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Direct comparison of SARS-CoV-2 variant specific neutralizing antibodies in human and hamster sera. 直接比较人和仓鼠血清中的 SARS-CoV-2 变异特异性中和抗体
IF 9.2 1区 医学
NPJ Vaccines Pub Date : 2024-05-18 DOI: 10.1038/s41541-024-00888-y
Annika Rössler, Antonia Netzl, Ludwig Knabl, Samuel H Wilks, Barbara Mühlemann, Sina Türeli, Anna Mykytyn, Dorothee von Laer, Bart L Haagmans, Derek J Smith, Janine Kimpel
{"title":"Direct comparison of SARS-CoV-2 variant specific neutralizing antibodies in human and hamster sera.","authors":"Annika Rössler, Antonia Netzl, Ludwig Knabl, Samuel H Wilks, Barbara Mühlemann, Sina Türeli, Anna Mykytyn, Dorothee von Laer, Bart L Haagmans, Derek J Smith, Janine Kimpel","doi":"10.1038/s41541-024-00888-y","DOIUrl":"10.1038/s41541-024-00888-y","url":null,"abstract":"<p><p>Antigenic characterization of newly emerging SARS-CoV-2 variants is important to assess their immune escape and judge the need for future vaccine updates. To bridge data obtained from animal sera with human sera, we analyzed neutralizing antibody titers in human and hamster single infection sera in a highly controlled setting using the same authentic virus neutralization assay performed in one laboratory. Using a Bayesian framework, we found that titer fold changes in hamster sera corresponded well to human sera and that hamster sera generally exhibited higher reactivity.</p>","PeriodicalId":19335,"journal":{"name":"NPJ Vaccines","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11102554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Modulating the immune response to SARS-CoV-2 by different nanocarriers delivering an mRNA expressing trimeric RBD of the spike protein: COVARNA Consortium 作者更正：通过不同的纳米载体传递表达尖峰蛋白三聚体 RBD 的 mRNA 来调节对 SARS-CoV-2 的免疫反应：COVARNA联盟
IF 9.2 1区 医学
NPJ Vaccines Pub Date : 2024-05-18 DOI: 10.1038/s41541-024-00882-4
L. Marcos-Villar, B. Perdiguero, S. Anthiya, Mireya L. Borrajo, Gustavo Lou, Lorenzo Franceschini, I. Esteban, Pedro J. Sánchez-Cordón, Carmen Zamora, C. Sorzano, Luis Jordá, L. Codó, J. Gelpí, Marta Sisteré-Oró, Andreas Meyerhans, Kris Thielemans, Francisco Martínez-Jiménez, Núria López-Bigas, Felipe García, M. Alonso, M. Plana, Mariano Esteban, Carmen Elena Gómez
{"title":"Author Correction: Modulating the immune response to SARS-CoV-2 by different nanocarriers delivering an mRNA expressing trimeric RBD of the spike protein: COVARNA Consortium","authors":"L. Marcos-Villar, B. Perdiguero, S. Anthiya, Mireya L. Borrajo, Gustavo Lou, Lorenzo Franceschini, I. Esteban, Pedro J. Sánchez-Cordón, Carmen Zamora, C. Sorzano, Luis Jordá, L. Codó, J. Gelpí, Marta Sisteré-Oró, Andreas Meyerhans, Kris Thielemans, Francisco Martínez-Jiménez, Núria López-Bigas, Felipe García, M. Alonso, M. Plana, Mariano Esteban, Carmen Elena Gómez","doi":"10.1038/s41541-024-00882-4","DOIUrl":"https://doi.org/10.1038/s41541-024-00882-4","url":null,"abstract":"","PeriodicalId":19335,"journal":{"name":"NPJ Vaccines","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Modulating the immune response to SARS-CoV-2 by different nanocarriers delivering an mRNA expressing trimeric RBD of the spike protein: COVARNA Consortium. 作者更正：通过不同的纳米载体传递表达尖峰蛋白三聚体 RBD 的 mRNA 来调节对 SARS-CoV-2 的免疫反应：COVARNA Consortium.
IF 9.2 1区 医学
NPJ Vaccines Pub Date : 2024-05-18 DOI: 10.1038/s41541-024-00882-4
Laura Marcos-Villar, Beatriz Perdiguero, Shubaash Anthiya, Mireya L Borrajo, Gustavo Lou, Lorenzo Franceschini, Ignasi Esteban, Pedro J Sánchez-Cordón, Carmen Zamora, Carlos Óscar S Sorzano, Luis Jordá, Laia Codó, Josep L Gelpí, Marta Sisteré-Oró, Andreas Meyerhans, Kris Thielemans, Francisco Martínez-Jiménez, Núria López-Bigas, Felipe García, María J Alonso, Montserrat Plana, Mariano Esteban, Carmen Elena Gómez
{"title":"Author Correction: Modulating the immune response to SARS-CoV-2 by different nanocarriers delivering an mRNA expressing trimeric RBD of the spike protein: COVARNA Consortium.","authors":"Laura Marcos-Villar, Beatriz Perdiguero, Shubaash Anthiya, Mireya L Borrajo, Gustavo Lou, Lorenzo Franceschini, Ignasi Esteban, Pedro J Sánchez-Cordón, Carmen Zamora, Carlos Óscar S Sorzano, Luis Jordá, Laia Codó, Josep L Gelpí, Marta Sisteré-Oró, Andreas Meyerhans, Kris Thielemans, Francisco Martínez-Jiménez, Núria López-Bigas, Felipe García, María J Alonso, Montserrat Plana, Mariano Esteban, Carmen Elena Gómez","doi":"10.1038/s41541-024-00882-4","DOIUrl":"10.1038/s41541-024-00882-4","url":null,"abstract":"","PeriodicalId":19335,"journal":{"name":"NPJ Vaccines","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11102484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140958645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High production of IL-12 by human dendritic cells stimulated with combinations of pattern-recognition receptor agonists 人树突状细胞在模式识别受体激动剂组合刺激下产生大量 IL-12
IF 9.2 1区 医学
NPJ Vaccines Pub Date : 2024-05-03 DOI: 10.1038/s41541-024-00869-1
Brian C. Gilmour, Alexandre Corthay, Inger Øynebråten
{"title":"High production of IL-12 by human dendritic cells stimulated with combinations of pattern-recognition receptor agonists","authors":"Brian C. Gilmour, Alexandre Corthay, Inger Øynebråten","doi":"10.1038/s41541-024-00869-1","DOIUrl":"https://doi.org/10.1038/s41541-024-00869-1","url":null,"abstract":"<p>The cytokine IL-12p70 is crucial for T helper 1 (Th1) polarization and the generation of type 1 immunity required to fight cancer and pathogens. Therefore, strategies to optimize the production of IL-12p70 by human dendritic cells (DCs) may significantly improve the efficacy of vaccines and immunotherapies. However, the rules governing the production of IL-12p70 remain obscure. Here, we stimulated pattern recognition receptors (PRRs) representing five families of PRRs, to evaluate their ability to elicit high production of IL-12p70 by monocyte-derived DCs. We used ten well-characterized agonists and stimulated DCs in vitro with either single agonists or 27 different combinations. We found that poly(I:C), which engages the RNA-sensing PRRs TLR3 and MDA5, and LPS which stimulates TLR4, were the only agonists that could elicit notable IL-12p70 production when used as single ligands. We identified six different combinations of PRR agonists, all containing either the TLR3/MDA5 agonist poly(I:C) or the TLR7/8 agonist R848, that could synergize to elicit high production of IL-12p70 by human DCs. Five of the six combinations also triggered high production of the antiviral and antitumor cytokine IFNβ. Overall, the tested PRR ligands could be divided into three groups depending on whether they triggered production of both IL-12p70 and IFNβ, only one of the two, or neither. Thus, combinations of PRR agonists were found to increase the production of IL-12p70 by human DCs in a synergistic manner, and we identified six PRR agonist combinations that may represent strong adjuvant candidates, in particular for therapeutic cancer vaccines.</p>","PeriodicalId":19335,"journal":{"name":"NPJ Vaccines","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140834306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Realising the potential of correlates of protection for vaccine development, licensure and use: short summary 发挥保护相关性在疫苗开发、许可和使用方面的潜力：简短摘要
IF 9.2 1区 医学
NPJ Vaccines Pub Date : 2024-04-29 DOI: 10.1038/s41541-024-00872-6
Deborah F. King, Helen Groves, Charlie Weller, Ian Jones, Jakob P. Cramer, Peter B. Gilbert, David Goldblatt, Marion F. Gruber, Beate Kampmann, Diadié Maïga, Marcela F. Pasetti, Stanley A. Plotkin, Alexander Precioso, Liya Wassie, Frederick Wittke, David C. Kaslow
{"title":"Realising the potential of correlates of protection for vaccine development, licensure and use: short summary","authors":"Deborah F. King, Helen Groves, Charlie Weller, Ian Jones, Jakob P. Cramer, Peter B. Gilbert, David Goldblatt, Marion F. Gruber, Beate Kampmann, Diadié Maïga, Marcela F. Pasetti, Stanley A. Plotkin, Alexander Precioso, Liya Wassie, Frederick Wittke, David C. Kaslow","doi":"10.1038/s41541-024-00872-6","DOIUrl":"https://doi.org/10.1038/s41541-024-00872-6","url":null,"abstract":"On 27–29th of September 2022, Wellcome convened an international multi-stakeholder workshop to discuss the use of Correlates of Protection (CoP) to accelerate vaccine development, the hybrid format meeting was attended by 80 delegates including developers, manufacturers, regulators, public health officials and policy-makers from 17 countries, including 7 LMIC’s.","PeriodicalId":19335,"journal":{"name":"NPJ Vaccines","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140833953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strep A: challenges, opportunities, vaccine-based solutions, and economics 甲型链球菌：挑战、机遇、疫苗解决方案和经济学
IF 9.2 1区 医学
NPJ Vaccines Pub Date : 2024-04-19 DOI: 10.1038/s41541-024-00863-7
David E. Bloom, Jonathan Carapetis
{"title":"Strep A: challenges, opportunities, vaccine-based solutions, and economics","authors":"David E. Bloom, Jonathan Carapetis","doi":"10.1038/s41541-024-00863-7","DOIUrl":"https://doi.org/10.1038/s41541-024-00863-7","url":null,"abstract":"<p>This collection of articles focuses on Streptococcus pyogenes (Strep A) vaccine research and innovation, with a focus on emerging efforts to understand and estimate the full societal value of Strep A vaccination.</p>","PeriodicalId":19335,"journal":{"name":"NPJ Vaccines","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140625073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strep A: challenges, opportunities, vaccine-based solutions and economics 甲型链球菌：挑战、机遇、疫苗解决方案和经济学
IF 9.2 1区 医学
NPJ Vaccines Pub Date : 2024-04-19 DOI: 10.1038/s41541-024-00864-6
David E. Bloom, R. Titball, Jonathan R. Carapetis
{"title":"Strep A: challenges, opportunities, vaccine-based solutions and economics","authors":"David E. Bloom, R. Titball, Jonathan R. Carapetis","doi":"10.1038/s41541-024-00864-6","DOIUrl":"https://doi.org/10.1038/s41541-024-00864-6","url":null,"abstract":"","PeriodicalId":19335,"journal":{"name":"NPJ Vaccines","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140682790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Enhanced attenuation of chikungunya vaccines expressing antiviral cytokines. 作者更正：增强表达抗病毒细胞因子的基孔肯雅疫苗的减毒作用。
IF 9.2 1区 医学
NPJ Vaccines Pub Date : 2024-04-16 DOI: 10.1038/s41541-024-00868-2
Christina Chuong, Chelsea Cereghino, Pallavi Rai, Tyler A Bates, Megan Oberer, James Weger-Lucarelli
{"title":"Author Correction: Enhanced attenuation of chikungunya vaccines expressing antiviral cytokines.","authors":"Christina Chuong, Chelsea Cereghino, Pallavi Rai, Tyler A Bates, Megan Oberer, James Weger-Lucarelli","doi":"10.1038/s41541-024-00868-2","DOIUrl":"https://doi.org/10.1038/s41541-024-00868-2","url":null,"abstract":"","PeriodicalId":19335,"journal":{"name":"NPJ Vaccines","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11021412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of correlates of protection in overcoming barriers to vaccine development and demonstrating efficacy 保护相关因素在克服疫苗开发障碍和证明有效性方面的作用
IF 9.2 1区 医学
NPJ Vaccines Pub Date : 2024-04-13 DOI: 10.1038/s41541-024-00873-5
Deborah F. King, Helen Groves, Charlotte Weller
{"title":"The role of correlates of protection in overcoming barriers to vaccine development and demonstrating efficacy","authors":"Deborah F. King, Helen Groves, Charlotte Weller","doi":"10.1038/s41541-024-00873-5","DOIUrl":"https://doi.org/10.1038/s41541-024-00873-5","url":null,"abstract":"","PeriodicalId":19335,"journal":{"name":"NPJ Vaccines","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140706711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights into vaccines for elderly individuals: from the impacts of immunosenescence to delivery strategies 洞察老年人疫苗：从免疫衰老的影响到接种策略
IF 9.2 1区 医学
NPJ Vaccines Pub Date : 2024-04-10 DOI: 10.1038/s41541-024-00874-4
Yingying Hou, Min Chen, Yuan Bian, Yuan Hu, Junlan Chuan, Lei Zhong, Yuxuan Zhu, Rongsheng Tong
{"title":"Insights into vaccines for elderly individuals: from the impacts of immunosenescence to delivery strategies","authors":"Yingying Hou, Min Chen, Yuan Bian, Yuan Hu, Junlan Chuan, Lei Zhong, Yuxuan Zhu, Rongsheng Tong","doi":"10.1038/s41541-024-00874-4","DOIUrl":"https://doi.org/10.1038/s41541-024-00874-4","url":null,"abstract":"<p>Immunosenescence increases the risk and severity of diseases in elderly individuals and leads to impaired vaccine-induced immunity. With aging of the global population and the emerging risk of epidemics, developing adjuvants and vaccines for elderly individuals to improve their immune protection is pivotal for healthy aging worldwide. Deepening our understanding of the role of immunosenescence in vaccine efficacy could accelerate research focused on optimizing vaccine delivery for elderly individuals. In this review, we analyzed the characteristics of immunosenescence at the cellular and molecular levels. Strategies to improve vaccination potency in elderly individuals are summarized, including increasing the antigen dose, preparing multivalent antigen vaccines, adding appropriate adjuvants, inhibiting chronic inflammation, and inhibiting immunosenescence. We hope that this review can provide a review of new findings with regards to the impacts of immunosenescence on vaccine-mediated protection and inspire the development of individualized vaccines for elderly individuals.</p>","PeriodicalId":19335,"journal":{"name":"NPJ Vaccines","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140591502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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