Nitric oxide : biology and chemistry最新文献_第5页

IF 3.2 2区生物学

Nitric oxide : biology and chemistry Pub Date : 2024-09-17 DOI: 10.1016/j.niox.2024.09.004

Surupa Chakraborty, Ankita Choudhuri , Akansha Mishra , Rajib Sengupta

{"title":"The hunt for transnitrosylase","authors":"Surupa Chakraborty, Ankita Choudhuri , Akansha Mishra , Rajib Sengupta","doi":"10.1016/j.niox.2024.09.004","DOIUrl":"10.1016/j.niox.2024.09.004","url":null,"abstract":"<div><div>The biochemical interplay between antioxidants and pro-oxidants maintains the redox homeostatic balance of the cell, which, when perturbed to moderate or high extents, has been implicated in the onset and/or progression of chronic diseases such as diabetes mellitus, cancer, and neurodegenerative diseases. Thioredoxin, glutaredoxin, and lipoic acid-like thiol oxidoreductase systems constitute a unique ensemble of robust cellular antioxidant defenses, owing to their indispensable roles as S-denitrosylases, S-deglutathionylases, and disulfide reductants in maintaining a reduced free thiol state with biological relevance. Thus, in cells subjected to nitrosative stress, cellular antioxidants will S-denitrosylate their cognate S-nitrosoprotein substrates, rather than participate in <em>trans</em>-S-nitrosylation <em>via</em> protein-protein interactions. Researchers have been at the forefront of vaguely establishing the concept of ‘transnitrosylation’ and its influence on pathophysiology with experimental evidence from <em>in vitro</em> studies that lack proper biochemical logic. The suggestive and reiterative use of antioxidants as transnitrosylases in the scientific literature leaves us on a cliffhanger with several open-ended questions that prompted us to ‘hunt’ for scientific logic behind the <em>trans</em>-S-nitrosylation chemistry. Given the gravity of the situation and to look at the bigger picture of ‘<em>trans</em>-S-nitrosylation’, we aim to present a novel attempt at justifying the hesitance in accepting antioxidants as capable of transnitrosylating their cognate protein partners and reflecting on the need to resolve the controversy that would be crucial from the perspective of understanding therapeutic outcomes involving such cellular antioxidants in disease pathogenesis. Further characterization is required to identify the regulatory mechanisms or conditions where an antioxidant like Trx, Grx, or DJ-1 can act as a cellular transnitrosylase.</div></div>","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"152 ","pages":"Pages 31-47"},"PeriodicalIF":3.2,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of hydrogen sulfide-microRNA crosstalk in health and disease 硫化氢-微小核糖核酸串扰在健康和疾病中的作用

IF 3.2 2区生物学

Nitric oxide : biology and chemistry Pub Date : 2024-09-12 DOI: 10.1016/j.niox.2024.09.002

Mi-Rong Jing , Xiao-Yi Liang , Yan-Xia Zhang , Yi-Wen Zhu , Yan Wang , Ti Chu , Yu-Qing Jin , Chuan-Hao Zhang , Shuai-Gang Zhu , Chao-Jing Zhang , Qi-Meng Wang , Zhi-Fen Feng , Xin-Ying Ji , Dong-Dong Wu

{"title":"Role of hydrogen sulfide-microRNA crosstalk in health and disease","authors":"Mi-Rong Jing , Xiao-Yi Liang , Yan-Xia Zhang , Yi-Wen Zhu , Yan Wang , Ti Chu , Yu-Qing Jin , Chuan-Hao Zhang , Shuai-Gang Zhu , Chao-Jing Zhang , Qi-Meng Wang , Zhi-Fen Feng , Xin-Ying Ji , Dong-Dong Wu","doi":"10.1016/j.niox.2024.09.002","DOIUrl":"10.1016/j.niox.2024.09.002","url":null,"abstract":"<div><div>The mutual regulation between hydrogen sulfide (H<sub>2</sub>S) and microRNA (miRNA) is involved in the development of many diseases, including cancer, cardiovascular disease, inflammatory disease, and high-risk pregnancy. Abnormal expressions of endogenous H<sub>2</sub>S-producing enzyme and miRNA in tissues and cells often indicate the occurrence of diseases, so the maintenance of their normal levels in the body can mitigate damages caused by various factors. Many studies have found that H<sub>2</sub>S can promote the migration, invasion, and proliferation of cancer cells by regulating the expression of miRNA, while many H<sub>2</sub>S donors can inhibit cancer progression by interfering with the proliferation, apoptosis, cell cycle, metastasis, and angiogenesis of cancer cells. Furthermore, the mutual regulation between H<sub>2</sub>S and miRNA can also prevent cell injury in cardiovascular disease and inflammatory disease through anti-inflammation, anti-oxidation, anti-apoptosis, and pro-autophagy. In addition, H<sub>2</sub>S can promote angiogenesis and relieve vasoconstriction by regulating the expression of miRNA, thereby improving fetal growth in high-risk pregnancy. In this review, we discuss the mechanism of mutual regulation between H<sub>2</sub>S and miRNA in various diseases, which may provide reliable therapeutic targets for these diseases.</div></div>","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"152 ","pages":"Pages 19-30"},"PeriodicalIF":3.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142221526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

H2S alleviated sepsis-induced acute kidney injury by inhibiting PERK/Bax-Bcl2 pathway H2S 通过抑制 PERK/Bax-Bcl2 通路减轻败血症诱发的急性肾损伤

IF 3.2 2区生物学

Nitric oxide : biology and chemistry Pub Date : 2024-09-11 DOI: 10.1016/j.niox.2024.09.003

Chengqing Song , Qian Chen , Jiao Xu , Kaichuan He , Qi Guo , Xu Teng , Hongmei Xue , Lin Xiao , Danyang Tian , Sheng Jin , Cuixia An , Yuming Wu

{"title":"H2S alleviated sepsis-induced acute kidney injury by inhibiting PERK/Bax-Bcl2 pathway","authors":"Chengqing Song , Qian Chen , Jiao Xu , Kaichuan He , Qi Guo , Xu Teng , Hongmei Xue , Lin Xiao , Danyang Tian , Sheng Jin , Cuixia An , Yuming Wu","doi":"10.1016/j.niox.2024.09.003","DOIUrl":"10.1016/j.niox.2024.09.003","url":null,"abstract":"<div><p>To investigate the protective mechanisms of hydrogen sulfide (H<sub>2</sub>S) in sepsis-induced acute kidney injury (SAKI), we conducted an in vivo study using a SAKI mouse model induced by intraperitoneal lipopolysaccharide (LPS) injection. Following 6 h of LPS injection, levels of tumor necrosis factor-alpha (TNF-α) and blood urea nitrogen (Bun) were significantly elevated in mouse plasma. In the kidneys of SAKI mice, expression of H<sub>2</sub>S-generating enzymes cysteinyl-tRNA synthetase (CARS), cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS) was markedly downregulated, while glucose-regulated protein 78 (GRP78), activating transcription factor 6 (ATF6), phosphorylated protein kinase R-like endoplasmic reticulum kinase/protein kinase R-like endoplasmic reticulum kinase (p-PERK/PERK), and B-cell lymphoma-2 recombinant protein X/B-cell lymphoma-2 (Bax/Bcl2) expression was significantly upregulated. H<sub>2</sub>S improved renal function and attenuated renal histopathological changes in SAKI mice, thereby alleviating LPS-induced endoplasmic reticulum stress (ERS). Additionally, it inhibited the expression of p-PERK/PERK and Bax/Bcl2. After inhibiting CSE activity with <span>dl</span>-propargylglycine (PPG i. p.), the renal tissue pathology in LPS-induced AKI mice was further exacerbated, leading to enhanced activation of the PERK/Bax-Bcl2 pathway. Our findings suggest that endogenous H<sub>2</sub>S influences the pathogenesis of SAKI, while exogenous H<sub>2</sub>S protects against LPS-induced AKI by inhibiting the PERK/Bax-Bcl2 pathway involved in ERS.</p></div>","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"152 ","pages":"Pages 11-18"},"PeriodicalIF":3.2,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in increasing efficiency of hydrogen sulfide in therapeutics: Strategies for targeted delivery as prodrugs 提高硫化氢治疗效率的进展：作为原药进行靶向给药的策略。

IF 3.2 2区生物学

Nitric oxide : biology and chemistry Pub Date : 2024-09-06 DOI: 10.1016/j.niox.2024.09.001

Tejasvi Pandey , Vivek Pandey

{"title":"Advancements in increasing efficiency of hydrogen sulfide in therapeutics: Strategies for targeted delivery as prodrugs","authors":"Tejasvi Pandey , Vivek Pandey","doi":"10.1016/j.niox.2024.09.001","DOIUrl":"10.1016/j.niox.2024.09.001","url":null,"abstract":"<div><p>Hydrogen sulfide (H2S) has emerged as a potent therapeutic agent with diverse physiological functions, including vasodilation, anti-inflammation, and cytoprotection. However, its clinical application is limited due to its volatility and potential toxicity at high concentrations. To address these challenges, researchers have developed various H2S prodrugs that release H2S in a controlled and targeted manner. The review underscores the importance of targeting and delivery strategies in maximizing the therapeutic potential of H2S, a gasotransmitter with diverse physiological functions and therapeutic effects. By summarizing recent advancements, the review provides valuable insights for researchers and clinicians interested in harnessing the therapeutic benefits of H2S while minimizing off-target effects and toxicity. The integration of novel targeting and delivery approaches not only enhances the efficacy of H2S-based therapeutics but also expands the scope of potential applications, offering promising avenues for the development of new treatments for a variety of diseases and disorders.</p></div>","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"152 ","pages":"Pages 1-10"},"PeriodicalIF":3.2,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of nitroglycerin treatment on cerebral ischaemia: A systematic review and meta-analysis of animal studies 硝酸甘油治疗对脑缺血的影响：动物研究的系统回顾和元分析》。

IF 3.2 2区生物学

Nitric oxide : biology and chemistry Pub Date : 2024-08-23 DOI: 10.1016/j.niox.2024.08.003

Magdalena Litman , Neil J. Spratt , Daniel J. Beard

{"title":"The effect of nitroglycerin treatment on cerebral ischaemia: A systematic review and meta-analysis of animal studies","authors":"Magdalena Litman , Neil J. Spratt , Daniel J. Beard","doi":"10.1016/j.niox.2024.08.003","DOIUrl":"10.1016/j.niox.2024.08.003","url":null,"abstract":"<div><h3>Background</h3><p>Nitroglycerin has been of considerable interest as a treatment for ischaemic stroke. Recent clinical trials with nitroglycerin transdermal patches during the acute phase of stroke failed to improve functional outcomes. Systematic review and meta-analysis of the effectiveness of nitroglycerin in preclinical models of ischaemic stroke has not previously been reported, despite several clinical trials.</p></div><div><h3>Objective</h3><p>To conduct a systematic review and meta-analysis of preclinical evidence regarding the effect of nitroglycerin on infarct volume in animal models of ischaemic stroke.</p></div><div><h3>Summary of review</h3><p>The protocol was registered in PROSPERO (CRD42023432644). Our search identified 238 publications. Three publications met inclusion criteria (including 10 comparisons of infarct size). Study quality was modest (median 6 out of 9), with no evidence of publication bias. Nitroglycerin did not significantly reduce infarct volume (NMD point estimate 20.2 % reduction, 95 % CI −1.52–52.7 %, <em>p</em> = 0.068). Subgroup analysis suggested greater efficacy of nitroglycerin with direct intracarotid administration to the ischaemic territory at the time of reperfusion.</p></div><div><h3>Conclusions</h3><p>A small number of studies (three) were included in this review. Overall, nitroglycerin did not reduce infarct volume in experimental stroke models. However, nitroglycerin may be of benefit when administered directly into the ischaemic territory. Given nitroglycerin's short half-life, we propose this route may minimise harmful reduction of cerebral perfusion pressure resulting from hypotension following systemic administration.</p></div>","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"151 ","pages":"Pages 10-16"},"PeriodicalIF":3.2,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1089860324001046/pdfft?md5=91e5cfa784368db27ad66c40f95a18f4&pid=1-s2.0-S1089860324001046-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NO- and H2S- releasing nanomaterials: A crosstalk signaling pathway in cancer 释放 NO 和 H2S 的纳米材料：癌症中的串扰信号通路。

IF 3.2 2区生物学

Nitric oxide : biology and chemistry Pub Date : 2024-08-22 DOI: 10.1016/j.niox.2024.08.002

Roberta Albino dos Reis , Ishani Sarkar , Maiara Gonçalves Rodrigues , John B. Matson , Amedea Barozzi Seabra , Khosrow Kashfi

{"title":"NO- and H2S- releasing nanomaterials: A crosstalk signaling pathway in cancer","authors":"Roberta Albino dos Reis , Ishani Sarkar , Maiara Gonçalves Rodrigues , John B. Matson , Amedea Barozzi Seabra , Khosrow Kashfi","doi":"10.1016/j.niox.2024.08.002","DOIUrl":"10.1016/j.niox.2024.08.002","url":null,"abstract":"<div><p>The gasotransmitters nitric oxide (NO) and hydrogen sulfide (H<sub>2</sub>S) play important roles not only in maintaining physiological functions, but also in pathological conditions and events. Importantly, these molecules show a complex interplay in cancer biology, demonstrating both tumor-promoting and anti-tumor activities depending on their concentration, flux, and the environmental redox state. Additionally, various cell types respond differently to NO and H<sub>2</sub>S. These gasotransmitters can be synergistically combined with traditional anticancer treatments such as radiotherapy, immunotherapy, chemotherapy, and phototherapy. Notably, NO, and more recently H<sub>2</sub>S, have been shown to reverse multidrug resistance. Nanomaterials to deliver NO donors and, to a lesser extent, H<sub>2</sub>S donors, have emerged as a promising approach for targeted delivery of these gasotransmitters. Nanotechnology has advanced the delivery of anticancer drugs, enhancing efficiency and reducing side effects on non-cancerous cells. This review highlights recent progress in the design of NO and H<sub>2</sub>S-releasing nanomaterials for anticancer effects. It also explores the interactions between NO and H<sub>2</sub>S, which are crucial for developing combined therapies and nanomedicines with minimal side effects.</p></div>","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"151 ","pages":"Pages 17-30"},"PeriodicalIF":3.2,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cystathionine gamma-lyase deficiency exaggerates diethylnitrosamine-induced liver damage in mice 胱硫醚γ-赖氨酸酶缺乏症会加剧二乙基亚硝胺诱导的小鼠肝损伤。

IF 3.2 2区生物学

Nitric oxide : biology and chemistry Pub Date : 2024-08-14 DOI: 10.1016/j.niox.2024.08.001

Samantha Ligi , Arm Ali , Guangdong Yang

{"title":"Cystathionine gamma-lyase deficiency exaggerates diethylnitrosamine-induced liver damage in mice","authors":"Samantha Ligi , Arm Ali , Guangdong Yang","doi":"10.1016/j.niox.2024.08.001","DOIUrl":"10.1016/j.niox.2024.08.001","url":null,"abstract":"<div><p>Cystathionine gamma-lyase (CSE) is a key enzyme in reverse transsulfuration pathway and contributes to the majority of H<sub>2</sub>S generation in liver tissues via cysteine metabolism. Dysfunction of the CSE/H<sub>2</sub>S system is linked to both chronic and acute liver damage. This study investigated the regulatory role of CSE deficiency on diethylnitrosamine (DEN)-induced liver damage in mice. A single injection of DEN was administered into 4-week-old male CSE knockout (CSE-KO) mice and wild-type (WT) littermates, and the mice were sacrificed at 28 weeks of age. Compared to age-matched WT mice, CSE-KO mice spontaneously developed steatosis with increased oxidative stress and higher expressions of inflammation and fibrosis-related genes at 28-weeks of age. Following DEN injection, CSE-KO mice experienced more severe liver damage in comparison with the WT group as reflected by elevated levels of lipid accumulation, increased activities of alanine aminotransferase and aspartate aminotransferase, higher oxidative stress and fibrosis development, and increased expressions of inflammation and fibrosis-related genes. No visible tumors were observed in both types of mice with DEN treatment. In addition, the expression levels of the three H<sub>2</sub>S-generating proteins (CSE, cystathionine beta-synthase, and 3-mercaptopyruvate sulfurtransferase) and the H<sub>2</sub>S production rate in liver tissues were unaffected by DEN. Taken together, our study demonstrates that CSE provides a significant hepatoprotective effect and deficiency of CSE exaggerates DEN-induced liver damage in mice. Based on these findings, it can be suggested that targeting the CSE/H<sub>2</sub>S signaling pathway could be a potential therapeutic target for the treatment of liver diseases.</p></div>","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"151 ","pages":"Pages 1-9"},"PeriodicalIF":3.2,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The hemodynamic response to nitrite is acute and dependent upon tissue perfusion 血流动力学对亚硝酸盐的反应是急性的，取决于组织灌注情况。

IF 3.2 2区生物学

Nitric oxide : biology and chemistry Pub Date : 2024-08-02 DOI: 10.1016/j.niox.2024.07.005

Luke S. Dunaway , Khatera Saii , Anthea LoBue , Shruthi Nyshadham , Nasim Abib , Sophia K. Heuser , Skylar A. Loeb , Ulf Simonsen , Miriam M. Cortese-Krott , Brant E. Isakson

{"title":"The hemodynamic response to nitrite is acute and dependent upon tissue perfusion","authors":"Luke S. Dunaway , Khatera Saii , Anthea LoBue , Shruthi Nyshadham , Nasim Abib , Sophia K. Heuser , Skylar A. Loeb , Ulf Simonsen , Miriam M. Cortese-Krott , Brant E. Isakson","doi":"10.1016/j.niox.2024.07.005","DOIUrl":"10.1016/j.niox.2024.07.005","url":null,"abstract":"<div><p>In the vasculature, nitric oxide (NO) is produced in the endothelium by endothelial nitric oxide synthase (eNOS) and is critical for the regulation of blood flow and blood pressure. Blood flow may also be regulated by the formation of nitrite-derived NO catalyzed by hemoproteins under hypoxic conditions. We sought to investigate whether nitrite administration may affect tissue perfusion and systemic hemodynamics in WT and eNOS knockout mice. We found that global eNOS KO mice show decreased tissue perfusion compared to WT mice by using laser speckle contrast imaging. To study both the acute and long-term effects of sodium nitrite (0, 0.1, 1, and 10 mg/kg) on peripheral blood flow and systemic blood pressure, a bolus of nitrite was delivered intraperitoneally every 24 h over 4 consecutive days. We found that nitrite administration resulted in a dose-dependent and acute increase in peripheral blood flow in eNOS KO mice but had no effects in WT mice. The nitrite induced changes in tissue perfusion were transient, as determined by intraindividual comparisons of tissue perfusion 24-h after injection. Accordingly, 10 mg/kg sodium nitrite acutely decreased blood pressure in eNOS KO mice but not in WT mice as determined by invasive Millar catheterization. Interestingly, we found the vasodilatory effects of nitrite to be inversely correlated to baseline tissue perfusion. These results demonstrate the nitrite acutely recovers hypoperfusion and hypertension in global eNOS KO mice and suggest the vasodilatory actions of nitrite are dependent upon tissue hypoperfusion.</p></div>","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"150 ","pages":"Pages 47-52"},"PeriodicalIF":3.2,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spraying with encapsulated nitric oxide donor reduces weight loss and oxidative damage in papaya fruit 喷洒封装的一氧化氮供体可减少木瓜果实的重量损失和氧化损伤。

IF 3.2 2区生物学

Nitric oxide : biology and chemistry Pub Date : 2024-07-20 DOI: 10.1016/j.niox.2024.07.004

Julia C. da Veiga , Neidiquele M. Silveira , Amedea B. Seabra , Joana C. Pieretti , Yolanda Boza , Angelo P. Jacomino , Júlio César Z. Filho , Vinícius P. Campagnoli , Patrícia Cia , Ilana U. Bron

{"title":"Spraying with encapsulated nitric oxide donor reduces weight loss and oxidative damage in papaya fruit","authors":"Julia C. da Veiga , Neidiquele M. Silveira , Amedea B. Seabra , Joana C. Pieretti , Yolanda Boza , Angelo P. Jacomino , Júlio César Z. Filho , Vinícius P. Campagnoli , Patrícia Cia , Ilana U. Bron","doi":"10.1016/j.niox.2024.07.004","DOIUrl":"10.1016/j.niox.2024.07.004","url":null,"abstract":"<div><p>The combination of nitric oxide (NO) donors with nanomaterials has emerged as a promising approach to reduce postharvest losses. The encapsulation of NO donors provides protection from rapid degradation and controlled release, enhancing the NO effectiveness in postharvest treatments. Moreover, the application method can also influence postharvest responses. In this study, two application methods were evaluated, spraying and immersion, using <em>S</em>-nitrosoglutathione (GSNO, a NO donor) in free and encapsulated forms on papaya fruit. Our hypothesis was that GSNO encapsulated in chitosan nanoparticles would outperform the free form in delaying fruit senescence. In addition, this study marks the pioneering characterization of chitosan nanoparticles containing GSNO within the framework of a postharvest investigation. Overall, our findings indicate that applying encapsulated GSNO (GSNO-NP-S) through spraying preserves the quality of papaya fruit during storage. This method not only minimizes weight loss, ethylene production, and softening, but also stimulates antioxidant responses, thereby mitigating oxidative damage. Consequently, it stands out as the promising technique for delaying papaya fruit senescence. This innovative approach holds the potential to enhance postharvest practices and advance sustainable agriculture.</p></div>","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"150 ","pages":"Pages 37-46"},"PeriodicalIF":3.2,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141748676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of nitrate supplementation on oxygen saturation levels for acute mountain sickness prevention: A systematic review and meta-analysis 补充硝酸盐对预防急性晕山症血氧饱和度的影响：系统回顾与元分析》。

IF 3.2 2区生物学

Nitric oxide : biology and chemistry Pub Date : 2024-07-11 DOI: 10.1016/j.niox.2024.07.003

Muhammad Rizqi Tri Nafi'an , Rahmaningsih Mara Sabirin , Rakhmat Ari Wibowo , Meida Sofyana , Imtiyaz Hafizah Zahra , Danindra Ario Wiryawan , Qonita Jayanti Wijayatno , Abdul Rohman

{"title":"Effect of nitrate supplementation on oxygen saturation levels for acute mountain sickness prevention: A systematic review and meta-analysis","authors":"Muhammad Rizqi Tri Nafi'an , Rahmaningsih Mara Sabirin , Rakhmat Ari Wibowo , Meida Sofyana , Imtiyaz Hafizah Zahra , Danindra Ario Wiryawan , Qonita Jayanti Wijayatno , Abdul Rohman","doi":"10.1016/j.niox.2024.07.003","DOIUrl":"10.1016/j.niox.2024.07.003","url":null,"abstract":"<div><h3>Purpose</h3><p>This study aimed to systematically review the effect of nitrate supplementation on blood oxygen saturation<strong>.</strong></p></div><div><h3>Methods</h3><p>We searched PubMed, Scopus, and Cochrane Library databases from their inception up to October 2022. Two reviewers independently conducted two stages of the screening process to include a randomized controlled trial with nitrate supplementation versus placebo intervention assessing oxygen saturation among lowlanders going to either real or simulated high altitude environments. We used the Cochrane Risk of Bias 2.0 tool to assess the risk of bias in the included studies. Fixed-effect model meta-analyses were conducted for laboratory-based studies. Random-effect meta-analyses were conducted for real-world studies.</p></div><div><h3>Results</h3><p>We found 7 trials that met the eligibility criteria. A meta-analysis of studies with some bias concerns showed an increase of 1.26 % in the SpO2 with 44 % I<sup>2</sup> during submaximal exercise at simulated high altitudes (GRADE: low). On the contrary, a meta-analysis of studies without heterogeneity showed that nitrate supplementation aggravated oxygen saturation decline (−2.64 %, p = 0.03, GRADE: high) during rest in real high-altitude environments. A meta-analysis also showed that nitrate supplementation did not affect Acute Mountain Sickness (AMS) symptoms (GRADE: high).</p></div><div><h3>Conclusion</h3><p>Our results suggest that nitrate supplementation did not provide benefits for AMS prevention during rest at high altitudes. The low-quality evidence showing small beneficial effects of nitrate supplementation during exercise calls for further studies.</p></div>","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"150 ","pages":"Pages 27-36"},"PeriodicalIF":3.2,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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