NPJ Schizophrenia最新文献_第5页

Intrinsic cerebellar functional connectivity of social cognition and theory of mind in first-episode psychosis patients. 首发精神病患者的社会认知和思维理论的小脑内在功能连接。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-12-03 DOI: 10.1038/s41537-021-00193-w

Soo Hwan Park, Taekwan Kim, Minji Ha, Sun-Young Moon, Silvia Kyungjin Lho, Minah Kim, Jun Soo Kwon

{"title":"Intrinsic cerebellar functional connectivity of social cognition and theory of mind in first-episode psychosis patients.","authors":"Soo Hwan Park, Taekwan Kim, Minji Ha, Sun-Young Moon, Silvia Kyungjin Lho, Minah Kim, Jun Soo Kwon","doi":"10.1038/s41537-021-00193-w","DOIUrl":"10.1038/s41537-021-00193-w","url":null,"abstract":"Neuroimaging studies have revealed how intrinsic dysconnectivity among cortical regions of the mentalizing network (MENT) and the mirror neuron system (MNS) could explain the theory of mind (ToM) deficit in schizophrenia patients. However, despite the concurrent involvement of the cerebellum with the cortex in social cognition, the dysfunction in intrinsic interplay between the cerebellar nodes of MENT/MNS and the cortex in schizophrenia patients remains unknown. Thus, we aimed to investigate whether resting-state cerebello-cortical dysconnectivity exists in first-episode psychosis (FEP) patients in relationship with their ToM deficit. A total of 37 FEP patients and 80 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging. Using a priori-defined cerebellar seeds that functionally connect to the MENT (right crus II) and MNS (right crus I), we compared cerebello-cortical functional connectivities (FCs) in FEP patients and HCs. Correlations between cerebello-parietal connectivities and ToM performance were investigated in FEP patients. FEP patients showed hyperconnectivity between the right crus II and anterior cingulate gyrus and between the right crus I and supplementary motor area, bilateral postcentral gyrus, and right central/parietal operculum (CO/PO). Hypoconnectivity was found between the right crus II and left supramarginal gyrus (SMG) in FEP patients. FCs between the right crus II and left SMG and between the right crus I and right CO/PO were significantly correlated with ToM scores in FEP patients. In accordance with the \"cognitive dysmetria\" hypothesis, our results highlight the importance of cerbello-cortical dysconnectivities in understanding social cognitive deficits in schizophrenia patients.","PeriodicalId":19328,"journal":{"name":"NPJ Schizophrenia","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2021-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39690249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic review of pathways to care in the U.S. for Black individuals with early psychosis. 美国黑人早期精神病患者治疗途径的系统回顾。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-12-02 DOI: 10.1038/s41537-021-00185-w

Oladunni Oluwoye, Beshaun Davis, Franchesca S Kuhney, Deidre M Anglin

{"title":"Systematic review of pathways to care in the U.S. for Black individuals with early psychosis.","authors":"Oladunni Oluwoye, Beshaun Davis, Franchesca S Kuhney, Deidre M Anglin","doi":"10.1038/s41537-021-00185-w","DOIUrl":"https://doi.org/10.1038/s41537-021-00185-w","url":null,"abstract":"The pathway to receiving specialty care for first episode psychosis (FEP) among Black youth in the US has received little attention despite documented challenges that negatively impact engagement in care and clinical outcomes. We conducted a systematic review of US-based research, reporting findings related to the pathway experiences of Black individuals with FEP and their family members. A systematic search of PubMed, PsycInfo, and Embase/Medline was performed with no date restrictions up to April 2021. Included studies had samples with at least 75% Black individuals and/or their family members or explicitly examined racial differences. Of the 80 abstracts screened, 28 peer-reviewed articles met the inclusion criteria. Studies were categorized into three categories: premordid and prodromal phase, help-seeking experiences, and the duration of untreated psychosis (DUP). Compounding factors such as trauma, substance use, and structural barriers that occur during the premorbid and prodromal contribute to delays in treatment initiation and highlight the limited use of services for traumatic childhood experiences (e.g., sexual abuse). Studies focused on help-seeking experiences demonstrated the limited use of mental health services and the potentially traumatic entry to services (e.g., law enforcement), which is associated with a longer DUP. Although the majority of studies focused on help-seeking experiences and predictors of DUP, findings suggests that for Black populations, there is a link between trauma and substance use in the pathway to care that impacts the severity of symptoms, initiation of treatment, and DUP. The present review also identifies the need for more representative studies of Black individuals with FEP.","PeriodicalId":19328,"journal":{"name":"NPJ Schizophrenia","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9248710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

The effect of sex on social cognition and functioning in schizophrenia. 性别对精神分裂症患者社会认知和功能的影响。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-12-01 DOI: 10.1038/s41537-021-00188-7

Marta Ferrer-Quintero, Michael F Green, William P Horan, David L Penn, Robert S Kern, Junghee Lee

{"title":"The effect of sex on social cognition and functioning in schizophrenia.","authors":"Marta Ferrer-Quintero, Michael F Green, William P Horan, David L Penn, Robert S Kern, Junghee Lee","doi":"10.1038/s41537-021-00188-7","DOIUrl":"https://doi.org/10.1038/s41537-021-00188-7","url":null,"abstract":"Social cognitive impairment is a core feature of schizophrenia and plays a critical role in poor community functioning in the disorder. However, our understanding of the relationship between key biological variables and social cognitive impairment in schizophrenia is limited. This study examined the effect of sex on the levels of social cognitive impairment and the relationship between social cognitive impairment and social functioning in schizophrenia. Two hundred forty-eight patients with schizophrenia (61 female) and 87 healthy controls (31 female) completed five objective measures and one subjective measure of social cognition. The objective measures included the Facial Affect Identification, Emotion in Biological Motion, Self-Referential Memory, MSCEIT Branch 4, and Empathic Accuracy tasks. The subjective measure was the Interpersonal Reactivity Index (IRI), which includes four subscales. Patients completed measures of social and non-social functional capacity and community functioning. For objective social cognitive tasks, we found a significant sex difference only on one measure, the MSCEIT Branch 4, which in both patient and control groups, females performed better than males. Regarding the IRI, females endorsed higher empathy-related items on one subscale. The moderating role of sex was found only for the association between objective social cognition and non-social functional capacity. The relationship was stronger in male patients than female patients. In this study, we found minimal evidence of a sex effect on social cognition in schizophrenia across subjective and objective measures. Sex does not appear to moderate the association between social cognition and functioning in schizophrenia.","PeriodicalId":19328,"journal":{"name":"NPJ Schizophrenia","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10677865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Surface area in the insula was associated with 28-month functional outcome in first-episode psychosis. 首发精神病患者脑岛表面积与28个月功能预后相关。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-11-29 DOI: 10.1038/s41537-021-00186-9

Shinsuke Koike, Mao Fujioka, Yoshihiro Satomura, Daisuke Koshiyama, Mariko Tada, Eisuke Sakakibara, Naohiro Okada, Yosuke Takano, Norichika Iwashiro, Tatsunobu Natsubori, Yinghan Zhu, Osamu Abe, Kenji Kirihara, Hidenori Yamasue, Kiyoto Kasai

{"title":"Surface area in the insula was associated with 28-month functional outcome in first-episode psychosis.","authors":"Shinsuke Koike, Mao Fujioka, Yoshihiro Satomura, Daisuke Koshiyama, Mariko Tada, Eisuke Sakakibara, Naohiro Okada, Yosuke Takano, Norichika Iwashiro, Tatsunobu Natsubori, Yinghan Zhu, Osamu Abe, Kenji Kirihara, Hidenori Yamasue, Kiyoto Kasai","doi":"10.1038/s41537-021-00186-9","DOIUrl":"https://doi.org/10.1038/s41537-021-00186-9","url":null,"abstract":"Many studies have tested the relationship between demographic, clinical, and psychobiological measurements and clinical outcomes in ultra-high risk for psychosis (UHR) and first-episode psychosis (FEP). However, no study has investigated the relationship between multi-modal measurements and long-term outcomes for >2 years. Thirty-eight individuals with UHR and 29 patients with FEP were measured using one or more modalities (cognitive battery, electrophysiological response, structural magnetic resonance imaging, and functional near-infrared spectroscopy). We explored the characteristics associated with 13- and 28-month clinical outcomes. In UHR, the cortical surface area in the left orbital part of the inferior frontal gyrus was negatively associated with 13-month disorganized symptoms. In FEP, the cortical surface area in the left insula was positively associated with 28-month global social function. The left inferior frontal gyrus and insula are well-known structural brain characteristics in schizophrenia, and future studies on the pathological mechanism of structural alteration would provide a clearer understanding of the disease.","PeriodicalId":19328,"journal":{"name":"NPJ Schizophrenia","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39930447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduced intrinsic neural timescales in schizophrenia along posterior parietal and occipital areas. 精神分裂症患者沿后顶叶和枕叶区的内在神经时间尺度减少。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-11-22 DOI: 10.1038/s41537-021-00184-x

Lavinia Carmen Uscătescu, Sarah Said-Yürekli, Lisa Kronbichler, Renate Stelzig-Schöler, Brandy-Gale Pearce, Luise Antonia Reich, Stefanie Weber, Wolfgang Aichhorn, Martin Kronbichler

引用次数: 9

Reply to: "Historical pursuits of the language pathway hypothesis of schizophrenia". 答复"精神分裂症语言通路假说的历史追求"。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-11-09 DOI: 10.1038/s41537-021-00183-y

Lena Palaniyappan, Jingnan Du, Jie Zhang, Jianfeng Feng

引用次数: 0

Historical pursuits of the language pathway hypothesis of schizophrenia. 精神分裂症语言路径假说的历史追寻。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-11-09 DOI: 10.1038/s41537-021-00182-z

Lynn E DeLisi

引用次数: 5

Salivary microbiome profiling reveals a dysbiotic schizophrenia-associated microbiota. 唾液微生物组分析揭示了与精神分裂症相关的微生物群失调。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-10-28 DOI: 10.1038/s41537-021-00180-1

Ying Qing, Lihua Xu, Gaoping Cui, Liya Sun, Xiaowen Hu, Xuhan Yang, Jie Jiang, Juan Zhang, Tianhong Zhang, Tao Wang, Lin He, Jijun Wang, Chunling Wan

{"title":"Salivary microbiome profiling reveals a dysbiotic schizophrenia-associated microbiota.","authors":"Ying Qing, Lihua Xu, Gaoping Cui, Liya Sun, Xiaowen Hu, Xuhan Yang, Jie Jiang, Juan Zhang, Tianhong Zhang, Tao Wang, Lin He, Jijun Wang, Chunling Wan","doi":"10.1038/s41537-021-00180-1","DOIUrl":"https://doi.org/10.1038/s41537-021-00180-1","url":null,"abstract":"Schizophrenia is a debilitating mental disorder and often has a prodromal period, referred to as clinical high risk (CHR) for psychosis, prior to the first episode. The etiology and pathogenesis of schizophrenia remain unclear. Despite the human gut microbiome being associated with schizophrenia, the role of the oral microbiome, which is a vital player in the mouth-body connection, is not well understood. To address this, we performed 16S rRNA gene sequencing to investigate the salivary microbiome in 85 patients with drug-naïve first-episode schizophrenia (FES), 43 individuals at CHR, and 80 healthy controls (HCs). The salivary microbiome of FES patients was characterized by higher α-diversity and lower β-diversity heterogeneity than those of CHR subjects and HCs. Proteobacteria, the predominant phylum, was depleted, while Firmicutes and the Firmicutes/Proteobacteria ratio was enriched, in a stepwise manner from HC to CHR to FES. H2S-producing bacteria exhibited disease-stage-specific enrichment and could be potential diagnostic biomarkers for FES and CHR. Certain salivary microbiota exhibited disease-specific correlation patterns with symptomatic severities, peripheral pro-inflammatory cytokines, thioredoxin, and S100B in FES. Furthermore, the metabolic functions from inferred metagenomes of the salivary microbiome were disrupted in FES, especially amino acid metabolism, carbohydrate metabolism, and xenobiotic degradation. This study has established a link between salivary microbiome alterations and disease initiation and provided the hypothesis of how the oral microbiota could influence schizophrenia.","PeriodicalId":19328,"journal":{"name":"NPJ Schizophrenia","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2021-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39660094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Cognitive, creative, functional, and clinical symptom improvements in schizophrenia after an integrative cognitive remediation program: a randomized controlled trial. 综合认知补救方案后精神分裂症患者的认知、创造性、功能和临床症状改善:一项随机对照试验

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-10-28 DOI: 10.1038/s41537-021-00181-0

Agurne Sampedro, Javier Peña, Pedro Sánchez, Naroa Ibarretxe-Bilbao, Ainara Gómez-Gastiasoro, Nagore Iriarte-Yoller, Cristóbal Pavón, Mikel Tous-Espelosin, Natalia Ojeda

{"title":"Cognitive, creative, functional, and clinical symptom improvements in schizophrenia after an integrative cognitive remediation program: a randomized controlled trial.","authors":"Agurne Sampedro, Javier Peña, Pedro Sánchez, Naroa Ibarretxe-Bilbao, Ainara Gómez-Gastiasoro, Nagore Iriarte-Yoller, Cristóbal Pavón, Mikel Tous-Espelosin, Natalia Ojeda","doi":"10.1038/s41537-021-00181-0","DOIUrl":"https://doi.org/10.1038/s41537-021-00181-0","url":null,"abstract":"This study analyzed the effectiveness of an integrative cognitive remediation program (REHACOP) in improving neurocognition, social cognition, creativity, functional outcome, and clinical symptoms in patients with schizophrenia. In addition, possible mediators predicting improvement in functional outcomes were explored. The program combined cognitive remediation with social cognitive training and social and functional skill training over 20 weeks. The sample included 94 patients, 47 in the REHACOP group and 47 in the active control group (occupational activities). Significant differences were found between the two groups in change scores of processing speed, working memory, verbal memory (VM), inhibition, theory of mind, emotion processing (EP), figural creative strengths, functional competence, disorganization, excitement, and primary negative symptoms. A mediational analysis revealed that changes in VM, inhibition, and EP partially explained the effect of cognitive remediation on functional competence improvement. This study provides initial evidence of the effect of integrative cognitive remediation on primary negative symptoms and creativity.","PeriodicalId":19328,"journal":{"name":"NPJ Schizophrenia","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2021-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9217241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The interaction of lipids and inflammatory markers predict negative symptom severity in patients with schizophrenia. 脂质和炎症标志物的相互作用预测精神分裂症患者的阴性症状严重程度。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-10-20 DOI: 10.1038/s41537-021-00179-8

David R Goldsmith, Nicholas Massa, Brian J Miller, Andrew H Miller, Erica Duncan

引用次数: 6