Nutrition & Diabetes最新文献

{"title":"Postprandial glucose response to a low-sucrose chocolate spread in adults with type 1 diabetes: a randomized, double-blinded, cross-over, controlled trial.","authors":"Naama Fisch-Shvalb, Revital Nimri, Moshe Phillip, Michal Yackobovitch-Gavan","doi":"10.1038/s41387-026-00429-7","DOIUrl":"10.1038/s41387-026-00429-7","url":null,"abstract":"<p><strong>Background: </strong>Novel advances in food technology enable the production of foods with significantly reduced sucrose without the use of additives. We tested the glycemic response of subjects with Type 1 Diabetes (T1D) to a novel sucrose-reduced chocolate spread, as well as its acceptance and palatability.</p><p><strong>Methods: </strong>A randomized, double-blind, crossover, active-controlled trial comparing the glycemic response to two test-meals: 20 grams of the sugar-reduced spread (1.6 grams sucrose), and 20 grams of control chocolate spread, (11 grams sucrose) in people with T1D.</p><p><strong>Results: </strong>Thirty adults (50% males), aged 18-28 years (mean 23.0 ± 3.0), mean HbA1C of 55 ± 9 mmol/mol (7.2 ± 0.9%) were recruited. Postprandial glucose (PPG) excursions were significantly lower following consumption of the study spread compared to the control spread: pre-meal to peak glucose difference (mean 25.8 ± 34.9 mg/dL lower, P < 0.001), postprandial CGM iAUC (mean 2271 ± 3789 min×mg/dL, P = 0.003). Median time in range was higher for the study versus control spread (100% and 64.6%, respectively, P = 0.030). In the sweetness scale questionnaire, the study spread rated higher than the control (\"right degree of sweetness\" 53.3% and 26.7% respectively, P < 0.001).</p><p><strong>Conclusions: </strong>This new technology for producing sugar-reduced food is able to reduce PPG with a limited effect on palatability.</p>","PeriodicalId":19339,"journal":{"name":"Nutrition & Diabetes","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147982485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of long-chain and very-long-chain saturated fatty acids with neutrophil related inflammatory markers and insulin resistance markers.","authors":"Xuan Li, Qin Yang, Long Zhou","doi":"10.1038/s41387-026-00428-8","DOIUrl":"10.1038/s41387-026-00428-8","url":null,"abstract":"<p><strong>Background: </strong>Saturated fatty acids (SFAs) have been recognized as an important risk factor for cardiovascular diseases (CVDs). SFAs with varying carbon chain lengths may differentially influence CVD progression. Both inflammation and insulin resistance (IR) are primary drivers of CVDs. Therefore, this study aims to compare the associations of long-chain SFAs (LCSFAs) and very-long-chain SFAs (VLCSFAs) with neutrophil-related inflammatory markers and IR markers using data from the NHANES 2011-2014 cohort.</p><p><strong>Methods: </strong>We measured five LCSFAs (C14:0, C15:0, C16:0, C17:0, C18:0) and four VLCSFAs (C20:0, C22:0, C23:0, C24:0) in blood samples. Subsequently, weighted linear regression and restricted cubic spline models were used to assess associations between different SFAs and neutrophil-related and IR-related markers.</p><p><strong>Results: </strong>A total of 3424 individuals were included in the analysis. Relative to participants in the lowest quartile of C16:0, those in the highest quartile exhibited 0.048 to 4.023 units higher levels of neutrophil counts, neutrophil-to-erythrocyte ratio (NER), neutrophil-to-high-density lipoprotein ratio (NHR), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), and metabolic score for insulin resistance (METS-IR). Conversely, participants in the highest quartile of C24:0 showed 0.016 to 1.709 units lower levels of these markers compared with the lowest quartile.</p><p><strong>Conclusions: </strong>Circulating LCSFAs were positively associated with neutrophil-mediated inflammation and IR markers. In contrast, VLCSFAs, specifically C22:0, C23:0, and C24:0, exhibited inverse associations with these inflammatory and IR markers.</p>","PeriodicalId":19339,"journal":{"name":"Nutrition & Diabetes","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13346868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147949037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the phase angle with type 2 diabetes and related traits: results from two prospective KORA studies.","authors":"Feiling Ai, Marie-Theres Huemer, Wolfgang Rathmann, Michael Roden, Christian Herder, Tanja Zeller, Wolfgang Koenig, Jana Nano, Michael Drey, Annette Peters, Barbara Thorand","doi":"10.1038/s41387-026-00425-x","DOIUrl":"10.1038/s41387-026-00425-x","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate associations of the bioelectrical impedance analysis (BIA)-derived phase angle (PhA), an indicator of body cell mass, hydration status, and cell membrane integrity, with type 2 diabetes (T2D), prediabetes, and glycemic and insulin-related traits.</p><p><strong>Methods: </strong>Using data from the Cooperative Health Research in the Region of Augsburg (KORA) S3/S4 studies, we analyzed 7728 participants aged 25-74 years for prevalent T2D and 7006 participants who did not have diabetes at baseline for incident T2D. A subsample aged 55-74 years at S4 was followed to assess incident oral glucose tolerance test (OGTT)-defined prediabetes or T2D (prediabetes/T2D), and glycemic and insulin-related traits (S4/F4/FF4). The PhA was calculated from BIA 2000-S at 50 kHz. Logistic and Cox regressions were applied for binary outcomes, and two-level growth models for continuous traits.</p><p><strong>Results: </strong>In S3/S4, 324 participants had prevalent T2D at baseline, and 707 developed T2D during a median 15.7-year follow-up. In S4/F4/FF4, during up to 14 years of follow-up, 251 out of 626 normoglycemic participants at S4 developed incident prediabetes/T2D, and 792-804 participants without diabetes at S4 had three repeated measurements of continuous traits. The PhA (per 1-degree) was positively associated with incident T2D (hazard ratio [HR] and 95% confidence interval [CI] in S3/S4: 1.37 [1.21-1.54]) and incident prediabetes/T2D (HR [95% CI] in S4/F4/FF4: 1.33 [1.07-1.67]) without sex differences. The PhA (per 1-degree) was also positively associated with fasting glucose (beta [95% CI]: 1.2% [0.1-2.2%]) and insulin resistance (beta [95% CI]: 7.0% [2.3-11.7%]) cross-sectionally, and with changes in 2-h glucose longitudinally (beta [95% CI]: 4.5% [2.3-6.7%]) (S4/F4/FF4). In contrast, the PhA (per 1-degree) was inversely associated with prevalent T2D (odds ratio [95% CI] in S3/S4: 0.72 [0.56-0.93]) in men only.</p><p><strong>Conclusions: </strong>The PhA at 50 kHz had stage-dependent associations with glucose metabolism, with higher values observed during subclinical stages and lower values after diabetes manifestation.</p>","PeriodicalId":19339,"journal":{"name":"Nutrition & Diabetes","volume":"16 1","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13157506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global trends in tea and diabetes research: a bibliometric analysis of literature from 2000 to 2024.","authors":"Yao Zhang, Rui Ren, Liying Wang, Jilong Bai, Jinyan Liu, Wenxu Wang, Yanan Ma, Na Li, Difei Wang","doi":"10.1038/s41387-026-00427-9","DOIUrl":"10.1038/s41387-026-00427-9","url":null,"abstract":"<p><p>Tea has attracted significant attention for its potential antidiabetic properties, primarily attributed to its bioactive compounds such as polyphenols. This study aims to systematically evaluate the global research landscape and emerging trends in tea and diabetes. Publications were retrieved from the Web of Science Core Collection and analyzed using bibliometric tools, including VOSviewer, RStudio, and CiteSpace. A total of 2634 publications from 103 countries/regions (2000-2024) were included, with an annual growth rate of 12.25%. China, the United States, and Japan were the leading contributors. Harvard University and Gan RY were the most influential institution and author, respectively, while Nutrients was the leading journal. Research themes have evolved from early mechanistic studies focusing on antioxidant and anti-inflammatory properties of tea polyphenols to more integrative investigations involving gut microbiota, inflammation, and metabolic regulation. Research on tea and diabetes has shifted toward a more comprehensive and translational framework. Tea polyphenols play important roles in improving insulin sensitivity, reducing oxidative stress and inflammation, and modulating metabolic pathways, although challenges such as low bioavailability remain. These findings provide valuable insights into the current research landscape and may inform future studies on diabetes prevention and management.</p>","PeriodicalId":19339,"journal":{"name":"Nutrition & Diabetes","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13323750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The molecular mechanisms of incretin resistance in Type 2 Diabetes Mellitus (T2DM).","authors":"Rawayh Muslim Albaghlany, Abbas Ali Mansour","doi":"10.1038/s41387-026-00426-w","DOIUrl":"10.1038/s41387-026-00426-w","url":null,"abstract":"<p><p>Incretin hormones, specifically glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), serve as crucial mediators of postprandial glucose homeostasis by primarily enhancing glucose-stimulated insulin secretion. Research indicates that the incretin effect accounts for approximately 50% of insulin secretion in individuals without diabetes, which is significantly reduced to 30% or less in those with Type 2 Diabetes Mellitus (T2DM). The mechanisms underlying this incretin resistance have emerged as critical causes of postprandial hyperglycemia. Incretin-based therapies, including GLP-1 receptor agonists (GLP-1RAs) and DPP-4 inhibitors, have demonstrated efficacy in managing T2DM; however, intrinsic resistance mechanisms may limit their effectiveness. Understanding the processes by which T2DM affects incretin action, from hormone secretion to the modulation of signal transduction, is essential for optimizing current therapies and developing new interventions to enhance β-cell responsiveness and improve glycemic control. The concept of incretin resistance has a well-established history in literature, dating back to at least the early 1990 s. It is used to describe a reduced insulinotropic responsiveness to incretin hormones in individuals diagnosed with T2DM. This review examines how hyperglycemia, chronic inflammation, and genetic susceptibility collectively inhibit incretin signaling through distinct yet interconnected molecular pathways. This impairment exacerbates postprandial hyperglycemia and accelerates β-cell dysfunction. We propose novel hypotheses regarding selective β-arrestin signaling, enhancers, epigenetic regulation, interactions between gut microbiota and incretins, inflammation-induced endoplasmic reticulum (ER) stress, and genotype-specific therapeutic responses. The hypotheses presented in this review serve as a framework for future research and therapeutic development to combat the phenomenon of incretin resistance and improve the clinical management of T2DM.</p>","PeriodicalId":19339,"journal":{"name":"Nutrition & Diabetes","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13315620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"And just like that, quiet\": a content analysis of TikTok videos on food noise.","authors":"Daisuke Hayashi, Janelle Kort, Isabel M Robles-Martinez, Diana Orabueze, Katrina Bakhl, Travis D Masterson","doi":"10.1038/s41387-026-00423-z","DOIUrl":"10.1038/s41387-026-00423-z","url":null,"abstract":"<p><strong>Background: </strong>Food Noise is a topic of growing interest in media, social media, and reports from patients and clinicians. A theoretical definition of \"Food Noise\" has recently been established as \"heightened and/or persistent manifestations of food cue reactivity, often leading to food-related intrusive thoughts and maladaptive eating behaviors,\" but research focusing on the lived experiences of people who report experiencing it is limited. TikTok has become a major outlet for content creators to disseminate information on Food Noise, with over 3600 videos under the hashtag #FoodNoise as of June 2024.</p><p><strong>Objectives: </strong>This study aimed to examine the top videos on TikTok under the hashtag \"FoodNoise\" and explore what content creators discuss around food noise.</p><p><strong>Methods: </strong>We analyzed 100 videos on TikTok under the hashtag #FoodNoise. Video links and metadata (such as engagement metrics) were retrieved on June 24^th, 2024. After one duplicated video was excluded, the final analysis included 99 videos. Following pilot testing of the codebook, we conducted a quantitative content analysis of the videos. This study required no ethical approval.</p><p><strong>Results: </strong>The sampled videos had a mean of 1,173,323.63 views, 8,154.57 likes, 246.99 comments, and 582.65 shares. Content creators were primarily female (91.92%), aged 30 or older (82.83%), and White (85.86%). 22.22% of content creators were healthcare professionals, and 70.71% of videos were patient testimonies. 49.49% of videos mentioned medications, mainly GLP-1 receptor agonists. 42.42% mentioned food, mostly candies, desserts, and fast foods. Of the videos that defined Food Noise (82.82%), 93.9% defined it consistently with the current theoretical definition. Most videos (85.86%) depicted food noise negatively.</p><p><strong>Conclusion: </strong>The top content available on TikTok on food noise is mainly comprised of patient testimonies that describe food noise as negative and distressful, and depict the use of medications, mostly GLP-1RAs, as a positive strategy to help manage food noise.</p>","PeriodicalId":19339,"journal":{"name":"Nutrition & Diabetes","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13265739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct meal timing and frequency patterns contribute to daily glycemic variability.","authors":"Dong-Hwa Jeong, YoonJu Song","doi":"10.1038/s41387-026-00424-y","DOIUrl":"10.1038/s41387-026-00424-y","url":null,"abstract":"<p><p>Glycemic variability is an emerging marker of metabolic health, yet its behavioral determinants in healthy populations remain unclear. This study investigated whether meal patterns-specifically timing, distribution, and frequency-are associated with glycemic variability. Ninety-six individuals aged 18-27 years wore continuous glucose monitors for 14 consecutive days, providing 1036 complete daily records. Daily glucose profiles were clustered using dynamic time warping, and concurrent meal and sleep logs were analyzed to characterize dietary patterns across clusters. Cluster 2 (765 days) exhibited broader distributions and higher densities of elevated glucose values compared with cluster 1 (271 days), reflecting greater variability (17.7% vs. 14.1%, p = 0.0001). Peak daily glucose was also significantly higher in cluster 2, although average glucose did not differ. Total energy intake was lower in cluster 2 than cluster 1 (1781.1 vs. 1981.4 kcal, p = 0.0003), with no significant differences in macronutrient composition. By contrast, meal patterns differed substantially: cluster 2 was characterized by fewer eating occasions, later breakfast timing, and a greater proportion of daily energy intake at dinner. These findings suggest that meal timing and distribution are important dimensions of dietary recommendations, indicating a shift in focus from nutrient intake alone toward including meal patterns.</p>","PeriodicalId":19339,"journal":{"name":"Nutrition & Diabetes","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13269695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex- and adipose depot-specific glucose metabolism following carbohydrate-enriched diets consumption with (un)interrupted prolonged sitting.","authors":"Yung-Chih Chen, Yun-Ting Lin, Li-Chieh Wang, Chien-Hsing Lee, Sheng-Chiang Su, Chieh-Hua Lu, Peng-Fei Li, Chia-Luen Huang, Li-Ju Ho, Ming-Hsun Lin, Hsin-Ya Liu, Feng-Chih Kuo","doi":"10.1038/s41387-026-00422-0","DOIUrl":"10.1038/s41387-026-00422-0","url":null,"abstract":"<p><strong>Background/objectives: </strong>Carbohydrate-enriched diets and sedentary behavior contribute to diabetes risk. However, their impacts on glucose metabolism in abdominal (ASAT) and gluteal subcutaneous adipose tissues (GSAT), especially considering sex differences, remain unexplored.</p><p><strong>Subjects/methods: </strong>Twenty (median age 29.2 years, median BMI 23.1 kg/m²) healthy participants (10 females) underwent mixed-feeding trials lasting 320 min, with carbohydrate-enriched meals following either prolonged sitting (SIT) or interrupted prolonged sitting (ACTIVE) in a randomized crossover design. Continuous glucose monitoring (CGM) was inserted simultaneously at abdominal and gluteal fat depots. Body composition was quantified by dual-energy x-ray absorptiometry. Oral glucose tolerance test was performed for measuring insulin sensitivity and resistance. In vitro experiments using paired human abdominal and gluteal preadipocyte cell lines were conducted to investigate molecular mechanisms.</p><p><strong>Results: </strong>In the SIT trial, GSAT CGM showed a slower increase in interstitial glucose during lunch compared to ASAT CGM, particularly in females. In the ACTIVE trial, intermittent brisk walking led to numerically lower interstitial glucose levels in both ASAT and GSAT CGM, with the most significant impact observed in female ASAT CGM. While males with higher hepatic insulin resistance or android fat displayed a notable correlation with decreased interstitial glucose levels in the ACTIVE trial. Our in vitro experiments further revealed steady glucose uptake (GLUT1 expression) and de novo lipogenesis (ChREBP protein) were specifically enhanced in gluteal adipocytes during post-feeding 3-6 h.</p><p><strong>Conclusions: </strong>Breaking up prolonged sitting improves postprandial glucose control. Whereas gluteal fat depot may play roles to stabilize carbohydrate-enriched diets-induced hyperglycemia.</p>","PeriodicalId":19339,"journal":{"name":"Nutrition & Diabetes","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13265985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of High-Protein Instant Ramen Noodles in Inducing and Maintaining Satiety: Acute, Randomized, Crossover Study.","authors":"Princess U Ozioma, Gaurav M Kudchadkar, Sara Ranjbar, Marleigh Hefner, Tanvi Kale, Raksa Andalib Hia, Marsa Zaroudi, Surya Niraula, Nikhil V Dhurandhar","doi":"10.1038/s41387-026-00421-1","DOIUrl":"10.1038/s41387-026-00421-1","url":null,"abstract":"<p><strong>Objective: </strong>This study tested if a breakfast meal of high-protein instant ramen noodles would increase satiety, reduce hunger, improve glycemic response, and reduce lunch-time energy intake compared to an isocaloric breakfast of standard protein instant ramen noodles.</p><p><strong>Methods: </strong>A double-blind randomized crossover study was conducted. Twenty-five men and women (age 25-45 y; BMI 20-30 kg/m²) in a random sequence completed 2 testing days that included a 71 g breakfast of high-protein (HP) ramen noodles (320 kcal; protein 20 g [25% kcal]; carbohydrates 29 g [36% kcal]; fat 14 g [39% kcal]) and 71 g breakfast of standard protein (SP) ramen noodles (311 kcal; protein 6 g [8% kcal]; carbohydrates 41 g [53% kcal]; fat 13 g [38% kcal]). Appetite and hormonal responses were collected over 5 h followed by an ad libitum buffet lunch. Mixed effect model was used to examine the parameters. A paired t-test was used to examine differences in lunch intake between the two conditions.</p><p><strong>Results: </strong>HP vs SP breakfast conditions showed that appetite score, the primary outcome, was similar. HP led to greater reduction of the desire for prospective food consumption and reduced lunch-time energy intake compared to SP (-94kcal; 95% CI: 8.63, 179.75 kcal; p < 0.04). Glucose, insulin, ghrelin, GLP-1 and PYY3-36 were not different between the treatments. Greater desire to eat something savory or something sweet was observed following HP breakfast compared to SP breakfast (p < 0.05). Perceived feeling of hunger, satiety, and the desire to eat something fatty or something salty was not different between the conditions.</p><p><strong>Conclusions: </strong>A breakfast of high-protein instant ramen noodles acutely decreased the desire for prospective food consumption and subsequently reduced lunch-time energy intake compared to an isocaloric standard protein instant ramen noodles breakfast. Among individuals who consume noodles, the incorporation of a high-protein version might be an effective strategy for reducing short-term subsequent food intake.</p><p><strong>Clinical trial registration: </strong>This trial was registered at ClinicalTrials.gov with the identifier NCT05725681.</p>","PeriodicalId":19339,"journal":{"name":"Nutrition & Diabetes","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147776947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food noise: integrating experience and evidence.","authors":"Rashmi Prakash, Arif Khan","doi":"10.1038/s41387-026-00419-9","DOIUrl":"10.1038/s41387-026-00419-9","url":null,"abstract":"","PeriodicalId":19339,"journal":{"name":"Nutrition & Diabetes","volume":"16 1","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}