你读懂了我的想法:持续精神病经历的人的威胁评估的fMRI标记。

IF 8.3 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Raphael Underwood, Liam Mason, Owen O'Daly, Jeffrey Dalton, Andrew Simmons, Gareth J Barker, Emmanuelle Peters, Veena Kumari
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引用次数: 1

摘要

异常的知觉体验在一般人群中相对常见。有证据表明,区分有持续性精神病经历(pe)需要照顾的人与没有需要照顾的人的关键是他们如何评估自己的异常经历。在这里,我们的目的是分别描述需要和不需要pe护理的人的威胁性和非威胁性评估的神经回路。共有48名参与者,包括精神病谱系障碍患者(临床组,n = 16),不需要护理的pe患者(非临床组,n = 16)和无pe健康对照者(n = 16),在完成旨在诱导异常知觉体验的心灵感应任务时接受了功能磁共振成像。对异常知觉经验的评估进行了检查,以及在此窗口期间的功能性大脑反应,以获得显着的组差异。我们还研究了激活是否与参与者在任务中报告的主观威胁评估共同变化。与非临床和非pe对照组相比,临床组报告的主观威胁评估升高,两个非临床组之间没有差异。与非临床组和对照组相比,这种结果模式伴随着临床组额上回和额下回的激活减少。楔前叶激活与任务中报告的威胁评估成比例。在持续异常经历的背景下,恢复力可以通过额顶叶区域的完整功能来解释,并且可能与情境化和灵活评估精神病经历的能力相对应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

You read my mind: fMRI markers of threatening appraisals in people with persistent psychotic experiences.

You read my mind: fMRI markers of threatening appraisals in people with persistent psychotic experiences.

You read my mind: fMRI markers of threatening appraisals in people with persistent psychotic experiences.

You read my mind: fMRI markers of threatening appraisals in people with persistent psychotic experiences.

Anomalous perceptual experiences are relatively common in the general population. Evidence indicates that the key to distinguishing individuals with persistent psychotic experiences (PEs) with a need for care from those without is how they appraise their anomalous experiences. Here, we aimed to characterise the neural circuits underlying threatening and non-threatening appraisals in people with and without a need for care for PEs, respectively. A total of 48 participants, consisting of patients with psychosis spectrum disorder (clinical group, n = 16), non-need-for-care participants with PEs (non-clinical group, n = 16), and no-PE healthy control participants (n = 16), underwent functional magnetic resonance imaging while completing the Telepath task, designed to induce an anomalous perceptual experience. Appraisals of the anomalous perceptual experiences were examined, as well as functional brain responses during this window, for significant group differences. We also examined whether activation co-varied with the subjective threat appraisals reported in-task by participants. The clinical group reported elevated subjective threat appraisals compared to both the non-clinical and no-PE control groups, with no differences between the two non-clinical groups. This pattern of results was accompanied by reduced activation in the superior and inferior frontal gyri in the clinical group as compared to the non-clinical and control groups. Precuneus activation scaled with threat appraisals reported in-task. Resilience in the context of persistent anomalous experiences may be explained by intact functioning of fronto-parietal regions, and may correspond to the ability to contextualise and flexibly evaluate psychotic experiences.

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来源期刊
ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces 工程技术-材料科学:综合
CiteScore
16.00
自引率
6.30%
发文量
4978
审稿时长
1.8 months
期刊介绍: ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.
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