameters between cultures initiated with CD34+ cells from PBSC or CB. Our data show that cytokine mediated ex-vivo expansion of blood CD34+ cells can produce a large number of committed precursors without affecting the compartment of the most immature progenitors. These results suggest that cytokine-mediated amplification technology could be of great interest in the autologous transplantation setting.","PeriodicalId":19366,"journal":{"name":"Nouvelle revue francaise d'hematologie","volume":"37 6","pages":"343-9"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19873341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pheochromocytoma and secondary erythrocytosis: role of tumour erythropoietin secretion. 嗜铬细胞瘤与继发性红细胞增多:肿瘤促红细胞生成素分泌的作用。

Nouvelle revue francaise d'hematologie Pub Date : 1995-01-01

B Drénou, Y Le Tulzo, S Caulet-Maugendre, A Le Guerrier, C Leclercq, I Guilhem, N Lecoq, R Fauchet, R Thomas

引用次数: 0