[幽门螺杆菌基因组和表观基因组多样性]。

Y. Furuta
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引用次数: 1

摘要

幽门螺杆菌感染人的胃,引起包括胃癌在内的各种胃疾病。该物种还以快速进化和广泛的基因组序列地理多样性而闻名。本团队对日本患者幽门螺杆菌分离株的全基因组序列进行了测序,并与其他地理来源的幽门螺杆菌菌株的全基因组序列进行了比较,发现不仅基因库,而且基因组结构和DNA甲基化等表观遗传修饰具有很大的多样性,其机制多种多样。基因组倒置事件具有地理特异性,其中一些在其末端发生基因复制。幽门螺杆菌基因组的DNA甲基化状态表明,甲基转移酶基因库的存在和缺失以及甲基转移酶基因中靶识别结构域的移动使它们的DNA甲基化状态多样化。组学分析表明,甲基化靶序列和转录组状态实际上是通过结构域序列的移动而多样化的。我们认为幽门螺杆菌利用这些基因组结构和甲基组多样性进行适应性进化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Diversity in genome and epigenome of Helicobacter pylori].
Helicobacter pylori infects human stomach and cause various gastric diseases including gastric cancer. The species is also known for rapid evolution and wide geographical diversity of genome sequence. Our team sequenced whole genome sequences of H. pylori strains isolated from Japanese patients and compared with whole genome sequences of H. pylori strains with other geographic origin and found that not only the gene repertoire but also genome structures and epigenetic modifications such as DNA methylations had large diversity with various mechanisms. Genome inversion events were geography specific and some of them were found to occur with gene duplication at their termini. DNA methylation states of H. pylori genomes suggested that they are diversified by both existence/absence repertoire of methyltransferase genes and by the movement of target recognition domain in the methyltransferase genes. Omics analysis revealed that methylation target sequence and transcriptome status are actually diversified by the domain sequence movement. We suggested that H. pylori utilizes these genome structure and methylome diversity for its adaptive evolution.
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