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Nihon saikingaku zasshi. Japanese journal of bacteriology最新文献

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Studies on the mechanism of bacterial flagellar rotation and the flagellar number regulation. 细菌鞭毛旋转机制及鞭毛数目调节的研究。
Nihon saikingaku zasshi. Japanese journal of bacteriology Pub Date : 2016-01-01 DOI: 10.3412/jsb.71.185
Seiji Kojima
{"title":"Studies on the mechanism of bacterial flagellar rotation and the flagellar number regulation.","authors":"Seiji Kojima","doi":"10.3412/jsb.71.185","DOIUrl":"https://doi.org/10.3412/jsb.71.185","url":null,"abstract":"<p><p>Many motile bacteria have the motility organ, the flagellum. It rotates by the rotary motor driven by the ion-motive force and is embedded in the cell surface at the base of each flagellar filament. Many researchers have been studying its rotary mechanism for years, but most of the energy conversion processes have been remained in mystery. We focused on the flagellar stator, which works at the core process of energy conversion, and found that the periplasmic region of the stator changes its conformation to be activated only when the stator units are incorporated into the motor and anchored at the cell wall. Meanwhile, the physiologically important supramolecular complex is localized in the cell at the right place and the right time with a proper amount. How the cell achieves such a proper localization is the fundamental question for life science, and we undertake this problem by analyzing the mechanism for biogenesis of a single polar flagellum of Vibrio alginolyticus. Here I describe the molecular mechanism of how the flagellum is generated at the specific place with a proper number, and also how the flagellar stator is incorporated into the motor to complete the functional motor assembly, based on our studies.</p>","PeriodicalId":19308,"journal":{"name":"Nihon saikingaku zasshi. Japanese journal of bacteriology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3412/jsb.71.185","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34407262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A complete view of the Escherichia coli O-antigen biosynthesis gene cluster and the development of molecular-based O-serogrouping methods. 大肠杆菌o型抗原生物合成基因簇的完整观点和基于分子的o型血清分组方法的发展。
Nihon saikingaku zasshi. Japanese journal of bacteriology Pub Date : 2016-01-01 DOI: 10.3412/JSB.71.209
A. Iguchi
{"title":"A complete view of the Escherichia coli O-antigen biosynthesis gene cluster and the development of molecular-based O-serogrouping methods.","authors":"A. Iguchi","doi":"10.3412/JSB.71.209","DOIUrl":"https://doi.org/10.3412/JSB.71.209","url":null,"abstract":"Much of what we know about Escherichia coli populations and epidemiology is defined at some level by O serogroups. Moreover, in our collective knowledge, outbreak and disease reports and elsewhere, all information of pathogenic E. coli have O serogroup records. O-serogroup diversification shows a strong association with the genetic diversity of O-antigen biosynthesis genes, and O-serogroup-specific sequences can be used as genetic markers for identifying O serogroups. We sequenced all the known O-antigen biosynthesis gene clusters (O-AGCs) from the 184 E. coli defined O serogroups and determined their genetic makeup and diversity. Subsequently, based on a highly detailed analysis of O-AGCs, we developed comprehensive and practical molecular O-serogrouping platforms; PCR-based \"E. coli O-genotuping PCR\" and in silico-based \"SerotypeFinder\". These simple and exhaustive systems may integrate microbial typing, genomics and evolutionary analyses.","PeriodicalId":19308,"journal":{"name":"Nihon saikingaku zasshi. Japanese journal of bacteriology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88868743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Obituary. 讣告。
Nihon saikingaku zasshi. Japanese journal of bacteriology Pub Date : 2016-01-01 DOI: 10.3412/jsb.71.181
{"title":"Obituary.","authors":"","doi":"10.3412/jsb.71.181","DOIUrl":"https://doi.org/10.3412/jsb.71.181","url":null,"abstract":"","PeriodicalId":19308,"journal":{"name":"Nihon saikingaku zasshi. Japanese journal of bacteriology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34559480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Actin cytoskeleton-modulating T3SS2 effectors and their contribution to the Vibrio parahaemolyticus-induced diarrhea. 肌动蛋白细胞骨架调节T3SS2效应物及其对副溶血性弧菌诱导腹泻的作用。
Nihon saikingaku zasshi. Japanese journal of bacteriology Pub Date : 2016-01-01 DOI: 10.3412/JSB.71.199
Hirotaka Hiyoshi
{"title":"Actin cytoskeleton-modulating T3SS2 effectors and their contribution to the Vibrio parahaemolyticus-induced diarrhea.","authors":"Hirotaka Hiyoshi","doi":"10.3412/JSB.71.199","DOIUrl":"https://doi.org/10.3412/JSB.71.199","url":null,"abstract":"To understand how bacterial pathogens cause diseases is the most important step in order to prevent the infection and develop an effective treatment. However, the past proceeding studies make us aware of quite-complicated interactions between the host and pathogenic bacteria. Vibrio parahaemolyticus, a food-born pathogen that is a subject of our study, causes inflammatory diarrhea in human upon ingestion of contaminated raw or undercooked seafood. Many virulence factors has been proposed since its discovery in Osaka around 70 years ago, while our research group has revealed that one of these virulence factors, type 3 secretion system 2 (T3SS2), is necessary for diarrhea induced by this bacterium. In addition, we recently found two novel T3SS2 effectors (VopO and VopV) that manipulate the actin cytoskeleton in infected host cells. In this article, I would like to show our findings with regard to biological activities of the effectors and their contributions to the T3SS2-induced enterotoxicity.","PeriodicalId":19308,"journal":{"name":"Nihon saikingaku zasshi. Japanese journal of bacteriology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90808809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pathogenicity of Enterococcus]. [肠球菌的致病性]。
Nihon saikingaku zasshi. Japanese journal of bacteriology Pub Date : 2016-01-01 DOI: 10.3412/jsb.71.1
Yasuyoshi Ike
{"title":"[Pathogenicity of Enterococcus].","authors":"Yasuyoshi Ike","doi":"10.3412/jsb.71.1","DOIUrl":"10.3412/jsb.71.1","url":null,"abstract":"","PeriodicalId":19308,"journal":{"name":"Nihon saikingaku zasshi. Japanese journal of bacteriology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90622328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Luncheon Seminar. 午餐研讨会。
Nihon saikingaku zasshi. Japanese journal of bacteriology Pub Date : 2016-01-01 DOI: 10.3412/jsb.71.165
{"title":"Luncheon Seminar.","authors":"","doi":"10.3412/jsb.71.165","DOIUrl":"https://doi.org/10.3412/jsb.71.165","url":null,"abstract":"","PeriodicalId":19308,"journal":{"name":"Nihon saikingaku zasshi. Japanese journal of bacteriology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91183335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Evaluation of resistance mechanism against antimicrobial factors in gram positive bacteria]. [革兰氏阳性菌对抗菌因子的耐药机制评价]。
Nihon saikingaku zasshi. Japanese journal of bacteriology Pub Date : 2015-01-01 DOI: 10.3412/jsb.70.391
M. Kawada-Matsuo
{"title":"[Evaluation of resistance mechanism against antimicrobial factors in gram positive bacteria].","authors":"M. Kawada-Matsuo","doi":"10.3412/jsb.70.391","DOIUrl":"https://doi.org/10.3412/jsb.70.391","url":null,"abstract":"It is known that various antibacterial agents are observed in human for preventing bacterial infection. In this study, in order to elucidate the resistance mechanism against antimicrobial agents derived of human and bacteriocins derived of commensal bacteria, we systematically evaluated the roles of the bacteria-specific two-component systems of Staphylococcus aureus and Streptococcus mutans which colonize to different sites. Two-component systems (TCSs) are specific regulatory systems in bacteria that play an important role in sensing and adapting to the environment. As the result, four TCSs of S. aureus and three TCSs of S. mutans were associated with resistance against defensin and LL37 as antimaicrobial peptides and nisin A and nukacin ISK-1 as bacteriocins. Two TCSs that are individually associated with resistance against the bacteriocins nisin A (class I type A[I]) and nukacin ISK-1 (class I type A[II]) were identified in S. mutans, whereas one TCS is associated with main resistance against the both of nisin A and nukacin ISK-1. This result suggested that TCSs play important roles on acquisition of human- and bacteria-derived antibacterial agents. However, the resistance mechanism via TCS in S. aureus is quite different from that of in S. mutans. Additional evidence suggests that these TCSs are required for co-existence with other bacteria producing to nisin A or nukacin ISK-1, meaning that the roles of bacteriocins in the interactions between different species of commensal bacteria and the importance of TCSs in this process. Our results will highlight the roles of bacterial colonization in human being are constituted on the adaptation against antibacterial agents derived from human and commensal bacteria via TCSs.","PeriodicalId":19308,"journal":{"name":"Nihon saikingaku zasshi. Japanese journal of bacteriology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76839520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Structure and function of the bacterial flagellar type III protein export system in Salmonella
]. [沙门氏菌鞭毛III型蛋白输出系统的结构与功能
]。
Nihon saikingaku zasshi. Japanese journal of bacteriology Pub Date : 2015-01-01 DOI: 10.3412/jsb.70.351
Tohru Minamino
{"title":"[Structure and function of the bacterial flagellar type III protein export system in Salmonella\u2029].","authors":"Tohru Minamino","doi":"10.3412/jsb.70.351","DOIUrl":"https://doi.org/10.3412/jsb.70.351","url":null,"abstract":"<p><p>The bacterial flagellum is a filamentous organelle that propels the bacterial cell body in liquid media. For construction of the bacterial flagellum beyond the cytoplasmic membrane, flagellar component proteins are transported by its specific protein export apparatus from the cytoplasm to the distal end of the growing flagellar structure. The flagellar export apparatus consists of a transmembrane export gate complex and a cytoplasmic ATPase ring complex. Flagellar substrate-specific chaperones bind to their cognate substrates in the cytoplasm and escort the substrates to the docking platform of the export gate. The export apparatus utilizes ATP and proton motive force across the cytoplasmic membrane as the energy sources to drive protein export and coordinates protein export with assembly by ordered export of substrates to parallel with their order of assembly. In this review, we summarize our current understanding of the structure and function of the flagellar protein export system in Salmonella enterica serovar Typhimurium. </p>","PeriodicalId":19308,"journal":{"name":"Nihon saikingaku zasshi. Japanese journal of bacteriology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3412/jsb.70.351","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34124916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
[Current status of bacteriological studies at prefectural and municipal public health institutes in Japan]. [日本县和市公共卫生机构细菌学研究的现状]。
Nihon saikingaku zasshi. Japanese journal of bacteriology Pub Date : 2015-01-01 DOI: 10.3412/jsb.70.309
Hiroto Shinomiya, Kazuko Seto, Jun Kawase, Kentaro Arikawa, Keiji Funatogawa, Masahiro Suzuki, Hiroaki Kubota, Komei Shirabe
{"title":"[Current status of bacteriological studies at prefectural and municipal public health institutes in Japan].","authors":"Hiroto Shinomiya,&nbsp;Kazuko Seto,&nbsp;Jun Kawase,&nbsp;Kentaro Arikawa,&nbsp;Keiji Funatogawa,&nbsp;Masahiro Suzuki,&nbsp;Hiroaki Kubota,&nbsp;Komei Shirabe","doi":"10.3412/jsb.70.309","DOIUrl":"https://doi.org/10.3412/jsb.70.309","url":null,"abstract":"<p><p>Prefectural and municipal public health institutes are located in prefectures and ordinance-designated cities in Japan, and play a vital role in the regional surveillance of infectious diseases and foodborne illnesses. These institutes, in close cooperation with national institutes such as the National Institute of Infectious Diseases and the National Institute of Health Sciences, construct the national surveillance network for infectious diseases and their causative agents. Bacteriological examinations and studies on a variety of infectious diseases and foodborne illnesses are core activities of prefectural and municipal public health institutes, through which novel and important bacteriological findings have been acquired. In this article, we report the latest findings regarding bacteriological examinations/studies and interesting cases at these institutes, especially concerning foodborne illnesses, tuberculosis, and antimicrobial resistances. </p>","PeriodicalId":19308,"journal":{"name":"Nihon saikingaku zasshi. Japanese journal of bacteriology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33348650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Molecular targets of bacterial effectors and toxins that underlie vulnerability to diseases]. [导致疾病易感性的细菌效应物和毒素的分子目标]。
Nihon saikingaku zasshi. Japanese journal of bacteriology Pub Date : 2015-01-01 DOI: 10.3412/jsb.70.319
Takeshi Shimizu, Yukako Fujinaga, Akiko Takaya, Hiroshi Ashida, Toshio Kodama, Masanori Hatakeyama
{"title":"[Molecular targets of bacterial effectors and toxins that underlie vulnerability to diseases].","authors":"Takeshi Shimizu,&nbsp;Yukako Fujinaga,&nbsp;Akiko Takaya,&nbsp;Hiroshi Ashida,&nbsp;Toshio Kodama,&nbsp;Masanori Hatakeyama","doi":"10.3412/jsb.70.319","DOIUrl":"https://doi.org/10.3412/jsb.70.319","url":null,"abstract":"<p><p>Pathogenic bacteria produce a variety of effectors and/or toxins, which subvert target cell/tissue functions in the infected hosts. Some of those effectors/toxins also perturb host defense mechanism, thereby making up more complicated pathophysiological conditions. Such bacterial effectors/toxins may have been positively selected during evolution because they directly strike vulnerable points in the host system. In turn, this indicates that systemic exploration of molecules and signaling pathways targeted by bacterial effectors/toxins provides a powerful tool in digging up an unexpected Achilles' heel(s), malfunctioning of which gives rise to disorders not restricted to infectious diseases. Based on this viewpoint, this review shows molecular basis underlying host susceptibility and vulnerability to diseases through the studies of host molecules targeted by bacterial effectors and toxins. </p>","PeriodicalId":19308,"journal":{"name":"Nihon saikingaku zasshi. Japanese journal of bacteriology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3412/jsb.70.319","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33348651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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