脂质和炎症标志物的相互作用预测精神分裂症患者的阴性症状严重程度。

IF 5.7 2区医学 Q1 PSYCHIATRY

NPJ Schizophrenia Pub Date : 2021-10-20 DOI:10.1038/s41537-021-00179-8

David R Goldsmith, Nicholas Massa, Brian J Miller, Andrew H Miller, Erica Duncan

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引用次数: 6

摘要

由于缺乏有效的治疗方法，寻找精神分裂症阴性症状的生物学预测因子和新机制具有重要意义。越来越多的数据支持代谢功能障碍和炎症在精神疾病的奖励处理缺陷中的作用。在此，我们发现脂质和炎症之间的相互作用是精神分裂症患者更严重的阴性症状严重程度的预测因子。未来的研究可能会寻求进一步阐明这种关系，从而揭示阴性症状的新治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The interaction of lipids and inflammatory markers predict negative symptom severity in patients with schizophrenia.

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The interaction of lipids and inflammatory markers predict negative symptom severity in patients with schizophrenia.

Finding biological predictors and novel mechanisms underlying negative symptoms of schizophrenia is of significant importance given the lack of effective treatments. Increasing data support a role for metabolic dysfunction and inflammation in reward processing deficits in psychiatric illness. Herein, we found an interaction between lipids and inflammation as a predictor of worse negative symptom severity in individuals with schizophrenia. Future studies may seek to further elucidate this relationship and thereby reveal novel treatment targets for negative symptoms.

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来源期刊

NPJ Schizophrenia Medicine-Psychiatry and Mental Health

CiteScore

6.30

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： npj Schizophrenia is an international, peer-reviewed journal that aims to publish high-quality original papers and review articles relevant to all aspects of schizophrenia and psychosis, from molecular and basic research through environmental or social research, to translational and treatment-related topics. npj Schizophrenia publishes papers on the broad psychosis spectrum including affective psychosis, bipolar disorder, the at-risk mental state, psychotic symptoms, and overlap between psychotic and other disorders.