肌动蛋白细胞骨架调节T3SS2效应物及其对副溶血性弧菌诱导腹泻的作用。

Hirotaka Hiyoshi
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引用次数: 0

摘要

了解细菌病原体如何引起疾病是预防感染和开发有效治疗方法的最重要步骤。然而,过去进行的研究使我们意识到宿主与致病菌之间相当复杂的相互作用。副溶血性弧菌是一种食源性病原体,是我们研究的主题,在食用被污染的生或未煮熟的海鲜后引起人类炎症性腹泻。自70年前在大阪发现以来,已经提出了许多毒力因子,而我们的研究小组已经发现其中一种毒力因子,3型分泌系统2 (T3SS2),是由这种细菌引起的腹泻所必需的。此外,我们最近发现了两种新的T3SS2效应物(VopO和VopV),它们在感染的宿主细胞中操纵肌动蛋白细胞骨架。在这篇文章中,我想展示我们关于效应物的生物活性及其对t3ss2诱导的肠毒性的贡献的发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Actin cytoskeleton-modulating T3SS2 effectors and their contribution to the Vibrio parahaemolyticus-induced diarrhea.
To understand how bacterial pathogens cause diseases is the most important step in order to prevent the infection and develop an effective treatment. However, the past proceeding studies make us aware of quite-complicated interactions between the host and pathogenic bacteria. Vibrio parahaemolyticus, a food-born pathogen that is a subject of our study, causes inflammatory diarrhea in human upon ingestion of contaminated raw or undercooked seafood. Many virulence factors has been proposed since its discovery in Osaka around 70 years ago, while our research group has revealed that one of these virulence factors, type 3 secretion system 2 (T3SS2), is necessary for diarrhea induced by this bacterium. In addition, we recently found two novel T3SS2 effectors (VopO and VopV) that manipulate the actin cytoskeleton in infected host cells. In this article, I would like to show our findings with regard to biological activities of the effectors and their contributions to the T3SS2-induced enterotoxicity.
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