NPJ Vaccines最新文献

Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination. 实体瘤恶性患者炎症失调影响对COVID-19疫苗接种的多功能抗体反应

IF 6.5 1区医学

NPJ Vaccines Pub Date : 2025-10-06 DOI: 10.1038/s41541-025-01268-w

Ruth A Purcell, Marios Koutsakos, Lukasz Kedzierski, Lilith F Allen, Oscar H Lloyd Williams, Jo-Wai Douglas Wang, George Cavic, Adam K Wheatley, Wen Shi Lee, Bruce D Wines, P Mark Hogarth, Emily M Eriksson, Ivo Mueller, Katherine A Bond, Deborah A Williamson, Janine M Trevillyan, Jason A Trubiano, Thi H O Nguyen, Pradhipa Ramanathan, Stephen J Rogerson, Kelly B Arnold, Kanta Subbarao, Adrian Lee, Amanda L Hudson, Alexander Yuile, Helen R Wheeler, Stephen J Kent, Kevin John Selva, Siddhartha Mahanty, Katherine Kedzierska, Aude M Fahrer, Yada Kanjanapan, Amy W Chung

{"title":"Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination.","authors":"Ruth A Purcell, Marios Koutsakos, Lukasz Kedzierski, Lilith F Allen, Oscar H Lloyd Williams, Jo-Wai Douglas Wang, George Cavic, Adam K Wheatley, Wen Shi Lee, Bruce D Wines, P Mark Hogarth, Emily M Eriksson, Ivo Mueller, Katherine A Bond, Deborah A Williamson, Janine M Trevillyan, Jason A Trubiano, Thi H O Nguyen, Pradhipa Ramanathan, Stephen J Rogerson, Kelly B Arnold, Kanta Subbarao, Adrian Lee, Amanda L Hudson, Alexander Yuile, Helen R Wheeler, Stephen J Kent, Kevin John Selva, Siddhartha Mahanty, Katherine Kedzierska, Aude M Fahrer, Yada Kanjanapan, Amy W Chung","doi":"10.1038/s41541-025-01268-w","DOIUrl":"https://doi.org/10.1038/s41541-025-01268-w","url":null,"abstract":"Solid tumor malignancy (STM) patients experience increased risk of breakthrough SARS-CoV-2 infection owing to reduced COVID-19 vaccine immunogenicity. However, the underlying immunological causes of impaired neutralization remain poorly characterized. Furthermore, non-neutralizing antibody functions can contribute to reduced disease severity but remain understudied within high-risk populations. We dissected polyfunctional antibody responses in STM patients and age-matched controls who received adenoviral vector- or mRNA-based COVID-19 vaccine regimens. Elevated inflammatory biomarkers, including agalactosylated IgG, interleukin (IL)-6, IL-18, and an expanded population of CD11c-CD21- double negative 3 (DN3) B cells were observed in STM patients and were associated with impaired neutralization. In contrast, mRNA vaccination induced Fc effector functions that were comparable in patients and controls and were cross-reactive against SARS-CoV-2 variants. These data highlight the resilience of Fc functional antibodies and identify systemic inflammatory biomarkers that may underpin impaired neutralizing antibody responses, suggesting potential avenues for immunomodulation via rational vaccine design.","PeriodicalId":19335,"journal":{"name":"NPJ Vaccines","volume":"10 1","pages":"217"},"PeriodicalIF":6.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single dose of foot-and-mouth disease peptide vaccine fully protects swine and achieves intraserotype crossed neutralization. 单剂口蹄疫多肽疫苗对猪具有充分的保护作用，实现了猪的内型交叉中和。

IF 6.5 1区医学

NPJ Vaccines Pub Date : 2025-10-06 DOI: 10.1038/s41541-025-01274-y

Esther Blanco, Elisa Torres, Patricia de León, Mar Forner, María J Bustos, Sabine E Hammer, Francisco Sobrino, David Andreu, Sira Defaus

{"title":"Single dose of foot-and-mouth disease peptide vaccine fully protects swine and achieves intraserotype crossed neutralization.","authors":"Esther Blanco, Elisa Torres, Patricia de León, Mar Forner, María J Bustos, Sabine E Hammer, Francisco Sobrino, David Andreu, Sira Defaus","doi":"10.1038/s41541-025-01274-y","DOIUrl":"https://doi.org/10.1038/s41541-025-01274-y","url":null,"abstract":"Foot-and-mouth disease virus (FMDV) poses a persistent threat to the livestock sector, urging a need for safer and more effective vaccines. As traditional control approaches relying on inactivated virus vaccines face limitations, exploring subunit vaccine strategies such as those based on synthetic peptides represents an attractive alternative, compliant with DIVA vaccine requirements. We previously reported that dendrimer structures combining virus-specific B- and T-cell epitopes-referred to as B2T-conferred solid protection against type-O FMDV in swine. More recently, we designed a synthetic strategy with broad application prospects, assembling peptides into a modular dendrimer platform named B2T-TB2, a dimeric version of the preceding construct, harboring up to six immunologically relevant epitopes. In this study, we demonstrate that a single low dose of this multiepitopic vaccine induces in swine a fast and robust neutralizing response covering a broad antigenic spectrum and confers full protection, portraying B2T-TB2 as a promising FMDV emergency vaccine.","PeriodicalId":19335,"journal":{"name":"NPJ Vaccines","volume":"10 1","pages":"216"},"PeriodicalIF":6.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of major, minor and junctional circumsporozoite protein epitopes for malaria vaccine design. 疟疾疫苗设计中主要、次要和连接环孢子子蛋白表位的比较。

IF 6.5 1区医学

NPJ Vaccines Pub Date : 2025-10-03 DOI: 10.1038/s41541-025-01264-0

Emma Ryan, Dallas Brown, William Harrison, Shelby Foor, Kutub Ashraf, Jessica S Bolton, Yevel Flores-Garcia, Randall S MacGill, Emily Locke, Elke Bergmann-Leitner, Alison E Roth, Paul M Robben, Gary Matyas, Lorraine Soisson, Robin Miller, Adrian H Batchelor, Fidel Zavala, Sheetij Dutta

{"title":"Comparison of major, minor and junctional circumsporozoite protein epitopes for malaria vaccine design.","authors":"Emma Ryan, Dallas Brown, William Harrison, Shelby Foor, Kutub Ashraf, Jessica S Bolton, Yevel Flores-Garcia, Randall S MacGill, Emily Locke, Elke Bergmann-Leitner, Alison E Roth, Paul M Robben, Gary Matyas, Lorraine Soisson, Robin Miller, Adrian H Batchelor, Fidel Zavala, Sheetij Dutta","doi":"10.1038/s41541-025-01264-0","DOIUrl":"10.1038/s41541-025-01264-0","url":null,"abstract":"Currently approved malaria vaccines (RTS,S/AS01 and R21/Matrix-M) contain the tetrapeptide major repeats (19x NPNA) and C-terminal domain of the circumsporozoite protein of Plasmodium falciparum. Incorporating the junctional (NPDP) and minor repeat (NPNV) epitope targeted by protective human monoclonal antibodies into immunogens is hypothesized to improve vaccine efficacy. However, comparisons of such candidates have yielded contradictory results due to inter-study differences. Tobacco mosaic virus (TMV) capsid virus-like particles displaying the minor repeat, junctional, and major repeat epitopes were compared in an intravenous challenge model. Despite high cross-reactivity and in vitro inhibition, minor repeat candidates did not confer sterile protection in vivo. Constructs displaying major repeats NPNAx20, NPNAx5, and a junctional+minor repeat epitope induced sterile protection. Head-to-head comparisons of selected TMV vaccines and RTS,S revealed equivalent in vivo liver burden reduction. TMV-NPNAx20 was selected for clinical-grade antigen manufacture based on its equivalent reduction in parasite burden at lower antibody concentrations.","PeriodicalId":19335,"journal":{"name":"NPJ Vaccines","volume":"10 1","pages":"215"},"PeriodicalIF":6.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cocktail vaccine induces immunoprotection and modulates the fecal microbiota in dogs against Echinococcus granulosus infection. 鸡尾酒疫苗诱导免疫保护和调节狗对颗粒棘球绦虫感染的粪便微生物群。

IF 6.5 1区医学

NPJ Vaccines Pub Date : 2025-10-01 DOI: 10.1038/s41541-025-01275-x

Guoqing Shao, Xiaowei Zhu, Ruiqi Hua, Zhiwei Lu, Yanxin Chen, Aiguo Yang, Guangyou Yang

{"title":"Cocktail vaccine induces immunoprotection and modulates the fecal microbiota in dogs against Echinococcus granulosus infection.","authors":"Guoqing Shao, Xiaowei Zhu, Ruiqi Hua, Zhiwei Lu, Yanxin Chen, Aiguo Yang, Guangyou Yang","doi":"10.1038/s41541-025-01275-x","DOIUrl":"10.1038/s41541-025-01275-x","url":null,"abstract":"Cystic echinococcosis (CE) is a global zoonotic parasitic disease that represents a significant public health challenge. Although vaccination is considered an ideal strategy for controlling CE, no effective vaccines are currently available for dogs. Herein, bioinformatic approaches were employed to identify vaccine candidates. The selected proteins, including Echinococcus granulosus enolase (EgENO), severin (EgSev), cyclophilin (EgCyc), fatty acid-binding protein 1 (EgFABP1), calmodulin (EgCaM), and serine protease inhibitor 1 (EgSrp1), were expressed in Escherichia coli. These proteins were grouped into cocktail vaccines: rEgENO&rEgSev&rEgCyc and rEgFABP1&rEgCaM&rEgSrp1, and were combined with the Quil-A adjuvant to evaluate vaccine efficacy in beagles. After two subcutaneous immunizations, the rEgENO&rEgSev&rEgCyc and rEgFABP1&rEgCaM&rEgSrp1 vaccines reduced the parasite burden by 80.58% (p < 0.01) and 47.92% (p < 0.01), respectively. Additionally, Ligilactobacillus, Fusobacterium, and Streptococcus correlated significantly with immunoprotection. This study demonstrated bioinformatically screened antigens were effective vaccine candidates, and vaccine-microbiota interactions provided a potential strategy to improve vaccine efficacy.","PeriodicalId":19335,"journal":{"name":"NPJ Vaccines","volume":"10 1","pages":"214"},"PeriodicalIF":6.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunization with virus-like vesicle-based COVID-19 vaccine induces robust systemic and mucosal immunity. 基于病毒样囊泡的COVID-19疫苗免疫可诱导强大的全身和粘膜免疫。

IF 6.5 1区医学

NPJ Vaccines Pub Date : 2025-09-29 DOI: 10.1038/s41541-025-01260-4

Lei Yang, Timur O Yarovinsky, Kien Pham, Yibo Xi, Peiwen Lu, Akiko Iwasaki, John K Rose, Chen Liu

{"title":"Immunization with virus-like vesicle-based COVID-19 vaccine induces robust systemic and mucosal immunity.","authors":"Lei Yang, Timur O Yarovinsky, Kien Pham, Yibo Xi, Peiwen Lu, Akiko Iwasaki, John K Rose, Chen Liu","doi":"10.1038/s41541-025-01260-4","DOIUrl":"10.1038/s41541-025-01260-4","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) has led to significant global morbidity and mortality. Although several vaccines are approved, developing more effective candidates remains essential for long-term prevention. In this study, we present a COVID-19 vaccine candidate using a virus-like vesicle (VLV) platform, an enveloped self-amplifying RNA replicon incorporating an evolved Semliki Forest virus RNA polymerase and VSV glycoprotein. Two constructs were generated: VLV-S-FL (full-length spike protein) and VLV-S-RBD (receptor-binding domain). In C57BL/6J mice, VLV-S-FL elicited robust anti-spike antibody and T cell responses, with antibody levels comparable to those induced by the BNT162b2 mRNA vaccine. Prime-boost immunization with VLV-S-FL provided in vivo protection against SARS-CoV-2. Notably, intranasal boosting enhanced mucosal immunity, including IgA production and recruitment of CD4+ T, CD8+ T, and B cells in BALF. These findings suggest that VLV-S-FL is a promising COVID-19 vaccine capable of inducing both systemic and mucosal immune responses to prevent infection and reduce disease severity.","PeriodicalId":19335,"journal":{"name":"NPJ Vaccines","volume":"10 1","pages":"211"},"PeriodicalIF":6.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12480480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic effect of nucleoside modification and ionizable lipid composition on translation and immune responses to mRNA vaccines. 核苷修饰和可电离脂质组成对mRNA疫苗翻译和免疫应答的协同作用。

IF 6.5 1区医学

NPJ Vaccines Pub Date : 2025-09-29 DOI: 10.1038/s41541-025-01263-1

Hillary Danz, Allison Dauner, Shraddha Sharma, Mihaela Babiceanu, Nicholas Clark, Robert Jordan Ontiveros, Robert Amezquita, Alisa Zhilin-Roth, Eric Reyes, Catherine Khoo, Kara Gilbert, Janhavi Nadkarni, Omkar Chaudhary, Christina Lee, Ana Kume, Azadeh Bahadoran, Mona Motwani, Bin Lu, Wei Zong, Andrew Kettring, Alex Shumate, Shrirang Karve, Anusha Dias, Monica Wu, Xiaobo Gu, Yanhua Yan, Daniel G Anderson, Brian Schanen, Sudha Chivukula, Frank DeRosa

{"title":"Synergistic effect of nucleoside modification and ionizable lipid composition on translation and immune responses to mRNA vaccines.","authors":"Hillary Danz, Allison Dauner, Shraddha Sharma, Mihaela Babiceanu, Nicholas Clark, Robert Jordan Ontiveros, Robert Amezquita, Alisa Zhilin-Roth, Eric Reyes, Catherine Khoo, Kara Gilbert, Janhavi Nadkarni, Omkar Chaudhary, Christina Lee, Ana Kume, Azadeh Bahadoran, Mona Motwani, Bin Lu, Wei Zong, Andrew Kettring, Alex Shumate, Shrirang Karve, Anusha Dias, Monica Wu, Xiaobo Gu, Yanhua Yan, Daniel G Anderson, Brian Schanen, Sudha Chivukula, Frank DeRosa","doi":"10.1038/s41541-025-01263-1","DOIUrl":"10.1038/s41541-025-01263-1","url":null,"abstract":"Lipid nanoparticle (LNP) components can impact the safety and immunogenicity of mRNA vaccines. Here we examine the mechanisms contributing to the performance of mRNA-LNP vaccines by exploring the impact of nucleoside modifications and LNP components on translational efficiency, innate immune activation, and immunogenicity. Our data reveals several molecular and immunological parameters affected by nucleoside modification including a synergistic effect of the mRNA and ionizable lipid composition on the immune activation triggered by the mRNA-LNP formulation. Our results indicate changes in the LNP composition, independent from whether the mRNA is modified or unmodified, caused differential expression of genes associated with innate and antiviral immunity. We believe these findings offer valuable insights into mRNA vaccine function and offer strategies for enhancing vaccine efficacy and reducing the reactogenicity of next generation mRNA vaccines.","PeriodicalId":19335,"journal":{"name":"NPJ Vaccines","volume":"10 1","pages":"212"},"PeriodicalIF":6.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of repeated influenza vaccination and infection on durable seroprotection in healthcare workers. 重复流感疫苗接种和感染对卫生保健工作者持久血清保护的影响。

IF 6.5 1区医学

NPJ Vaccines Pub Date : 2025-09-29 DOI: 10.1038/s41541-025-01259-x

Mai-Chi Trieu, Amit Bansal, Marianne Sævik, Sonja Ljostveit, Åsne Jul-Larsen, Rebecca Jane Cox

{"title":"Effects of repeated influenza vaccination and infection on durable seroprotection in healthcare workers.","authors":"Mai-Chi Trieu, Amit Bansal, Marianne Sævik, Sonja Ljostveit, Åsne Jul-Larsen, Rebecca Jane Cox","doi":"10.1038/s41541-025-01259-x","DOIUrl":"10.1038/s41541-025-01259-x","url":null,"abstract":"Rapid evolution of seasonal influenza viruses necessitates annual vaccine reformulation to match circulating strains. Healthcare workers (HCWs) and high-risk groups are prioritised for annual influenza vaccination. However, repeated annual vaccination may affect immune protection. This study investigated the hemaglutination-inhibition (HI) antibody responses following influenza infection or repeated seasonal vaccination over four seasons in 250 HCWs with well-defined vaccination histories. Unvaccinated HCWs had high infection rates, with pre-existing antibodies providing protection. Infection or hybrid immunity generated higher antibody responses to A/H3N2 viruses than vaccination alone, whereas vaccination induced more durable A/H1N1 and B virus-specific antibodies. Vaccination boosted seroprotective antibodies, irrespective of previous vaccination histories. Moreover, repeated vaccination with the same virus for more than three consecutive seasons blunted antibody responses, while updating vaccine strains improved immunity. Annual influenza vaccination of HCWs should be strengthened to increase uptake, but next-generation influenza vaccines must improve vaccine immunogenicity, particularly against A/H3N2 viruses.","PeriodicalId":19335,"journal":{"name":"NPJ Vaccines","volume":"10 1","pages":"213"},"PeriodicalIF":6.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12480258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A multivalent mRNA-LNP cocktail vaccine confers superior efficacy against Staphylococcus aureus infection in murine models. 一种多价mRNA-LNP鸡尾酒疫苗在小鼠模型中对金黄色葡萄球菌感染具有优越的疗效。

IF 6.5 1区医学

NPJ Vaccines Pub Date : 2025-09-25 DOI: 10.1038/s41541-025-01244-4

Xingyue Gao, Yueling Zheng, Xingyun Wang, Jiahui Jin, Cong Liu, Chuanlan Yang, Peng George Wang, Yunjiao He

{"title":"A multivalent mRNA-LNP cocktail vaccine confers superior efficacy against Staphylococcus aureus infection in murine models.","authors":"Xingyue Gao, Yueling Zheng, Xingyun Wang, Jiahui Jin, Cong Liu, Chuanlan Yang, Peng George Wang, Yunjiao He","doi":"10.1038/s41541-025-01244-4","DOIUrl":"10.1038/s41541-025-01244-4","url":null,"abstract":"Staphylococcus aureus has been posing a significant global health threat, underscoring an urgent need for innovative preventive strategies, notably vaccines. This study presents an evaluation of a multi-target mRNA vaccine against S. aureus, engineered to target five pivotal virulence factors: the manganese transporter MntC, enterotoxin SEB, exotoxin HLA, adhesion factor FnBPA, and iron surface binding protein IsdB. In a parallel control setting, mice were immunized with either monovalent mRNA-LNPs, a multivalent mRNA-LNP cocktail, or a protein cocktail, and were subsequently assessed for humoral and cellular immune responses as well as the vaccines' protective efficacy. The findings demonstrated that the multivalent mRNA-LNP cocktail vaccine induced a robust and sustained humoral immune response, along with a stronger cellular immune response compared to both monovalent mRNA vaccines and the protein cocktail vaccine. This was characterized by increased secretion of IFN-γ, IL-2, IL-4, and IL-17A, suggesting a potent Th1/Th2/Th17 mixed immune response. Moreover, the cocktail vaccine demonstrated improved survival rates and a reduction in bacterial loads and organ damage. These results underscore the promise of a multi-target mRNA vaccine strategy in combating antibiotic-resistant Staphylococcus aureus.","PeriodicalId":19335,"journal":{"name":"NPJ Vaccines","volume":"10 1","pages":"210"},"PeriodicalIF":6.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Publisher Correction: AI-driven epitope prediction: a systematic review, comparative analysis, and practical guide for vaccine development. 人工智能驱动的表位预测：系统综述、比较分析和疫苗开发实用指南。

IF 6.5 1区医学

NPJ Vaccines Pub Date : 2025-09-23 DOI: 10.1038/s41541-025-01273-z

Francisca Villanueva-Flores, Javier I Sanchez-Villamil, Igor Garcia-Atutxa

引用次数: 0

A combined designed CSP and Pfs48/45 infection and transmission blocking vaccine for malaria. 一种联合设计的CSP和Pfs48/45疟疾感染和传播阻断疫苗。

IF 6.5 1区医学

NPJ Vaccines Pub Date : 2025-09-02 DOI: 10.1038/s41541-025-01262-2

Richi Gupta, Thayne H Dickey, Nichole D Salinas, Palak N Patel, Rui Ma, Dashuang Shi, Myesha Singleton, Tarik Ouahes, Thao P Pham, Kazutoyo Miura, Carole A Long, Lynn E Lambert, Niraj H Tolia

{"title":"A combined designed CSP and Pfs48/45 infection and transmission blocking vaccine for malaria.","authors":"Richi Gupta, Thayne H Dickey, Nichole D Salinas, Palak N Patel, Rui Ma, Dashuang Shi, Myesha Singleton, Tarik Ouahes, Thao P Pham, Kazutoyo Miura, Carole A Long, Lynn E Lambert, Niraj H Tolia","doi":"10.1038/s41541-025-01262-2","DOIUrl":"10.1038/s41541-025-01262-2","url":null,"abstract":"The multiple stages of the malaria parasite life cycle hampers vaccine development. Combining a pre-erythrocytic antigen with a transmission-blocking antigen would target two independent stages of the life cycle for disease control, resulting in a multistage vaccine that can prevent infection and disease transmission simultaneously. Here, we generated a self-assembled ferritin nanoparticle vaccine that simultaneously presents designed immunogens CSPj5c and 17-4 from the infection-blocking circumsporozoite and the transmission-blocking Pfs48/45 antigens. These immunogens were designed, through structure-based approaches, to retain protective epitopes and confer protection upon vaccination. Immunization with CSPj5c-17-4-ferritin nanoparticles conferred protection against challenge with transgenic sporozoites expressing Plasmodium falciparum CSP in mice, and purified IgGs from immunized rabbits elicited potent transmission-reducing activity. Addition of the engineered 17-4 improved the immune responses to CSPj5c and protection from sporozoite challenge. CSPj5c-17-4-ferritin is therefore a promising multistage malaria vaccine with a potential role in malaria control.","PeriodicalId":19335,"journal":{"name":"NPJ Vaccines","volume":"10 1","pages":"208"},"PeriodicalIF":6.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12405497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0