Nutrition & Diabetes最新文献

{"title":"Acute glycaemic response of orange juice consumption with breakfast in individuals with type 2 diabetes: a randomized cross-over trial.","authors":"Kenneth Verboven, Lisa Van Ryckeghem, Ralf Schweiggert, Christof B Steingass, Tin Gojevic, Carrie H S Ruxton, Dominique Hansen","doi":"10.1038/s41387-025-00385-8","DOIUrl":"10.1038/s41387-025-00385-8","url":null,"abstract":"<p><strong>Background/objectives: </strong>Sugar-sweetened beverages are associated with an increased risk of obesity and type 2 diabetes (T2DM) and show clear differential metabolic responses compared with 100% fruit juice, which is unsweetened by law. This study investigated whether the postprandial glycaemic response following a standardized breakfast differed when accompanied by 100% orange juice, equivalent whole orange, or a sugar-sweetened control beverage in individuals with well-controlled T2DM.</p><p><strong>Subjects/methods: </strong>Fifteen individuals with T2DM (60 ± 6 y; BMI 28.7 ± 5.0 kg/m², HbA1C 49 ± 3 mmol/mol (6.6 ± 0.3%)) participated in this randomized cross-over trial. They consumed a standardized breakfast served with either 250 mL of 100% orange juice, a sugar-sweetened orange-flavoured beverage or whole orange pieces with identical total sugar content. Postprandial glycaemic and insulinaemic responses were checked during 4 h.</p><p><strong>Results: </strong>Following a single intake, no significant differences were found in acute glucose or insulin responses (expressed as total or incremental area under the curve or peak values; p_treatment > 0.05, respectively) when either whole orange pieces, orange juice or a sugar-sweetened control beverage were consumed with a standard high carbohydrate meal. Capillary glucose responses did not differ between conditions (p_treatment > 0.05).</p><p><strong>Conclusion: </strong>Acute glycaemic control in individuals with well-controlled T2DM is not significantly influenced by serving orange juice, whole orange pieces or a sugar-sweetened beverage with a standard high-carbohydrate meal.</p>","PeriodicalId":19339,"journal":{"name":"Nutrition & Diabetes","volume":"15 1","pages":"31"},"PeriodicalIF":4.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12238372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food noise: definition, measurement, and future research directions.","authors":"Emily J Dhurandhar, Kevin C Maki, Nikhil V Dhurandhar, Theodore K Kyle, Sydney Yurkow, Misty A W Hawkins, Jon Agley, Emily H Ho, Lawrence J Cheskin, Thorkild I A Sørensen, Xi Rita Wang, David B Allison","doi":"10.1038/s41387-025-00382-x","DOIUrl":"10.1038/s41387-025-00382-x","url":null,"abstract":"<p><p>The term food noise has been recently popularized by individuals managing their weight or adhering to specific diets for health reasons. Anecdotal evidence from patients and clinical observations suggests that food noise involves constant preoccupation with food-related decisions-such as which foods to eat, caloric intake, macronutrient balance, and meal timing-which can become intrusive and unpleasant. Food noise also appears to affect cognitive burden and quality of life, and is being cited as one reason weight-loss attempts fail. The increase in public discourse about food noise has highlighted its potential significance, yet a formal clinical definition and method of measurement of food noise are lacking. Herein, we define food noise through clinical and patient anecdotes, describe initial research validating a food noise questionnaire, and outline future research directions. The formal definition of food noise is persistent thoughts about food that are perceived by the individual as being unwanted and/or dysphoric and may cause harm to the individual, including social, mental, or physical problems. Food noise is distinguished from routine food-related thoughts by its intensity and intrusiveness, resembling rumination. We describe our initial research developing the Ro Allison Indiana Dhurandhar- Food Noise Inventory (RAID-FN Inventory) to measure food noise. We also outline future areas of research, including exploring the prevalence and physiological underpinnings of food noise and the role of cultural and sociodemographic factors. The effects of glucagon-like peptide 1 (GLP-1) receptor agonists on food noise, the potential role of food noise in weight management and metabolic health, understanding food noise's impact on health outcomes and quality of life, the stigma associated with food noise, and the potential influence of food noise on public health policies are discussed. Future research should aim to refine definitions, improve measurement tools, and evaluate therapeutic strategies for managing food noise.</p>","PeriodicalId":19339,"journal":{"name":"Nutrition & Diabetes","volume":"15 1","pages":"30"},"PeriodicalIF":4.6,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12238327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing the role of increased SK3 expression in sulfonylurea resistance triggered by prolonged exposure.","authors":"Jung Gyu Park, Minseok Kim, Sungje Yoo, Sun Wook Hwang, Jongsoo Mok, Joonghoon Park, Keon Wook Kang","doi":"10.1038/s41387-025-00384-9","DOIUrl":"10.1038/s41387-025-00384-9","url":null,"abstract":"<p><strong>Background: </strong>Sulfonylureas have long been utilized in the management of type-2 diabetes mellitus (T2DM) due to their insulin-secretagogue properties. However, their clinical efficacy is hindered by the risk of severe hypoglycemia and secondary sulfonylurea failure. While the mechanisms underlying sulfonylurea-induced hypoglycemia are well-documented, the precise factors contributing to sulfonylurea resistance (SR) remain poorly understood. This study aims to elucidate the molecular basis of SR in insulinoma cells and an animal model.</p><p><strong>Methods: </strong>INS-1E, rat insulinoma cells, were exposed to 10 μM glibenclamide for 7 days to induce sulfonylurea resistance (SR). Sprague-Dawley (SD) rats were fed a diet containing 0.01% glibenclamide for 3 weeks to induce sulfonylurea resistance.</p><p><strong>Results: </strong>Insulinoma cells resistant to sulfonylureas exhibited elevated resting membrane potentials compared to sensitive cells. Transcriptome analysis revealed differential expression of genes, notably highlighting the significance of kcnn3 (Potassium Calcium-Activated Channel Subfamily N Member 3) in SR insulinoma cells. Western blot analysis confirmed the upregulation of SK3 protein in correlation with the duration of sulfonylurea exposure. Long-term administration of sulfonylureas in SD rats led to a diminished anti-diabetic response and increased SK3 expression in islets.</p><p><strong>Conclusion: </strong>This study elucidates the molecular mechanisms underlying SR, with a specific focus on the overexpression of the SK3 channel in insulinoma cells. These findings enhance our understanding of the challenges associated with prolonged sulfonylurea therapy in the management of T2DM.</p>","PeriodicalId":19339,"journal":{"name":"Nutrition & Diabetes","volume":"15 1","pages":"29"},"PeriodicalIF":4.6,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Density of ectopic fat depots predict distinct biomarkers of glycemic and insulinemic status in persons with HIV.","authors":"Seungweon Park, Annaliese Widmer, Alison Z Swartz, John R Koethe, Heidi J Silver","doi":"10.1038/s41387-025-00381-y","DOIUrl":"10.1038/s41387-025-00381-y","url":null,"abstract":"<p><strong>Background: </strong>HIV and obesity are conditions of impaired lipid storage where ectopic lipid accumulates in organs and tissues, promoting glucose intolerance and insulin resistance. Persons with HIV (PWH) are at high risk for diabetes, and one indicator of risk is the density of organs and tissues involved in glucose metabolism, which reflects ectopic lipid content and can be quantified using CT-tissue attenuation. We investigated relationships between subcutaneous adipose (SAT), visceral adipose (VAT), liver, pancreas, and skeletal muscle densities with biomarkers of glycemic/insulinemic status.</p><p><strong>Methods: </strong>Demographic, anthropometric, and clinical data were utilized with automated segmentation of CT morphometric data from images acquired at the 3rd lumbar vertebra level in PWH who had normoglycemia, prediabetes, and T2DM.</p><p><strong>Results: </strong>Of 217 PWH, 29.0% had prediabetes and 30.4% had T2DM. Liver, pancreas, and skeletal muscle densities were lower, and SAT density was higher, in PWH with T2DM. No differences were observed for VAT density. Receiver operating curves adjusted for age, sex and BMI showed tissue densities had similar ability to discriminate glycemic/insulinemic status. Adjusted multivariable logistic regression showed higher SAT density associated with higher glucose (p = 0.002), HbA1c (p < 0.001), and diabetes status (p < 0.001). Lower liver density is associated with diabetes status (p = 0.007) and higher HbA1c (p = 0.03), whereas lower skeletal muscle density is associated with higher glucose (p = 0.03) and insulin (p = 0.04).</p><p><strong>Conclusions: </strong>Tissue densities, which differed significantly among the three groups, were robustly associated with various biomarkers of glycemic/insulinemic status. CT-morphometrics may enhance the detection of metabolic perturbations and diabetes risk, possibly earlier than some clinical biomarkers.</p>","PeriodicalId":19339,"journal":{"name":"Nutrition & Diabetes","volume":"15 1","pages":"28"},"PeriodicalIF":4.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12177074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific differences of advanced glycation end products in diabetes.","authors":"Michael Hellwig, Julia Decker, Leticia Prates Roma, Stefan Schunk, Emmanuel Ampofo, Sandra Rother","doi":"10.1038/s41387-025-00379-6","DOIUrl":"10.1038/s41387-025-00379-6","url":null,"abstract":"<p><p>Advanced glycation end products (AGEs) are formed through non-enzymatic glycation reactions and accumulate in tissues, particularly under pathological conditions such as diabetes mellitus. These compounds are linked to the progression of diabetic complications, including nephropathy, retinopathy, and cardiovascular disease, through mechanisms such as oxidative stress and chronic inflammation. Emerging evidence suggests significant sex-specific differences in AGE formation, accumulation, and their biological effects, influenced by hormonal variations, dietary patterns, and metabolic differences. While the underlying biochemistry of AGE formation, such as the Maillard reaction and dicarbonyl compound activity, is well-characterized, the implications of these processes for clinical outcomes remain underexplored. This mini-review highlights the interplay between molecular mechanisms and sex-specific factors in AGE-related pathophysiology. It further discusses potential therapeutic approaches targeting AGE formation and receptor-mediated pathways, emphasizing the importance of integrating sex-specific considerations into diabetes management. Bridging molecular insights with clinical practice could advance personalized treatment strategies for diabetic complications.</p>","PeriodicalId":19339,"journal":{"name":"Nutrition & Diabetes","volume":"15 1","pages":"27"},"PeriodicalIF":4.6,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12167377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144294171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interactions among nutrition, metabolism and the immune system in the context of starvation and nutrition-stimulated obesity.","authors":"Borros Arneth","doi":"10.1038/s41387-025-00383-w","DOIUrl":"10.1038/s41387-025-00383-w","url":null,"abstract":"<p><p>The endogenous intestinal microflora and environmental factors, such as diet, play central roles in immune homeostasis and reactivity. The microflora and diet both influence body weight and insulin resistance, notably through their effects on adipose cells. The aim of this study was to provide an update on how nutrient-derived factors (mostly focusing on fatty acids and glucose) impact the innate and acquired immune systems, including the immune system in the gut and its associated bacterial flora. The main source of fuel for energy-demanding immune cells is glucose. Insulin-responsive adipose tissue and Toll-like receptors (TLRs), which are part of the innate immune system and expressed in immune cells, intestinal cells, and adipocytes, are essential actors in the complex balance that ensures systemic immune and metabolic health. Leptin decreases during weight loss and increases brain activity in regions involved in the cognitive, emotional, and sensory control of food intake; restoring leptin levels maintains weight loss and reverses the alterations in brain activity. Obesity-triggering nutrients affect adipocytes, whereas proinflammatory leptin prompts the generation of cytokines and T cells. Collectively, data on nutrients demonstrate that starvation culminates in fat depletion, which then impacts the immune system. In people with obesity, inflammation originates largely from adipose tissue.</p>","PeriodicalId":19339,"journal":{"name":"Nutrition & Diabetes","volume":"15 1","pages":"26"},"PeriodicalIF":4.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary protein and risk of type 2 diabetes: findings from a registry-based cohort study and a meta-analysis of prospective cohort studies.","authors":"Mingjing Xu, Jianheng Zheng, Tao Ying, Yang Zhu, Jun Du, Fan Li, Bo Chen, Yuwei Liu, Gengsheng He","doi":"10.1038/s41387-025-00380-z","DOIUrl":"10.1038/s41387-025-00380-z","url":null,"abstract":"<p><strong>Objectives: </strong>Lifestyle intervention, especially dietary modification, has been the cornerstone in preventing type 2 diabetes (T2D). We aimed to investigate the associations of various protein intake exposures with the risk of incident T2D in adults with or without metabolic diseases.</p><p><strong>Methods: </strong>We followed 29517 residents enrolled in the Shanghai Suburban Adult Cohort and Biobank (SSACB) without diabetes at baseline through the electronic information system. Cox proportional hazard models were used to evaluate the associations of various protein intake exposures with the risk of incident T2D, visualized by restricted cubic splines (RCS). Propensity-score matching and subgroup analysis were used to characterize the association between total protein and incident T2D by metabolic diseases. Meta-analysis further explored the association between protein intake and incident T2D in broader populations.</p><p><strong>Results: </strong>In SSACB, 1511 (5.1%) participants developed T2D during a median follow-up period of 5.69 years. A U-shaped association between total protein and risk of incident T2D was found (protective range: 12.20-16.85 percentage energy (%E), cut-off point: 14.53%E). The U-shaped association (P-nonlinear < 0.001) remained in adults with hypertension with a narrower protective range (12.20-15.35%E), with a linear association in adults with NAFLD (HR per 1%E: 0.952, 95% CI: [0.910, 0.995]), whereas no significant association in adults with hyperlipidemia or central obesity. A negative association between plant protein and risk of incident T2D was also found in SSACB (HR per 1%E: 0.947, 95% CI: [0.900, 0.996]). In addition, the U-shaped association of total protein with the risk of incident T2D was reaffirmed in the dose-response meta-analysis (cut-off point: 15.10%E).</p><p><strong>Conclusion: </strong>In SSACB, a U-shaped association between total protein intake and risk of incident T2D was found, which was reaffirmed in the dose-response meta-analysis, and differed by metabolic diseases, especially hypertension and NAFLD. Moreover, plant protein was inversely associated with the risk of incident T2D.</p>","PeriodicalId":19339,"journal":{"name":"Nutrition & Diabetes","volume":"15 1","pages":"25"},"PeriodicalIF":4.6,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of whole course fine nursing combined with insulin pump blood glucose management on patients with diabetes mellitus combined with ischemic cerebral infarction.","authors":"Xiaobin Wu, Yayuan Yang, Xiufeng Huang, Liwen Chen","doi":"10.1038/s41387-025-00376-9","DOIUrl":"10.1038/s41387-025-00376-9","url":null,"abstract":"<p><strong>Objective: </strong>To probe the effectiveness of whole course fine nursing combined with insulin pump blood glucose management on patients with diabetes mellitus (DM) combined with ischemic cerebral infarction (ICI).</p><p><strong>Methods: </strong>The control group (conventional nursing plus insulin subcutaneous injection) and observation group (whole course fine nursing plus insulin pump blood glucose management) were established. General characteristics, glucose control effects, recovery of neurological and motor functions, self-care ability, health behaviors, quality of life, satisfaction, and adverse event incidence were compared in both groups.</p><p><strong>Results: </strong>Serum FBG, 2hPG, and HbA1c levels and NIHSS scores reduced and FMA, ESCA, 2-DSCS, and SF-36 scores increased after the intervention in both groups, and all significantly improved in the observation group. The observation group had higher satisfaction with blood glucose monitoring and feedback, health knowledge education, disposal of unexpected situations, treatment effect and comprehensive evaluation, and lower total adverse event incidence rate during hospitalization than the control group.</p><p><strong>Conclusion: </strong>Whole course fine nursing combined with insulin pump glucose management can enhance the glucose control effect, and improve the neurological and motor functions, self-care ability, health behaviors and quality of life in patients with DM plus ICI, with high satisfaction and reduced adverse event incidence.</p>","PeriodicalId":19339,"journal":{"name":"Nutrition & Diabetes","volume":"15 1","pages":"24"},"PeriodicalIF":4.6,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the effects of mycoprotein and guar gum on postprandial glucose in type 2 diabetes: a double-blind randomised controlled trial.","authors":"Anna Cherta-Murillo, Kexin Zhou, Martina Tashkova, James Frampton, Ana Cláudia Cepas de Oliveira, Claire Ho, Georgia Franco-Becker, Edward S Chambers, Anne Dornhorst, Gary S Frost","doi":"10.1038/s41387-025-00375-w","DOIUrl":"10.1038/s41387-025-00375-w","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes (T2D) is highly prevalent, particularly among south Asian populations, and diet is the first-line strategy to manage postprandial glucose (PG) response. Mycoprotein and guar gum reduce PG in normo-glycaemic people. This study investigates the independent and interactive effects of mycoprotein and guar gum on PG, insulin and appetite responses in white Europeans and south Asians with T2D.</p><p><strong>Methods: </strong>In this double-blind, crossover, acute, randomised controlled trial, 18 subjects with T2D (10 white European, 8 south Asian) completed six separate visits consuming soy, chicken, and mycoprotein with and without guar gum. Incremental area under the curve (iAUC_0-180 min) for PG, insulin, and appetite scores, and total AUC_0-180 min glucagon-like peptide-1 (GLP-1), peptide tyrosine-tyrosine (PYY), as well as ad libitum energy intake and 48h-post-visit energy intake were measured and analysed by linear mixed models with protein, guar gum and ethnicity as fixed effects.</p><p><strong>Results: </strong>We found independent effects of mycoprotein, guar gum and ethnicity on PG iAUC_0-180 min (mmol/L·min), where mycoprotein reduced PG vs. chicken (-129.84 [95% CI -203.16, -56.51]; p = 0.002), guar gum reduced PG vs. no guar gum (-197.35 [95% CI -254.30, -140.40; p < 0.001], and south Asian had increased PG vs. white Europeans (195.75 [95% CI 66.14, 325.35]; p = 0.005). An interaction between guar gum and ethnicity (p < 0.015) was found for insulin iAUC_0-180 min (µUI/mL·min), with guar gum lowering insulin responses in south Asian participants (-1909.69 [95% CI -2834.83, -984.511]; p < 0.001). No independent or interactive effects were observed for appetite-related outcomes.</p><p><strong>Conclusion: </strong>Mycoprotein and guar gum promote significant independent effects in lowering PG in both white European and south Asians with T2D.</p>","PeriodicalId":19339,"journal":{"name":"Nutrition & Diabetes","volume":"15 1","pages":"23"},"PeriodicalIF":4.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of jujube fruit on serum lipid profile, glycemic index, and liver function: a systematic review and meta-analysis.","authors":"Mostafa Ahmadi, Hoda Shirafkan, Seyyed Ali Mozaffarpur, Maedeh Rezghi","doi":"10.1038/s41387-025-00378-7","DOIUrl":"10.1038/s41387-025-00378-7","url":null,"abstract":"<p><p>Jujube is a widely consumed fruit with a long history in traditional medicine. Numerous studies have explored its potential effects on various health parameters. However, the overall quality of this evidence and the specific impact of jujube on metabolic syndrome remain unclear. This meta-analysis investigates the effect of jujube on body mass index, serum lipid profile, blood sugar levels, and other metabolic factors and blood indicators. The databases Web of Science, Scopus, PubMed, Google Scholar, and SID were searched up to September 2023. Our review included various clinical studies written in English and Persian that focused on the effect of jujube on lipid profiles. In vivo, in vitro, review studies, book chapters, observational studies, and low-quality studies based on critical appraisal tools were excluded from the analysis. A total of seven studies involving 483 participants were included in this review. Jujube significantly reduced BMI and TG, and also markedly decreased FBS in subjects with type 2 diabetes. Furthermore, the results varied significantly based on subgroups defined by dosage, treatment duration, and disease type. Notably, LDL and total cholesterol levels showed a significant decrease within some of these subgroups. However, HDL, AST, and ALT did not have significant changes. The findings suggest that jujube may exert beneficial effects on metabolic diseases, particularly in patients with hyperlipidemia and type 2 diabetes. However, the overall quality of the evidence is limited, and further research is needed to confirm these findings and elucidate the mechanisms underlying jujube's effects. Impact of jujube fruit on serum lipid profile, glycemic index, and liver function: a systematic review and meta-analysis.</p>","PeriodicalId":19339,"journal":{"name":"Nutrition & Diabetes","volume":"15 1","pages":"22"},"PeriodicalIF":4.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}