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Nouvelle revue francaise d'hematologie最新文献

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[Acute myelomonocytic leukemia with abnormal eosinophils]. 急性髓细胞白血病伴嗜酸性粒细胞异常。
Nouvelle revue francaise d'hematologie Pub Date : 2020-02-08 DOI: 10.32388/4gd936
J. Extra, M. Marty, F. Calvo, M. Daniel, R. Berger, M. Boiron
{"title":"[Acute myelomonocytic leukemia with abnormal eosinophils].","authors":"J. Extra, M. Marty, F. Calvo, M. Daniel, R. Berger, M. Boiron","doi":"10.32388/4gd936","DOIUrl":"https://doi.org/10.32388/4gd936","url":null,"abstract":"A total of 32 patients with acute myelomonocytic leukemia and abnormal bone marrow eosinophils (LAM4 Eo) have been treated at this Institute since 1977. Abnormalities of chromosome 16 have been noted in 14 of 22 evaluable cases. After a median follow-up of 4 years, median duration of complete remission was 46 months and median duration of survival had not been reached; 8 patients have been receiving no therapy for between 1 and 6 years. These results compare favorably with LAM4 without abnormal bone marrow eosinophils (median duration of complete remission: 12 months; median duration of survival: 14 months). LAM4 Eo constitute a particular entity, with a special hematological presentation, the incidence of abnormalities of chromosome 16, and a particularly good prognosis.","PeriodicalId":19366,"journal":{"name":"Nouvelle revue francaise d'hematologie","volume":"6 1","pages":"73-6"},"PeriodicalIF":0.0,"publicationDate":"2020-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84361674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[Myelodysplastic syndromes]. 骨髓增生异常综合征。
Nouvelle revue francaise d'hematologie Pub Date : 2018-11-26 DOI: 10.1002/9781119170655.ch15
F. Oberling, D. Hollard
{"title":"[Myelodysplastic syndromes].","authors":"F. Oberling, D. Hollard","doi":"10.1002/9781119170655.ch15","DOIUrl":"https://doi.org/10.1002/9781119170655.ch15","url":null,"abstract":"","PeriodicalId":19366,"journal":{"name":"Nouvelle revue francaise d'hematologie","volume":"45 1","pages":"159-60"},"PeriodicalIF":0.0,"publicationDate":"2018-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82117754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
XIVth Congress of the French Society of Hematology. Paris, France, February 3-4, 1995. Abstracts. 法国血液学学会第十四届大会。1995年2月3日至4日，法国巴黎。摘要。
Nouvelle revue francaise d'hematologie Pub Date : 1995-02-01
{"title":"XIVth Congress of the French Society of Hematology. Paris, France, February 3-4, 1995. Abstracts.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19366,"journal":{"name":"Nouvelle revue francaise d'hematologie","volume":"37 1","pages":"1-124"},"PeriodicalIF":0.0,"publicationDate":"1995-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18720332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thrombomodulin and von Willebrand factor in smokers and during smoking. 吸烟者和吸烟期间的血栓调节蛋白和血管性血友病因子。
Nouvelle revue francaise d'hematologie Pub Date : 1995-01-01
I Markuljak, J Ivankova, P Kubisz
{"title":"Thrombomodulin and von Willebrand factor in smokers and during smoking.","authors":"I Markuljak,&nbsp;J Ivankova,&nbsp;P Kubisz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Circulating thrombomodulin (TM) and von Willebrand factor (vWF) were determined in smokers before and after smoking of two filter cigarettes and in control subjects. The basal levels of TM and vWF were significantly increased in smokers relative to controls (p < 0.001). However, levels of these two factors remained unchanged immediately after smoking of two filter cigarettes, while a statistically significant correlation was observed only between plasma TM and number of years of smoking (p < 0.05).</p>","PeriodicalId":19366,"journal":{"name":"Nouvelle revue francaise d'hematologie","volume":"37 2","pages":"137-9"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18647696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein C activity in Gabonese children with sickle cell disease. 加蓬镰状细胞病儿童的蛋白C活性
Nouvelle revue francaise d'hematologie Pub Date : 1995-01-01
G Blavy, F Gnansounou, E NGou-Milama
{"title":"Protein C activity in Gabonese children with sickle cell disease.","authors":"G Blavy,&nbsp;F Gnansounou,&nbsp;E NGou-Milama","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Protein C levels were determined in 40 Gabonese children with sickle cell disease, in the steady state and during vasoocclusive crisis. In comparison with 40 healthy controls matched for age and sex, there was a significant decrease in protein C activity in the patients, although no difference was found between protein C levels in the steady state and during crisis.</p>","PeriodicalId":19366,"journal":{"name":"Nouvelle revue francaise d'hematologie","volume":"37 4","pages":"251-2"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19868444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacokinetics of a more reliable Chloraminophene formulation. 一种更可靠的氯胺酚制剂的药代动力学。
Nouvelle revue francaise d'hematologie Pub Date : 1995-01-01
C W Maboundou, J Magnette, G Paintaud, J L Dupond, T Fest, A Najman, E Solary, A Xicluna, A Sirito, J Y Cahn
{"title":"Pharmacokinetics of a more reliable Chloraminophene formulation.","authors":"C W Maboundou,&nbsp;J Magnette,&nbsp;G Paintaud,&nbsp;J L Dupond,&nbsp;T Fest,&nbsp;A Najman,&nbsp;E Solary,&nbsp;A Xicluna,&nbsp;A Sirito,&nbsp;J Y Cahn","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The pharmacokinetics of two formulations of chlorambucil, Chloraminophene capsules and Chloraminophene tablets, were compared in 12 patients in a randomized cross-over study. Chlorambucil concentrations in plasma were measured by HPLC over a period of 24 h after drug intake. The peak concentration (Cmax) occurred earlier after administration of capsules than after administration of tablets [median (range)]: 0.50 (0.33-0.66) h vs 2.00 (0.66-4.00) h (p < 0.01). Although values of Cmax and the area under the plasma concentration versus time curve (AUC) were not significantly different, the two formulations were not bioequivalent. Tolerance was in both cases acceptable, with only a transient decrease in haemoglobin one day after last drug intake. The variability of chlorambucil pharmacokinetics tended to be less important for capsules than for tablets: 38% vs 71% and 35% vs 113% for Cmax and AUC respectively. Capsules are therefore likely to be more reliable than tablets for clinical use.</p>","PeriodicalId":19366,"journal":{"name":"Nouvelle revue francaise d'hematologie","volume":"37 6","pages":"297-300"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19871430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronology of the formation of vesicles and membrane protein aggregates during erythrocyte aging. 红细胞衰老过程中囊泡和膜蛋白聚集体形成的年表。
Nouvelle revue francaise d'hematologie Pub Date : 1995-01-01
N Ghailani, C Guillemin, C Vigneron
{"title":"Chronology of the formation of vesicles and membrane protein aggregates during erythrocyte aging.","authors":"N Ghailani,&nbsp;C Guillemin,&nbsp;C Vigneron","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of the present work was to study the changes undergone by proteins in ghost cells, vesicles and membrane protein aggregates during erythrocyte aging. As a model of cell, whole blood collected into CPD was stored for eight weeks at +4 degrees C. SDS-PAGE and immunoblotting with antibodies against spectrin and band 3 showed that vesicles were mainly composed of band 3 and were devoid of spectrin, whereas membrane protein aggregates contained several membrane proteins but in a more advanced state of degradation. A study of spectrin and band 3 in the ghosts, vesicles and protein aggregates revealed increasing fragmentation of both proteins with storage time. Since this degradation was most important in membrane protein aggregates, it was possible to establish the chronological order of appearance of vesicles and aggregates. In view of our observations, we propose that membrane protein aggregates may be regarded as replacement structures resulting from membrane rearrangements occurring after the emission of vesicles.</p>","PeriodicalId":19366,"journal":{"name":"Nouvelle revue francaise d'hematologie","volume":"37 6","pages":"313-9"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19871433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Eprex: historical record and development]. [Eprex:历史记载与发展]。
Nouvelle revue francaise d'hematologie Pub Date : 1995-01-01
D Poisson
{"title":"[Eprex: historical record and development].","authors":"D Poisson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19366,"journal":{"name":"Nouvelle revue francaise d'hematologie","volume":"37 Suppl 1 ","pages":"S1-3"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18489194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Longitudinal melanonychia induced by hydroxyurea: four case reports and review of the literature. 羟基脲致纵向黑甲症4例报告及文献复习。
Nouvelle revue francaise d'hematologie Pub Date : 1995-01-01
B Delmas-Marsalet, P Beaulieu, F Teillet-Thiebaud, L Jary, F Teillet
{"title":"Longitudinal melanonychia induced by hydroxyurea: four case reports and review of the literature.","authors":"B Delmas-Marsalet,&nbsp;P Beaulieu,&nbsp;F Teillet-Thiebaud,&nbsp;L Jary,&nbsp;F Teillet","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Although the occurrence of skin lesions during long-term hydroxyurea therapy is well known, longitudinal melanonychia (LM) are more rarely described. In the present paper, we report four cases of LM associated with skin lesions induced by long-term daily hydroxyurea therapy (4 to 10 years), characterized by two uncommon aspects: late onset (2.5 to 5 years) and predominance of toenail involvement in three cases.</p>","PeriodicalId":19366,"journal":{"name":"Nouvelle revue francaise d'hematologie","volume":"37 3","pages":"205-10"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18573037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of factor VIII gene inversions using a non-radioactive detection method: a survey of 102 unrelated haemophilia A families from northern France. 使用非放射性检测方法表征因子VIII基因倒置:对法国北部102个无亲缘关系的血友病a家族的调查。
Nouvelle revue francaise d'hematologie Pub Date : 1995-01-01
C Gaucher, C Mazurier
{"title":"Characterization of factor VIII gene inversions using a non-radioactive detection method: a survey of 102 unrelated haemophilia A families from northern France.","authors":"C Gaucher,&nbsp;C Mazurier","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Intrachromosomal rearrangements of the long arm of chromosome X, between gene A (F8A) in intron 22 of the factor VIII gene and one of its two telomeric copies, are responsible for about half of the severe cases of haemophilia A. A group of 98 unrelated patients from Northern France with moderate to severe haemophilia A was screened for this gene inversion using a non-radioactive Southern blotting method. Whereas none of the 18 moderately affected patients presented the FVIII gene rearrangement, gene inversion was found in 38 (48%) of the 80 severe haemophilia A patients. Recombinations involving the distal copy of gene A (group 1) were more frequent (79%) than those involving the proximal copy (group 2). Individual variation in the number of gene A copies on the X chromosome probably explains an alternative Southern blot profile, referred to as group 3 inversion, which was observed in one of our patients. In the severely affected patients, neither the prevalence of inhibitor development nor the frequency of sporadic cases differed significantly in the group presenting gene inversion as compared to the group without chromosomal rearrangement. Study of four families where no patient was available enabled in one case direct carrier detection and prenatal diagnosis in the absence of an affected member. The Southern blotting technique described in the present work is relevant to about 50% of cases of severe haemophilia A, can be performed without use of a radiolabelled probe and represents a major advance in the diagnosis of the disease.</p>","PeriodicalId":19366,"journal":{"name":"Nouvelle revue francaise d'hematologie","volume":"37 2","pages":"131-6"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18647695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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